Articles

Importance of confirming the underlying diagnosis in patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): a single-centre retrospective cohort study

Many patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are discharged without a known aetiology for their clinical presentation. This study sought to assess the effect of this...

Authors: T. F. S. Pustjens, A. Meerman, N. P. A. Vranken, A. W. Ruiters, B. Gho, M. Stein, M. Ilhan, L. Veenstra, P. Winkler, Á. Lux, S. Rasoul and A. W. J. van ‘t Hof

Indoleamine 2,3 dioxygenase (IDO) level as a marker for significant coronary artery disease

Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation, and is regarded as a key molecule driving immunotolera...

Authors: Nattawut Wongpraparut, Ploy Pengchata, Sudarat Piyophirapong, Pariya Panchavinnin, Rungtiwa Pongakasira, Noppadol Arechep, Kanda Kasetsinsombat and Kittipong Maneechotesuwan

Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the U.S. National Health and Nutrition Examination Survey (NHANES)

We examined the relationship between ratios of select biomarkers of kidney and liver function on all-cause and coronary heart disease (CHD) mortality, both in isolation, and in combination with metabolic syndr...

Authors: Akinkunle Oye-Somefun, Jennifer L. Kuk and Chris I. Ardern

Identification of biomarkers associated with metabolic cardiovascular disease using mRNA-SNP-miRNA regulatory network analysis

CVD is the leading cause of death in T2DM patients. However, few biomarkers have been identified to detect and diagnose CVD in the early stage of T2DM. The aim of our study was to identify the important mRNAs,...

Authors: Zhiyuan Fan, Wenjuan Peng, Zhiwen Wang, Ling Zhang and Kuo Liu

A case of primary aldosteronism with a negative aldosterone-to-renin ratio

Primary aldosteronism (PA), as a cause of secondary hypertension, can cause more serious cardiovascular damage than essential hypertension. The aldosterone-to-renin ratio (ARR) is recommended as the most relia...

Authors: Fengyi Liu, Liang Wang and Yanchun Ding

Correction to: Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project

Authors: Nan Ye, Lijiao Yang, Guoqin Wang, Weijing Bian, Fengbo Xu, Changsheng Ma, Dong Zhao, Jing Liu, Yongchen Hao, Jun Liu, Na Yang and Hong Cheng

Electrical storm after correction of an uncomplicated congenital atrial septal defect in an adult: a case report

There is a paucity of published literature describing electrical storm after the correction of uncomplicated atrial septal defect (ASD) in an adult.

Authors: Ying Liang, Feilong Hei and Yulong Guan

Renoprotective effects of sodium glucose cotransporter 2 inhibitors in type 2 diabetes patients with decompensated heart failure

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) reduces the risk of the composite renal endpoint and weakens the progressive decline in renal function in patients with chronic heart failure (HF). However, a ...

Authors: Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura and Koichiro Kinugawa

Subclinical cardiac perforation by cardiac implantable electronic device leads detected by cardiac computed tomography

The relationship between the characteristics of cardiac implantable electronic device (CIED) leads and subclinical cardiac perforations remains unclear. This study aimed to evaluate the incidence of subclinica...

Authors: Yeong-Min Lim, Jae-Sun Uhm, Min Kim, In-Soo Kim, Moo-Nyun Jin, Hee Tae Yu, Tae-Hoon Kim, Hye-Jeong Lee, Young-Jin Kim, Boyoung Joung, Hui-Nam Pak and Moon-Hyoung Lee

The association between atrial fibrillation and in-hospital outcomes in chronic kidney disease patients with acute coronary syndrome: findings from the improving care for cardiovascular disease in China-acute coronary syndrome (CCC-ACS) project

Atrial fibrillation (AF) is the most common cardiac arrhythmia in patients with chronic kidney disease (CKD) and acute coronary syndrome (ACS). This study aimed to explore the frequency and impact of AF on cli...

Authors: Lijiao Yang, Nan Ye, Guoqin Wang, Weijing Bian, Fengbo Xu, Dong Zhao, Jing Liu, Yongchen Hao, Jun Liu, Na Yang and Hong Cheng

KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease

Myocardial infarction (MI) contributes to high mortality and morbidity and can also accelerate atherosclerosis, thus inducing recurrent event due to status changing of coronary artery walls or plaques. The res...

Authors: Qiang Zhang, Yue Zheng, Meng Ning and Tong Li

Serum free fatty acids are associated with severe coronary artery calcification, especially in diabetes: a retrospective study

Serum free fatty acid (FFA) concentrations are associated with coronary heart disease and diabetes mellitus (DM). Few studies focused on the relationship between serum FFA levels and coronary artery calcificat...

Authors: Yangxun Xin, Junfeng Zhang, Yuqi Fan and Changqian Wang

Evaluating the association of social needs assessment data with cardiometabolic health status in a federally qualified community health center patient population

Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients’ Risks, Assets, and Experiences (PRAPARE) to imp...

Authors: Connor Drake, Tyler Lian, Justin G. Trogdon, David Edelman, Howard Eisenson, Morris Weinberger, Kristin Reiter and Christopher M. Shea

Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation

Catheter ablation is widely used in atrial fibrillation (AF) management. In this study, we are aimed to investigate the incidence of postprocedural cognitive decline in a larger population undergoing AF ablati...

Authors: Jing Zhang, Shi-Jun Xia, Xin Du, Chao Jiang, Yi-Wei Lai, Yu-Feng Wang, Zhao-Xu Jia, Liu He, Ri-Bo Tang, Jian-Zeng Dong and Chang-Sheng Ma

Individualized mobile health interventions for cardiovascular event prevention in patients with coronary heart disease: study protocol for the iCARE randomized controlled trial

Mobile health-based individualized interventions have shown potential effects in managing cardiovascular risk factors. This study aims to assess whether or not mHealth based individualized interventions delive...

Authors: Yuling Chen, Meihua Ji, Ying Wu, Ying Deng, Fangqin Wu and Yating Lu

Current status and etiology of valvular heart disease in China: a population-based survey

The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investiga...

Authors: Ying Yang, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Suning Li, Congyi Zheng, Yuting Kang, Linlin Jiang, Zhenhui Zhu and Runlin Gao

Prevalence and differences of ideal cardiovascular health in urban and rural adolescents in the Region of Tyrol: results from the EVA Tyrol study

Early adoption of a healthy lifestyle has positive effects on cardiovascular health (CVH) in adulthood. In this study, we aimed to assess CVH metrics in a cohort of healthy teenagers with focus on differences ...

Authors: C. Hochmayr, J. P. Ndayisaba, N. Gande, A. Staudt, B. Bernar, K. Stock, R. Geiger, M. Knoflach and U. Kiechl-Kohlendorfer

Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients

Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of C...

Authors: Wen Wei, Lingyu Zhang, Yunhan Zhang, Ronghui Tang, Miao Zhao, Zhidong Huang, Jin Liu, Danyuan Xu, Yibo He, Bo Wang, Haozhang Huang, Qiang Li, Mengfei Lin, Yong Liu, Kaihong Chen and Shiqun Chen

Ten-year risk of fatal cardiovascular disease and its association with metabolic risk factors among waste pickers in South Africa

Cardiovascular disease (CVD) is the leading cause of death among non-communicable diseases in South Africa. Several metabolic risk factors contribute to the development of CVD. Informal workers such as waste p...

Authors: Felix Made, Engelbert A. Nonterah, Nonhlanhla Tlotleng, Vusi Ntlebi and Nisha Naicker

Endovascular embolization of spontaneous rupture of isolated splenic artery dissection associated with hemosuccus pancreaticus: a case report

Isolated splenic artery dissection (SAD) is extremely rare, life-threatening, and particularly difficult to diagnose. Moreover, SAD presenting as digestive hemorrhage has not been reported.

Authors: Jianjun Jiang, Yang Liu and Xiangjiu Ding

Comparison of the prognostic value of SYNTAX score and clinical SYNTAX score on outcomes of Chinese patients underwent percutaneous coronary intervention

Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of ...

Authors: Xiao-Qin Li, Chun Yin, Xiao-Li Li, Wen-Li Wu and Kun Cui

Leukocyte count and the risk of adverse outcomes in patients with HFpEF

Inflammation is a key feature of heart failure including HFpEF. The leukocyte count is a marker of inflammation that is widely used in clinical practice. However, there is little available evidence for the rel...

