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  1. Coronary computed tomography angiography (CCTA) is widely used as a first-line noninvasive modality that frequently exhibits no or nonobstructive coronary artery disease (CAD) in clinical practice, along with ...

    Authors: You-Jung Choi, Jun-Bean Park, Chan Soon Park, Inchang Hwang, Yeonyee E. Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho and Dae-Won Sohn
    Citation: BMC Cardiovascular Disorders 2021 21:187
  2. The association of infective endocarditis (IE) with spondylodiscitis (SD) was first reported in 1965, but few data are available about this issue. This study aimed to evaluate the prevalence of SD in patients ...

    Authors: Stefano Del Pace, Valentina Scheggi, Giacomo Virgili, Sabina Caciolli, Iacopo Olivotto, Nicola Zoppetti, Irene Merilli, Nicole Ceschia, Valentina Andrei, Bruno Alterini, Pier Luigi Stefàno and Niccolò Marchionni
    Citation: BMC Cardiovascular Disorders 2021 21:186
  3. Smoking, heavy alcohol drinking and drug abuse are detrimental lifestyle factors leading to loss of million years of healthy life annually. One of the major health complications caused by these substances is t...

    Authors: Zahra Jalali, Morteza Khademalhosseini, Narjes Soltani and Ali Esmaeili Nadimi
    Citation: BMC Cardiovascular Disorders 2021 21:185
  4. Development of acute kidney injury (AKI) in invasively managed patients with acute coronary syndrome (ACS) is associated with a markedly increased mortality risk. Different definitions of AKI are in use, leadi...

    Authors: Maren Weferling, Christoph Liebetrau, Daniel Kraus, Philipp Zierentz, Beatrice von Jeinsen, Oliver Dörr, Michael Weber, Holger Nef, Christian W. Hamm and Till Keller
    Citation: BMC Cardiovascular Disorders 2021 21:183
  5. The evidence of the long-term effects of multiple lifestyle intervention on cardiovascular risk is uncertain. We aimed to summarize the evidence from randomized clinical trials examining the efficacy of lifest...

    Authors: Hilde Bergum, Irene Sandven and Tor Ole Klemsdal
    Citation: BMC Cardiovascular Disorders 2021 21:181
  6. The benefits of chronic polytherapy in reducing readmissions and death after myocardial infarction (MI) have been clearly shown. However, real-world evidence shows poor medication adherence and large geographi...

    Authors: Mirko Di Martino, Michela Alagna, Adele Lallo, Kendall Jamieson Gilmore, Paolo Francesconi, Francesco Profili, Salvatore Scondotto, Giovanna Fantaci, Gianluca Trifirò, Valentina Isgrò, Marina Davoli and Danilo Fusco
    Citation: BMC Cardiovascular Disorders 2021 21:180
  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Abbas Alshami, Nasam Alfraji, Steven Douedi, Swapnil Patel, Mohammad Hossain, Deborah Alpert and Dawn Calderon
    Citation: BMC Cardiovascular Disorders 2021 21:179

    The original article was published in BMC Cardiovascular Disorders 2021 21:161

  8. The incidence of concurrent cancer and ischaemic heart disease (IHD) is increasing; however, the long-term patient prognoses remain unclear.

    Authors: Tatsuya Nishikawa, Toshitaka Morishima, Sumiyo Okawa, Yuki Fujii, Tomoyuki Otsuka, Toshihiro Kudo, Takeshi Fujita, Risa Kamada, Taku Yasui, Wataru Shioyama, Toru Oka, Takahiro Tabuchi, Masashi Fujita and Isao Miyashiro
    Citation: BMC Cardiovascular Disorders 2021 21:177
  9. Prenatal diagnosis of coarctation of the aorta (CoA) is challenging for most examiners. The malformation often occurs at the aortic isthmus, which is a short segment between the origin of the left subclavian a...

    Authors: Yu Wang, Caixia Liu, Ying Zhang and Meilian Wang
    Citation: BMC Cardiovascular Disorders 2021 21:176
  10. New-onset atrial fibrillation (NOAF) is common during acute myocardial infarction (AMI) and independently associated with worse prognosis. We aimed to validate the discrimination performance of CHA2DS2-VASc sc...

