Articles

Late presentation of arrhythmogenic right ventricular cardiomyopathy in an octogenarian associated with a pathogenic variant in the plakophilin 2 gene: a case report

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease characterized by fibrofatty replacement and ventricular arrhythmias. ARVC is believed to be a disease of the young, wit...

Authors: Yusuke Adachi, Takekuni Hayashi, Takeshi Mitsuhashi, Kenichi Sakakura, Yoko Yamada, Yuko Wada, Minoru Horie, Shin-ichi Momomura and Hideo Fujita

The expression profile analysis of atrial mRNA in rats with atrial fibrillation: the role of IGF1 in atrial fibrosis

Structural remodeling is critical to the initiation and maintenance of atrial fibrillation (AF). IGF1, insulin like growth factor 1, has been recognized as contributor to fibrosis. However, the roles and mecha...

Authors: Jiangrong Wang, Zhan Li, Juanjuan Du, Jianhua Li, Yong Zhang, Jing Liu and Yinglong Hou

Progression of coronary atherosclerotic plaque burden and relationship with adverse cardiovascular event in asymptomatic diabetic patients

The heterogeneity of risk in patients with diabetes mellitus (DM) is acknowledged in new guidelines promulgating different treatment recommendations for diabetics at low cardiac risk. We performed a retrospect...

Authors: Junjie Yang, Guanhua Dou, Christian Tesche, Carlo N. De Cecco, Brian E. Jacobs, U. Joseph Schoepf and Yundai Chen

Risk factors for medication non-adherence among atrial fibrillation patients

Atrial fibrillation (AF) patients are routinely prescribed medications to prevent and treat complications, including those from common co-occurring comorbidities. However, adherence to such medications may be ...

Authors: Stephanie R. Reading, Mary Helen Black, Daniel E. Singer, Alan S. Go, Margaret C. Fang, Natalia Udaltsova, Teresa N. Harrison, Rong X. Wei, In-Lu Amy Liu and Kristi Reynolds

Interatrial block in prediction of all-cause mortality after first-ever ischemic stroke

Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predic...

Authors: M. A. Baturova, A. Lindgren, Y. V. Shubik, J. Carlson and P. G. Platonov

The predictive value of the renal resistive index for contrast-induced nephropathy in patients with acute coronary syndrome

Percutaneous coronary intervention (PCI) has been associated with contrast-induced nephropathy (CIN) at a rate that varies depending on the patient’s risk factors. This study was conducted to evaluate the pred...

Authors: Zheng-rong Xu, Jun Chen, Yuan-hui Liu, Yong Liu and Ning Tan

Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium

Authors: Uma Chandrasekaran, Daniel Burkhoff, Kiyotake Ishikawa, Lija Swain, Kenji Sunagawa, Jacob Møller, Carlos Santos-Gallego, Shiva Annamalai, James Udelson, Ralf Westenfeld, Navin Kapur, Xiaoying Qiao, Julian Wiora, Andreas Schäfer, Alexander Bernhardt, Ajar Kochar…

Association between coronary dominance and acute inferior myocardial infarction: a matched, case-control study

Previous studies have found a connection between left coronary artery dominance and worse prognoses in patient with acute coronary syndrome, which remains a predominant cause of morbidity and mortality globall...

Authors: Li Wang, Jiamei Li, Ya Gao, Ruohan Li, Jingjing Zhang, Dan Su, Tao Wang, Guang Yang and Xiaochuang Wang

Serum IL8 is not associated with cardiovascular events but with all-cause mortality

The aim of this study is to investigate if IL8 levels were associated with incident cardiovascular (CV) events (CVE) and mortality (all-cause, CV, and cancer) in a cohort of 60 years old men and women from Sto...

Authors: Ilais Moreno Velásquez, Ashwini Gajulapuri, Karin Leander, Anita Berglund, Ulf de Faire and Bruna Gigante

Correction to: “in-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks”

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Authors: R. Chaban, A. Kornberger, N. Branski, K. Buschmann, N. Stumpf, A. Beiras-Fernandez and C. F. Vahl

Rationale and design of a prospective, randomised study of retrograde application of bone marrow aspirate concentrate (BMAC) through coronary sinus in patients with congestive heart failure of ischemic etiology (the RETRO study)

Heart failure (HF) is a major chronic illness and results in high morbidity and mortality. The most frequent cause of HF with reduced ejection fraction (HFREF) is coronary artery disease (CAD). Although revasc...

