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  1. Recombinant human B-type natriuretic peptide (rhBNP) has been indicated for the treatment of acute decompensated heart failure (ADHF). However, the therapeutic efficacy of intravenous rhBNP is not always satis...

    Authors: Hai-Yan Pan, Jian-Hua Zhu, Yong Gu, Xiao-Hong Yu, Min Pan and Hong-Yin Niu
    Citation: BMC Cardiovascular Disorders 2014 14:31
    Content type: Research article Published on:

  3. Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function ...

    Authors: Karien J Rodriguez, Laura M Piechura, Ana M Porras and Kristyn S Masters
    Citation: BMC Cardiovascular Disorders 2014 14:29
    Content type: Research article Published on:

  4. Rheumatic heart disease (RHD), the only long term consequence of acute rheumatic fever, remains a leading cause of morbidity and mortality among young adults in Uganda. An inherited susceptibility to acute rhe...

    Authors: Emmy Okello, Andrea Beaton, Charles K Mondo, Paul Kruszka, Noah Kiwanuka, Richard Odoi-Adome and Juergen Freers
    Citation: BMC Cardiovascular Disorders 2014 14:28
    Content type: Research article Published on:

  5. Indicators of cardiometabolic risk typically include non-clinical factors (e.g., smoking). While the incorporation of non-clinical factors can improve absolute risk prediction, it is impossible to study the co...

    Authors: Suzanne J Carroll, Catherine Paquet, Natasha J Howard, Robert J Adams, Anne W Taylor and Mark Daniel
    Citation: BMC Cardiovascular Disorders 2014 14:27
    Content type: Research article Published on:

  6. A link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial. This study sought to determine whether elevated s...

    Authors: Li Qin, Zhen Yang, Hongxia Gu, Shuai Lu, Qun Shi, Yin Xing, Xiaoyong Li, Rui Li, Guang Ning and Qing Su
    Citation: BMC Cardiovascular Disorders 2014 14:26
    Content type: Research article Published on:

  7. Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the pre...

    Authors: Julian PJ Halcox, Carine Roy, Florence Tubach, José R Banegas, Jean Dallongeville, Guy De Backer, Eliseo Guallar, Ogün Sazova, Jesús Medina, Joep Perk, Philippe Gabriel Steg, Fernando Rodríguez-Artalejo and Claudio Borghi
    Citation: BMC Cardiovascular Disorders 2014 14:25
    Content type: Research article Published on:

  8. Previous studies suggested that high dietary carbohydrate intake is associated with increased cardiovascular risk through raised triglyceride and decreased high-density lipoprotein-cholesterol levels. However,...

    Authors: Hiu-Ting Chan, Yap-Hang Chan, Kai Hang Yiu, Sheung-Wai Li, Sidney Tam, Chu-Pak Lau and Hung-Fat Tse
    Citation: BMC Cardiovascular Disorders 2014 14:24
    Content type: Research article Published on:

  9. We examined the relationship between central blood pressure (BP), brachial BP with carotid atherosclerosis and microvascular complications in type 2 diabetes mellitus (T2DM).

    Authors: Chan-Hee Jung, Sang-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang and Ji-Oh Mok
    Citation: BMC Cardiovascular Disorders 2014 14:23
    Content type: Research article Published on:

  10. The R518X/KCNQ1 mutation is a common cause of autosomal recessive (Jervell and Lange Nielsen Syndrome- JLNS) and autosomal dominant long QT syndrome (LQTS) worldwide. In Sweden p.R518X accounts for the majority o...

    Authors: Annika Winbo, Eva-Lena Stattin, Charlotte Nordin, Ulla-Britt Diamant, Johan Persson, Steen M Jensen and Annika Rydberg
    Citation: BMC Cardiovascular Disorders 2014 14:22
    Content type: Research article Published on:

  11. The optimal duration of dual antiplatelet therapy after percutaneous coronary intervention (PCI) remains uncertain. The objective of this study was to examine the association between duration of dual antiplate...

