Articles

Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease: the MIMeRiC randomized controlled trial

In the treatment of coronary heart disease, secondary prevention goals are still often unmet and poor adherence to prescribed drugs has been suggested as one of the reasons. We aimed to investigate whether pha...

Authors: Malin Johansson Östbring, Tommy Eriksson, Göran Petersson and Lina Hellström

The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting

To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-...

Authors: Mingxin Gao, Kangjun Fan, Wenyuan Yu, Hongli Liu, Yongxiang Wei and Yang Yu

Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN): protocol for a prospective international multicenter register of cardiac arrest in children

Cardiac arrest (CA) in children is a major public health problem. Thanks to advances in cardiopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. However, pediatric...

Authors: Jimena del Castillo, Débora Sanz, Laura Herrera and Jesús López-Herce

Winning hearts and minds: ECG reporting in the first seizure clinic

An electrocardiogram (ECG) is a mandatory test for anyone presenting with loss of consciousness. Many referrals to the first seizure clinic (FSC) are caused by syncope. We assessed the sensitivity of neurologi...

Authors: Xuya Huang, N. Malek, J. Simpson, D. Kalladka, F. G. Dunn and J. P. Leach

Extracellular volume quantification using synthetic haematocrit assessed from native and post-contrast longitudinal relaxation T1 times of a blood pool

In terms of cardiovascular magnetic resonance are haematocrit values required for calculation of extracellular volume fraction (ECV). Previously published studies have hypothesized that haematocrit could be ca...

Authors: Lukas Opatril, Roman Panovsky, Jan Machal, Tomas Holecek, Lucia Masarova, Vera Feitova, Vladimir Kincl, Marek Hodejovsky and Lenka Spinarova

Association of monocyte-to-high density lipoprotein ratio with arterial stiffness in patients with diabetes

Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein chole...

Authors: Dyah Samti Mayasari, Nahar Taufiq and Hariadi Hariawan

Role of community health volunteers in identifying people with elevated blood pressure for diagnosis and monitoring of hypertension in Malawi: a qualitative study

In recent years, there has been greater recognition of the important role of community health volunteers in many countries and their important role informs many health programs. This include health education, ...

Authors: Elvis Safary, Micrina Mwandeti, Beatrice Matanje, Claudia Beiersmann, Caroline Mtaita, Veronica Shiroya, Volker Winkler, Andreas Deckert, Pratap Kumar, Sam Phiri and Florian Neuhann

The rotational atherectomy with a guide extension catheter for calcified and tortuous lesions in left anterior descending artery: a case report

The interventional treatment of calcified lesions with severe tortuosity in the left anterior descending artery (LAD) was challenging and the report of rotational atherectomy with mother-and-child technique ha...

Authors: Taichi Kato, Masashi Fujino, Kensuke Takagi and Teruo Noguchi

Effectiveness of a new cardiac risk scoring model reclassified by QRS fragmentation as a predictor of postoperative cardiac event in patients with severe renal dysfunction

It is difficult to evaluate the risk of patients with severe renal dysfunction before surgery due to various limitations despite high postoperative cardiac events. This study aimed to investigate the value of ...

Authors: Hyun Jun Cho, Namkyun Kim, Hyeon Jeong Kim, Bo Eun Park, Hong Nyun Kim, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho and Shung Chull Chae

Dose approach matter? A meta-analysis of outcomes following transfemoral versus transapical transcatheter aortic valve replacement

Transcatheter aortic valve replacement (TAVR) has gained increasing acceptance for patients with aortic disease. Both transfemoral (TF-TAVR) and transapical (TA-TAVR) approach were widely adopted while their p...

Authors: Ruikang Guo, Minghui Xie, Wai Yen Yim, Wenconghui Wu, Weiwei Jiang, Yin Wang and Xingjian Hu

Importance of confirming the underlying diagnosis in patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): a single-centre retrospective cohort study

Many patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are discharged without a known aetiology for their clinical presentation. This study sought to assess the effect of this...

