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  1. Content type: Research article

    Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried o...

    Authors: Hamed Akbari, Gholamreza Asadikaram, Hamid Aria, Saba Fooladi, Sina Vakili and Mohammad Masoumi

    Citation: BMC Cardiovascular Disorders 2018 18:237

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  2. Content type: Research article

    Sleep-related investigations in acute myocardial infarction (AMI) patients are rare. The aim of this study was to examine sex-specific associations of patient-reported sleep disturbances within 4 weeks before ...

    Authors: Franziska Nairz, Christa Meisinger, Inge Kirchberger, Margit Heier, Christian Thilo, Bernhard Kuch, Annette Peters and Ute Amann

    Citation: BMC Cardiovascular Disorders 2018 18:235

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  3. Content type: Research article

    Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium cha...

    Authors: Chang-He Liu, Na Hua, Xi Fu, Yi-Long Pan, Bin Li and Xiao-Dong Li

    Citation: BMC Cardiovascular Disorders 2018 18:236

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  4. Content type: Research article

    The health-related quality of life (HRQoL) is an important treatment goal that could serve as low-cost prognostication tool in resource poor settings.

    Authors: Samson Okello, Fardous Charles Abeya, Boniface Amanee Elias Lumori, Suzan Joan Akello, Christopher Charles Moore, Brian H. Annex and Andrew J. Buda

    Citation: BMC Cardiovascular Disorders 2018 18:232

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  5. Content type: Study protocol

    Plaque composition and morphologic characteristics identified by virtual histology intravascular ultrasound (VH-IVUS) can determine plaques at increased risk of clinical events following percutaneous coronary ...

    Authors: Yin Liu, Hai-Bo Wang, Xiang Li, Jian-Yong Xiao, Ji-Xiang Wang, Kathleen H. Reilly, Bo Sun and Jing Gao

    Citation: BMC Cardiovascular Disorders 2018 18:233

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  6. Content type: Case report

    In the era of primary percutaneous coronary intervention (PPCI), the incidence of post-cardiac injury syndrome (PCIS) in patients with acute myocardial infarction (AMI) following PPCI has become less common. H...

    Authors: Yan Gao, Nanette H. Bishopric, Hong-wei Chen, Jiang-tao Li, Yu-lang Huang and He-xun Huang

    Citation: BMC Cardiovascular Disorders 2018 18:234

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  7. Content type: Case report

    Takotsubo syndrome (TTS) is an acute cardiac condition with reversible heart failure which is often triggered by psychological and physical stressful events. Although pulmonary embolism (PE) was reported as a ...

    Authors: Qi Jin, Qin Luo, Zhihui Zhao, Qing Zhao, Xue Yu, Lu Yan, Liu Gao and Zhihong Liu

    Citation: BMC Cardiovascular Disorders 2018 18:229

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  8. Content type: Research article

    The literature suggests that comorbid depression, defined in this paper as a history of depression prior to a cardiovascular event, has an impact on later onset depression as well as constituting increased ris...

    Authors: Serdar Sever, Su Golder and Patrick Doherty

    Citation: BMC Cardiovascular Disorders 2018 18:230

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  9. Content type: Debate

    Transcatheter aortic valve implantation (TAVI) has become an established therapeutic option for patients with symptomatic, severe aortic valve stenosis. Ageing of the Western and Asian population and expansion...

    Authors: Manik Chopra, Ngai H. V. Luk, Ole De Backer and Lars Søndergaard

    Citation: BMC Cardiovascular Disorders 2018 18:231

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  10. Content type: Research article

    Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device...

    Authors: Dóra Ujvárosy, Veronika Sebestyén, Tamás Pataki, Tamás Ötvös, István Lőrincz, György Paragh and Zoltán Szabó

    Citation: BMC Cardiovascular Disorders 2018 18:227

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  11. Content type: Research article

    The prognostic significance of changes in mean platelet volume (MPV) during hospitalization in ST segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (...

    Authors: Eyup Avci, Tuncay Kiris, Aykan Çelik, Eser Variş, Fatma Kayaalti Esin, Diyar Köprülü and Hasan Kadi

    Citation: BMC Cardiovascular Disorders 2018 18:226

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  12. Content type: Research article

    Physical activity programs (PAP) in patients with cardiovascular disease require evidence of cost-utility. To assess improvement in health-related quality of life (QoL) and reduction of health care consumption...

    Authors: Laurent Bailly, Philippe Mossé, Stéphane Diagana, Marion Fournier, Fabienne d’Arripe-Longueville, Odile Diagana, Jocelyn Gal, Jean Grebet, Mario Moncada, Jean-Jacques Domerego, Rémi Radel, Roxane Fabre, Alain Fuch and Christian Pradier

    Citation: BMC Cardiovascular Disorders 2018 18:225

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  13. Content type: Research article

    Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have...