    Authors: Shih-Chin Chen, Fei-Yuan Hsiao, Chii-Ming Lee, William Wei-Yuan Hsu and Churn-Shiouh Gau
    Citation: BMC Cardiovascular Disorders 2014 14:21
    Content type: Research article Published on:

  12. Coronary heart disease (CHD) is a major cause of morbidity and mortality, and cardiac rehabilitation (CR) is still not well developed in mainland China. The objective of this study is to investigate the barrie...

    Authors: Hong Jin, Qin Wei, Long Chen, Qin Sun, Yun Zhang, Juan Wu, Genshan Ma and Naifeng Liu
    Citation: BMC Cardiovascular Disorders 2014 14:20
    Content type: Research article Published on:

  13. Statins are commonly used to lower total cholesterol levels in the general population to prevent cardiovascular events. However, the effects of statins in patients with chronic kidney disease remain unclear. W...

    Authors: Xiao Zhang, Chun Xiang, Yu-Hao Zhou, An Jiang, Ying-Yi Qin and Jia He
    Citation: BMC Cardiovascular Disorders 2014 14:19
    Content type: Research article Published on:

  14. Coronary artery disease (CAD) is one of the most common diseases leading to mortality and morbidity worldwide. There is considerable debate on whether serum transforming growth factor β1 (TGF-β1) levels are as...

    Authors: Can Chen, Wei Lei, Wenjiang Chen, Jianfeng Zhong, Xiaoxin Gao, Bo Li, Huailong Wang and Congxin Huang
    Citation: BMC Cardiovascular Disorders 2014 14:18
    Content type: Research article Published on:

  15. The editors of BMC Cardiovascular Disorders would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).

    Authors: Tim Shipley
    Citation: BMC Cardiovascular Disorders 2014 14:17
    Content type: Reviewer acknowledgement Published on:

  16. Little is known about the relationship between cardiovascular risk, disease and actual use of aspirin in the community.

    Authors: Gregory A Roth, Catherine W Gillespie, Ali A Mokdad, Danny D Shen, David W Fleming, Andy Stergachis, Christopher JL Murray and Ali H Mokdad
    Citation: BMC Cardiovascular Disorders 2014 14:16
    Content type: Research article Published on:

  17. Chronic kidney disease is associated with increased risk of mortality. We examined the impact of moderate and severe renal insufficiency (RI) on short- and long-term mortality among unselected patients with ST...

    Authors: Jonas Emil Sabroe, Per Thayssen, Lisbeth Antonsen, Mikkel Hougaard, Knud Nørregaard Hansen and Lisette Okkels Jensen
    Citation: BMC Cardiovascular Disorders 2014 14:15
    Content type: Research article Published on:

  18. Chronic stable angina (CSA) has a major negative impact on health-related quality of life (HRQL) including poor general health status, psychological distress, and inability to self-manage.

    Authors: Michael McGillion, Sheila O’Keefe-McCarthy, Sandra L Carroll, J Charles Victor, Tammy Cosman, Allison Cook, John G Hanlon, E Marc Jolicoeur, Noorin Jamal, Robert McKelvie and Heather M Arthur
    Citation: BMC Cardiovascular Disorders 2014 14:14
    Content type: Research article Published on:

  19. Lactococcus garvieae is a rare cause of infective endocarditis (IE) in humans and the bacterium can easily be misidentified. Intracranial haemorrhage often occurs in conjunction with IE, but subdural haemorrhage...

    Authors: Magnus Rasmussen, Josefin Björk Werner, Mikaela Dolk and Bertil Christensson
    Citation: BMC Cardiovascular Disorders 2014 14:13
    Content type: Case report Published on:

  20. Weight monitoring is an important element of HF self-care, yet the most clinically meaningful way to evaluate weight monitoring adherence is uncertain. We conducted this study to evaluate the association of (1...