Authors: T. F. S. Pustjens, A. Meerman, N. P. A. Vranken, A. W. Ruiters, B. Gho, M. Stein, M. Ilhan, L. Veenstra, P. Winkler, Á. Lux, S. Rasoul and A. W. J. van ‘t Hof

Research on the correlation between activating transcription factor 3 expression in the human coronary artery and atherosclerotic plaque stability

Activating transcription factor 3 (ATF3) is an early response gene that is activated in response to atherosclerotic stimulation and may be an important factor in inhibiting the progression of atherosclerosis. ...

Authors: J. Peng, C. Y. Le, B. Xia, J. W. Wang, J. J. Liu, Z. Li, Q. J. Zhang, Q. Zhang, J. Wang and C. W. Wan

Mid-term (up to 12 years) clinical and echocardiographic outcomes of percutaneous transvenous mitral commissurotomy in patients with rheumatic mitral stenosis

Rheumatic heart disease (RHD) is still a concerning issue in developing countries. Among delayed RHD presentations, rheumatic mitral valve stenosis (MS) remains a prevalent finding. Percutaneous transvenous mi...

Authors: Yahya Dadjo, Maryam Moshkani Farahani, Reza Nowshad, Mohsen Sadeghi Ghahrodi, Alireza Moaref and Javad Kojuri

Concordance of recommendations across clinical practice guidelines for the management of hypertension in Southeast Asia with internationally reputable sources

This study aimed to assess the rate of concordance, and to investigate sources of non-concordance of recommendations in the management of hypertension across CPGs in Southeast Asia, with internationally reputa...

Authors: Chia Siang Kow, Syed Shahzad Hasan, Pei Se Wong and Rohit Kumar Verma

Indoleamine 2,3 dioxygenase (IDO) level as a marker for significant coronary artery disease

Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation, and is regarded as a key molecule driving immunotolera...

Authors: Nattawut Wongpraparut, Ploy Pengchata, Sudarat Piyophirapong, Pariya Panchavinnin, Rungtiwa Pongakasira, Noppadol Arechep, Kanda Kasetsinsombat and Kittipong Maneechotesuwan

Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the U.S. National Health and Nutrition Examination Survey (NHANES)

We examined the relationship between ratios of select biomarkers of kidney and liver function on all-cause and coronary heart disease (CHD) mortality, both in isolation, and in combination with metabolic syndr...

Authors: Akinkunle Oye-Somefun, Jennifer L. Kuk and Chris I. Ardern

Identification of biomarkers associated with metabolic cardiovascular disease using mRNA-SNP-miRNA regulatory network analysis

CVD is the leading cause of death in T2DM patients. However, few biomarkers have been identified to detect and diagnose CVD in the early stage of T2DM. The aim of our study was to identify the important mRNAs,...

Authors: Zhiyuan Fan, Wenjuan Peng, Zhiwen Wang, Ling Zhang and Kuo Liu

A case of primary aldosteronism with a negative aldosterone-to-renin ratio

Primary aldosteronism (PA), as a cause of secondary hypertension, can cause more serious cardiovascular damage than essential hypertension. The aldosterone-to-renin ratio (ARR) is recommended as the most relia...

Authors: Fengyi Liu, Liang Wang and Yanchun Ding

Correction to: Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project

Authors: Nan Ye, Lijiao Yang, Guoqin Wang, Weijing Bian, Fengbo Xu, Changsheng Ma, Dong Zhao, Jing Liu, Yongchen Hao, Jun Liu, Na Yang and Hong Cheng

Electrical storm after correction of an uncomplicated congenital atrial septal defect in an adult: a case report

There is a paucity of published literature describing electrical storm after the correction of uncomplicated atrial septal defect (ASD) in an adult.

Authors: Ying Liang, Feilong Hei and Yulong Guan

Renoprotective effects of sodium glucose cotransporter 2 inhibitors in type 2 diabetes patients with decompensated heart failure

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) reduces the risk of the composite renal endpoint and weakens the progressive decline in renal function in patients with chronic heart failure (HF). However, a ...

Authors: Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura and Koichiro Kinugawa

Subclinical cardiac perforation by cardiac implantable electronic device leads detected by cardiac computed tomography

The relationship between the characteristics of cardiac implantable electronic device (CIED) leads and subclinical cardiac perforations remains unclear. This study aimed to evaluate the incidence of subclinica...

