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  1. Chronic heart failure (CHF) comorbid with atrial fibrillation (AF) is a serious threat to human health and has become a major clinical burden. This prospective cohort study was performed to design a risk strat...

    Authors: Chu Zheng, Jing Tian, Ke Wang, Linai Han, Hong Yang, Jia Ren, Chenhao Li, Qing Zhang, Qinghua Han and Yanbo Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:379

    Content type: Research

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  2. Toll-like receptor 4 (TLR4) and matrix metalloproteinase 9 (MMP9) have been investigated to play significant roles in the formation of abdominal aortic aneurysm (AAA). But the reports on the expression pattern...

    Authors: Tan Li, Xintong Li, Xiaozheng Liu, Jun Yang and Chunyan Ma

    Citation: BMC Cardiovascular Disorders 2021 21:378

    Content type: Research article

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  3. Patients with both double orifice mitral valve (DOMV) and bicuspid aortic valve (BAV) malformation are rare. Although DOMV or BAV can be detected in some genetic syndromes, it has not been reported to simultan...

    Authors: Feifei Sun, Xueying Tan, Aijiao Sun, Xintong Zhang, Yanxiao Liang and Weidong Ren

    Citation: BMC Cardiovascular Disorders 2021 21:377

    Content type: Case report

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  4. H type hypertension is defined as homocysteine (Hcy) ≥ 10 μmol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the po...

    Authors: Xiao-lin Qian, Hong Cao, Jun Zhang, Zhi-hui Gu, Wei-qin Tang, Lei Shen, Jia-lu Hu, Zhi-feng Yao, Lei Zhang, Min-na Tang, Xu-cheng Lv, Jun Zhou, Xue-juan Jin, Bin Hong, Zhao-qiang Cui and Jun-bo Ge

    Citation: BMC Cardiovascular Disorders 2021 21:376

    Content type: Research

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  5. Half of U.S. adults have received at least one dose of the COVID-19 vaccines produced by either Pfizer, Moderna, or Johnson and Johnson, which represents a major milestone in the ongoing pandemic. Given the em...

    Authors: Ammar A. Hasnie, Usman A. Hasnie, Nirav Patel, Muhammad U. Aziz, Min Xie, Steven G. Lloyd and Sumanth D. Prabhu

    Citation: BMC Cardiovascular Disorders 2021 21:375

    Content type: Case report

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  6. As the burden of cardiovascular disease increases in sub-Saharan Africa, there is a growing need for low-cost interventions to mitigate its impact. Providing self-care health education to patients with chronic...

    Authors: Getenet Dessie, Sahai Burrowes, Henok Mulugeta, Dessalegn Haile, Ayenew Negess, Dubie Jara, Girma Alem, Bekele Tesfaye, Haymanot Zeleke, Tenaw Gualu, Temsgen Getaneh, Getiye Dejenu Kibret, Desalegne Amare, Endalkachew Worku Mengesha, Fasil Wagnew and Rasheda Khanam

    Citation: BMC Cardiovascular Disorders 2021 21:374

    Content type: Research article

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  7. The aim of the present study is to evaluate the short-term efficacy and feasibility of radiofrequency ablation in the treatment of complex diffuse arteriovenous (AV) malformations.

    Authors: Chun-Xiao Ge, Mao-Zhong Tai, Tao Chen, Ke-Lei Li, Zhen-Guo Xu and Zhong-Ping Qin

    Citation: BMC Cardiovascular Disorders 2021 21:373

    Content type: Research article

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  8. Complete atrioventricular block (AVB) is a life-threatening condition that usually occurs in elderly people with organic heart disease. We herein describe a rare case of complete AVB in a young man with hypert...

    Authors: Shu Fang, Lan Gao, Fan Yang and Yan-jun Gong

    Citation: BMC Cardiovascular Disorders 2021 21:372

    Content type: Case report

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  9. Among changes in demographics, aging is the most relevant cardiovascular risk factor. The prevalence of peripheral artery disease (PAD) is high in elderly patients and is associated with a worse prognosis. Des...

    Authors: Christos Rammos, Aristotelis Kontogiannis, Amir A. Mahabadi, Martin Steinmetz, Daniel Messiha, Julia Lortz and Tienush Rassaf

    Citation: BMC Cardiovascular Disorders 2021 21:370

    Content type: Research

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  10. Age-associated inflammation and immune system dysfunction have been implicated as mechanisms that increase risk for adverse long-term procedural outcomes in older adults. The purpose of this study was to inves...