    Authors: Katsuaki Yokoyama, Shigemasa Tani, Rei Matsuo and Naoya Matsumoto

    Citation: BMC Cardiovascular Disorders 2018 18:224

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  14. Content type: Research article

    The rate of incidentally diagnosed congenital heart disease (CHD) in adulthood has not been reported. The aim of this study was to investigate the detection rate of CHD in adults by routine, general health che...

    Authors: Eun Min Kwag, Ju Suk Lee and Sung Hoon Kim

    Citation: BMC Cardiovascular Disorders 2018 18:223

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  15. Content type: Research article

    Cardiac Amyloidosis (CA) pertains to the cardiac involvement of a group of diseases, in which misfolded proteins deposit in tissues and cause progressive organ damage. The vast majority of CA cases are caused ...

    Authors: Panagiota Kyriakou, Dimitrios Mouselimis, Anastasios Tsarouchas, Angelos Rigopoulos, Constantinos Bakogiannis, Michel Noutsias and Vasileios Vassilikos

    Citation: BMC Cardiovascular Disorders 2018 18:221

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  16. Content type: Research article

    Cardiac arrhythmias (CA) are very common and may occur with or without heart disease. Causes of these disturbances can be components of the metabolic syndrome (MetS) or deficits of micronutrients especially ma...

    Authors: Elke Parsi, Norman Bitterlich, Anne Winkelmann, Daniela Rösler and Christine Metzner

    Citation: BMC Cardiovascular Disorders 2018 18:220

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  17. Content type: Research article

    Self-administered health-status questionnaires are important tools in epidemiology. The objective of the presented validation study is to measure the agreement between breast cancer patients’ self-reports and ...

    Authors: Hiltrud Merzenich, Maria Blettner, Dorothea Niehoff, Lukas Schwentner, Marcus Schmidt, Margit Schmitt and Daniel Wollschläger

    Citation: BMC Cardiovascular Disorders 2018 18:218

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  18. Content type: Research article

    Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patien...

    Authors: Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin and Yuan Yuan

    Citation: BMC Cardiovascular Disorders 2018 18:219

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  19. Content type: Research article

    Ticagrelor has been acknowledged as a new oral antagonist of P2Y12-adenosine diphosphate receptor, as a strategy with more rapid onset as well as more significant platelet inhibition function in acute coronary...

    Authors: Dong Wang, Xiao-Hong Yang, Ji-Dong Zhang, Rui-Bin Li, Min Jia and Xiao-Ran Cui

    Citation: BMC Cardiovascular Disorders 2018 18:217

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  20. Content type: Research article

    To decrease the morbidity burden of cardiovascular disease and to avoid the development of potentially preventable complications, early assessment and treatment of acute coronary syndrome (ACS) are important. ...

    Authors: Mats Holmberg, Henrik Andersson, Karin Winge, Camilla Lundberg, Thomas Karlsson, Johan Herlitz and Birgitta Wireklint Sundström

    Citation: BMC Cardiovascular Disorders 2018 18:216

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  21. Content type: Research article

    Sclerostin is known to be a canonical Wnt/β-catenin signaling pathway inhibitor, while the Wnt/β-catenin signaling pathway is proposed to be involved in the development of arterial stiffness. This study aims t...

    Authors: Yu-Chi Chang, Bang-Gee Hsu, Hung-Hsiang Liou, Chung-Jen Lee and Ji-Hung Wang

    Citation: BMC Cardiovascular Disorders 2018 18:214

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  22. Content type: Research article

    Obstructive sleep apnea (OSA) and insomnia are frequent sleep problems that are associated with poor prognosis in patients with coronary heart disease. The mechanisms linking poor sleep with an increased cardi...

    Authors: Roland von Känel, Mary Princip, Jean-Paul Schmid, Jürgen Barth, Hansjörg Znoj, Ulrich Schnyder and Rebecca E. Meister-Langraf

    Citation: BMC Cardiovascular Disorders 2018 18:213

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  23. Content type: Research article

    Implantable cardioverter defibrillator (ICD) implantation is associated with driving restrictions which may have profound effects on the patient’s life. However, there is limited patient-reported data on the i...

    Authors: Jenny Bjerre, Simone Hofman Rosenkranz, Anne Mielke Christensen, Morten Schou, Christian Jøns, Gunnar Gislason and Anne-Christine Ruwald

    Citation: BMC Cardiovascular Disorders 2018 18:212

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  24. Content type: Research article

    The objective of our study was to compare resource use and clinical outcomes among atrial fibrillation (AF) patients who underwent catheter ablation versus antiarrhythmic drug (AAD) treatment.

