Herve P, Le Pavec J, Sztrymf B, Decante B, Savale L, Sitbon O. Pulmonary vascular abnormalities in cirrhosis. Best Pract Res Clin Gastroenterol. 2007;21(1):141–59.
Article
PubMed
Google Scholar
Rodríguez-Roisin R, Agustí AG, Roca J. The hepatopulmonary syndrome: new name, old complexities. Thorax. 1992;47(11):897–902.
Article
PubMed
PubMed Central
Google Scholar
Benjaminov FS, Prentice M, Sniderman KW, Siu S, Liu P, Wong F. Portopulmonary hypertension in decompensated cirrhosis with refractory ascites. Gut. 2003;52(9):1355–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang YY, Lin HC, Lee WC, Hou MC, Lee FY, Chang FY, Lee SD. Portopulmonary hypertension: distinctive hemodynamic and clinical manifestations. J Gastroenterol. 2001;36(3):181–6.
Article
CAS
PubMed
Google Scholar
Krowka MJ, Mandell MS, Ramsay MA, Kawut SM, Fallon MB, Manzarbeitia C, Pardo M Jr, Marotta P, Uemoto S, Stoffel MP, et al. Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database. Liver Transpl. 2004;10(2):174–82.
Article
PubMed
Google Scholar
Terao M, Takaki A, Maruyama T, Oe H, Yasunaka T, Tamaki N, Nakamura K, Tomofuji T, Yagi T, Sadamori H, et al. Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study. Intern Med. 2015;54(22):2815–26.
Article
CAS
PubMed
Google Scholar
Zhang J, Yang W, Luo B, Hu B, Maheshwari A, Fallon MB. The role of CX(3)CL1/CX(3)CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental Hepatopulmonary syndrome. J Hepatol. 2012;57(4):752–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Medarov BI, Chopra A, Judson MA. Clinical aspects of portopulmonary hypertension. Respir Med. 2014;108(7):943–54.
Article
PubMed
Google Scholar
Raevens S, Geerts A, Van Steenkiste C, Verhelst X, Van Vlierberghe H, Colle I. Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. Liver Int. 2015;35(6):1646–60.
Article
PubMed
Google Scholar
Tumgor G. Cirrhosis and hepatopulmonary syndrome. World J Gastroenterol. 2014;20(10):2586–94.
Article
PubMed
PubMed Central
CAS
Google Scholar
Luo B, Liu L, Tang L, Zhang J, Stockard CR, Grizzle WE, Fallon MB. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. J Hepatol. 2003;38(5):556–63.
Article
CAS
PubMed
Google Scholar
Zhang J, Ling Y, Tang L, Luo B, Pollock DM, Fallon MB. Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. Am J Physiol Gastrointest Liver Physiol. 2009;296(4):G704–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J. 2000;15(4):640–8.
Article
CAS
PubMed
Google Scholar
Khoramzadeh M, Dehghanian A, Ketabchi F. Roles of Endothelin B receptors and endothelial nitric oxide synthase in the regulation of pulmonary hemodynamic in cirrhotic rats. J Cardiovasc Pharmacol. 2019;73(3):178–85.
Article
CAS
PubMed
Google Scholar
Vujanac A, Jakovljevic V, Djordjevic D, Zivkovic V, Stojkovic M, Celikovic D, Andjelkovic N, Skevin AJ, Djuric D. Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension. World J Gastroenterol. 2012;18(4):331–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Angermayr B, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J, Fernandez M. Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats. J Hepatol. 2006;44(6):1033–9.
Article
CAS
PubMed
Google Scholar
Izzet T, Osman K, Ethem U, Nihat Y, Ramazan K, Mustafa D, Hafize U, Riza KA, Birsen A, Habibe G, et al. Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals. World J Gastroenterol. 2005;11(23):3570–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nacif LS, Andraus W, Kubrusly MS, Kubrusly FS, Gebara VC, Ishizawa A, D'Albuquerque LA. Surfactant protein a is decreased in the lung of rats with hepatopulmonary syndrome. Acta Cir Bras. 2014;29(9):573–8.
Article
PubMed
Google Scholar
Incalza MA, D'Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vasc Pharmacol. 2018;100:1–19.
Article
CAS
Google Scholar
Ferrari RS, Tieppo M, Rosa DP, Forgiarini LA Jr, Dias AS, Marroni NP. Lung and liver changes due to the induction of cirrhosis in two experimental models. Arq Gastroenterol. 2013;50(3):208–13.
Article
PubMed
Google Scholar
Hiyama E. Pulmonary vascular changes after portasystemic shunt operation in rats. Nihon Geka Gakkai zasshi. 1989;90(6):874–85.
