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  1. The minimal clinically important difference (MCID) of a patient-reported outcome (PRO) represents the threshold value of the change in the score for that PRO. It is deemed to have an important implication in c...

    Authors: Jing Tian, Jinghua Zhao, Qing Zhang, Jia Ren, Linai Han, Jing Li, Yanbo Zhang and Qinghua Han

    Citation: BMC Cardiovascular Disorders 2021 21:58

    Content type: Research article

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  2. Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents.

    Authors: Changsong Liu, Yanfen Liao, Zongyuan Zhu, Lili Yang, Qin Zhang and Li Li

    Citation: BMC Cardiovascular Disorders 2021 21:57

    Content type: Research article

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  3. The absence of a pulmonary artery is a rare congenital anomaly that occurs isolated or with other congenital cardiac disorders, particularly tetralogy of Fallot (TOF); meanwhile, a hidden pulmonary artery migh...

    Authors: Mohammadreza Edraki, Bahram Ghasemzadeh, Kambiz Keshavarz, Ahmadali Amirghofran, Hamid Mohammadi, Zahra Kheirandish, Hamid Amoozgar, Elahe Nirooei, Gholamhossein Ajami, Nima Mehdizadegan, Amir Naghshzan, Farah Peiravian, Sirous Cheriki and Mohammad Javad Nobahkti

    Citation: BMC Cardiovascular Disorders 2021 21:56

    Content type: Research article

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  4. Pericardiocentesis is frequently performed when fluid needs to be removed from the pericardial sac, for both therapeutic and diagnostic purposes, however, it can still be a high-risk procedure in inexperienced...

    Authors: Daisuke Kanda, Takuro Takumi, Takeshi Sonoda, Ryo Arikawa, Kazuhiro Anzaki, Yuichi Sasaki and Mitsuru Ohishi

    Citation: BMC Cardiovascular Disorders 2021 21:55

    Content type: Case report

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  6. The model for end-stage liver disease excluding international normalized ratio (MELD-XI) is a simple score for risk assessment. However, the prognostic role of MELD-XI and its additional value to current risk ...

    Authors: Song-jian He, Jian-xin Weng, Hai-jun Chen, Hua-qiu Li, Wen-qin Guo, Qian Cao, Shuai Xu, Hong-bing Yan and Chang-nong Peng

    Citation: BMC Cardiovascular Disorders 2021 21:53

    Content type: Research article

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  7. Atrial fibrillation (AF) is the most common arrhythmia with poorly understood mechanisms. We aimed to investigate the biological mechanism of AF and to discover feature genes by analyzing multi-omics data and ...

    Authors: Yaozhong Liu, Fan Bai, Zhenwei Tang, Na Liu and Qiming Liu

    Citation: BMC Cardiovascular Disorders 2021 21:52

    Content type: Research article

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  8. To identify the association between tricuspid annular circumference and secondary tricuspid regurgitation and analyze the risk factors of recurrent tricuspid regurgitation after concomitant tricuspid annulopla...

    Authors: JinGuo Xu, Jie Han, Haibo Zhang, Fei Meng, Tiange Luo, BaiYu Tian, JianGang Wang, YuQing Jiao, HuiMei Yu and Xu Meng

    Citation: BMC Cardiovascular Disorders 2021 21:50

    Content type: Research article

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  9. Hospital volume is known to be associated with outcomes of patients requiring complicated medical care. However, the relationship between hospital volume and prognosis of hospitalized patients with heart failu...

    Authors: Hidehiro Kaneko, Hidetaka Itoh, Haruki Yotsumoto, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Kojiro Morita, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Hideo Yasunaga and Issei Komuro

    Citation: BMC Cardiovascular Disorders 2021 21:49

    Content type: Research article

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  10. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the two most commonly used coronary indices of physiological stenosis severity based on pressure. To minimize the effect of wedge press...

    Authors: Soohong Min, Gwansuk Kang, Dong-Guk Paeng and Joon Hyouk Choi

    Citation: BMC Cardiovascular Disorders 2021 21:48

    Content type: Research article

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  11. The prevalence of acute coronary syndrome (ACS) continues to increase among young Chinese adults. Homocysteine (HCY) has been suggested as a promoter of atherosclerosis leading to coronary artery disease (CAD)...