    Authors: Christine D Jones, George M Holmes, Darren A DeWalt, Brian Erman, Jia-Rong Wu, Crystal W Cene, David W Baker, Dean Schillinger, Bernice Ruo, Kirsten Bibbins-Domingo, Aurelia Macabasco-O’Connell, Victoria Hawk, Kimberly Broucksou and Michael Pignone
    Citation: BMC Cardiovascular Disorders 2014 14:12
    Content type: Research article Published on:

  21. Even though intra-cardiac cystic lesions are extremely unusual in adults, they should be considered in the differential diagnosis of patients presenting with valvular masses. Cardiac magnetic resonance imaging...

    Authors: Ursula Reiter, Gert Reiter, Martin Asslaber, Drago Dacar, Ralph Maderthaner, Josepha Binder, Andreas Greiser, Meinrad Beer and Michael Fuchsjäger
    Citation: BMC Cardiovascular Disorders 2014 14:11
    Content type: Case report Published on:

  22. Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, and alterations in microRNA (miRNA) expression profiles of the right atr...

    Authors: Hai Liu, Guang-xian Chen, Meng-ya Liang, Han Qin, Jian Rong, Jian-ping Yao and Zhong-kai Wu
    Citation: BMC Cardiovascular Disorders 2014 14:10
    Content type: Research article Published on:

  23. Deaths from coronary heart disease (CHD) have been decreasing in most Western countries over the last few decades. In contrast, a flattening of the decrease in mortality has been recently reported among younge...

    Authors: Johanna Berg, Lena Björck, Georgios Lappas, Martin O’Flaherty, Simon Capewell and Annika Rosengren
    Citation: BMC Cardiovascular Disorders 2014 14:9
    Content type: Research article Published on:

  24. There is a paucity of diagnostic and therapeutic facilities in Nigeria to confirm coronary artery disease and offer appropriate interventional therapy. There is now a private cardiac catheterization laboratory...

    Authors: Adeyemi Johnson, Bode Falase, Ifeoluwa Ajose and Yemi Onabowale
    Citation: BMC Cardiovascular Disorders 2014 14:8
    Content type: Research article Published on:

  25. Insulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial infarction (MI). IR often manifests in MI and is regarded as an independent predictor of in-hospital mortality, which can pro...

    Authors: Olga Gruzdeva, Evgenya Uchasova, Ekaterina Belik, Yulia Dyleva, Ekaterina Shurygina and Olga Barbarash
    Citation: BMC Cardiovascular Disorders 2014 14:7
    Content type: Research article Published on:

  26. The Ryanodine receptor 3 gene (RYR3) encodes an intracellular calcium channel that mediates the efflux of Ca2+ from intracellular stores. Two single-nucleotide polymorphisms (SNPs) in the RYR3 gene have been show...

    Authors: Chenxi Zhao, Shinobu Ikeda, Tomio Arai, Makiko Naka-Mieno, Noriko Sato, Masaaki Muramatsu and Motoji Sawabe
    Citation: BMC Cardiovascular Disorders 2014 14:6
    Content type: Research article Published on:

  27. Both carotid-femoral (cf) pulse wave velocity (PWV) and brachial-ankle (ba) PWV employ arterial sites that are not consistent with the path of blood flow. Few previous studies have reported the differential chara...

    Authors: Jina Choo, Chol Shin, Emma Barinas-Mitchell, Kamal Masaki, Bradley J Willcox, Todd B Seto, Hirotsugu Ueshima, Sunghee Lee, Katsuyuki Miura, Lakshmi Venkitachalam, Rachel H Mackey, Rhobert W Evans, Lewis H Kuller, Kim Sutton-Tyrrell and Akira Sekikawa
    Citation: BMC Cardiovascular Disorders 2014 14:5
    Content type: Research article Published on:

  28. Despite recommended pharmacotherapies the use of secondary prevention therapy after myocardial infarction (MI) remains suboptimal. Patients with diabetes mellitus (DM) have worse prognosis after MI compared to...