CAS
PubMed
Google Scholar
Yan G, He J, Yu Y, Liu Y, Yuan Y, Guo Z. Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomed Rep. 2016;4(1):51–4.
Article
PubMed
Google Scholar
Frost AE, Badesch DB, Barst RJ, Benza RL, Elliott CG, Farber HW, Krichman A, Liou TG, Raskob GE, Wason P, et al. The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US contemporary registries. Chest. 2011;139(1):128–37.
Article
PubMed
Google Scholar
Lahm T, Albrecht M, Fisher AJ, Selej M, Patel NG, Brown JA, Justice MJ, Brown MB, Van Demark M, Trulock KM, et al. 17beta-estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med. 2012;185(9):965–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tofovic SP, Zhang X, Jackson EK, Dacic S, Petrusevska G. 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. Vasc Pharmacol. 2006;45(6):358–67.
Article
CAS
Google Scholar
Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M. Estrogen rescues preexisting severe pulmonary hypertension in rats. Am J Respir Crit Care Med. 2011;184(6):715–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Umar S, Rabinovitch M, Eghbali M. Estrogen paradox in pulmonary hypertension: current controversies and future perspectives. Am J Respir Crit Care Med. 2012;186(2):125–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kobayashi H, Yoshida S, Sun YJ, Shirasawa N, Naito A. Gastric estradiol-17beta (E2) and liver ERalpha correlate with serum E2 in the cholestatic male rat. J Endocrinol. 2013;219(1):39–49.
Article
CAS
PubMed
Google Scholar
Kobayashi H, Yoshida S, Sun YJ, Shirasawa N, Naito A. 17beta-estradiol in the systemic circulation derives mainly from the parietal cells in cholestatic female rats. J Endocrinol Investig. 2016;39(4):389–400.
Article
CAS
Google Scholar
Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, et al. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008;135(4):1168–75.
Article
PubMed
Google Scholar
Santa-Cruz RA, Pearson MD, Cohen MG, Shrestha R, Willis PW, Hinderliter A, Menon V. Clinical predictors and characteristics of patients with chronic liver disease and intrapulmonary shunts. Clin Cardiol. 2005;28(9):437–41.
Article
PubMed
Google Scholar
Schenk P, Fuhrmann V, Madl C, Funk G, Lehr S, Kandel O, Muller C. Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut. 2002;51(6):853–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo B, Liu L, Tang L, Zhang J, Ling Y, Fallon MB. ET-1 and TNF-alpha in HPS: analysis in prehepatic portal hypertension and biliary and nonbiliary cirrhosis in rats. Am J Physiol Gastrointest Liver Physiol. 2004;286(2):G294–303.
Article
CAS
PubMed
Google Scholar
Daoud FS, Reeves JT, Schaefer JW. Failure of hypoxic pulmonary vasoconstriction in patients with liver cirrhosis. J Clin Investig. 1972;51(5):1076.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nunes H, Lebrec D, Mazmanian M, Capron F, Heller J, Tazi KA, Zerbib E, Dulmet E, Moreau R, Dinh-Xuan AT, et al. Role of nitric oxide in hepatopulmonary syndrome in cirrhotic rats. Am J Respir Crit Care Med. 2001;164(5):879–85.
Article
CAS
PubMed
Google Scholar
Cora MC, Kooistra L, Travlos G. Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears. Toxicol Pathol. 2015;43(6):776–93.
Article
CAS
PubMed
Google Scholar
Schwenke D, Pearson J, Tsuchimochi H, Kangawa K, Shirai M. Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide. Clin Exp Pharmacol Physiol. 2007;34(1–2):88–94.
Article
CAS
PubMed
Google Scholar
Ketabchi F, Bajoovand S, Adlband M, Naseh M, Nekooeian AA, Mashghoolozekr E. Right ventricular pressure elevated in one-kidney, one clip Goldblatt hypertensive rats. Clin Exp Hypertens(New York, NY : 1993). 2017;39(4):344–9.
CAS
Google Scholar
Koizuka S, Obata H, Sasaki M, Saito S, Goto F. Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats. Can J Anaesth. 2005;52(5):498–505.
Article
PubMed
Google Scholar
Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S, Fallon MB. Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology. 2009;136(3):1070–80.
Article
CAS
PubMed
Google Scholar
Rodrigues DA, da Silva AR, Serigiolle LC, Fidalgo Rde S, Favero SS, Leme PL. Constriction rate variation produced by partial ligation of the portal vein at pre-hepatic portal hypertension induced in rats. Arq Bras Cir Dig. 2014;27(4):280–4.