    Authors: Jiayin Sun, Wei Han, Sijing Wu, Shuo Jia, Zhenxian Yan, Yonghe Guo, Yingxin Zhao, Yujie Zhou and Wei Liu

    Citation: BMC Cardiovascular Disorders 2021 21:47

    Content type: Research article

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  13. Hypertension is a major source of cardiovascular morbidity and mortality. Recent evidence from mouse models, genetic, and cross-sectional human studies suggest increased proportions of selected immune cell sub...

    Authors: Joseph A. C. Delaney, Nels C. Olson, Colleen M. Sitlani, Alison E. Fohner, Sally A. Huber, Alan L. Landay, Susan R. Heckbert, Russell P. Tracy, Bruce M. Psaty, Matt Feinstein and Margaret F. Doyle

    Citation: BMC Cardiovascular Disorders 2021 21:45

    Content type: Research article

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  14. Adherence to clinical practice guidelines for coronary heart disease (CHD) reduces morbidity, mortality and treatment costs. We aimed to describe and compare adherence to prescription guidelines for persons wi...

    Authors: Elisabeth Pedersen, Beate Hennie Garcia, Kjell H. Halvorsen, Anne Elise Eggen, Henrik Schirmer and Marit Waaseth

    Citation: BMC Cardiovascular Disorders 2021 21:44

    Content type: Research article

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  15. Light-chain (AL) amyloidosis is the most common type of systemic amyloidosis with poor prognosis. Currently, the predictors of cardiac involvement and prognostic staging systems are primarily based on conventi...

    Authors: Changhui Lei, Xiaoli Zhu, David H. Hsi, Jing Wang, Lei Zuo, Shengjun Ta, Qianli Yang, Lei Xu, Xueli Zhao, Yan Wang, Shiren Sun and Liwen Liu

    Citation: BMC Cardiovascular Disorders 2021 21:43

    Content type: Research article

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  16. To compare the diagnostic accuracy of Doppler ultrasound (DUS) with contrast-enhanced ultrasound (CEUS) for detection of iliac vein stent stenosis using multidetector computed tomography venography (MDCTV) as ...

    Authors: Hong Liu, Jing Wang, Yu Zhao, Zheng Chen, Dong Wang, Miao Wei, Fajin Lv and Xiaoping Ye

    Citation: BMC Cardiovascular Disorders 2021 21:42

    Content type: Research article

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  17. Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in LDL-C and Lp(a) control. The appropriate level of LDL-C and Lp(a) in the preventi...

    Authors: Chuang Li, Qiwen Chen, Mei Zhang, Yin Liu, Yushun Chu, Fanpeng Meng, Jianyu Wang, Jie Tang, Jian Luo, Xiulong Niu and Maoti Wei

    Citation: BMC Cardiovascular Disorders 2021 21:41

    Content type: Research article

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  18. A simple and accurate scoring system to guide perioperative blood transfusion in patients with coronary artery disease (CAD) undergoing cardiac surgery is lacking. The trigger point for blood transfusions for ...

    Authors: Hai-Ping Ma, Lei Zhang, Chun-ling Chen, Jin Li, Zhi Tong Ma, Qiao Qiao Jiang, Yuan Yuan Liang, Shan Shan Li, Fei Long and Hong Zheng

    Citation: BMC Cardiovascular Disorders 2021 21:40

    Content type: Research article

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  19. Primary care physicians (PCP) play an important role in detecting Familial Hypercholesterolaemia (FH) early. However, knowledge, awareness and practice (KAP) regarding FH among Malaysian PCP are not well estab...

    Authors: Ahmad Baihaqi Azraii, Anis Safura Ramli, Zaliha Ismail, Suraya Abdul-Razak, Siti Fatimah Badlishah-Sham, Noor Alicezah Mohd-Kasim, Norsiah Ali, Gerald F. Watts and Hapizah Nawawi

    Citation: BMC Cardiovascular Disorders 2021 21:39

    Content type: Research article

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  20. Due to the limited number of studies with long term follow-up of patients undergoing Percutaneous Coronary Intervention (PCI), we investigated the occurrence of Major Adverse Cardiac and Cerebrovascular Events...