    Authors: Yuan Fu, Yuxia Pan, Yuanfeng Gao, Xinchun Yang and Mulei Chen
    Citation: BMC Cardiovascular Disorders 2021 21:175
  11. Autopsies regularly aim to clarify the cause of death; however, relatives may directly benefit from autopsy results in the setting of heritable traits (“mortui vivos docent”).

    Authors: Benno Hartung, Anne Tank, Sven Dittmann, Stefanie Ritz-Timme and Eric Schulze-Bahr
    Citation: BMC Cardiovascular Disorders 2021 21:174
  12. Stent ablation with rotational atherectomy has been considered a bail-out strategy for the treatment of severe stent underexpansion. Only a few reports have yet shown rotational ablation for double-layer metal...

    Authors: Tong Yaliang, Liu Guohui, Zhang Cheng, Du Beibei, Zhao Yanan, He Yuquan and Yang Ping
    Citation: BMC Cardiovascular Disorders 2021 21:173
  13. Epicardial adipose tissue (EAT) shares the same microcirculation with coronary arteries through coronary arteries branches, and contributes to the development of atherosclerosis. MicroRNAs (miRNAs) are involve...

    Authors: Fan Zhang, Naixuan Cheng, Jie Du, Haibo Zhang and Congcong Zhang
    Citation: BMC Cardiovascular Disorders 2021 21:172
  14. Preclinical models that resemble the clinical setting as closely as possible are essential in translating promising therapies for the treatment of acute myocardial infarction. Closed chest pig left anterior de...

    Authors: Max J. M. Silvis, Gerardus P. J. van Hout, Aernoud T. L. Fiolet, Mirthe Dekker, Lena Bosch, Martijn M. J. van Nieuwburg, Joyce Visser, Marlijn S. Jansen, Leo Timmers and Dominique P. V. de Kleijn
    Citation: BMC Cardiovascular Disorders 2021 21:171
  15. The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset ...

    Authors: Maurício Fregonesi Barbosa, Daniéliso Renato Fusco, Rafael Dezen Gaiolla, Konrad Werys, Suzana Erico Tanni, Rômulo Araújo Fernandes, Sergio Marrone Ribeiro and Gilberto Szarf
    Citation: BMC Cardiovascular Disorders 2021 21:170
  16. Residual risk remained significant despite effective low density lipoprotein cholesterol (LDL-C) lowering treatment. Small dense low density lipoprotein cholesterol (sdLDL-C) as part of LDL-C has been found to...

    Authors: Jianwei Zhang and Lingjie He
    Citation: BMC Cardiovascular Disorders 2021 21:169
  17. Hypertension and diabetes mellitus (DM), are highly prevalent worldwide health non-communicable diseases, and are associated with chronic complications. The co-existence of both conditions accelerates the rela...

    Authors: Omer Abdelbagi, Imad R. Musa, Shaza M. Musa, Salim A. ALtigani and Ishag Adam
    Citation: BMC Cardiovascular Disorders 2021 21:168
  18. Septic shock with myocardial depression is very common in intensive care units. However, the exact molecular mechanisms underlying sepsis-induced myocardial depression remain unclear. Whether the profiles of t...

    Authors: Tie-Ning Zhang, Ri Wen, Ni Yang and Chun-Feng Liu
    Citation: BMC Cardiovascular Disorders 2021 21:166
  19. Anthracyclines and monoclonal antibodies against human epidermal growth factor receptor-2 (HER2) are frequently used to treat breast cancer but they are associated with risk of developing cardiotoxicity. Imple...

    Authors: Estíbaliz Díaz-Balboa, Violeta González-Salvado, Beatriz Rodríguez-Romero, Amparo Martínez-Monzonís, Milagros Pedreira-Pérez, Patricia Palacios-Ozores, Rafael López-López, Carlos Peña-Gil and José R. González-Juanatey
    Citation: BMC Cardiovascular Disorders 2021 21:165
  20. The primary aim was to observe the predictive value of P-wave ECG index and left atrial appendage volume (LLAV) for atrial fibrillation recurrence after first radiofrequency catheter ablation.