Authors: L. Pleva, P. Kukla, K. Vítková and V. Procházka

Low expression of PRMT5 in peripheral blood may serve as a potential independent risk factor in assessments of the risk of stable CAD and AMI

Protein arginine methyltransferases (PRMTs) can catalyse the methylation of arginine and participate in many important cellular reaction processes. The purpose of this research is to determine whether the expr...

Authors: Buchuan Tan, Qian Liu, Liping Yang, Yushuang Yang, Dongna Liu, Long Liu and Fanbo Meng

Trends in electrocardiographic abnormalities and risk of cardiovascular mortality in Lithuania, 1986–2015

This study aimed to assess the trends in the prevalence of electrocardiographic (ECG) abnormalities from 1986 to 2015 and impact of ECG abnormalities on risk of death from cardiovascular diseases (CVD) in the ...

Authors: Abdonas Tamosiunas, Janina Petkeviciene, Ricardas Radisauskas, Gailute Bernotiene, Dalia Luksiene, Mindaugas Kavaliauskas, Irena Milvidaitė and Dalia Virviciute

Assessment of hypertension management and control: a registry-based observational study in two municipalities in Cuba

To determine the prevalence of hypertension treatment and control among hypertensive patients in the Cuban municipalities of Cardenas and Santiago and to explore the main associated predictors.

Authors: Esteban Londoño Agudelo, Armando Rodríguez Salvá, Addys Díaz Piñera, René García Roche, Pol De Vos, Tullia Battaglioli and Patrick Van der Stuyft

Extreme ST-segment elevations in seemingly no significant angiographic coronary artery abnormalities: a case report

Obstructive coronary artery disease is found in approximately 97% of patients presenting with ST-elevation myocardial infarction and 92% of patients with non ST-elevation myocardial infarction (Bainey KR, Wels...

Authors: M. Piels, T. Faes and J. Vainer

Abstracts from the 3rd Annual A-CURE Symposium

Authors:

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.

Authors: Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, Jochen Renner, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Frank Kletzin, Jan Roesner, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner…

Metabolic syndrome increases operative mortality in patients with impaired left ventricular systolic function who undergo coronary artery bypass grafting: a retrospective observational study

Metabolic syndrome (MetS) is a prevalent risk factor for coronary artery disease progression. Past studies have shown that MetS and its components tends to increase mortality after coronary artery bypass graft...

Authors: Shuangkun Chen, Jiahui Li, Qianzhen Li, Zhihuang Qiu, Xijie Wu and Liangwan Chen

Correction to: does stress perfusion imaging improve the diagnostic accuracy of late gadolinium enhanced cardiac magnetic resonance for establishing the etiology of heart failure?

Following publication of the original article [1], the author reported his name has erroneously spelled as Abishek Shetye. The correct name is Abhishek Shetye.

Authors: Gaurav S. Gulsin, Abhishek Shetye, Jeffrey Khoo, Daniel J. Swarbrick, Eylem Levelt, Florence Y. Lai, Iain B. Squire, Jayanth R. Arnold and Gerry P. McCann

Association between transitional care factors and hospital readmission after transcatheter aortic valve replacement: a retrospective observational cohort study

Studies have shown that patients who undergo trans-catheter aortic valve replacement (TAVR) have high rates of hospital readmission. Our objectives were to identify the causes of readmission after TAVR, determ...

Authors: Andrew Czarnecki, Peter C. Austin, Stephen E. Fremes, Jack V. Tu, Harindra C. Wijeysundera and Dennis T. Ko

Clinical results of bioresorbable drug-eluting scaffolds in short and long coronary artery lesions using the PSP technique

Data on bioresorbable vascular scaffolds (BVS) for the treatment of long lesions are limited. We studied the use of BVS-Absorb in routine clinical practice and compared the outcome of long lesions with short l...

