Skip to main content

Advertisement

Download PDF

Effect of garlic on blood pressure: A systematic review and meta-analysis

BMC Cardiovascular Disorders volume 8, Article number: 13 (2008) Cite this article

Abstract

Background

Non-pharmacological treatment options for hypertension have the potential to reduce the risk of cardiovascular disease at a population level. Animal studies have suggested that garlic reduces blood pressure, but primary studies in humans and non-systematic reviews have reported mixed results. With interest in complementary medicine for hypertension increasing, it is timely to update a systematic review and meta-analysis from 1994 of studies investigating the effect of garlic preparations on blood pressure.

Methods

We searched the Medline and Embase databases for studies published between 1955 and October 2007. Randomised controlled trials with true placebo groups, using garlic-only preparations, and reporting mean systolic and/or diastolic blood pressure (SBP/DBP) and standard deviations were included in the meta-analysis. We also conducted subgroup meta-analysis by baseline blood pressure (hypertensive/normotensive), for the first time. Meta-regression analysis was performed to test the associations between blood pressure outcomes and duration of treatment, dosage, and blood pressure at start of treatment.

Results

Eleven of 25 studies included in the systematic review were suitable for meta-analysis. Meta-analysis of all studies showed a mean decrease of 4.6 ± 2.8 mm Hg for SBP in the garlic group compared to placebo (n = 10; p = 0.001), while the mean decrease in the hypertensive subgroup was 8.4 ± 2.8 mm Hg for SBP (n = 4; p < 0.001), and 7.3 ± 1.5 mm Hg for DBP (n = 3; p < 0.001). Regression analysis revealed a significant association between blood pressure at the start of the intervention and the level of blood pressure reduction (SBP: R = 0.057; p = 0.03; DBP: R = -0.315; p = 0.02).

Conclusion

Our meta-analysis suggests that garlic preparations are superior to placebo in reducing blood pressure in individuals with hypertension.

Peer Review reports

Background

Hypertension (systolic blood pressure (SBP) ≥ 140 mm Hg; diastolic blood pressure (DBP) ≥ 90 mm Hg) is a known risk factor for cardiovascular morbidity and mortality, affecting an estimated 1 billion individuals worldwide [1]. Recently updated guidelines for the treatment of high blood pressure stress the importance of preventive strategies, and recommend extending the management of blood pressure to include pre-hypertensive individuals (SBP 120–139/DBP 80–89 mm Hg) [1]. Primary management should include relevant lifestyle modifications such as increased exercise, weight loss and dietary changes which could incorporate dietary supplementation.

Garlic (Allium sativum) has played an important dietary as well as medicinal role in human history [2]. Blood pressure reducing properties of garlic have been linked to its hydrogen sulphide production [3] and allicin content – liberated from alliin and the enzyme alliinase [4, 5] – which has angiotensin II inhibiting and vasodilating effects, as shown in animal and human cell studies [3, 6–10].

Primary studies in humans and reviews of garlic preparations and blood pressure have been inconclusive [11–40]. A meta-analysis published in 1994 reported promising results in subjects with mild hypertension but found insufficient evidence to recommend garlic for clinical therapy [41]. The increasing use of alternative and complementary therapies for hypertension [42, 43] makes it timely to provide an updated systematic review and meta-analysis of trials investigating the effect of garlic preparations on blood pressure. Inclusion of additional data from studies published since 1994 has enabled subgroup meta-analyses of hypertensive and normotensive subjects.

Methods

Literature search

We searched the Medline, Embase and Cochrane databases for studies published between 1955 and Oct 2007 using the search terms [garlic AND ("blood pressure" OR hypertens* OR pre-hypertens* OR prehypertens*)] to identify intervention studies investigating the effect of garlic on blood pressure. We also checked reference lists of previously published systematic reviews and meta-analyses for additional primary studies [36, 41].

Study selection

In the systematic review we included published intervention studies (these included randomised controlled trials and non-placebo controlled trials), reporting effects of garlic on blood pressure and published in English or German (Table 1 and Additional File 1). Stricter criteria were required for inclusion in meta-analysis: Only studies with placebo control groups, using garlic-only supplements, and reporting mean systolic and/or diastolic blood pressure (SBP/DBP) and standard deviation (SD) were eligible for meta-analysis (Table 1). We contacted authors of studies with suitable study design but incomplete published data (mean SBP/DBP or SD) to retrieve complete data sets for meta-analysis. Figure 1 summarises the study selection process.

Table 1 Characteristics of randomised controlled trials included in meta-analysis examining the effect of garlic on blood pressure
Full size table
Figure 1
figure1

Flow diagram of study selection for systematic review and meta-analysis. Abbreviations: BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; SD, standard deviation; RCT, randomised controlled trial

Full size image

Data extraction and quality assessment for meta-analysis

The number of subjects in intervention and control groups, mean SBP and DBP at start and end of intervention and SD were collated from text, tables or figures. Methodological quality was assessed independently by two investigators (KR and PF) using guidelines by the Cochrane Collaboration [44] (Tables 2 and 3), and disagreements were resolved by consensus. All studies considered for meta-analysis (n = 11, Table 2) reported adequate randomisation and double blinding, and all but one [14] assessed blood pressure as co-primary outcome measure. Six of eleven studies reported drop-out rates between 0 and 13% [13, 14, 17, 18, 20, 21], two studies of less than 22% [15, 19], and three studies did not provide details [11, 12, 16]. We considered the quality of all eleven studies as sufficient to be included in meta-analysis.

Table 2 Assessment of study quality for studies included in meta-analysis
Full size table
Table 3 Assessment of study quality for studies excluded from meta-analysis
Full size table

Data synthesis and meta-analysis

Changes in mean SBP or DBP of garlic and control groups before and after intervention were entered into the meta-analysis using Review Manager version 4.2 [45]. Standard deviations of these differences were estimated applying the equation published in Taubert et al. [46] and using a conservative correlation coefficient of R = 0.68 as suggested by the Cochrane Handbook for Systematic Reviews of Interventions [44]. If heterogeneity was high (I2>50%) we used the random effects model for meta-analysis, otherwise the fixed effects model was considered appropriate [47, 48].

In addition, we performed subgroup meta-analysis of trials with hypertensive subjects at start of treatment (mean SBP ≥ 140 mm Hg or mean DBP ