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Table 2 The comparison of the experimental variables in the CBDL+PPVL versus CBDL models

From: Impact of liver damage on blood-borne variables and pulmonary hemodynamic responses to hypoxia and hyperoxia in anesthetized rats

CBD + PPVL

Effect

CBDL

Effect

Liver damage ↑↑

Liver dysfunction

Liver damage ↑↑

Liver dysfunction

Liver enzymes ↑↑

Liver dysfunction

Liver enzymes ↑↑

Liver dysfunction

WBC ↑↑

Systemic Inflammation

WBC ↑

Systemic inflammation

PLT ↓↓

Vascular thrombosis

PLT ↔

No change

Basal RVSP ↑↑

 

Basal RVSP ↑

 

HPV

No response

HPV

No response

ROS ↑

Systemic Inflammation

ROS ↑

Systemic Inflammation

PaO2

Impairment of gas exchange

PaO2

Little effect

PaO2/FIO2

Impairment of gas exchange

PaO2/FIO2

Little effect

Estradiol ↑

 

Estradiol ↑↑