Authors: Christine Reichart, Jochen Wöhrle, Sinisa Markovic, Wolfgang Rottbauer and Julia Seeger

Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum

Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant p...

Authors: Shui-Ming Li, Wan-Ting Liu, Fang Yang, Qi-Jian Yi, Shuai Zhang and Hong-Ling Jia

Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study

Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical conditi...

Authors: Eugenio Roberto Cosentino, Matteo Landolfo, Crescenzio Bentivenga, Luca Spinardi, Daniela Degli Esposti, Arrigo Francesco Cicero, Rinaldo Miceli, Virna Bui, Emanuela Berardi and Claudio Borghi

Cardiovascular outcomes among elderly patients with heart failure and coronary artery disease and without atrial fibrillation: a retrospective cohort study

Coronary artery disease accelerates heart failure progression, leading to poor prognosis and a substantial increase in morbidity and mortality. This study was aimed to assess the impact of coronary artery dise...

Authors: Qi Zhao, Li Wang, Paul A. Kurlansky, Jeff Schein, Onur Baser and Jeffrey S. Berger

Catheter ablation for atrial fibrillation in heart failure with reduced ejection fraction: a systematic review and meta-analysis of randomized controlled trials

Previous randomized controlled trials (RCT)s showed similar outcomes in patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) treated with anti-arrhythmic drugs (AAD) ...

Authors: Ahmed AlTurki, Riccardo Proietti, Ahmed Dawas, Hasan Alturki, Thao Huynh and Vidal Essebag

Critical appraisal of international guidelines for the screening and treatment of asymptomatic peripheral artery disease: a systematic review

Peripheral artery disease (PAD) is often asymptomatic but increases the risk of developing cardiovascular events. Due to the uncertainties regarding the quality of related guidelines and a lack of clear-cut ev...

Authors: Qinchang Chen, Lingling Li, Qingui Chen, Xixia Lin, Yonghui Li, Kai Huang and Chen Yao

A case of hypertrophic cardiomyopathy combined with muscular ventricular septal defect and abnormal origin of right coronary artery

Hypertrophic cardiomyopathy (HCM) is a myocardial disease. However, the coexistence of HCM with muscular ventricular septal defect (VSD), especially those with both incomplete spontaneous closure and coronary ...

Authors: Guang-mei Zheng, Jiao Bai, Jun-ming Tang, Fang-cheng Zhu and Hong-xia Jing

Usefulness of apical area index to predict left ventricular thrombus in patients with systolic dysfunction: a novel index from cardiac magnetic resonance

LV systolic dysfunction presents an elevated risk of thromboembolism. Previous studies demonstrated low left ventricular ejection fraction (LVEF), ischemic cardiomyopathy and increased myocardial scarring as i...

Authors: Yodying Kaolawanich and Thananya Boonyasirinant

Why complicate an important task? An orderly display of the limb leads in the 12-lead electrocardiogram and its implications for recognition of acute coronary syndrome

In the standard ECG display, limb leads are presented in a non-anatomical sequence: I, II, III, aVR, aVL, aVF. The Cabrera system is a display format which instead presents the limb leads in a cranial/left-to-...

Authors: T. Lindow, Y. Birnbaum, K. Nikus, A. Maan, U. Ekelund and O. Pahlm

Long-term treatment effect and adverse events of a modified jailed-balloon technique for side branch protection in patients with coronary bifurcation lesions

Percutaneous coronary interventions (PCI) of bifurcation lesions is technically challenging and associated with lower success rates and higher frequency of adverse outcomes. In the present study, we aimed to e...

Authors: Wenduo Zhang, Fusui Ji, Xue Yu and Xinyue Wang

Effect of using cardiovascular risk scoring in routine risk assessment in primary prevention of cardiovascular disease: an overview of systematic reviews

Our objectives were to critically appraise and summarise the current evidence for the effectiveness of using cardiovascular disease (CVD) risk scoring (total risk assessment - TRA) in routine risk assessment i...