Authors: Yeong-Min Lim, Jae-Sun Uhm, Min Kim, In-Soo Kim, Moo-Nyun Jin, Hee Tae Yu, Tae-Hoon Kim, Hye-Jeong Lee, Young-Jin Kim, Boyoung Joung, Hui-Nam Pak and Moon-Hyoung Lee

The association between atrial fibrillation and in-hospital outcomes in chronic kidney disease patients with acute coronary syndrome: findings from the improving care for cardiovascular disease in China-acute coronary syndrome (CCC-ACS) project

Atrial fibrillation (AF) is the most common cardiac arrhythmia in patients with chronic kidney disease (CKD) and acute coronary syndrome (ACS). This study aimed to explore the frequency and impact of AF on cli...

Authors: Lijiao Yang, Nan Ye, Guoqin Wang, Weijing Bian, Fengbo Xu, Dong Zhao, Jing Liu, Yongchen Hao, Jun Liu, Na Yang and Hong Cheng

KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease

Myocardial infarction (MI) contributes to high mortality and morbidity and can also accelerate atherosclerosis, thus inducing recurrent event due to status changing of coronary artery walls or plaques. The res...

Authors: Qiang Zhang, Yue Zheng, Meng Ning and Tong Li

Serum free fatty acids are associated with severe coronary artery calcification, especially in diabetes: a retrospective study

Serum free fatty acid (FFA) concentrations are associated with coronary heart disease and diabetes mellitus (DM). Few studies focused on the relationship between serum FFA levels and coronary artery calcificat...

Authors: Yangxun Xin, Junfeng Zhang, Yuqi Fan and Changqian Wang

Evaluating the association of social needs assessment data with cardiometabolic health status in a federally qualified community health center patient population

Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients’ Risks, Assets, and Experiences (PRAPARE) to imp...

Authors: Connor Drake, Tyler Lian, Justin G. Trogdon, David Edelman, Howard Eisenson, Morris Weinberger, Kristin Reiter and Christopher M. Shea

Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation

Catheter ablation is widely used in atrial fibrillation (AF) management. In this study, we are aimed to investigate the incidence of postprocedural cognitive decline in a larger population undergoing AF ablati...

Authors: Jing Zhang, Shi-Jun Xia, Xin Du, Chao Jiang, Yi-Wei Lai, Yu-Feng Wang, Zhao-Xu Jia, Liu He, Ri-Bo Tang, Jian-Zeng Dong and Chang-Sheng Ma

Individualized mobile health interventions for cardiovascular event prevention in patients with coronary heart disease: study protocol for the iCARE randomized controlled trial

Mobile health-based individualized interventions have shown potential effects in managing cardiovascular risk factors. This study aims to assess whether or not mHealth based individualized interventions delive...

Authors: Yuling Chen, Meihua Ji, Ying Wu, Ying Deng, Fangqin Wu and Yating Lu

Current status and etiology of valvular heart disease in China: a population-based survey

The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investiga...

Authors: Ying Yang, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Suning Li, Congyi Zheng, Yuting Kang, Linlin Jiang, Zhenhui Zhu and Runlin Gao

Prevalence and differences of ideal cardiovascular health in urban and rural adolescents in the Region of Tyrol: results from the EVA Tyrol study

Early adoption of a healthy lifestyle has positive effects on cardiovascular health (CVH) in adulthood. In this study, we aimed to assess CVH metrics in a cohort of healthy teenagers with focus on differences ...

Authors: C. Hochmayr, J. P. Ndayisaba, N. Gande, A. Staudt, B. Bernar, K. Stock, R. Geiger, M. Knoflach and U. Kiechl-Kohlendorfer

Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients

Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of C...

Authors: Wen Wei, Lingyu Zhang, Yunhan Zhang, Ronghui Tang, Miao Zhao, Zhidong Huang, Jin Liu, Danyuan Xu, Yibo He, Bo Wang, Haozhang Huang, Qiang Li, Mengfei Lin, Yong Liu, Kaihong Chen and Shiqun Chen

Ten-year risk of fatal cardiovascular disease and its association with metabolic risk factors among waste pickers in South Africa

Cardiovascular disease (CVD) is the leading cause of death among non-communicable diseases in South Africa. Several metabolic risk factors contribute to the development of CVD. Informal workers such as waste p...