    Authors: Ruibin Li, Xiaohong Yang, Min Jia, Dong Wang, Xiaoran Cui, Long Bai, Lei Zhao and Jidong Zhang
    Citation: BMC Cardiovascular Disorders 2021 21:164
  21. A distorted blood lipid profile is an important risk factor for ischemic heart disease (IHD) but the predictive ability of the different lipid measures has rarely been studied. Our aim was to examine and compa...

    Authors: Susanna Calling, Sven-Erik Johansson, Moa Wolff, Jan Sundquist and Kristina Sundquist
    Citation: BMC Cardiovascular Disorders 2021 21:163
  22. Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum leve...

    Authors: Widet Gallo, Filip Ottosson, Cecilia Kennbäck, Amra Jujic, Jonathan Lou S. Esguerra, Lena Eliasson and Olle Melander
    Citation: BMC Cardiovascular Disorders 2021 21:162
  23. Psoriasis is a chronic inflammatory skin condition commonly associated with psoriatic arthritis, malignancy, diabetes, inflammatory bowel disease, and cardiovascular disease. Several reports and studies have r...

    Authors: Abbas Alshami, Nasam Alfraji, Steven Douedi, Swapnil Patel, Mohammad Hossain, Deborah Alpert and Dawn Calderon
    Citation: BMC Cardiovascular Disorders 2021 21:161

    The Correction to this article has been published in BMC Cardiovascular Disorders 2021 21:179

  24. Prevention of recurrent stroke in patients with embolic stroke of undetermined source (ESUS) is challenging. The advent of safer anticoagulation in the form of direct oral anticoagulants (DOACs) has prompted e...

    Authors: Klaus K. Witte, Georgios Tsivgoulis, Matthew R. Reynolds, Stelios I. Tsintzos, Simon Eggington, Eleni Ismyrloglou, Julie Lyon, Marianne Huynh, Marta Egea, Bonnie de Brouwer, Paul D. Ziegler, Noreli Franco, Rashmi Joglekar, Sarah C. Rosemas, Shufeng Liu and Vincent Thijs
    Citation: BMC Cardiovascular Disorders 2021 21:160
  25. Electrocardiographic left ventricular hypertrophy (ECG-LVH) is a common manifestation of preclinical cardiovascular disease. The present study aimed to investigate risk factors for ECG-LVH and its prevalence i...

    Authors: Yue-Yuan Liao, Ke Gao, Bo-Wen Fu, Lei Yang, Wen-Jing Zhu, Qiong Ma, Chao Chu, Yu Yan, Yang Wang, Wen-Ling Zheng, Jia-Wen Hu, Ke-Ke Wang, Yue Sun, Chen Chen and Jian-Jun Mu
    Citation: BMC Cardiovascular Disorders 2021 21:159
  26. The cause-and-effect relationship of QTc prolongation in Coronavirus disease 2019 (COVID-19) patients has not been studied well.

    Authors: Khalid Changal, David Paternite, Sean Mack, Spiro Veria, Rehana Bashir, Mitra Patel, Ronak Soni, Muhammad Ali, Tanveer Mir, Mujeeb Sheikh and P. Kasi Ramanathan
    Citation: BMC Cardiovascular Disorders 2021 21:158
  27. Acute hyperglycemia has been recognized as a robust predictor for occurrence of acute kidney injury (AKI) in nondiabetic patients with acute myocardial infarction (AMI), however, its discriminatory ability for...

    Authors: Side Gao, Qingbo Liu, Hui Chen, Mengyue Yu and Hongwei Li
    Citation: BMC Cardiovascular Disorders 2021 21:157
  28. The pathophysiology of isolated coronary artery ectasia (CAE) with the coronary slow flow (CSF) phenomenon is still unclear. The purpose of this study was to investigate the risk factors for isolated CAE compl...

