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  1. Left ventricular geometry and left atrium (LA) enlargement are risk factors for cardiovascular disease. However, reports on the relationship between left ventricular geometry and LA volume yielded contradictor...

    Authors: Yong Zhang, Wen Shui, Yun Tian, Zhenxia Zhang, Juan Li and Jian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:209

    Content type: Research

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  2. With the development of cardiac surgery techniques, myocardial injury is gradually reduced, but cannot be completely avoided. Myocardial injury biomarkers (MIBs) can quickly and specifically reflect the degree...

    Authors: Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li and Yangyang Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:208

    Content type: Research

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  3. Circular RNAs have shown important regulatory roles in cardiovascular diseases, containing atherosclerosis (AS). We intended to explore the role of circ_0004104 in AS using oxidized low-density lipoprotein (ox...

    Authors: Chi Zhang, Liyue Wang and Ying Shen

    Citation: BMC Cardiovascular Disorders 2021 21:207

    Content type: Research article

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  4. Antithrombotic medications (antiplatelets and anticoagulants) reduce the risk of cardiovascular disease (CVD), but with the disadvantage of increasing bleeding risk. Ethnicity and socioeconomic deprivation are...

    Authors: Wai Chung Tse, Corina Grey, Matire Harwood, Rod Jackson, Andrew Kerr, Suneela Mehta, Katrina Poppe, Romana Pylypchuk, Sue Wells and Vanessa Selak

    Citation: BMC Cardiovascular Disorders 2021 21:206

    Content type: Research article

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  5. The purpose of the study is to identify off-pump patients who are at higher risk of mortality after re-exploration for bleeding or tamponade.

    Authors: Tongxiao Luan, Yingzhu Zhuang, Weihong Nie, Sumin Yang, Yuhui Wu, Rongmei Wang, Yunyan Dai and Hong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:204

    Content type: Research

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  6. Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations, including acute cardiac complications (ACCs) and subclinical myocardial injur...

    Authors: Jing Zhou, He Xuan, Yunxiang Miao, Junting Hu and Yunlang Dai

    Citation: BMC Cardiovascular Disorders 2021 21:203

    Content type: Research article

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  7. Several studies have shown that N-terminal pro-B-type natriuretic peptide (NT-proBNP) is strongly correlated with the complexity of coronary artery disease and the prognosis of patients with non-ST segment el...

    Authors: Wen-fei He, Lei Jiang, Yi-yue Chen, Yuan-hui Liu, Peng-yuan Chen, Chong-yang Duan, Li-huan Zeng, Hua-lin Fan, Xue-biao Wei, Wei Guo, Wei Chen, Jun Li, Wen-sheng Li, Zhi-qiang Guo, Zhi-kai Liu, Ning Tan…

    Citation: BMC Cardiovascular Disorders 2021 21:202

    Content type: Research article

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  8. Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an exploratory endpoint in a Phase 2 trial evaluating the eff...

    Authors: David Lin, Allan Klein, David Cella, Anna Beutler, Fang Fang, Matt Magestro, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, Antonio Abbate, Andrew Ertel, Leighann Litcher-Kelly, Brittany Klooster and John F. Paolini

    Citation: BMC Cardiovascular Disorders 2021 21:201

    Content type: Research article

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  9. Myocardial ischemia–reperfusion (IR) injury is a damage due to an initial reduction in blood flow to the heart, preventing it from receiving enough oxygen, and subsequent restoration of blood flow through the ...

    Authors: Xinyi Deng, Peng Yang, Tong Gao, Mengru Liu and Xianlun Li

    Citation: BMC Cardiovascular Disorders 2021 21:200

    Content type: Research article

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  10. Functional tricuspid regurgitation (FTR) is common in left-sided heart pathology involving the mitral valve. The incidence, clinical impact, risk factors, and natural history of FTR in the setting of ischemic ...

    Authors: Ofir Koren, Henda Darawsha, Ehud Rozner, Daniel Benhamou and Yoav Turgeman

    Citation: BMC Cardiovascular Disorders 2021 21:199

    Content type: Research article

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  11. The hemodynamics in the left ventricle (LV) and the ascending aorta (AAO) before and after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) is elucidated. Our objec...

    Authors: Kenichiro Suwa, Keitaro Akita, Keisuke Iguchi, Takasuke Ushio and Yuichiro Maekawa

    Citation: BMC Cardiovascular Disorders 2021 21:198

    Content type: Research

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  12. The mid-term and long-term efficacies of valve preservation in acute DeBakey I aortic dissection (AD) are controversial. Thus, it is unclear whether middle-aged patients with acute DeBakey I AD should undergo ...