    Authors: Deena S. Goldwater, Mei Leng, Arun Karlamangla, Teresa Seeman, David Elashoff, Jonathan M. Wanagat, David B. Reuben, Brian R. Lindman and Steve Cole

    Citation: BMC Cardiovascular Disorders 2021 21:368

    Content type: Research article

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  11. In the treatment of coronary heart disease, secondary prevention goals are still often unmet and poor adherence to prescribed drugs has been suggested as one of the reasons. We aimed to investigate whether pha...

    Authors: Malin Johansson Östbring, Tommy Eriksson, Göran Petersson and Lina Hellström

    Citation: BMC Cardiovascular Disorders 2021 21:367

    Content type: Research

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  12. To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-...

    Authors: Mingxin Gao, Kangjun Fan, Wenyuan Yu, Hongli Liu, Yongxiang Wei and Yang Yu

    Citation: BMC Cardiovascular Disorders 2021 21:366

    Content type: Research article

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  13. Cardiac arrest (CA) in children is a major public health problem. Thanks to advances in cardiopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. However, pediatric...

    Authors: Jimena del Castillo, Débora Sanz, Laura Herrera and Jesús López-Herce

    Citation: BMC Cardiovascular Disorders 2021 21:365

    Content type: Study protocol

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  14. An electrocardiogram (ECG) is a mandatory test for anyone presenting with loss of consciousness. Many referrals to the first seizure clinic (FSC) are caused by syncope. We assessed the sensitivity of neurologi...

    Authors: Xuya Huang, N. Malek, J. Simpson, D. Kalladka, F. G. Dunn and J. P. Leach

    Citation: BMC Cardiovascular Disorders 2021 21:364

    Content type: Research article

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  15. In terms of cardiovascular magnetic resonance are haematocrit values required for calculation of extracellular volume fraction (ECV). Previously published studies have hypothesized that haematocrit could be ca...

    Authors: Lukas Opatril, Roman Panovsky, Jan Machal, Tomas Holecek, Lucia Masarova, Vera Feitova, Vladimir Kincl, Marek Hodejovsky and Lenka Spinarova

    Citation: BMC Cardiovascular Disorders 2021 21:363

    Content type: Research

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  16. Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein chole...

    Authors: Dyah Samti Mayasari, Nahar Taufiq and Hariadi Hariawan

    Citation: BMC Cardiovascular Disorders 2021 21:362

    Content type: Research article

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  17. In recent years, there has been greater recognition of the important role of community health volunteers in many countries and their important role informs many health programs. This include health education, ...

    Authors: Elvis Safary, Micrina Mwandeti, Beatrice Matanje, Claudia Beiersmann, Caroline Mtaita, Veronica Shiroya, Volker Winkler, Andreas Deckert, Pratap Kumar, Sam Phiri and Florian Neuhann

    Citation: BMC Cardiovascular Disorders 2021 21:361

    Content type: Research

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  18. The interventional treatment of calcified lesions with severe tortuosity in the left anterior descending artery (LAD) was challenging and the report of rotational atherectomy with mother-and-child technique ha...

    Authors: Taichi Kato, Masashi Fujino, Kensuke Takagi and Teruo Noguchi

    Citation: BMC Cardiovascular Disorders 2021 21:360

    Content type: Case report

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  19. It is difficult to evaluate the risk of patients with severe renal dysfunction before surgery due to various limitations despite high postoperative cardiac events. This study aimed to investigate the value of ...

    Authors: Hyun Jun Cho, Namkyun Kim, Hyeon Jeong Kim, Bo Eun Park, Hong Nyun Kim, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho and Shung Chull Chae

    Citation: BMC Cardiovascular Disorders 2021 21:359

    Content type: Research

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  20. Transcatheter aortic valve replacement (TAVR) has gained increasing acceptance for patients with aortic disease. Both transfemoral (TF-TAVR) and transapical (TA-TAVR) approach were widely adopted while their p...

    Authors: Ruikang Guo, Minghui Xie, Wai Yen Yim, Wenconghui Wu, Weiwei Jiang, Yin Wang and Xingjian Hu

    Citation: BMC Cardiovascular Disorders 2021 21:358

    Content type: Review

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  21. Many patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are discharged without a known aetiology for their clinical presentation. This study sought to assess the effect of this...

    Authors: T. F. S. Pustjens, A. Meerman, N. P. A. Vranken, A. W. Ruiters, B. Gho, M. Stein, M. Ilhan, L. Veenstra, P. Winkler, Á. Lux, S. Rasoul and A. W. J. van ‘t Hof

    Citation: BMC Cardiovascular Disorders 2021 21:357

    Content type: Research

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  22. Activating transcription factor 3 (ATF3) is an early response gene that is activated in response to atherosclerotic stimulation and may be an important factor in inhibiting the progression of atherosclerosis. ...