    Authors: Casper H Jørgensen, Gunnar H Gislason, Ole Ahlehoff, Charlotte Andersson, Christian Torp-Pedersen and Peter R Hansen
    Citation: BMC Cardiovascular Disorders 2014 14:4
    Content type: Research article Published on:

  29. Metabolic syndrome (MetS) is related with left ventricular diastolic dysfunction (LVDD) and poor cardiovascular outcome. Epicardial adipose tissue (EAT) thickness, measured by echocardiography, is increased in...

    Authors: Hyo Eun Park, Su-Yeon Choi and Minkyung Kim
    Citation: BMC Cardiovascular Disorders 2014 14:3
    Content type: Research article Published on:

  30. Doubts remain about atherosclerotic disease and risk stratification of asymptomatic type-2 diabetic patients (T2DP). This study aims to evaluate the usefulness of calcium score (CS) and coronary computed tomog...

    Authors: Ana Faustino, Rui Providência, Paula Mota, Sérgio Barra, Joana Silva, Andreia Fernandes, Rui Catarino, Susana Basso, Marco Costa and António Leitão-Marques
    Citation: BMC Cardiovascular Disorders 2014 14:2
    Content type: Research article Published on:

  31. Most patients with heart failure are diagnosed and managed in primary care, however, underdiagnosis and undertreatment are common. We assessed whether implementation of a diagnostic-therapeutic strategy improv...

    Authors: Evelien ES van Riet, Arno W Hoes, Alexander Limburg, Henk van der Hoeven, Marcel AJ Landman and Frans H Rutten
    Citation: BMC Cardiovascular Disorders 2014 14:1
    Content type: Study protocol Published on:

  32. The high burden and rising incidence of cardiovascular disease (CVD) in resource constrained countries necessitates implementation of robust and pragmatic primary and secondary prevention strategies. Many curr...

    Authors: Jacob K Kariuki, Eileen M Stuart-Shor, Suzanne G Leveille and Laura L Hayman
    Citation: BMC Cardiovascular Disorders 2013 13:123
    Content type: Research article Published on:

  33. Compression of the trachea, bronchi, and pulmonary arteries are complications in patients with large thoracic aortic aneurysms. In this case, we report unexpected cardiopulmonary collapse manifested by general...

    Authors: Oto Inoue, Hisayoshi Murai, Shuichi Kaneko, Soichiro Usui, Hiroshi Furusho and Masayuki Takamura
    Citation: BMC Cardiovascular Disorders 2013 13:122
    Content type: Case report Published on:

  34. Little is known on whether there are ethnic differences in outcomes following percutaneous coronary intervention (PCI) and coronary artery bypass grafting surgery (CABG) after acute myocardial infarction (AMI)...

    Authors: Danijela Gasevic, Nadia A Khan, Hong Qian, Shahzad Karim, Gerald Simkus, Hude Quan, Martha H Mackay, Blair J O’Neill and Amir F Ayyobi
    Citation: BMC Cardiovascular Disorders 2013 13:121
    Content type: Research article Published on:

  35. Advanced lower extremity peripheral artery disease (PAD), whether presenting as acute limb ischemia (ALI) or chronic critical limb ischemia (CLI), is associated with high rates of cardiovascular ischemic event...

    Authors: Hong H Keo, Sue Duval, Iris Baumgartner, Niki C Oldenburg, Michael R Jaff, JoAnne Goldman, James M Peacock, Alexander S Tretinyak, Timothy D Henry, Russell V Luepker and Alan T Hirsch
    Citation: BMC Cardiovascular Disorders 2013 13:120
    Content type: Study protocol Published on:

  36. Peripheral arterial disease (PAD) of the lower limbs is a cardiovascular disease highly prevalent particularly in the asymptomatic form. Its prevalence starts to be a concern in low coronary risk countries lik...