    Authors: Qingsong Wu, Zhisheng Wang, Zhihuang Qiu, Yue Shen, Xiaodong Chen, Xingfeng Chen and Liangwan Chen

    Citation: BMC Cardiovascular Disorders 2021 21:196

    Content type: Research

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  13. In‐hospital cardiac arrest (IHCA) is a major public health problem with significant mortality. Rapid cardiopulmonary resuscitation and early defibrillation is extremely connected to patient outcome. In this st...

    Authors: G. Spinelli, E. Brogi, A. Sidoti, N. Pagnucci and F. Forfori

    Citation: BMC Cardiovascular Disorders 2021 21:195

    Content type: Research article

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  14. Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of hypertension and the resulting target organ damage. In this study, we observed alterations in the monocyte phenotype and i...

    Authors: Jingsi Zhang, Lina Yang and Yanchun Ding

    Citation: BMC Cardiovascular Disorders 2021 21:194

    Content type: Research

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  15. Antegrade cerebral perfusion (ACP) under moderate hypothermic circulatory arrest is used during total aortic arch replacement surgery (TARS) in patients with acute type A aortic dissection, but it is associate...

    Authors: Jing Lin, Zhen Qin, Xinhao Liu, Jiyue Xiong, Zhong Wu, Yingqiang Guo, Deying Kang and Lei Du

    Citation: BMC Cardiovascular Disorders 2021 21:193

    Content type: Research article

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  16. Coronary artery fistula (CAF) is a rare congenital anomaly with a challenging scenario in children. This study reports our experience in transcatheter closure of CAF with Nit-Occlude PDA coil and midterm clini...

    Authors: Hamid Amoozgar, Mohammad Reza Edraki, Amir Naghshzan, Nima Mehdizadegan, Hamid Mohammadi, Gholamhossein Ajami and Ahmad Ali Amirghofran

    Citation: BMC Cardiovascular Disorders 2021 21:192

    Content type: Research article

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  17. Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the ...

    Authors: Motahareh Hasani, Asieh Mansour, Hamid Asayesh, Shirin Djalalinia, Armita Mahdavi Gorabi, Fatemeh Ochi and Mostafa Qorbani

    Citation: BMC Cardiovascular Disorders 2021 21:190

    Content type: Research

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  18. Resuscitation using a percutaneous mechanical circulatory support device (iCPR) improves survival after cardiac arrest (CA). We hypothesized that the addition of inhaled nitric oxide (iNO) during iCPR might pr...

    Authors: Christoph Nix, Rashad Zayat, Andreas Ebeling, Andreas Goetzenich, Uma Chandrasekaran, Rolf Rossaint, Nima Hatam and Matthias Derwall

    Citation: BMC Cardiovascular Disorders 2021 21:189

    Content type: Research article

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  19. Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorp...

    Authors: Damir Raljević, Viktor Peršić, Elitza Markova-Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić and Sandra Kraljević Pavelić

    Citation: BMC Cardiovascular Disorders 2021 21:188

    Content type: Research article

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  20. Coronary computed tomography angiography (CCTA) is widely used as a first-line noninvasive modality that frequently exhibits no or nonobstructive coronary artery disease (CAD) in clinical practice, along with ...

    Authors: You-Jung Choi, Jun-Bean Park, Chan Soon Park, Inchang Hwang, Yeonyee E. Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho and Dae-Won Sohn

    Citation: BMC Cardiovascular Disorders 2021 21:187

    Content type: Research

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  21. The association of infective endocarditis (IE) with spondylodiscitis (SD) was first reported in 1965, but few data are available about this issue. This study aimed to evaluate the prevalence of SD in patients ...

    Authors: Stefano Del Pace, Valentina Scheggi, Giacomo Virgili, Sabina Caciolli, Iacopo Olivotto, Nicola Zoppetti, Irene Merilli, Nicole Ceschia, Valentina Andrei, Bruno Alterini, Pier Luigi Stefàno and Niccolò Marchionni

    Citation: BMC Cardiovascular Disorders 2021 21:186

    Content type: Research article

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  22. Smoking, heavy alcohol drinking and drug abuse are detrimental lifestyle factors leading to loss of million years of healthy life annually. One of the major health complications caused by these substances is t...

    Authors: Zahra Jalali, Morteza Khademalhosseini, Narjes Soltani and Ali Esmaeili Nadimi

    Citation: BMC Cardiovascular Disorders 2021 21:185

    Content type: Review

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  23. Autologous pericardium is widely used as a plastic material in intracardiac structures, in the pulmonary artery, and in aortic valve leaflets. For aortic valve reconstruction (AVRec) using the Ozaki procedure,...

    Authors: Keitaro Okamoto, Tadashi Umeno, Takashi Shuto, Tomoyuki Wada, Hirofumi Anai, Haruto Nishida, Yasuhide Nakayama and Shinji Miyamoto

    Citation: BMC Cardiovascular Disorders 2021 21:184

    Content type: Research article

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  24. Development of acute kidney injury (AKI) in invasively managed patients with acute coronary syndrome (ACS) is associated with a markedly increased mortality risk. Different definitions of AKI are in use, leadi...