    Authors: Zhuoxuan Yang, Jiansong Yuan, JinGang Cui, Hao Guan and Shubin Qiao
    Citation: BMC Cardiovascular Disorders 2021 21:156
  29. The study evaluated the cost of baroreflex activation therapy plus guideline directed therapy (BAT + GDT) compared to GDT alone for HF patients with reduced ejection fraction and New York Heart Association Cla...

    Authors: John Bisognano, John E. Schneider, Shawn Davies, Robert L. Ohsfeldt, Elizabeth Galle, Ivana Stojanovic, Thomas F. Deering, JoAnn Lindenfeld and Michael R. Zile
    Citation: BMC Cardiovascular Disorders 2021 21:155
  30. Appropriate use criteria (AUC) have been developed in response to growth in cardiac imaging utilization and concern regarding associated costs. Cardiac computed tomography angiography (CCTA) has emerged as an ...

    Authors: Michael Hammer, Muhtashim Mian, Levi Elhadad, Mary Li and Idan Roifman
    Citation: BMC Cardiovascular Disorders 2021 21:154
  31. Cardiac myxomas (CMs) and thrombi are associated with high morbidity and mortality. These two conditions need totally different treatments. However, they are difficult to distinguish using naked eye. In clinic...

    Authors: Wen-lei Qian, Yu Jiang, Xi Liu, Ying-kun Guo, Yuan Li, Xin Tang and Zhi-gang Yang
    Citation: BMC Cardiovascular Disorders 2021 21:152
  32. Atherosclerosis (AS) is a leading cause of vascular disease worldwide. MicroRNAs (miRNAs) play an essential role in the development of AS. However, the miRNAs-based biomarkers for the diagnosis of AS are still...

    Authors: Xiujiang Han, Huimin Wang, Yongjian Li, Lina Liu and Sheng Gao
    Citation: BMC Cardiovascular Disorders 2021 21:150
  33. Dyslipidaemia refers to lipid abnormalities consisting of either one or any combination of the following: elevated total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-c), elevated triglyc...

    Authors: Mohamed-Syarif Mohamed-Yassin, Noorhida Baharudin, Aqil Mohammad Daher, Najmin Abu Bakar, Anis Safura Ramli, Suraya Abdul-Razak, Nor-Ashikin Mohamed Noor Khan, Mariam Mohamad and Khalid Yusoff
    Citation: BMC Cardiovascular Disorders 2021 21:149
  34. In China, there has been a precipitous increase in the number of percutaneous coronary interventions (PCI) conducted. We sought to characterize the clinical and psychosocial trajectory of PCI patients from the...

    Authors: Xia Liu, Adeleke Fowokan, Sherry L. Grace, Biao Ding, Shu Meng, Xiu Chen, Yinghua Xia and Yaqing Zhang
    Citation: BMC Cardiovascular Disorders 2021 21:148
  35. The recreational drugs cannabis and nitrous oxide (N2O) are known for pro-atherogenic effects and are associated with an elevated risk of myocardial infarction. These cardiovascular effects might be underestimate...

    Authors: Sarah Bär, Fabien Praz and Lorenz Räber
    Citation: BMC Cardiovascular Disorders 2021 21:147
  36. Patients with atrial fibrillation (AF) underwent a high risk of hospitalization, which has not been paid much attention to in practice. Therefore, we aimed to assess the incidence, causes and predictors of hos...

    Authors: Zhaojie Dong, Xin Du, Shangxin Lu, Chao Jiang, Shijun Xia, Liu He, Xin Su, Zhaoxu Jia, Deyong Long, Caihua Sang, Ribo Tang, Nian Liu, Rong Bai, Ronghui Yu, Jianzeng Dong and Changsheng Ma
    Citation: BMC Cardiovascular Disorders 2021 21:146
  37. Inconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated the association between ALT and hypertensio...