    Authors: Maria Teresa Alzamora, Rosa Forés, Guillem Pera, Pere Torán, Antonio Heras, Marta Sorribes, Jose Miguel Baena-Diez, Magalí Urrea, Judit Alegre, María Viozquez and Carme Vela
    Citation: BMC Cardiovascular Disorders 2013 13:119
    Content type: Research article Published on:

  37. Coronary heart disease remains the leading cause of death in developed countries. In Africa, the disease continues to rise with varying rates of progression in different countries. At present, there is little ...

    Authors: Moustapha Sarr, Djibril Mari Ba, Mouhamadou Bamba Ndiaye, Malick Bodian, Modou Jobe, Adama Kane, Maboury Diao, Alassane Mbaye, Mouhamadoul Mounir Dia, Soulemane Pessinaba, Abdoul Kane and Serigne Abdou Ba
    Citation: BMC Cardiovascular Disorders 2013 13:118
    Content type: Research article Published on:

  38. Ischemic preconditioning is a powerful mechanism of myocardial protection and in humans it can be evaluated by sequential exercise tests. Coronary Artery Disease in the presence of diabetes mellitus may be ass...

    Authors: Paulo Cury Rezende, Rosa Maria Rahmi Garcia, Augusto Hiroshi Uchida, Leandro Menezes Alves Costa, Thiago Luis Scudeler, Rodrigo Morel Vieira Melo, Fernando Teiichi Costa Oikawa, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Carlos Alexandre Wainrober Segre, Desiderio Favarato, Priscyla Girardi, Myrthes Takiuti, Celia Cassaro Strunz, Whady Hueb, José Antonio Franchini Ramires…
    Citation: BMC Cardiovascular Disorders 2013 13:117
    Content type: Study protocol Published on:

  39. There is an association between cryptogenic stroke and patent foramen ovale (PFO). The optimal treatment strategy for secondary prevention remains unclear. The purpose of this study was to analyze aggregate da...

    Authors: Irbaz Bin Riaz, Abhijeet Dhoble, Ahmad Mizyed, Chiu-Hsieh Hsu, Muhammad Husnain, Justin Z Lee, Kapildeo Lotun and Kwan S Lee
    Citation: BMC Cardiovascular Disorders 2013 13:116
    Content type: Research article Published on:

  40. The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consiste...

    Authors: Hilde M Storhaug, Jon V Norvik, Ingrid Toft, Bjorn O Eriksen, Maja-Lisa Løchen, Svetlana Zykova, Marit Solbu, Sarah White, Steve Chadban and Trond Jenssen
    Citation: BMC Cardiovascular Disorders 2013 13:115
    Content type: Research article Published on:

  41. Canadians of Chinese descent, represent one of the fastest growing visible minority groups in Canada, (as well as the second largest), but relatively little is known about the clinical features of heart failur...

    Authors: Darwin F Yeung, Nicole K Van Dyke, Laura C Maclagan, Gordon W Moe, Baiju R Shah, Maria Chiu, Douglas S Lee, Dennis T Ko, Ching Lau and Jack V Tu
    Citation: BMC Cardiovascular Disorders 2013 13:114
    Content type: Research article Published on:

  42. Data regarding the association between red cell distribution width (RDW) values and mortality in patients with stable coronary artery disease are scarce. We aimed to investigate the link between mortality and ...

    Authors: Tadeusz Osadnik, Joanna Strzelczyk, Michał Hawranek, Andrzej Lekston, Jarosław Wasilewski, Anna Kurek, Aleksander Rafał Gutowski, Krzysztof Wilczek, Krzysztof Dyrbuś, Marek Gierlotka, Andrzej Wiczkowski, Mariusz Gąsior, Andrzej Szafranek and Lech Poloński
    Citation: BMC Cardiovascular Disorders 2013 13:113
    Content type: Research article Published on:

  43. Coronary heart disease (CHD) causes an estimated 7 million deaths worldwide each year. In the last few decades, mortality from CHD has been decreasing in many countries. The aim of this study was to analyze th...