Article
PubMed
PubMed Central
Google Scholar
Walkowska A, Skaroupkova P, Huskova Z, Vanourkova Z, Chabova VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, et al. Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats. J Hypertens. 2010;28(3):582–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Strubelt O, Younes M. Influence of hypoxia and hyperoxia on the cardiovascular and lethal effects of ethanol. Pharmacol Toxicol. 1999;84(3):101–6.
Article
CAS
PubMed
Google Scholar
Eroglu A. The effect of intravenous anesthetics on ischemia-reperfusion injury. Biomed Res Int. 2014;2014:821513.
PubMed
PubMed Central
Google Scholar
Hinojosa-Laborde C, Mifflin SW. Sex differences in blood pressure response to intermittent hypoxia in rats. Hypertension. 2005;46(4):1016–21.
Article
CAS
PubMed
Google Scholar
Edmunds N, Marshall JM. Vasodilatation, oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: roles of nitric oxide. J Physiol. 2001;532(1):251–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goodman ZD. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol. 2007;47(4):598–607.
Article
PubMed
Google Scholar
Karimi Z, Ketabchi F, Alebrahimdehkordi N, Fatemikia H, Owji SM, Moosavi SM. Renal ischemia/reperfusion against nephrectomy for induction of acute lung injury in rats. Ren Fail. 2016;38(9):1503–15.
Article
CAS
PubMed
Google Scholar
Mansoori S, Moosavi SMS, Ketabchi F. The interaction between Trolox and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid on hypoxic pulmonary vasoconstriction in the isolated rabbit lung. Iran J Med Sci. 2017;42(3):284–91.
PubMed
PubMed Central
Google Scholar
Earley S, Resta TC. Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. Am J Physiol Lung Cell Mol Physiol. 2002;283(1):L86–93.
Article
CAS
PubMed
Google Scholar
Tofovic SP, Salah EM, Mady HH, Jackson EK, Melhem MF. Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol. 2005;46(4):430–7.
Article
CAS
PubMed
Google Scholar
Ciarlone GE, Dean JB. Normobaric hyperoxia stimulates superoxide and nitric oxide production in the caudal solitary complex of rat brain slices. Am J Physiol Cell Physiol. 2016;311(6):C1014–c1026.
Article
PubMed
Google Scholar
Moller S, Bendtsen F. The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. Liver Int. 2018;38(4):570–80.
Article
PubMed
Google Scholar
Moezi L, Gaskari S, Liu H, Baik S, Dehpour A, Lee S. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB1 and VR1 receptors. Br J Pharmacol. 2006;149(7):898–908.
Article
CAS
PubMed
PubMed Central
Google Scholar
Winkler L, Lhuissier FJ, Richalet JP. Systemic blood pressure at exercise in hypoxia in hypertensive and normotensive patients. J Hypertens. 2017;35(12):2402–10.
Article
CAS
PubMed
Google Scholar
Marcus NJ, Olson EB Jr, Bird CE, Philippi NR, Morgan BJ. Time-dependent adaptation in the hemodynamic response to hypoxia. Respir Physiol Neurobiol. 2009;165(1):90–6.
Article
PubMed
Google Scholar
Siebenmann C, Lundby C. Regulation of cardiac output in hypoxia. Scand J Med Sci Sports. 2015;25(Suppl 4):53–9.
Article
PubMed
Google Scholar
Cowburn AS, Macias D, Summers C, Chilvers ER. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. Elife. 2017;6.
Cowburn AS, Macias D, Summers C, Chilvers ER, and Johnson RS. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. eLIFE. 2017;6:1-23.
Thomson AJ, Drummond GB, Waring WS, Webb DJ, Maxwell SR. Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function. J Appl Physiol. 2006;101(3):809–16.
Article
CAS
PubMed
Google Scholar
Iwasaki K, Ogawa Y, Shibata S, Aoki K. Acute exposure to normobaric mild hypoxia alters dynamic relationships between blood pressure and cerebral blood flow at very low frequency. J Cereb Blood Flow Metab. 2007;27(4):776–84.
Article
PubMed
Google Scholar
Barton CH, Ni Z, Vaziri ND. Blood pressure response to hypoxia: role of nitric oxide synthase. Am J Hypertens. 2003;16(12):1043–8.
Article
CAS
PubMed
Google Scholar
Bosc LVG, Resta T, Walker B, Kanagy NL. Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med. 2010;14(1–2):3–17.
Article
PubMed
CAS
Google Scholar
Foster GE, Hanly PJ, Ahmed SB, Beaudin AE, Pialoux V, Poulin MJ. Intermittent hypoxia increases arterial blood pressure in humans through a renin-angiotensin system-dependent mechanism. Hypertension. 2010;56(3):369–77.
