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  1. 8–28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim...

    Authors: Shirjel R. Alam, Anoop S. V. Shah, Kevin O. Ombati, Edward Nganga, Samuel Gitau, Khalid Makhdomi, Michael H. Chung and Sudhir Vinayak

    Citation: BMC Cardiovascular Disorders 2021 21:234

    Content type: Study protocol

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  2. The Cathepsins family, including cathepsin B and cathepsin D, potentially affects the entire processes involved in atherosclerosis. Although coronary heart disease (CHD) has been widely studied as the basis of...

    Authors: Jialin Dai, Qiong Zhang, Changwu Wan, Jiangjin Liu, Qiaojun Zhang, Yanni Yu and Jie Wang

    Citation: BMC Cardiovascular Disorders 2021 21:233

    Content type: Research article

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  3. The jailed balloon technique is widely used for coronary bifurcation lesions, but a residual risk of SB occlusion remains, necessitating SB rewiring and further interventions, including balloon inflation or st...

    Authors: Hongbo Yang, Yanan Song, Jiatian Cao, Xueyi Weng, Feng Zhang, Yuxiang Dai, Hao Lu, Chenguang Li, Zheyong Huang, Juying Qian and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2021 21:232

    Content type: Technical advance

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  4. Little is known about the quality of life (QOL) and health status of adults with congenital heart disease (CHD) in developing countries. Therefore, this study aimed to describe the QOL and health status of hos...

    Authors: Thanh-Huong Truong, Ngoc-Thanh Kim, Mai-Ngoc Thi Nguyen, Doan-Loi Do, Hong Thi Nguyen, Thanh-Tung Le and Hong-An Le

    Citation: BMC Cardiovascular Disorders 2021 21:229

    Content type: Research

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  5. Acute decompensated heart failure (ADHF) contributes millions of emergency department (ED) visits and it is associated with high in-hospital mortality. The aim of this study was to develop and validate a multi...

    Authors: Ran Mo, Li-tian Yu, Hui-qiong Tan, Yang Wang, Yan-min Yang, Yan Liang and Jun Zhu

    Citation: BMC Cardiovascular Disorders 2021 21:228

    Content type: Research

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  6. Percutaneous left atrial appendage (LAA) closure is an alternative to oral anticoagulation (OAC) for atrial fibrillation (AF) patients with high thromboembolism risk, particularly with contraindications to OAC...

    Authors: Nicolas Lellouche, Raphaele Arrouasse, Julien Ternacle, Romain Gallet, Jean-Sylvain Hermida, David Hamon, Jean-Michel Juliard, Jean-Luc Pasquie, Tarvinder Dhanjal, Emmanuel Teiger and Philippe Le Corvoisier

    Citation: BMC Cardiovascular Disorders 2021 21:227

    Content type: Research article

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  7. Galectin-3 (Gal-3) is currently recognized as a promising biomarker for myocardial fibrosis. This study aimed to explore the potential association between plasma Gal-3 concentrations and atrial fibrillation (A...

    Authors: Qianhui Wang, Li Xu, Ying Dong, Yuan Fu, Yuxia Pan, Qianran Luan, Ye Liu, Zheng Liu, Xinchun Yang, Mulei Chen and Yuanfeng Gao

    Citation: BMC Cardiovascular Disorders 2021 21:226

    Content type: Research

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  8. Primary cardiac tumors are rare, and approximately 90% of them are benign. Myxoma is the most common type of these tumors occurring in the left atrium in 75–85% of cases. The tumor can cause the left atrio-ven...

    Authors: Sadegh Shabab, Majid Erfanzadeh, Shamsa Ahmadian, Maryam Mahmoudabady and Naser Mazloum

    Citation: BMC Cardiovascular Disorders 2021 21:225

    Content type: Case report

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  9. Incretin therapies appear to provide cardioprotection and improve cardiovascular outcomes in patients with diabetes, but the mechanism of this effect remains elusive. We have previously shown that glucagon-lik...