    Authors: Isidora S Vujcic, Sandra B Sipetic, Eleonora S Dubljanin and Hristina D Vlajinac
    Citation: BMC Cardiovascular Disorders 2013 13:112
    Content type: Research article Published on:

  44. Medical treatment of hypertension is not always sufficient to achieve blood pressure control. Despite this, previous studies on supplementary therapies, such as yoga, are relatively few. We investigated the ef...

    Authors: Moa Wolff, Kristina Sundquist, Sara Larsson Lönn and Patrik Midlöv
    Citation: BMC Cardiovascular Disorders 2013 13:111
    Content type: Research article Published on:

  45. Cardiovascular-MR (CMR) is the gold standard for quantifying myocardial infarction using late gadolinium enhancement (LGE) technique. Both 2D- and 3D-LGE-sequences are used in clinical practise and in clinical...

    Authors: Robert Jablonowski, David Nordlund, Mikael Kanski, Joey Ubachs, Sasha Koul, Einar Heiberg, Henrik Engblom, David Erlinge, HÃ¥kan Arheden and Marcus Carlsson
    Citation: BMC Cardiovascular Disorders 2013 13:110
    Content type: Research article Published on:

  46. The present study analyses the relation between smoking status and the parameters used to assess vascular structure and function.

    Authors: Jose I Recio-Rodriguez, Manuel A Gomez-Marcos, Maria C Patino Alonso, Carlos Martin-Cantera, Elisa Ibañez-Jalon, Amor Melguizo-Bejar and Luis Garcia-Ortiz
    Citation: BMC Cardiovascular Disorders 2013 13:109
    Content type: Research article Published on:

  47. Long-term management of chronic conditions, such as atrial fibrillation (AF), require frequent interactions with the healthcare systems. The multinational EUropean Patient Survey in Atrial Fibrillation (EUPS-A...

    Authors: Ameet Bakhai, Anna Sandberg, Thomas Mittendorf, Wolfgang Greiner, André MS Oberdiek, Patrizia Berto, Edith Franczok, Trudie Lobban and Jose L Zamorano
    Citation: BMC Cardiovascular Disorders 2013 13:108
    Content type: Research article Published on:

  48. The diagnosis of ventilator-associated pneumonia (VAP) is a challenge, particularly after cardiac surgery. The use of biological markers of infection has been suggested to improve the accuracy of VAP diagnosis...

    Authors: Alessandra K Matsuno and Ana PCP Carlotti
    Citation: BMC Cardiovascular Disorders 2013 13:107
    Content type: Research article Published on:

  49. Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweigh...

    Authors: Lene Rørholm Pedersen, Rasmus Huan Olsen, Marianne Frederiksen, Arne Astrup, Elizaveta Chabanova, Philip Hasbak, Jens Juul Holst, Andreas Kjær, John W Newman, Rosemary Walzem, Ulrik Wisløff, Ahmad Sajadieh, Steen Bendix Haugaard and Eva Prescott
    Citation: BMC Cardiovascular Disorders 2013 13:106
    Content type: Study protocol Published on:

  50. The decreased number and senescence of circulating endothelial progenitor cells (EPCs) are considered markers of vascular senescence associated with aging, atherosclerosis, and coronary artery disease (CAD) in...

    Authors: Kranthi Vemparala, Ambuj Roy, Vinay Kumar Bahl, Dorairaj Prabhakaran, Neera Nath, Subrata Sinha, Pradipta Nandi, Ravindra Mohan Pandey, Kolli Srinath Reddy, Ajay Manhapra and Ramakrishnan Lakshmy
    Citation: BMC Cardiovascular Disorders 2013 13:104
    Content type: Research article Published on:
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BMC Cardiovascular Disorders

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