Article
CAS
PubMed
Google Scholar
Stowe DF, Bosnjak ZJ, Kampine JP. Effects of hypoxia on adult and neonatal pacemaker rates. Obstet Gynecol. 1985;66(5):649–56.
CAS
PubMed
Google Scholar
Gole Y, Gargne O, Coulange M, Steinberg JG, Bouhaddi M, Jammes Y, Regnard J, Boussuges A. Hyperoxia-induced alterations in cardiovascular function and autonomic control during return to normoxic breathing. Eur J Appl Physiol. 2011;111(6):937–46.
Article
PubMed
Google Scholar
Rodriguez-Roisin R, Krowka MJ, Agusti A. Hepatopulmonary disorders: gas exchange and vascular manifestations in chronic liver disease. Compr Physiol. 2018;8(2):711–29.
Article
PubMed
Google Scholar
Deibert P, Allgaier HP, Loesch S, Muller C, Olschewski M, Hamm H, Maier KP, Blum HE. Hepatopulmonary syndrome in patients with chronic liver disease: role of pulse oximetry. BMC Gastroenterol. 2006;6:15.
Article
PubMed
PubMed Central
Google Scholar
Gomez FP, Martinez-Palli G, Barbera JA, Roca J, Navasa M, Rodriguez-Roisin R. Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology. 2004;40(3):660–6.
Article
PubMed
Google Scholar
Halank M, Miehlke S, Kolditz M, Hoeffken G. Portopulmonary hypertension. Zeitschrift fur Gastroenterologie. 2005;43(7):677–85.
Article
CAS
PubMed
Google Scholar
Huang YT, Hsu YC, Chen CJ, Liu CT, Wei YH. Oxidative-stress-related changes in the livers of bile-duct-ligated rats. J Biomed Sci. 2003;10(2):170–8.
Article
CAS
PubMed
Google Scholar
Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2016;47(1):288–303.
Article
CAS
PubMed
Google Scholar
Casey DB, Pankey EA, Badejo AM, Bueno FR, Bhartiya M, Murthy SN, Uppu RM, Nossaman BD, Kadowitz PJ. Peroxynitrite has potent pulmonary vasodilator activity in the rat. Can J Physiol Pharmacol. 2012;90(4):485–500.
Article
CAS
PubMed
Google Scholar
Battista S, Bar F, Mengozzi G, Zanon E, Grosso M, Molino G. Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins. J Hepatol. 1997;26(1):75–80.
Article
CAS
PubMed
Google Scholar
Oswald-Mammosser M, Rashid S, Boehm N, Agin A, Geny B, Schini-Kerth V, Charloux A. Effect of the oestrogen receptor antagonist fulvestrant on the cirrhotic rat lung. Fundam Clin Pharmacol. 2015;29(3):269–77.
Article
CAS
PubMed
Google Scholar
Bosch J, Abraldes JG, Fernandez M, Garcia-Pagan JC. Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol. 2010;53(3):558–67.
Article
CAS
PubMed
Google Scholar
White RE, Gerrity R, Barman SA, Han G. Estrogen and oxidative stress: a novel mechanism that may increase the risk for cardiovascular disease in women. Steroids. 2010;75(11):788–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taguchi H, Kataoka M, Yanagisawa R, Kawakami T, Tamura Y, Fukuda K, Yoshino H, Satoh T. Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy. Circ J. 2012;76(6):1494–500.
Article
PubMed
Google Scholar
Mojadidi MK, Goodman-Meza D, Eshtehardi P, Pamerla M, Msaouel P, Roberts SC, Winoker JS, Jadeja NM, Zolty R. Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension. Heart Lung. 2014;43(6):569–73.
Article
PubMed
Google Scholar
Elias JE, Mackie I, Eapen CE, Chu P, Shaw JC, Elias E. Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency. J Hepatol. 2013;58(4):827–30.
Article
CAS
PubMed
Google Scholar
Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H. Management of thrombocytopenia due to liver cirrhosis: a review. World J Gastroenterol. 2014;20(10):2595–605.
Article
CAS
PubMed
PubMed Central
Google Scholar
Budhiraja R, Hassoun PM. Portopulmonary hypertension: a tale of two circulations. Chest. 2003;123(2):562–76.
Article
PubMed
Google Scholar
Porres-Aguilar M, Altamirano JT, Torre-Delgadillo A, Charlton MR, Duarte-Rojo A. Portopulmonary hypertension and hepatopulmonary syndrome: a clinician-oriented overview. Eur Respir Rev. 2012;21(125):223–33.
Article
PubMed
Google Scholar