    Authors: Muhammad Aetesam-ur-Rahman, Joel P. Giblett, Bharat Khialani, Stephen Kyranis, Sophie J. Clarke, Tian X. Zhao, Denise M. Braganza, Sarah C. Clarke, Nick E. J. West, Martin R. Bennett and Stephen P. Hoole

    Citation: BMC Cardiovascular Disorders 2021 21:223

    Content type: Research article

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  10. There is limited evidence of Aboriginal and Torres Strait Islander people attending cardiac rehabilitation (CR) programs despite high levels of heart disease. One key enabler for CR attendance is a culturally ...

    Authors: Nicole Freene, Roslyn Brown, Paul Collis, Chris Bourke, Katharine Silk, Alicia Jackson, Rachel Davey and Holly L. Northam

    Citation: BMC Cardiovascular Disorders 2021 21:222

    Content type: Research article

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  11. The dysfunction and injury of human umbilical vein endothelial cells (HUVECs) are key events of atherosclerosis (AS). Atorvastatin (ATV) has been shown to play a protective role on endothelial cells. However, ...

    Authors: Gang Su, Guangli Sun, Jian Lv, Weiwei Zhang, Hai Liu, Yajing Tang and Haoang Su

    Citation: BMC Cardiovascular Disorders 2021 21:221

    Content type: Research article

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  12. Leriche syndrome is the triad of symptoms consisting of claudication, erectile dysfunction, and absence of femoral pulses. Inflammatory disease of the heart muscle, myocarditis, may occur because of immune sys...

    Authors: Abudi Mohamed, Gustav Mattsson and Peter Magnusson

    Citation: BMC Cardiovascular Disorders 2021 21:220

    Content type: Case report

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  13. In adult patients with pulmonary arterial hypertension (PAH), right ventricular (RV) failure may worsen rapidly, resulting in a poor prognosis. In this population, non-invasive assessment of RV function is cha...

    Authors: Raluca Jumatate, Annika Ingvarsson, Gustav Jan Smith, Anders Roijer, Ellen Ostenfeld, Johan Waktare, Göran Rådegran, Carl Meurling and Anna Werther Evaldsson

    Citation: BMC Cardiovascular Disorders 2021 21:219

    Content type: Research

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  14. Due to the technical limitations of coronary artery angiography (CAG), ramus intermedius (RI) is sometimes difficult to distinguish from a high-origin obtuse marginal branch or a high-origin diagonal branch. T...

    Authors: Xue Gong, Zheyong Huang, Zhonghan Sun, Qibing Wang, Juying Qian, Lei Ge and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2021 21:218

    Content type: Research

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  15. Diabetes mellitus-related cardiomyopathy (DMCMP), defined as left ventricular (LV) dysfunction caused by hyperglycemia in the absence of coronary artery disease, leads to heart failure (HF). Previous studies h...

    Authors: Satoshi Oka, Takahiko Kai, Katsuomi Hoshino, Kazunori Watanabe, Jun Nakamura, Makoto Abe and Akinori Watanabe

    Citation: BMC Cardiovascular Disorders 2021 21:217

    Content type: Research article

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  16. To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to eva...

    Authors: Fang Liu, Zheng Wang, Xia Cao, Yingxia Pan, Erqiang Zhang, Jiahuan Zhou and Lina Zheng

    Citation: BMC Cardiovascular Disorders 2021 21:216

    Content type: Research

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  17. Myocardial ischemia–reperfusion injury (MIRI) is the main pathological manifestation of cardiovascular diseases such as myocardial infarction. The potential therapeutic effects of bone marrow-derived mesenchym...

    Authors: Ling-Xiao Pang, Wen-Wei Cai, Qian Li, Heng-Jie Li, Min Fei, Yong-Sheng Yuan, Bin Sheng, Ke Zhang, Rong-Cheng An, Ying-Wei Ou and Wen-Jie Zeng

    Citation: BMC Cardiovascular Disorders 2021 21:215

    Content type: Research

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  18. To clarify the appropriate initial dosage of heparin during radiofrequency catheter ablation (RFCA) in patients with atrial fibrillation (AF) receiving uninterrupted nonvitamin K antagonist oral anticoagulant ...