    Authors: Julian W. E. Jarman, Wajid Hussain, Tom Wong, Vias Markides, Jamie March, Laura Goldstein, Ray Liao, Iftekhar Kalsekar, Abhishek Chitnis and Rahul Khanna

    Citation: BMC Cardiovascular Disorders 2018 18:211

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  25. Content type: Case report

    The crista terminalis is a variation of normal anatomical structure within the right atrium which may be misdiagnosed with an abnormal atrial mass normally visualized in the standard views on the transthoracic...

    Authors: Jiang Wang, Gang Wang, Xiao Bi, Ran Zhang and Changfu Liu

    Citation: BMC Cardiovascular Disorders 2018 18:210

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  26. Content type: Research article

    The current study evaluated time trends of statin use and incidence of recurrent CVD in secondary prevention from 1999 to 2013 and investigated which factors were associated with statin use in secondary preven...

    Authors: Nele Laleman, Séverine Henrard, Marjan van den Akker, Geert Goderis, Frank Buntinx, Gijs Van Pottelbergh and Bert Vaes

    Citation: BMC Cardiovascular Disorders 2018 18:209

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  27. Content type: Study protocol

    Hypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to ...

    Authors: Wilby Williamson, Odaro J. Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen, Richard McManus, Helen Dawes, Charlie Foster, Adam J. Lewandowski and Paul Leeson

    Citation: BMC Cardiovascular Disorders 2018 18:208

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  28. Content type: Research article

    Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impac...

    Authors: Hongwei Tian, Jingang Cui, Chengzhi Yang, Fenghuan Hu, Jiansong Yuan, Shengwen Liu, Weixian Yang, Xiaowei Jiang and Shubin Qiao

    Citation: BMC Cardiovascular Disorders 2018 18:207

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  29. Content type: Research article

    Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospital...

    Authors: José González-Costello, Josep Comín-Colet, Josep Lupón, Cristina Enjuanes, Marta de Antonio, Lara Fuentes, Pedro Moliner-Borja, Nuria Farré, Elisabet Zamora, Nicolás Manito, Ramón Pujol and Antoni Bayés-Genis

    Citation: BMC Cardiovascular Disorders 2018 18:206

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  30. Content type: Research article

    Compared to ST-segment elevation myocardial infarction (STEMI) patients who present at centres with catheterization facilities, those transferred for primary percutaneous coronary intervention (PCI) have subst...

    Authors: Oumin Shi, Anam M. Khan, Mohammad R. Rezai, Cynthia A. Jackevicius, Jafna Cox, Clare L. Atzema, Dennis T. Ko, Thérèse A. Stukel, Laurie J. Lambert, Madhu K. Natarajan, Zhi-jie Zheng and Jack V. Tu

    Citation: BMC Cardiovascular Disorders 2018 18:204

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  31. Content type: Research article

    In diabetes, dysregulated substrate utilization and energy metabolism of myocardium can lead to heart failure. To examine the dynamic changes of myocardium, most of the previous studies conducted dynamic myoca...

    Authors: Lijun Hu, Chun Qiu, Xiaosong Wang, Mei Xu, Xiaoliang Shao and Yuetao Wang

    Citation: BMC Cardiovascular Disorders 2018 18:203

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  32. Content type: Research article

    Matrix metalloproteinase-9 (MMP9) has been reported to play a key role in the pathogenesis of aortic aneurysm. However, few studies have assessed serum MMP9 levels in both abdominal aortic aneurysm (AAA) and t...

    Authors: Tan Li, Bo Jiang, Xuan Li, Hai-yang Sun, Xin-tong Li, Jing-jing Jing and Jun Yang

    Citation: BMC Cardiovascular Disorders 2018 18:202

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  33. Content type: Correspondence

    Standard pharmacological therapy in Takotsubo syndrome (TTS) is still debated and there is a lack of prospective data. In their recent work in BMC Cardiovascular Disorders Abanador-Kamper et al. found that str...

    Authors: Francesco Santoro, Thomas Stiermaier, Francesca Guastafierro, Nicola Tarantino, Ingo Eitel and Natale Daniele Brunetti

    Citation: BMC Cardiovascular Disorders 2018 18:205

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  34. Content type: Research article

    We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patient...

    Authors: Wonjae Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn and In-Ho Chae

    Citation: BMC Cardiovascular Disorders 2018 18:201

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  35. Content type: Case report

    Radiofrequency ablation is a common and minimally invasive procedure used to treat liver tumors. However, the potential threat of heat injury to adjacent structures if the hepatic lesion is near the diaphragm ...