    Authors: Maryam Farhadian, Sahar Dehdar Karsidani, Azadeh Mozayanimonfared and Hossein Mahjub

    Citation: BMC Cardiovascular Disorders 2021 21:38

    Content type: Research article

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  21. Worldwide cardiovascular disease is the major cause of disability and premature death. This is due to the ascending trend of consuming an unhealthy diet and obesity which increases the risk of hypertension and...

    Authors: Dessie Abebaw Angaw, Rahma Ali, Afework Tadele and Shegaye Shumet

    Citation: BMC Cardiovascular Disorders 2021 21:37

    Content type: Research article

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  22. The aim of this study was to determine the difference in effects of beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those ...

    Authors: Jun Shitara, Ryo Naito, Takatoshi Kasai, Hirohisa Endo, Hideki Wada, Shinichiro Doi, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Tomotaka Dohi, Shinya Okazaki, Katsumi Miyauchi and Hiroyuki Daida

    Citation: BMC Cardiovascular Disorders 2021 21:36

    Content type: Research article

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  23. Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness ...

    Authors: Yu Sang, Ming Cao, Xiaofen Wu, Lei Ruan and Cuntai Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:34

    Content type: Research article

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  25. Del Nido cardioplegia (DNC) has been proven safe and effective in pediatric patients. However, the use of DNC in adult undergoing cardiovascular surgery lacks support with substantial evidence. This study aime...

    Authors: Chang Shu, Liang Hong, Xiao Shen, Wenhao Zhang, Yongsheng Niu, Xiaochun Song, Jie Kong and Cui Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:32

    Content type: Research article

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  26. US and European guidelines diverge on whether to vaccinate adults who are not at high risk for cardiovascular events against influenza. Here, we investigated the associations between influenza vaccination and ...

    Authors: Abhijit Sen, Inger Johanne Bakken, Ragna Elise Støre Govatsmark, Torunn Varmdal, Kaare Harald Bønaa, Kenneth Jay Mukamal, Siri Eldevik Håberg and Imre Janszky

    Citation: BMC Cardiovascular Disorders 2021 21:31

    Content type: Research article

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  27. Previous studies have demonstrated the feasibility of primary percutaneous coronary intervention (PPCI) in carefully selected nonagenarians. Although current guidelines recommend immediate revascularization in...

    Authors: Mohammed M. N. Meah, Tobin Joseph, Wern Yew Ding, Matthew Shaw, Jonathan Hasleton, Nick D. Palmer, Periaswamy Velavan and Suneil K. Aggarwal

    Citation: BMC Cardiovascular Disorders 2021 21:30

    Content type: Research article

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  28. High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associ...

    Authors: Svein Ivar Bekkelund

    Citation: BMC Cardiovascular Disorders 2021 21:29

    Content type: Research article

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  29. Mortality in infective endocarditis (IE) is still high, and the long term prognosis remains uncertain. This study aimed to identify predictors of long-term mortality for any cause, adverse event rate, relapse ...

    Authors: Valentina Scheggi, Irene Merilli, Rossella Marcucci, Stefano Del Pace, Iacopo Olivotto, Nicola Zoppetti, Nicole Ceschia, Valentina Andrei, Bruno Alterini, Pier Luigi Stefàno and Niccolò Marchionni

    Citation: BMC Cardiovascular Disorders 2021 21:28

    Content type: Research article

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  30. Up to over half of the patients with ST-segment elevation myocardial infarction (STEMI) are reported to undergo spontaneous reperfusion without therapeutic interventions. Our objective was to evaluate the appl...

    Authors: Abdolmohammad Ranjbar, Bahram Sohrabi, Seyyed-Reza Sadat-Ebrahimi, Samad Ghaffari, Babak Kazemi, Naser Aslanabadi, Babak Seyvani and Reza Hajizadeh

    Citation: BMC Cardiovascular Disorders 2021 21:27

    Content type: Research article

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  31. Anxiety is associated with poorer prognosis in patients with coronary artery disease (CAD). Due to their severity and chronic course, anxiety disorders, particularly generalized anxiety disorder (GAD) and pani...