    Authors: Rong-feng Zhang, Cheng-ming Ma, Na Wang, Ming-hui Yang, Wen-wen Li, Xiao-meng Yin, Ying-xue Dong, Xiao-hong Yu, Xian-jie Xiao, Yun-long Xia and Lian-jun Gao

    Citation: BMC Cardiovascular Disorders 2021 21:214

    Content type: Research

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  19. Orthostatic hypotension (OH) and orthostatic hypertension (OHT) are often unrecognized in clinical care for diabetic individuals, yet they are associated with increased risk for adverse cardiovascular outcomes...

    Authors: Richard Migisha, David Collins Agaba, Godfrey Katamba, Jennifer Manne-Goehler, Anthony Muyingo and Mark J. Siedner

    Citation: BMC Cardiovascular Disorders 2021 21:213

    Content type: Research article

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  20. Endovascular treatment is standard of care for transplant renal artery stenosis (TRAS). No study has evaluated long-term outcomes compared between percutaneous transluminal renal angioplasty (PTRA) and PTRA wi...

    Authors: Nattawut Wongpraparut, Thunyarat Chaipruckmalakarn, Thongtum Tongdee, Archan Jaspttananon, Attapong Vongwiwatana, Nalinee Premasathian, Kawin Anusonadisai and Rungtiwa Pongakasira

    Citation: BMC Cardiovascular Disorders 2021 21:212

    Content type: Research article

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  21. Coronary microvascular dysfunction (CMD) is common in end-stage renal disease (ESRD) and is an adverse prognostic marker. Coronary flow velocity reserve (CFVR) is a measure of coronary microvascular function a...

    Authors: Ashwin Radhakrishnan, Luke C. Pickup, Anna M. Price, Jonathan P. Law, Kirsty C. McGee, Larissa Fabritz, Roxy Senior, Richard P. Steeds, Charles J. Ferro and Jonathan N. Townend

    Citation: BMC Cardiovascular Disorders 2021 21:211

    Content type: Research

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  22. Little is known regarding the effect of cardiopulmonary bypass (CPB) reoxygenation on cardiac function following tetralogy of Fallot repair. We hypothesized that hyperoxic reoxygenation would be more strongly ...

    Authors: Ji-nong Yang, Xiao-ming Zhang, Lu-yao Ma, Zhan-jie Lu, Si-qiang Zheng, Al-Wajih Hamzah, Yong-feng Shao, Hong Liu and Gao-li Liu

    Citation: BMC Cardiovascular Disorders 2021 21:210

    Content type: Research

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  23. Left ventricular geometry and left atrium (LA) enlargement are risk factors for cardiovascular disease. However, reports on the relationship between left ventricular geometry and LA volume yielded contradictor...

    Authors: Yong Zhang, Wen Shui, Yun Tian, Zhenxia Zhang, Juan Li and Jian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:209

    Content type: Research

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  24. With the development of cardiac surgery techniques, myocardial injury is gradually reduced, but cannot be completely avoided. Myocardial injury biomarkers (MIBs) can quickly and specifically reflect the degree...

    Authors: Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li and Yangyang Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:208

    Content type: Research

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  25. Circular RNAs have shown important regulatory roles in cardiovascular diseases, containing atherosclerosis (AS). We intended to explore the role of circ_0004104 in AS using oxidized low-density lipoprotein (ox...

    Authors: Chi Zhang, Liyue Wang and Ying Shen

    Citation: BMC Cardiovascular Disorders 2021 21:207

    Content type: Research article

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  26. Antithrombotic medications (antiplatelets and anticoagulants) reduce the risk of cardiovascular disease (CVD), but with the disadvantage of increasing bleeding risk. Ethnicity and socioeconomic deprivation are...