    Authors: Jiajing Jia, Ying Yang, Fangchao Liu, Minjin Zhang, Qin Xu, Tonglei Guo, Long Wang, Zuoqi Peng, Yuan He, Yuanyuan Wang, Ya Zhang, Hongguang Zhang, Haiping Shen, Yiping Zhang, Donghai Yan, Xu Ma…
    Citation: BMC Cardiovascular Disorders 2021 21:145
  38. The PEGASUS-TIMI 54 trial inclusion criteria effectively identified high-risk patients with recent myocardial infarction (MI) who would benefit from continuing dual antiplatelet therapy (DAPT) with ticagrelor ...

    Authors: Federico Sanchez, Valentina Boasi, Matteo Vercellino, Chiara Tacchi, Pierpaolo Cannarile, Nicoletta Pingelli, Dino Perri, Laura Gomez, Stefano Cattunar and Giovanni Mascelli
    Citation: BMC Cardiovascular Disorders 2021 21:144
  39. Pericardial tamponade is a serious condition which may eventually lead to severe haemodynamic disturbances and cardiac arrest. It is most often caused by the accumulation of fluid inside the pericardium, as a ...

    Authors: Miklós Pólos, Dominika Domokos, Cristina-Maria Şulea, Kálmán Benke, Gergely Csikós, Andrea Nagy, Réka Skoda, András Szabó, Eperke Merkel, István Hartyánszky, Zoltán Szabolcs, Béla Merkely and Dávid Becker
    Citation: BMC Cardiovascular Disorders 2021 21:143
  40. The aim of the present study was to investigate whether the disappearance of ischemic post-processing (IPO) in the myocardium of diabetes mellitus (DM) is associated with the increase of succinate dehydrogenas...

    Authors: Mengyuan Deng, Wei Chen, Haiying Wang, Yan Wang, Wenjing Zhou and Tian Yu
    Citation: BMC Cardiovascular Disorders 2021 21:142
  41. The predictive importance of visit-to-visit blood pressure variability (VVV) for high blood pressure (HBP) in a pediatric population has been largely unsettled. We aimed to evaluate it based on Health Promotio...

    Authors: Jiaxiang Wang, Hui Shen, Jieyu Liu, Chengqi Xiao, Cailong Chen, Haoyue Teng, Jia Hu and Jieyun Yin
    Citation: BMC Cardiovascular Disorders 2021 21:141
  42. Sudden cardiac deaths are twice more frequent in diabetic patients with cardiac autonomic neuropathy. Sudden cardiac death etiologies remain unclear and no recommendations are made to identify factors associat...

    Authors: Louis Schubert, Suzanne Laroche, Agnès Hartemann, Olivier Bourron and Franck Phan
    Citation: BMC Cardiovascular Disorders 2021 21:140
  43. The ambulatory arterial stiffness index (AASI) is an indirect measure of arterial stiffness obtained during ambulatory blood pressuring monitoring (ABPM). Its relationship to nocturnal blood pressure dipping s...

    Authors: Christopher J. Boos, Lin-Thiri Toon and Halah Almahdi
    Citation: BMC Cardiovascular Disorders 2021 21:139
  44. Nationwide hospital admissions data series have contributed to a reliable assessment of the changing epidemiology of infective endocarditis, even though conclusions are not uniform. We sought to use a recent p...

    Authors: Catarina Sousa, Paulo Nogueira and Fausto J. Pinto
    Citation: BMC Cardiovascular Disorders 2021 21:138
  45. Supraventricular tachycardias (SVTs) are common in the first year of life and may be life-threatening. Acute cardioversion is usually effective, with both pharmacological and non-pharmacological procedures. Ho...

    Authors: Guglielmo Capponi, Gilda Belli, Mattia Giovannini, Giulia Remaschi, Alice Brambilla, Francesca Vannuccini, Silvia Favilli, Giulio Porcedda and Luciano De Simone
    Citation: BMC Cardiovascular Disorders 2021 21:137
  46. Abiraterone is a medication frequently used for metastatic castrate-resistant prostate cancer. We report a case of non-sustained episodes of TdP associated with severe hypokalemia due to androgen-deprivation t...

    Authors: Ximena Morales, Diego Garnica, Daniel Isaza, Nicolas Isaza and Felipe Durán-Torres
    Citation: BMC Cardiovascular Disorders 2021 21:136

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