Authors: Felix Made, Engelbert A. Nonterah, Nonhlanhla Tlotleng, Vusi Ntlebi and Nisha Naicker

Endovascular embolization of spontaneous rupture of isolated splenic artery dissection associated with hemosuccus pancreaticus: a case report

Isolated splenic artery dissection (SAD) is extremely rare, life-threatening, and particularly difficult to diagnose. Moreover, SAD presenting as digestive hemorrhage has not been reported.

Authors: Jianjun Jiang, Yang Liu and Xiangjiu Ding

Comparison of the prognostic value of SYNTAX score and clinical SYNTAX score on outcomes of Chinese patients underwent percutaneous coronary intervention

Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of ...

Authors: Xiao-Qin Li, Chun Yin, Xiao-Li Li, Wen-Li Wu and Kun Cui

Leukocyte count and the risk of adverse outcomes in patients with HFpEF

Inflammation is a key feature of heart failure including HFpEF. The leukocyte count is a marker of inflammation that is widely used in clinical practice. However, there is little available evidence for the rel...

Authors: Zhaowei Zhu and Shenghua Zhou

The vicious cycle: a history of obesity and COVID-19

Recently, we face a surge in the fast-forward Coronavirus Disease 2019 (COVID-19) pandemic with nearly 170 million confirmed cases and almost 3.5 million confirmed deaths at the end of May 2021. Obesity, also ...

Authors: Jacek Bil and Olga Możeńska

High-fat diet attenuates the improvement of hypoxia-induced pulmonary hypertension in mice during reoxygenation

It is widely recognized that metabolic disorder is associated with pulmonary hypertension (PH). It is known that hypoxia-induced elevated pulmonary artery pressure in mice returns to normal pressure during reo...

Authors: Koichi Sugimoto, Tetsuro Yokokawa, Tomofumi Misaka, Takashi Kaneshiro, Akiomi Yoshihisa, Kazuhiko Nakazato and Yasuchika Takeishi

Integration of transcriptomic data identifies key hallmark genes in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) represents one of the most common inherited heart diseases. To identify key molecules involved in the development of HCM, gene expression patterns of the heart tissue samples ...

Authors: Jing Xu, Xiangdong Liu and Qiming Dai

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis

Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of people all over the world. HF occurs when the cardiac overload and injury, which is a worldwide complaint. The aim of this study ...

Authors: Vijayakrishna Kolur, Basavaraj Vastrad, Chanabasayya Vastrad, Shivakumar Kotturshetti and Anandkumar Tengli

IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study

Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalenc...

Authors: Jennifer M. T. A. Meessen, Giulia Cesaroni, Gian F. Mureddu, Alessandro Boccanelli, Ursula-Henrike Wienhues-Thelen, Peter Kastner, Luisa Ojeda-Fernandez, Deborah Novelli, Gianfranco Bazzoni, Maurizio Mangiavacchi, Nera Agabiti, Serge Masson, Lidia Staszewsky and Roberto Latini

Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19

The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear.

Authors: Kevin O’Gallagher, Anthony Shek, Daniel M. Bean, Rebecca Bendayan, Alexandros Papachristidis, James T. H. Teo, Richard J. B. Dobson, Ajay M. Shah and Rosita Zakeri

One-year outcomes of drug-coated balloon treatment for long femoropopliteal lesions: a multicentre cohort and real-world study

Drug-coated balloons (DCBs) have shown superiority in the endovascular treatment of short femoropopliteal artery disease. Few studies have focused on outcomes in long lesions. This study aimed to evaluate the ...