    Authors: J. Peng, C. Y. Le, B. Xia, J. W. Wang, J. J. Liu, Z. Li, Q. J. Zhang, Q. Zhang, J. Wang and C. W. Wan

    Citation: BMC Cardiovascular Disorders 2021 21:356

    Content type: Research

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  23. Rheumatic heart disease (RHD) is still a concerning issue in developing countries. Among delayed RHD presentations, rheumatic mitral valve stenosis (MS) remains a prevalent finding. Percutaneous transvenous mi...

    Authors: Yahya Dadjo, Maryam Moshkani Farahani, Reza Nowshad, Mohsen Sadeghi Ghahrodi, Alireza Moaref and Javad Kojuri

    Citation: BMC Cardiovascular Disorders 2021 21:355

    Content type: Research article

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  24. This study aimed to assess the rate of concordance, and to investigate sources of non-concordance of recommendations in the management of hypertension across CPGs in Southeast Asia, with internationally reputa...

    Authors: Chia Siang Kow, Syed Shahzad Hasan, Pei Se Wong and Rohit Kumar Verma

    Citation: BMC Cardiovascular Disorders 2021 21:354

    Content type: Research

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  25. Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation, and is regarded as a key molecule driving immunotolera...

    Authors: Nattawut Wongpraparut, Ploy Pengchata, Sudarat Piyophirapong, Pariya Panchavinnin, Rungtiwa Pongakasira, Noppadol Arechep, Kanda Kasetsinsombat and Kittipong Maneechotesuwan

    Citation: BMC Cardiovascular Disorders 2021 21:353

    Content type: Research article

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  26. We examined the relationship between ratios of select biomarkers of kidney and liver function on all-cause and coronary heart disease (CHD) mortality, both in isolation, and in combination with metabolic syndr...

    Authors: Akinkunle Oye-Somefun, Jennifer L. Kuk and Chris I. Ardern

    Citation: BMC Cardiovascular Disorders 2021 21:352

    Content type: Research

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  27. CVD is the leading cause of death in T2DM patients. However, few biomarkers have been identified to detect and diagnose CVD in the early stage of T2DM. The aim of our study was to identify the important mRNAs,...

    Authors: Zhiyuan Fan, Wenjuan Peng, Zhiwen Wang, Ling Zhang and Kuo Liu

    Citation: BMC Cardiovascular Disorders 2021 21:351

    Content type: Research

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  28. Citation: BMC Cardiovascular Disorders 2021 21:349

    Content type: Correction

    Published on:

    The original article was published in BMC Cardiovascular Disorders 2020 20:380

  29. Sodium-glucose cotransporter 2 inhibitor (SGLT2i) reduces the risk of the composite renal endpoint and weakens the progressive decline in renal function in patients with chronic heart failure (HF). However, a ...

    Authors: Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura and Koichiro Kinugawa

    Citation: BMC Cardiovascular Disorders 2021 21:347

    Content type: Research article

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  30. The relationship between the characteristics of cardiac implantable electronic device (CIED) leads and subclinical cardiac perforations remains unclear. This study aimed to evaluate the incidence of subclinica...

    Authors: Yeong-Min Lim, Jae-Sun Uhm, Min Kim, In-Soo Kim, Moo-Nyun Jin, Hee Tae Yu, Tae-Hoon Kim, Hye-Jeong Lee, Young-Jin Kim, Boyoung Joung, Hui-Nam Pak and Moon-Hyoung Lee

    Citation: BMC Cardiovascular Disorders 2021 21:346

    Content type: Research

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  31. Atrial fibrillation (AF) is the most common cardiac arrhythmia in patients with chronic kidney disease (CKD) and acute coronary syndrome (ACS). This study aimed to explore the frequency and impact of AF on cli...

    Authors: Lijiao Yang, Nan Ye, Guoqin Wang, Weijing Bian, Fengbo Xu, Dong Zhao, Jing Liu, Yongchen Hao, Jun Liu, Na Yang and Hong Cheng

    Citation: BMC Cardiovascular Disorders 2021 21:345

    Content type: Research article

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  32. Myocardial infarction (MI) contributes to high mortality and morbidity and can also accelerate atherosclerosis, thus inducing recurrent event due to status changing of coronary artery walls or plaques. The res...

    Authors: Qiang Zhang, Yue Zheng, Meng Ning and Tong Li

    Citation: BMC Cardiovascular Disorders 2021 21:344

    Content type: Research article

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  33. Serum free fatty acid (FFA) concentrations are associated with coronary heart disease and diabetes mellitus (DM). Few studies focused on the relationship between serum FFA levels and coronary artery calcificat...