Authors: Zhaowei Zhu and Shenghua Zhou

The vicious cycle: a history of obesity and COVID-19

Recently, we face a surge in the fast-forward Coronavirus Disease 2019 (COVID-19) pandemic with nearly 170 million confirmed cases and almost 3.5 million confirmed deaths at the end of May 2021. Obesity, also ...

Authors: Jacek Bil and Olga Możeńska

High-fat diet attenuates the improvement of hypoxia-induced pulmonary hypertension in mice during reoxygenation

It is widely recognized that metabolic disorder is associated with pulmonary hypertension (PH). It is known that hypoxia-induced elevated pulmonary artery pressure in mice returns to normal pressure during reo...

Authors: Koichi Sugimoto, Tetsuro Yokokawa, Tomofumi Misaka, Takashi Kaneshiro, Akiomi Yoshihisa, Kazuhiko Nakazato and Yasuchika Takeishi

Integration of transcriptomic data identifies key hallmark genes in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) represents one of the most common inherited heart diseases. To identify key molecules involved in the development of HCM, gene expression patterns of the heart tissue samples ...

Authors: Jing Xu, Xiangdong Liu and Qiming Dai

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis

Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of people all over the world. HF occurs when the cardiac overload and injury, which is a worldwide complaint. The aim of this study ...

Authors: Vijayakrishna Kolur, Basavaraj Vastrad, Chanabasayya Vastrad, Shivakumar Kotturshetti and Anandkumar Tengli

IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study

Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalenc...

Authors: Jennifer M. T. A. Meessen, Giulia Cesaroni, Gian F. Mureddu, Alessandro Boccanelli, Ursula-Henrike Wienhues-Thelen, Peter Kastner, Luisa Ojeda-Fernandez, Deborah Novelli, Gianfranco Bazzoni, Maurizio Mangiavacchi, Nera Agabiti, Serge Masson, Lidia Staszewsky and Roberto Latini

Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19

The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear.

Authors: Kevin O’Gallagher, Anthony Shek, Daniel M. Bean, Rebecca Bendayan, Alexandros Papachristidis, James T. H. Teo, Richard J. B. Dobson, Ajay M. Shah and Rosita Zakeri

One-year outcomes of drug-coated balloon treatment for long femoropopliteal lesions: a multicentre cohort and real-world study

Drug-coated balloons (DCBs) have shown superiority in the endovascular treatment of short femoropopliteal artery disease. Few studies have focused on outcomes in long lesions. This study aimed to evaluate the ...

Authors: Xiaoxi Yu, Xin Zhang, Zhichao Lai, Jiang Shao, Rong Zeng, Wei Ye, Yuexin Chen, Bihui Zhang, Bo Ma, Wenteng Cao, Xiaolong Liu, Jinghui Yuan, Yuehong Zheng, Min Yang, Zhidong Ye and Bao Liu

Combined evaluation of coronary artery disease and high-sensitivity cardiac troponin T for prediction of adverse events in patients with hypertrophic cardiomyopathy

This study was performed to investigate the clinical significance of combined evaluation of both coronary artery disease (CAD) and high-sensitivity cardiac troponin T (hs-cTnT) for prediction of major adverse ...

Authors: Hang Liao, Huay Cheem Tan, Ziqiong Wang, Xiaoping Chen, Yong He and Sen He

Real-world experience of angiotensin receptor/neprilysin inhibitor (ARNI) usage in Thailand: a single-center, retrospective analysis

Treatment of heart failure with reduced ejection fraction (HFrEF) has been revolutionized by angiotensin receptor/neprilysin inhibitor (ARNI). ARNI has been shown to significantly reduce morbidity and mortalit...

Authors: Wipharak Rattanavipanon, Thanyaluck Sotananusak, Fairus Yamaae, Arisa Chandrsawang, Pitchapa Kaewkan, Surakit Nathisuwan and Teerapat Yingchoncharoen

Impact of chronic outward force on arterial responses of proximal and distal of long superficial femoral artery stent

Self-expanding nitinol stent (SENS) implantation is commonly oversized in the superficial femoral artery (SFA), and leads to chronic outward force (COF) and in-stent restenosis (ISR). This study aimed to inves...

Authors: Hu Li, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Sang Ki Moon, Won Young Jang, Woohyeun Kim, Ji Hun Ahn, Sang-Ho Park, Woong Gil Choi, Rui Feng Yang, Wen Wei Bai, Cheol Ung Choi, Yang gi Ryu, Man Jong Baek and Dong Joo Oh

Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES)

The risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular end...