    Authors: Guillaume Foldes-Busque, Clermont E. Dionne, Stéphane Turcotte, Phillip J. Tully, Marie-Andrée Tremblay, Paul Poirier and Isabelle Denis

    Citation: BMC Cardiovascular Disorders 2021 21:26

    Content type: Study protocol

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  32. The progression of paroxysmal AF (PAF) to persistent AF (PsAF) worsens the prognosis of AF, but its underlying mechanisms remain elusive. Recently, circular RNAs (circRNAs) were reported to be associated with ...

    Authors: Yuanfeng Gao, Ye Liu, Yuan Fu, Qianhui Wang, Zheng Liu, Roumu Hu, Xinchun Yang and Mulei Chen

    Citation: BMC Cardiovascular Disorders 2021 21:25

    Content type: Research article

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  33. The present study aimed to assess the correlation of fibroblast growth factor (FGF)-23 expression with clinical characteristics, then further explore its value in predicting 2-year in-stent restenosis (ISR) ri...

    Authors: Tingting Song, Yang Fu, Yanbo Wang, Wei Li, Jiayu Zhao, Xun Wang, Haiyan Wang, Ying Zhao and Xianghua Fu

    Citation: BMC Cardiovascular Disorders 2021 21:24

    Content type: Research article

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  34. A high prevalence of cardiovascular risk factors including age, male sex, hypertension, diabetes, and tobacco use, has been reported in patients with Coronavirus disease 2019 (COVID-19) who experienced adverse...

    Authors: Angelo Silverio, Marco Di Maio, Rodolfo Citro, Luca Esposito, Giuseppe Iuliano, Michele Bellino, Cesare Baldi, Giuseppe De Luca, Michele Ciccarelli, Carmine Vecchione and Gennaro Galasso

    Citation: BMC Cardiovascular Disorders 2021 21:23

    Content type: Research article

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  35. Hypercholesterolemia (HC) is an important precursor to many cardiovascular, cerebrovascular, and peripheral vascular diseases. A report conducted by the American Heart Association showed the prevalence of HC t...

    Authors: Jamaan Al-Zahrani, Mamdouh M. Shubair, Sameer Al-Ghamdi, Abdullah A. Alrasheed, Abdulrahman A. Alduraywish, Fayez Saud Alreshidi, Saeed Mastour Alshahrani, Majid Alsalamah, Badr F. Al-Khateeb, Aljawharah Ibraheem Ashathri, Ashraf El-Metwally and Khaled K. Aldossari

    Citation: BMC Cardiovascular Disorders 2021 21:22

    Content type: Research article

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  36. Microvascular insufficiency plays an important role in the development of diabetic cardiomyopathy (DCM), therapeutic angiogenesis has been mainly used for the treatment of ischemic diseases. This study sought ...

    Authors: Xijun Zhang, Xinqiao Tian, Peng Li, Haohui Zhu, Nanqian Zhou, Zhixin Fang, Yuping Yang, Yun Jing and Jianjun Yuan

    Citation: BMC Cardiovascular Disorders 2021 21:21

    Content type: Research article

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  37. One in five patients with ischaemic heart disease (IHD) develop comorbid depression or anxiety. Depression is associated with risk of non-adherence to cardiac rehabilitation (CR) and dropout, inadequate risk f...

    Authors: Susanne S. Pedersen, Christina M. Andersen, Robert Ahm, Søren J. Skovbakke, Robin Kok, Charlotte Helmark, Uffe K. Wiil, Thomas Schmidt, Kim Rose Olsen, Jacob Hjelmborg, Ann-Dorthe Zwisler and Lisbeth Frostholm

    Citation: BMC Cardiovascular Disorders 2021 21:20

    Content type: Study protocol

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  39. Cardiovascular diseases are still the main cause of death in the western world. However, diminishing mortality rates of acute myocardial infarction (AMI) are motivating the need to investigate the process of s...

    Authors: Christian Fischer, Jens Höpner, Saskia Hartwig, Michel Noutsias and Rafael Mikolajczyk

    Citation: BMC Cardiovascular Disorders 2021 21:18

    Content type: Research article

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  40. Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study ...

