Impact of liver damage on blood-borne variables and pulmonary hemodynamic responses to hypoxia and hyperoxia in anesthetized rats

Table 1 Blood parameters in the experimental groups

	Sham	PPVL	CBDL	CBDL+PPVL
ALT (U/L)	54.14 ± 5.1	69.7 ± 10.9	121.8 ± 19.1*	154.1 ± 18.78 **##
AST (U/L)	88.77 ± 5.87	104.57 ± 8.86	486 ± 45.5 **##	610.29 ± 62.55**##
ALP (U/L)	40.85 ± 10.4	31.57 ± 10.26	164.3 ± 11.9**##	203.8 ± 36.05**##
PaO2 (mmHg)	61.4 ± 2.57	63.8 ± 0.75	58.6 ± 3.23	50.8 ± 1.84 *#†
PaCO₂ (mmHg)	36.38 ± 1.55	32.7 ± 0.51	27.98 ± 2.36 *	40.9 ± 1.47
HCO₃⁻ (mmol/L)	24.04 ± 0.72	22.9 ± 0.39	22.84 ± 0.99	27.18 ± 0.60*#†
pH	7.46 ± 0.01	7.44 ± 0.01	7.52 ± 0.02 *#	7.43 ± 0.00 †
PaO₂/FIO₂	292.4 ± 12.26	303.80 ± 3.59	279.04 ± 15.39	241.90 ± 8.79 *#†
WBC (10³/μl)	5.52 ± 0.12	3.96 ± 0.67	13.52 ± 1.55 **##	16.42 ± 0.59 **##†
PLT(103/μl)	532.9 ± 25.5	386.46 ± 28.7	465.7 ± 33.8	244 ± 36.15** #††

n = 7 in each group. Data are presented as mean ± SE. **(P < 0.01) and * (P < 0.05) vs. the Sham group., ## (P < 0.01) vs. the PPVL group, †† (P < 0.01), and † (P < 0.05) vs. the CBDL group. The blood samples were taken at the end of the steady state period while animals were ventilated with room air. The atmospheric pressure is 630 mmHg. AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, WBC white blood cell count and PLT Platelet

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