Authors: Benedicta Ngwenchi Nkeh-Chungag, Godwill Azeh Engwa, Charles Businge, Mziwohlanga Mdondolo, Magdevy Pajaro Medina and Nandu Goswami

Identification and functional study of GATA4 gene regulatory variants in atrial septal defects

Congenital heart disease (CHD) is the leading cause of mortality from birth defects. In adult CHD patients with successful surgical repair, cardiac complications including heart failure develop at late stage, ...

Authors: Dongchen Fan, Shuchao Pang, Jing Chen, Jiping Shan, Qianjin Cheng and Bo Yan

Cardio-metabolic outcomes in South Asians compared to White Europeans in the United Kingdom: a matched controlled population-based cohort study

There appears to be an inequality in the risk of cardio-metabolic disease between those from a South Asian (SA) background when compared to those of White Europeans (WE) descendance, however, this association ...

Authors: Munerah Almulhem, Joht Singh Chandan, Krishna Gokhale, Nicola J. Adderley, Rasiah Thayakaran, Kamlesh Khunti, Abd A. Tahrani, Wasim Hanif and Krishnarajah Nirantharakumar

Contemporary procedure characteristics and outcomes of accessory atrioventricular pathway ablations in an integrated community-based health care system using a tiered approach

Since the early descriptions of large series of accessory atrioventricular pathway ablations in adults and adolescents over 20 years ago, there have been limited published reports based on more recent experien...

Authors: Charlie Young, Annie Kwan, Lisa Yepez, Meghan McCarty, Amanda Chan, Dora Hsu, Jennifer Han, Taresh Taneja, Shirley Park, Robert Hayward and Taylor I. Liu

Study rationale and design of a study of EMPAgliflozin’s effects in patients with type 2 diabetes mellitus and Coronary ARtery disease: the EMPA-CARD randomized controlled trial

Recent trials have revealed that sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are effective against hyperglycemia and also reduce micro- and macro-vascular complications in patients with type 2 diabete...

Authors: Sepehr Gohari, Tara Reshadmanesh, Hadi Khodabandehloo, Mojtaba Fathi, Hassan Ahangar, Shahram Arsang-Jang, Faramarz Ismail-Beigi, Samin Ghanbari, Mohsen Dadashi, Muhammad Javad Muhammadi, Sheida Gohari and Saeid Ghaffari

C-factor: a summary measure for systemic arterial calcifications

Arterial calcification, the hallmark of arteriosclerosis, has a widespread distribution in the human body with only moderate correlation among sites. Hitherto, a single measure capturing the systemic burden of...

Authors: Lieke M. Kuiper, M. Kamran Ikram, Maryam Kavousi, Meike W. Vernooij, M. Arfan Ikram and Daniel Bos

Real-world long-term outcomes based on three therapeutic strategies in very old patients with three-vessel disease

There are relatively limited data regarding real-world outcomes in very old patients with three-vessel disease (3VD) receiving different therapeutic strategies. This study aimed to perform analysis of long-ter...

Authors: Deshan Yuan, Sida Jia, Ce Zhang, Lin Jiang, Lianjun Xu, Yin Zhang, Jingjing Xu, Ru Liu, Bo Xu, Rutai Hui, Runlin Gao, Zhan Gao, Lei Song and Jinqing Yuan

Application of three-dimensional transesophageal echocardiography in preoperative evaluation of transcatheter aortic valve replacement

Our goal was to determine the accuracy of 3-dimensional transesophageal echocardiography (3D-TEE) compared with that of computed tomography (CT) in the preoperative evaluation for transcatheter aortic valve re...

Authors: Peng Ding, Chennian Xu, Yang Liu, Xin Meng, Ping Jin, Jiayou Tang, Lanlan Li, Yanyan Ma and Jian Yang

Long-term results after mitral valve surgery using minimally invasive versus sternotomy approach: a propensity matched comparison of a large single-center series

Mitral valve (MV) surgery has traditionally been performed by conventional sternotomy (CS), but more recently minimally invasive surgery (MIS) has become another treatment option. The aim of this study is to c...