    Authors: Maren Weferling, Christoph Liebetrau, Daniel Kraus, Philipp Zierentz, Beatrice von Jeinsen, Oliver Dörr, Michael Weber, Holger Nef, Christian W. Hamm and Till Keller

    Citation: BMC Cardiovascular Disorders 2021 21:183

    Content type: Research

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  25. Coronary chronic total occlusions (CTOs) are related to increased risk of adverse clinical outcomes. The optimal treatment strategy for CTO has not been well established. We sought to examine the impact of CTO...

    Authors: Xuhe Gong, Li Zhou, Xiaosong Ding, Hui Chen and Hongwei Li

    Citation: BMC Cardiovascular Disorders 2021 21:182

    Content type: Research article

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  26. The evidence of the long-term effects of multiple lifestyle intervention on cardiovascular risk is uncertain. We aimed to summarize the evidence from randomized clinical trials examining the efficacy of lifest...

    Authors: Hilde Bergum, Irene Sandven and Tor Ole Klemsdal

    Citation: BMC Cardiovascular Disorders 2021 21:181

    Content type: Article

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  27. The benefits of chronic polytherapy in reducing readmissions and death after myocardial infarction (MI) have been clearly shown. However, real-world evidence shows poor medication adherence and large geographi...

    Authors: Mirko Di Martino, Michela Alagna, Adele Lallo, Kendall Jamieson Gilmore, Paolo Francesconi, Francesco Profili, Salvatore Scondotto, Giovanna Fantaci, Gianluca Trifirò, Valentina Isgrò, Marina Davoli and Danilo Fusco

    Citation: BMC Cardiovascular Disorders 2021 21:180

    Content type: Research article

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  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Abbas Alshami, Nasam Alfraji, Steven Douedi, Swapnil Patel, Mohammad Hossain, Deborah Alpert and Dawn Calderon

    Citation: BMC Cardiovascular Disorders 2021 21:179

    Content type: Correction

    Published on:

    The original article was published in BMC Cardiovascular Disorders 2021 21:161

  29. The incidence of concurrent cancer and ischaemic heart disease (IHD) is increasing; however, the long-term patient prognoses remain unclear.

    Authors: Tatsuya Nishikawa, Toshitaka Morishima, Sumiyo Okawa, Yuki Fujii, Tomoyuki Otsuka, Toshihiro Kudo, Takeshi Fujita, Risa Kamada, Taku Yasui, Wataru Shioyama, Toru Oka, Takahiro Tabuchi, Masashi Fujita and Isao Miyashiro

    Citation: BMC Cardiovascular Disorders 2021 21:177

    Content type: Research article

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  30. Prenatal diagnosis of coarctation of the aorta (CoA) is challenging for most examiners. The malformation often occurs at the aortic isthmus, which is a short segment between the origin of the left subclavian a...

    Authors: Yu Wang, Caixia Liu, Ying Zhang and Meilian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:176

    Content type: Case report

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  31. New-onset atrial fibrillation (NOAF) is common during acute myocardial infarction (AMI) and independently associated with worse prognosis. We aimed to validate the discrimination performance of CHA2DS2-VASc sc...

    Authors: Yuan Fu, Yuxia Pan, Yuanfeng Gao, Xinchun Yang and Mulei Chen

    Citation: BMC Cardiovascular Disorders 2021 21:175

    Content type: Research article

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  32. Autopsies regularly aim to clarify the cause of death; however, relatives may directly benefit from autopsy results in the setting of heritable traits (“mortui vivos docent”).

    Authors: Benno Hartung, Anne Tank, Sven Dittmann, Stefanie Ritz-Timme and Eric Schulze-Bahr

    Citation: BMC Cardiovascular Disorders 2021 21:174

    Content type: Case report

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  33. Stent ablation with rotational atherectomy has been considered a bail-out strategy for the treatment of severe stent underexpansion. Only a few reports have yet shown rotational ablation for double-layer metal...

    Authors: Tong Yaliang, Liu Guohui, Zhang Cheng, Du Beibei, Zhao Yanan, He Yuquan and Yang Ping

    Citation: BMC Cardiovascular Disorders 2021 21:173

    Content type: Case report

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  34. Epicardial adipose tissue (EAT) shares the same microcirculation with coronary arteries through coronary arteries branches, and contributes to the development of atherosclerosis. MicroRNAs (miRNAs) are involve...

    Authors: Fan Zhang, Naixuan Cheng, Jie Du, Haibo Zhang and Congcong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:172

    Content type: Research article

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  35. Preclinical models that resemble the clinical setting as closely as possible are essential in translating promising therapies for the treatment of acute myocardial infarction. Closed chest pig left anterior de...