    Authors: Wai Chung Tse, Corina Grey, Matire Harwood, Rod Jackson, Andrew Kerr, Suneela Mehta, Katrina Poppe, Romana Pylypchuk, Sue Wells and Vanessa Selak

    Citation: BMC Cardiovascular Disorders 2021 21:206

    Content type: Research article

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  27. The purpose of the study is to identify off-pump patients who are at higher risk of mortality after re-exploration for bleeding or tamponade.

    Authors: Tongxiao Luan, Yingzhu Zhuang, Weihong Nie, Sumin Yang, Yuhui Wu, Rongmei Wang, Yunyan Dai and Hong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:204

    Content type: Research

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  28. Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations, including acute cardiac complications (ACCs) and subclinical myocardial injur...

    Authors: Jing Zhou, He Xuan, Yunxiang Miao, Junting Hu and Yunlang Dai

    Citation: BMC Cardiovascular Disorders 2021 21:203

    Content type: Research article

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  29. Several studies have shown that N-terminal pro-B-type natriuretic peptide (NT-proBNP) is strongly correlated with the complexity of coronary artery disease and the prognosis of patients with non-ST segment el...

    Authors: Wen-fei He, Lei Jiang, Yi-yue Chen, Yuan-hui Liu, Peng-yuan Chen, Chong-yang Duan, Li-huan Zeng, Hua-lin Fan, Xue-biao Wei, Wei Guo, Wei Chen, Jun Li, Wen-sheng Li, Zhi-qiang Guo, Zhi-kai Liu, Ning Tan…

    Citation: BMC Cardiovascular Disorders 2021 21:202

    Content type: Research article

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  30. Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an exploratory endpoint in a Phase 2 trial evaluating the eff...

    Authors: David Lin, Allan Klein, David Cella, Anna Beutler, Fang Fang, Matt Magestro, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, Antonio Abbate, Andrew Ertel, Leighann Litcher-Kelly, Brittany Klooster and John F. Paolini

    Citation: BMC Cardiovascular Disorders 2021 21:201

    Content type: Research article

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  31. Myocardial ischemia–reperfusion (IR) injury is a damage due to an initial reduction in blood flow to the heart, preventing it from receiving enough oxygen, and subsequent restoration of blood flow through the ...

    Authors: Xinyi Deng, Peng Yang, Tong Gao, Mengru Liu and Xianlun Li

    Citation: BMC Cardiovascular Disorders 2021 21:200

    Content type: Research article

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  32. Functional tricuspid regurgitation (FTR) is common in left-sided heart pathology involving the mitral valve. The incidence, clinical impact, risk factors, and natural history of FTR in the setting of ischemic ...

    Authors: Ofir Koren, Henda Darawsha, Ehud Rozner, Daniel Benhamou and Yoav Turgeman

    Citation: BMC Cardiovascular Disorders 2021 21:199

    Content type: Research article

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  33. The hemodynamics in the left ventricle (LV) and the ascending aorta (AAO) before and after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) is elucidated. Our objec...

    Authors: Kenichiro Suwa, Keitaro Akita, Keisuke Iguchi, Takasuke Ushio and Yuichiro Maekawa

    Citation: BMC Cardiovascular Disorders 2021 21:198

    Content type: Research

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  34. The mid-term and long-term efficacies of valve preservation in acute DeBakey I aortic dissection (AD) are controversial. Thus, it is unclear whether middle-aged patients with acute DeBakey I AD should undergo ...

    Authors: Qingsong Wu, Zhisheng Wang, Zhihuang Qiu, Yue Shen, Xiaodong Chen, Xingfeng Chen and Liangwan Chen

    Citation: BMC Cardiovascular Disorders 2021 21:196

    Content type: Research

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  35. In‐hospital cardiac arrest (IHCA) is a major public health problem with significant mortality. Rapid cardiopulmonary resuscitation and early defibrillation is extremely connected to patient outcome. In this st...