Authors: Ayse Cetinkaya, Anna Geier, Karin Bramlage, Stefan Hein, Peter Bramlage, Markus Schönburg, Yeong-Hoon Choi and Manfred Richter

Concomitant acute myocardial infarction and acute pulmonary embolism caused by paradoxical embolism: a case report

Due to its low incidence and diverse manifestations, paradoxical embolism (PDE) is still under-reported and is not routinely considered in differential diagnoses. Concomitant acute myocardial infarction (AMI) ...

Authors: Weiwei Chen, Zhixi Yu, Siming Li, Kenji Wagatsuma, Beibei Du and Ping Yang

Assessment of electrocardiogram abnormality and associated factors among apparently healthy adult type 2 diabetic patients on follow-up at Jimma Medical Center, Southwest Ethiopia: Cross-sectional study

Diabetes mellitus is a group of metabolic disorders causing long-term damage to the cardiovascular system which remains asymptomatic among diabetic patients. An electrocardiograph is a simple and first-line to...

Authors: Deriba A. Bedane, Samuel Tadesse, Moyeta Bariso, Wondu Reta and Gaddisa Desu

Non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio serve as a predictor for coronary collateral circulation in chronic total occlusive patients

The present study investigated the potential correlation between non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (non-HDL-C/HDL) and the formation of coronary collateral cir...

Authors: Ya Li, Xin Chen, Shu Li, Yulin Ma, Jialing Li, Mingying Lin and Jing Wan

Hypertensive crisis in patients with obstructive sleep apnea-induced hypertension

Hypertensive crisis is an urgent/emergency condition. Although obstructive sleep apnea (OSA) in resistant hypertension has been thoroughly examined, information regarding the risk factors and prevalence of hyp...

Authors: Sittichai Khamsai, Apichart Chootrakool, Panita Limpawattana, Jarin Chindaprasirt, Wattana Sukeepaisarnjaroen, Verajit Chotmongkol, Songkwan Silaruks, Vichai Senthong, Yuwares Sittichanbuncha, Bundit Sawunyavisuth and Kittisak Sawanyawisuth

Correction to: The GEnetic Syntax Score: a genetic risk assessment implementation tool grading the complexity of coronary artery disease—rationale and design of the GESS study

Authors: Ioannis S. Vizirianakis, Fani Chatzopoulou, Andreas S. Papazoglou, Efstratios Karagiannidis, Georgios Sofdis, Nikolaos Stalikas, Christos Stefopoulos, Konstantinos A. Kyritsis, Nikolaos Mittas, Nikoleta F. Theodoroula, Aggeliki Lampri, Eleni Mezarli, Anastasios Kartas, Dimitrios Chatzidimitriou, Anna Papa-Konidari, Eleftherios Angelis…

Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes

Circular RNA (circRNA) have been reported to play important roles in cardiovascular diseases including myocardial infarction and heart failure. However, the role of circRNA in atrial fibrillation (AF) has rare...

Authors: Na Wu, Chengying Li, Bin Xu, Ying Xiang, Xiaoyue Jia, Zhiquan Yuan, Long Wu, Li Zhong and Yafei Li

Temporal trends in outcome and patient characteristics in dilated cardiomyopathy, data from the Swedish Heart Failure Registry 2003–2015

Temporal trends in clinical composition and outcome in dilated cardiomyopathy (DCM) are largely unknown, despite considerable advances in heart failure management. We set out to study clinical characteristics ...

Authors: Helen Sjöland, Jonas Silverdal, Entela Bollano, Aldina Pivodic, Ulf Dahlström and Michael Fu

Minimising radiation exposure in catheter ablation of ventricular arrhythmias

Conventional fluoroscopy guided catheter ablation (CA) is an established treatment option for ventricular arrhythmias (VAs). However, with the complex nature of most procedures, patients and staff bare an incr...

Authors: Matevž Jan, David Žižek, Tine Prolič Kalinšek, Dimitrij Kuhelj, Primož Trunk, Tadeja Kolar, Juš Kšela, Martin Rauber and Mehmet Yazici

Primitive neuroectodermal tumor of the pericardium: a case report and literature review

The primitive neuroectodermal tumors (PNETs) are a family of highly malignant tumors with a multidirectional differential potential. The tumors are characterized by aggressive small round tumor cells that orig...

Authors: Jingjing Wang, Jing Li, Xiao Zhang, Xiaobo Zhang and Yueyong Xiao