    Authors: Jung-Chi Hsu, Han-Lin Tsai, Yu-Ling Lin and Rei-Yeuh Chang

    Citation: BMC Cardiovascular Disorders 2018 18:200

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  36. Content type: Research article

    Few studies have suggested that patients with myocardial infarction (MI) may be at increased risk of cancer, but further large register-based studies are needed to evaluate this subject. The aim of this study ...

    Authors: Morten Malmborg, Christine Benn Christiansen, Michelle D. Schmiegelow, Christian Torp-Pedersen, Gunnar Gislason and Morten Schou

    Citation: BMC Cardiovascular Disorders 2018 18:198

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  37. Content type: Research article

    It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a gro...

    Authors: Alina S. Kerimkulova, Olga S. Lunegova, Aibek E. Mirrakhimov, Saamay S. Abilova, Malik P. Nabiev, Ksenia V. Neronova, Erkaiym E. Bektasheva, Ulan M. Toktomamatov, Jyldyz E. Esenbekova and Erkin M. Mirrakhimov

    Citation: BMC Cardiovascular Disorders 2018 18:199

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  38. Content type: Research article

    Receptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or a...

    Authors: Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen and Klaus Elenius

    Citation: BMC Cardiovascular Disorders 2018 18:196

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  39. Content type: Review

    Long noncoding RNAs (lncRNAs) are endogenous RNA transcripts longer than 200 nucleotides which regulate epigenetically the expression of genes but do not have protein-coding potential. They are emerging as pot...

    Authors: Tarun Pant, Anuradha Dhanasekaran, Juan Fang, Xiaowen Bai, Zeljko J. Bosnjak, Mingyu Liang and Zhi-Dong Ge

    Citation: BMC Cardiovascular Disorders 2018 18:197

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  40. Content type: Research article

    The association of sodium intake with the risk of cardiovascular morbidity and mortality is inconsistent. Thus, the present meta-analysis was conducted to summarize the strength of association between sodium i...

    Authors: Yaobin Zhu, Jing Zhang, Zhiqiang Li, Yang Liu, Xing Fan, Yaping Zhang and Yanbo Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:192

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  41. Content type: Case report

    Infective endocarditis due to Escherichia coli is a rare disease but is increasing in frequency, especially among older women. In addition, its mortality rate is higher than that of endocarditis due to the HACEK-...

    Authors: Nobuhiro Akuzawa and Masahiko Kurabayashi

    Citation: BMC Cardiovascular Disorders 2018 18:195

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  42. Content type: Research article

    Treatment adherence play important roles in blood pressure control leading to reduction in morbidity and mortality. This study therefore assessed adherence to pharmacological and non-pharmacological therapies ...

    Authors: Rasaq Adisa, Olumide Ayodeji Ilesanmi and Titilayo Oyelola Fakeye

    Citation: BMC Cardiovascular Disorders 2018 18:194

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  43. Content type: Research article

    Experimental studies suggest that morphine may protect the myocardium against ischemia-reperfusion injury by activating salvage kinase pathways. The objective of this two-center, randomized, double-blind, cont...

    Authors: Philippe Le Corvoisier, Romain Gallet, Pierre-François Lesault, Etienne Audureau, Muriel Paul, Julien Ternacle, Saïd Ghostine, Stéphane Champagne, Raphaele Arrouasse, Dalila Bitari, Gauthier Mouillet, Jean-Luc Dubois-Randé, Alain Berdeaux, Bijan Ghaleh, Jean-François Deux and Emmanuel Teiger

    Citation: BMC Cardiovascular Disorders 2018 18:193

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  44. Content type: Research article

    The association between pre-operative cardiac catheterization and cardiac surgery associated acute kidney injury (CSA-AKI) has been reported inconsistently. The purpose of this study is to evaluate the effect ...

    Authors: Wuhua Jiang, Jiawei Yu, Jiarui Xu, Bo Shen, Yimei Wang, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding and Jie Teng

    Citation: BMC Cardiovascular Disorders 2018 18:191

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  45. Content type: Research article

    Recent studies have shown a significant role of the endocannabinoid system, apelin and S100A6 protein in the regulation of cardiovascular system functioning. The aim of the study was to compare and evaluate th...

    Authors: Irena Kasacka, Żaneta Piotrowska, Anna Filipek and Wojciech Lebkowski

    Citation: BMC Cardiovascular Disorders 2018 18:190

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  46. Content type: Research article

    Ideal cardiovascular health (CVH) metrics have been found to be associated with subclinical vascular abnormalities. However, the relationship between ideal CVH metrics and retinal vessel calibers and retinal n...

    Authors: Qian Zhang, Dandan Wang, Anxin Wang, Shufeng Zhang, Yuesong Pan, Yang Li, Shengyun Chen, Shouling Wu, Wenbin Wei and Xingquan Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:187

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