    Authors: Max J. M. Silvis, Gerardus P. J. van Hout, Aernoud T. L. Fiolet, Mirthe Dekker, Lena Bosch, Martijn M. J. van Nieuwburg, Joyce Visser, Marlijn S. Jansen, Leo Timmers and Dominique P. V. de Kleijn

    Citation: BMC Cardiovascular Disorders 2021 21:171

    Content type: Research

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  36. The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset ...

    Authors: Maurício Fregonesi Barbosa, Daniéliso Renato Fusco, Rafael Dezen Gaiolla, Konrad Werys, Suzana Erico Tanni, Rômulo Araújo Fernandes, Sergio Marrone Ribeiro and Gilberto Szarf

    Citation: BMC Cardiovascular Disorders 2021 21:170

    Content type: Research

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  37. Residual risk remained significant despite effective low density lipoprotein cholesterol (LDL-C) lowering treatment. Small dense low density lipoprotein cholesterol (sdLDL-C) as part of LDL-C has been found to...

    Authors: Jianwei Zhang and Lingjie He

    Citation: BMC Cardiovascular Disorders 2021 21:169

    Content type: Research article

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  38. Hypertension and diabetes mellitus (DM), are highly prevalent worldwide health non-communicable diseases, and are associated with chronic complications. The co-existence of both conditions accelerates the rela...

    Authors: Omer Abdelbagi, Imad R. Musa, Shaza M. Musa, Salim A. ALtigani and Ishag Adam

    Citation: BMC Cardiovascular Disorders 2021 21:168

    Content type: Research article

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  39. Septic shock with myocardial depression is very common in intensive care units. However, the exact molecular mechanisms underlying sepsis-induced myocardial depression remain unclear. Whether the profiles of t...

    Authors: Tie-Ning Zhang, Ri Wen, Ni Yang and Chun-Feng Liu

    Citation: BMC Cardiovascular Disorders 2021 21:166

    Content type: Research article

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  40. Anthracyclines and monoclonal antibodies against human epidermal growth factor receptor-2 (HER2) are frequently used to treat breast cancer but they are associated with risk of developing cardiotoxicity. Imple...

    Authors: Estíbaliz Díaz-Balboa, Violeta González-Salvado, Beatriz Rodríguez-Romero, Amparo Martínez-Monzonís, Milagros Pedreira-Pérez, Patricia Palacios-Ozores, Rafael López-López, Carlos Peña-Gil and José R. González-Juanatey

    Citation: BMC Cardiovascular Disorders 2021 21:165

    Content type: Study protocol

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  41. The primary aim was to observe the predictive value of P-wave ECG index and left atrial appendage volume (LLAV) for atrial fibrillation recurrence after first radiofrequency catheter ablation.

    Authors: Ruibin Li, Xiaohong Yang, Min Jia, Dong Wang, Xiaoran Cui, Long Bai, Lei Zhao and Jidong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:164

    Content type: Research article

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  42. A distorted blood lipid profile is an important risk factor for ischemic heart disease (IHD) but the predictive ability of the different lipid measures has rarely been studied. Our aim was to examine and compa...

    Authors: Susanna Calling, Sven-Erik Johansson, Moa Wolff, Jan Sundquist and Kristina Sundquist

    Citation: BMC Cardiovascular Disorders 2021 21:163

    Content type: Research article

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  43. Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum leve...

    Authors: Widet Gallo, Filip Ottosson, Cecilia Kennbäck, Amra Jujic, Jonathan Lou S. Esguerra, Lena Eliasson and Olle Melander

    Citation: BMC Cardiovascular Disorders 2021 21:162

    Content type: Research article

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  44. Psoriasis is a chronic inflammatory skin condition commonly associated with psoriatic arthritis, malignancy, diabetes, inflammatory bowel disease, and cardiovascular disease. Several reports and studies have r...

    Authors: Abbas Alshami, Nasam Alfraji, Steven Douedi, Swapnil Patel, Mohammad Hossain, Deborah Alpert and Dawn Calderon

    Citation: BMC Cardiovascular Disorders 2021 21:161

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cardiovascular Disorders 2021 21:179

  45. Electrocardiographic left ventricular hypertrophy (ECG-LVH) is a common manifestation of preclinical cardiovascular disease. The present study aimed to investigate risk factors for ECG-LVH and its prevalence i...

    Authors: Yue-Yuan Liao, Ke Gao, Bo-Wen Fu, Lei Yang, Wen-Jing Zhu, Qiong Ma, Chao Chu, Yu Yan, Yang Wang, Wen-Ling Zheng, Jia-Wen Hu, Ke-Ke Wang, Yue Sun, Chen Chen and Jian-Jun Mu

    Citation: BMC Cardiovascular Disorders 2021 21:159

    Content type: Research article

    Published on:

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