    Authors: Dae-Young Kim, Jae-Sun Uhm, Min Kim, In-Soo Kim, Moo-Nyun Jin, Hee Tae Yu, Tae-Hoon Kim, Jong-Youn Kim, Boyoung Joung, Hui-Nam Pak and Moon-Hyoung Lee

    Citation: BMC Cardiovascular Disorders 2021 21:17

    Content type: Research article

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  41. Berry syndrome, a rare combination of cardiac anomalies, consists of aortopulmonary window (APW); aortic origin of the right pulmonary artery; interrupted aortic arch (IAA) or hypoplastic aortic arch or coarct...

    Authors: Wen-jing Bi, Yang-jie Xiao, Yue-jia Liu, Yang Hou and Wei-dong Ren

    Citation: BMC Cardiovascular Disorders 2021 21:15

    Content type: Case report

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  42. Aneurysm is a severe and fatal disease. This study aims to comprehensively identify the highly conservative co-expression modules and hub genes in the abdominal aortic aneurysm (AAA), thoracic aortic aneurysm ...

    Authors: Siwei Bi, Ruiqi Liu, Linfeng He, Jingyi Li and Jun Gu

    Citation: BMC Cardiovascular Disorders 2021 21:14

    Content type: Research article

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  43. The incompetent bicuspid aortic valve (BAV) can be replaced or repaired using various surgical techniques. This study sought to assess the efficacy of external annuloplasty and postoperative reverse remodellin...

    Authors: Marek J. Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy and Marek A. Deja

    Citation: BMC Cardiovascular Disorders 2021 21:13

    Content type: Research article

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    The Correction to this article has been published in BMC Cardiovascular Disorders 2021 21:89

  44. Although most cases of atrial septal defect (ASD) are sporadic, familial cases have been reported, which may be caused by mutation of transcription factor GATA binding protein 4 (GATA4). Herein we combined whole-...

    Authors: Haisong Bu, Guowen Sun, Yun Zhu, Yifeng Yang, Zhiping Tan, Tianli Zhao and Shijun Hu

    Citation: BMC Cardiovascular Disorders 2021 21:12

    Content type: Research article

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  45. Peripheral artery disease (PAD) is common in persons with type 2 diabetes (T2DM) and contributes significantly to cardiovascular morbidity and mortality. Controversy exists regarding the utility of ankle brach...

    Authors: Ejiofor Ugwu, Anthony Anyanwu and Michael Olamoyegun

    Citation: BMC Cardiovascular Disorders 2021 21:10

    Content type: Research article

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  47. Partial anomalous pulmonary venous return (PAPVR) is a congenital heart defect. Reports of repair and treatment in pediatric cases have been published, but incidence of PAPVR in adults is not common. To our kn...

    Authors: Ismael A. Salas de Armas, Manish K. Patel, Bindu Akkanti, Jorge Salazar, Biswajit Kar and Igor D. Gregoric

    Citation: BMC Cardiovascular Disorders 2021 21:8

    Content type: Case report

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  48. Cardiac vasculitis is recognized as a heterogeneous disease process with a wide spectrum of manifestations including pericarditis, myocarditis, valvular heart disease and less frequently, coronary artery vascu...

    Authors: Shaun Khanna, Kartheek Garikapati, Daniel S. L. Goh, Kenneth Cho, Phillip Lo, Mohan V. Bhojaraja and Surjit Tarafdar

    Citation: BMC Cardiovascular Disorders 2021 21:7

    Content type: Review

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  49. The relationship between IL-35 genes polymorphism and susceptibility to coronary heart disease has not been tested in the largest Han population in China. The aim of this study was to explore the effect of sin...

    Authors: Hu Li, Ying-Xue Liu, Jin-Yan Huang, Yu-Feng Zhu and Kui Wang

    Citation: BMC Cardiovascular Disorders 2021 21:6

    Content type: Research article

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  50. Inflammatory cells infiltrate into the ischemic and hypoxic myocardial tissue after myocardial infarction. B cells gather at the site of myocardial injury and secrete cytokines to regulate immune inflammation ...

    Authors: Fanrui Mo, Ying Luo, Yuluan Yan, Juan Li, Shayi Lai and Weifeng Wu

    Citation: BMC Cardiovascular Disorders 2021 21:5

    Content type: Research article

    Published on:

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