Authors: Xiaoxi Yu, Xin Zhang, Zhichao Lai, Jiang Shao, Rong Zeng, Wei Ye, Yuexin Chen, Bihui Zhang, Bo Ma, Wenteng Cao, Xiaolong Liu, Jinghui Yuan, Yuehong Zheng, Min Yang, Zhidong Ye and Bao Liu

Combined evaluation of coronary artery disease and high-sensitivity cardiac troponin T for prediction of adverse events in patients with hypertrophic cardiomyopathy

This study was performed to investigate the clinical significance of combined evaluation of both coronary artery disease (CAD) and high-sensitivity cardiac troponin T (hs-cTnT) for prediction of major adverse ...

Authors: Hang Liao, Huay Cheem Tan, Ziqiong Wang, Xiaoping Chen, Yong He and Sen He

Real-world experience of angiotensin receptor/neprilysin inhibitor (ARNI) usage in Thailand: a single-center, retrospective analysis

Treatment of heart failure with reduced ejection fraction (HFrEF) has been revolutionized by angiotensin receptor/neprilysin inhibitor (ARNI). ARNI has been shown to significantly reduce morbidity and mortalit...

Authors: Wipharak Rattanavipanon, Thanyaluck Sotananusak, Fairus Yamaae, Arisa Chandrsawang, Pitchapa Kaewkan, Surakit Nathisuwan and Teerapat Yingchoncharoen

Impact of chronic outward force on arterial responses of proximal and distal of long superficial femoral artery stent

Self-expanding nitinol stent (SENS) implantation is commonly oversized in the superficial femoral artery (SFA), and leads to chronic outward force (COF) and in-stent restenosis (ISR). This study aimed to inves...

Authors: Hu Li, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Sang Ki Moon, Won Young Jang, Woohyeun Kim, Ji Hun Ahn, Sang-Ho Park, Woong Gil Choi, Rui Feng Yang, Wen Wei Bai, Cheol Ung Choi, Yang gi Ryu, Man Jong Baek and Dong Joo Oh

Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES)

The risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular end...

Authors: Benedicta Ngwenchi Nkeh-Chungag, Godwill Azeh Engwa, Charles Businge, Mziwohlanga Mdondolo, Magdevy Pajaro Medina and Nandu Goswami

Identification and functional study of GATA4 gene regulatory variants in atrial septal defects

Congenital heart disease (CHD) is the leading cause of mortality from birth defects. In adult CHD patients with successful surgical repair, cardiac complications including heart failure develop at late stage, ...

Authors: Dongchen Fan, Shuchao Pang, Jing Chen, Jiping Shan, Qianjin Cheng and Bo Yan

Cardio-metabolic outcomes in South Asians compared to White Europeans in the United Kingdom: a matched controlled population-based cohort study

There appears to be an inequality in the risk of cardio-metabolic disease between those from a South Asian (SA) background when compared to those of White Europeans (WE) descendance, however, this association ...

Authors: Munerah Almulhem, Joht Singh Chandan, Krishna Gokhale, Nicola J. Adderley, Rasiah Thayakaran, Kamlesh Khunti, Abd A. Tahrani, Wasim Hanif and Krishnarajah Nirantharakumar

Contemporary procedure characteristics and outcomes of accessory atrioventricular pathway ablations in an integrated community-based health care system using a tiered approach

Since the early descriptions of large series of accessory atrioventricular pathway ablations in adults and adolescents over 20 years ago, there have been limited published reports based on more recent experien...

Authors: Charlie Young, Annie Kwan, Lisa Yepez, Meghan McCarty, Amanda Chan, Dora Hsu, Jennifer Han, Taresh Taneja, Shirley Park, Robert Hayward and Taylor I. Liu

Study rationale and design of a study of EMPAgliflozin’s effects in patients with type 2 diabetes mellitus and Coronary ARtery disease: the EMPA-CARD randomized controlled trial

Recent trials have revealed that sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are effective against hyperglycemia and also reduce micro- and macro-vascular complications in patients with type 2 diabete...

Authors: Sepehr Gohari, Tara Reshadmanesh, Hadi Khodabandehloo, Mojtaba Fathi, Hassan Ahangar, Shahram Arsang-Jang, Faramarz Ismail-Beigi, Samin Ghanbari, Mohsen Dadashi, Muhammad Javad Muhammadi, Sheida Gohari and Saeid Ghaffari