    Authors: Yangxun Xin, Junfeng Zhang, Yuqi Fan and Changqian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:343

    Content type: Research article

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  34. Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients’ Risks, Assets, and Experiences (PRAPARE) to imp...

    Authors: Connor Drake, Tyler Lian, Justin G. Trogdon, David Edelman, Howard Eisenson, Morris Weinberger, Kristin Reiter and Christopher M. Shea

    Citation: BMC Cardiovascular Disorders 2021 21:342

    Content type: Research article

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  35. Catheter ablation is widely used in atrial fibrillation (AF) management. In this study, we are aimed to investigate the incidence of postprocedural cognitive decline in a larger population undergoing AF ablati...

    Authors: Jing Zhang, Shi-Jun Xia, Xin Du, Chao Jiang, Yi-Wei Lai, Yu-Feng Wang, Zhao-Xu Jia, Liu He, Ri-Bo Tang, Jian-Zeng Dong and Chang-Sheng Ma

    Citation: BMC Cardiovascular Disorders 2021 21:341

    Content type: Research article

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  36. Mobile health-based individualized interventions have shown potential effects in managing cardiovascular risk factors. This study aims to assess whether or not mHealth based individualized interventions delive...

    Authors: Yuling Chen, Meihua Ji, Ying Wu, Ying Deng, Fangqin Wu and Yating Lu

    Citation: BMC Cardiovascular Disorders 2021 21:340

    Content type: Study protocol

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  37. The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investiga...

    Authors: Ying Yang, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Suning Li, Congyi Zheng, Yuting Kang, Linlin Jiang, Zhenhui Zhu and Runlin Gao

    Citation: BMC Cardiovascular Disorders 2021 21:339

    Content type: Research

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  38. Early adoption of a healthy lifestyle has positive effects on cardiovascular health (CVH) in adulthood. In this study, we aimed to assess CVH metrics in a cohort of healthy teenagers with focus on differences ...

    Authors: C. Hochmayr, J. P. Ndayisaba, N. Gande, A. Staudt, B. Bernar, K. Stock, R. Geiger, M. Knoflach and U. Kiechl-Kohlendorfer

    Citation: BMC Cardiovascular Disorders 2021 21:338

    Content type: Research

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  39. Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of C...

    Authors: Wen Wei, Lingyu Zhang, Yunhan Zhang, Ronghui Tang, Miao Zhao, Zhidong Huang, Jin Liu, Danyuan Xu, Yibo He, Bo Wang, Haozhang Huang, Qiang Li, Mengfei Lin, Yong Liu, Kaihong Chen and Shiqun Chen

    Citation: BMC Cardiovascular Disorders 2021 21:337

    Content type: Research

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  40. Cardiovascular disease (CVD) is the leading cause of death among non-communicable diseases in South Africa. Several metabolic risk factors contribute to the development of CVD. Informal workers such as waste p...

    Authors: Felix Made, Engelbert A. Nonterah, Nonhlanhla Tlotleng, Vusi Ntlebi and Nisha Naicker

    Citation: BMC Cardiovascular Disorders 2021 21:336

    Content type: Research article

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  41. Isolated splenic artery dissection (SAD) is extremely rare, life-threatening, and particularly difficult to diagnose. Moreover, SAD presenting as digestive hemorrhage has not been reported.

    Authors: Jianjun Jiang, Yang Liu and Xiangjiu Ding

    Citation: BMC Cardiovascular Disorders 2021 21:335

    Content type: Case report

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  42. Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of ...

    Authors: Xiao-Qin Li, Chun Yin, Xiao-Li Li, Wen-Li Wu and Kun Cui

    Citation: BMC Cardiovascular Disorders 2021 21:334

    Content type: Research

    Published on:

  43. Recently, we face a surge in the fast-forward Coronavirus Disease 2019 (COVID-19) pandemic with nearly 170 million confirmed cases and almost 3.5 million confirmed deaths at the end of May 2021. Obesity, also ...

    Authors: Jacek Bil and Olga Możeńska

    Citation: BMC Cardiovascular Disorders 2021 21:332

    Content type: Commentary

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  44. It is widely recognized that metabolic disorder is associated with pulmonary hypertension (PH). It is known that hypoxia-induced elevated pulmonary artery pressure in mice returns to normal pressure during reo...

    Authors: Koichi Sugimoto, Tetsuro Yokokawa, Tomofumi Misaka, Takashi Kaneshiro, Akiomi Yoshihisa, Kazuhiko Nakazato and Yasuchika Takeishi

    Citation: BMC Cardiovascular Disorders 2021 21:331

    Content type: Research

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