Authors: Krzysztof Studziński, Tomasz Tomasik, Janusz Krzysztoń, Jacek Jóźwiak and Adam Windak

In-hospital and post-discharge outcomes of pediatric acute myocarditis underwent after high-dose steroid or intravenous immunoglobulin therapy

High-dose steroids and intravenous immunoglobulin (IVIG) are controversial treatments for pediatric patients with acute myocarditis. This study aimed to investigate their efficacies in the Taiwanese pediatric ...

Authors: Ming-Shyan Lin, Yu-Hsiang Tseng, Mei-Yen Chen, Chang-Min Chung, Ming-Horng Tsai, Po-Chang Wang, Jung-Jung Chang, Tien-Hsing Chen and Yu-Sheng Lin

Myocardial contrast echocardiography in the diagnosis of postoperative takotsubo myocardiopathy: case report and literature review

Takotsubo cardiomyopathy (TCM) is a brief ventricular dysfunction that usually occurs after emotional or physical stress. Here, we report a patient who underwent cardiac surgery and then developed TCM during t...

Authors: Jia-Hui Zeng, Wei Li, Feng-Juan Yao, Dong-Hong Liu, Cui-Ling Li, Yan-Qiu Liu, Rui Fan, Min Ye and Hong Lin

First cardiovascular event in patients with type 2 diabetes mellitus of a cardiovascular risk management program of a poor Colombian population: a cohort study

According to several studies in population of high-income countries (HIC), patients with Type 2 diabetes mellitus (DM) have a considerably higher risk of cardiovascular morbidity and mortality. However, it is ...

Authors: Pablo Miranda-Machado, Fernando Salcedo-Mejía, Justo Paz Wilches, Juan Fernandez-Mercado, Fernando De la Hoz-Restrepo and Nelson Alvis-Guzmán

Cardiovascular imaging approach in pre and postoperative tetralogy of Fallot

Advances in the medical and surgical management of Tetralogy of Fallot have led to marked increase of the number and age of survivors. Imaging in patients with Tetralogy of Fallot plays a crucial role in the d...

Authors: Sotiria C. Apostolopoulou, Athanassios Manginas, Nikolaos L. Kelekis and Michel Noutsias

The influence of LV geometry on the occurrence of abnormal exercise tests in athletes

Previous studies revealed a high rate of abnormal exercise test (ET) results in the absence of obstructive coronary artery disease (CAD) in asymptomatic athletes. The physiological background of this phenomeno...

Authors: Danny A. J. P. van de Sande, Jan Hoogsteen, Pieter A. Doevendans and Hareld M. C. Kemps

Circulating microRNA-1 in the diagnosis and predicting prognosis of patients with chest pain: a prospective cohort study

To investigate the early diagnostic and prognostic value of microRNA-1 in patients with acute chest pain.

Authors: Tong Su, Xiaonan Shao, Xiaopu Zhang, Zhijun Han, Chengjian Yang and Xun Li

Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure

Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. T...

Authors: Viera Stubnova, Ingrid Os, Aud Høieggen, Marit D. Solbu, Morten Grundtvig, Arne S. Westheim, Dan Atar and Bård Waldum-Grevbo

Ablation of unmappable ventricular parasystole originating from the right ventricular outflow tract: a case report

When the coupling interval is matched, ventricular parasystole can form a stable fusion QRS complex with sinus rhythm. Ablation of a fusion QRS complex has been rarely reported and is unexpectedly difficult.

Authors: Huan Wang and Lihong Wang

A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug

Elevated plasma triglycerides (TGs) are widely used as a major cardiovascular risk predictor and are thought to play an important role in the progression of coronary heart disease (CHD). It has been demonstrat...

Authors: Neda M. Bogari, Ashwag Aljohani, Amr A. Amin, Faisal A. Al-Allaf, Anas Dannoun, Mohiuddin M. Taher, Atalla Elsayed, Dareen ibrahim Rednah, Osama Elkhatee, Massimo Porqueddu, Francesco Alamanni, Soud Abdulraof A. Khogeer and Ahmed Fawzy

Modes of death and clinical outcomes in adult patients with hypertrophic cardiomyopathy in Thailand

There are limited data about modes of death and major adverse cardiovascular events (MACEs) in patients with hypertrophic cardiomyopathy (HCM) in South East Asian population. The aim of the study was to examin...