    Authors: G. Spinelli, E. Brogi, A. Sidoti, N. Pagnucci and F. Forfori

    Citation: BMC Cardiovascular Disorders 2021 21:195

    Content type: Research article

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  36. Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of hypertension and the resulting target organ damage. In this study, we observed alterations in the monocyte phenotype and i...

    Authors: Jingsi Zhang, Lina Yang and Yanchun Ding

    Citation: BMC Cardiovascular Disorders 2021 21:194

    Content type: Research

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  37. Antegrade cerebral perfusion (ACP) under moderate hypothermic circulatory arrest is used during total aortic arch replacement surgery (TARS) in patients with acute type A aortic dissection, but it is associate...

    Authors: Jing Lin, Zhen Qin, Xinhao Liu, Jiyue Xiong, Zhong Wu, Yingqiang Guo, Deying Kang and Lei Du

    Citation: BMC Cardiovascular Disorders 2021 21:193

    Content type: Research article

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  38. Coronary artery fistula (CAF) is a rare congenital anomaly with a challenging scenario in children. This study reports our experience in transcatheter closure of CAF with Nit-Occlude PDA coil and midterm clini...

    Authors: Hamid Amoozgar, Mohammad Reza Edraki, Amir Naghshzan, Nima Mehdizadegan, Hamid Mohammadi, Gholamhossein Ajami and Ahmad Ali Amirghofran

    Citation: BMC Cardiovascular Disorders 2021 21:192

    Content type: Research article

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  39. Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the ...

    Authors: Motahareh Hasani, Asieh Mansour, Hamid Asayesh, Shirin Djalalinia, Armita Mahdavi Gorabi, Fatemeh Ochi and Mostafa Qorbani

    Citation: BMC Cardiovascular Disorders 2021 21:190

    Content type: Research

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  40. Resuscitation using a percutaneous mechanical circulatory support device (iCPR) improves survival after cardiac arrest (CA). We hypothesized that the addition of inhaled nitric oxide (iNO) during iCPR might pr...

    Authors: Christoph Nix, Rashad Zayat, Andreas Ebeling, Andreas Goetzenich, Uma Chandrasekaran, Rolf Rossaint, Nima Hatam and Matthias Derwall

    Citation: BMC Cardiovascular Disorders 2021 21:189

    Content type: Research article

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  41. Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorp...

    Authors: Damir Raljević, Viktor Peršić, Elitza Markova-Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić and Sandra Kraljević Pavelić

    Citation: BMC Cardiovascular Disorders 2021 21:188

    Content type: Research article

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  42. The association of infective endocarditis (IE) with spondylodiscitis (SD) was first reported in 1965, but few data are available about this issue. This study aimed to evaluate the prevalence of SD in patients ...

    Authors: Stefano Del Pace, Valentina Scheggi, Giacomo Virgili, Sabina Caciolli, Iacopo Olivotto, Nicola Zoppetti, Irene Merilli, Nicole Ceschia, Valentina Andrei, Bruno Alterini, Pier Luigi Stefàno and Niccolò Marchionni

    Citation: BMC Cardiovascular Disorders 2021 21:186

    Content type: Research article

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  43. Autologous pericardium is widely used as a plastic material in intracardiac structures, in the pulmonary artery, and in aortic valve leaflets. For aortic valve reconstruction (AVRec) using the Ozaki procedure,...

    Authors: Keitaro Okamoto, Tadashi Umeno, Takashi Shuto, Tomoyuki Wada, Hirofumi Anai, Haruto Nishida, Yasuhide Nakayama and Shinji Miyamoto

    Citation: BMC Cardiovascular Disorders 2021 21:184

    Content type: Research article

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  44. Coronary chronic total occlusions (CTOs) are related to increased risk of adverse clinical outcomes. The optimal treatment strategy for CTO has not been well established. We sought to examine the impact of CTO...

    Authors: Xuhe Gong, Li Zhou, Xiaosong Ding, Hui Chen and Hongwei Li

    Citation: BMC Cardiovascular Disorders 2021 21:182

    Content type: Research article

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