Authors: Nattakorn Songsirisuk, Veraprapas Kittipibul, Nilubon Methachittiphan, Vorawan Charoenattasil, Nath Zungsontiporn, Ittikorn Spanuchart, Saranya Buppajarntham, Charoen Mankongpaisarnrung, Sudarat Satitthummanid, Suphot Srimahachota, Pairoj Chattranukulchai, Smonporn Boonyaratavej Songmuang and Sarinya Puwanant

Use of speckle-tracking echocardiography–derived strain and systolic strain rate measurements to predict rejection in transplant hearts with preserved ejection fraction

Noninvasive diagnosis of allograft rejection in heart transplant recipients is challenging. The utility of 2-dimensional speckle-tracking echocardiography (2D-STE) to predict severe rejection in heart transpla...

Authors: Andrew S. Tseng, Umama S. Gorsi, Sergio Barros-Gomes, Fletcher A. Miller, Patricia A. Pellikka, Alfredo L. Clavell and Hector R. Villarraga

Feasibility of a checklist in treating hypertension in primary care – base line results from a cluster-randomised controlled trial (check and support)

Most patients with antihypertensive medication do not achieve their blood pressure (BP) target. The most important factor behind this failure is poor medication adherence. However, non-adherence to therapy doe...

Authors: Aapo Tahkola, Päivi Korhonen, Hannu Kautiainen, Teemu Niiranen and Pekka Mäntyselkä

Cardiac autotransplantation and ex vivo surgical repair of giant left atrium: a case presentation

Chronic Mitral Valve disease is strongly associated with Left atrial enlargement; the condition has a high mortality risk. Clinical manifestations include atrial fibrillation, pulmonary hypertension, thromboem...

Authors: Zan Mitrev, Milka Klincheva, Tanja Anguseva, Igor Zdravkovski and Rodney Alexander Rosalia

Incomplete intestinal obstruction as the possible main complaint in Behcet’s disease after surgery for recurrent abdominal aortic pseudoaneurysms: a case report and literature review

Behcet’s disease (BD) is a systemic vasculitis characterized by oral and genital aphthosis, and ocular and skin lesions. The disease is involved in vascular, gastrointestinal, and central nervous systems. Vasc...

Authors: Fang Jiang, Hui Xiang and Zhi-Yong Peng

Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried o...

Authors: Hamed Akbari, Gholamreza Asadikaram, Hamid Aria, Saba Fooladi, Sina Vakili and Mohammad Masoumi

Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats

Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium cha...

Authors: Chang-He Liu, Na Hua, Xi Fu, Yi-Long Pan, Bin Li and Xiao-Dong Li

Association of sleep disturbances within 4 weeks prior to incident acute myocardial infarction and long-term survival in male and female patients: an observational study from the MONICA/KORA Myocardial Infarction Registry

Sleep-related investigations in acute myocardial infarction (AMI) patients are rare. The aim of this study was to examine sex-specific associations of patient-reported sleep disturbances within 4 weeks before ...

Authors: Franziska Nairz, Christa Meisinger, Inge Kirchberger, Margit Heier, Christian Thilo, Bernhard Kuch, Annette Peters and Ute Amann

Post-cardiac injury syndrome in acute myocardial infarction patients undergoing PCI: a case report and literature review

In the era of primary percutaneous coronary intervention (PPCI), the incidence of post-cardiac injury syndrome (PCIS) in patients with acute myocardial infarction (AMI) following PPCI has become less common. H...

Authors: Yan Gao, Nanette H. Bishopric, Hong-wei Chen, Jiang-tao Li, Yu-lang Huang and He-xun Huang

Relationship between plaque composition by virtual histology intravascular ultrasound and clinical outcomes after percutaneous coronary intervention in saphenous vein graft disease patients: study protocol of a prospective cohort study

Plaque composition and morphologic characteristics identified by virtual histology intravascular ultrasound (VH-IVUS) can determine plaques at increased risk of clinical events following percutaneous coronary ...

Authors: Yin Liu, Hai-Bo Wang, Xiang Li, Jian-Yong Xiao, Ji-Xiang Wang, Kathleen H. Reilly, Bo Sun and Jing Gao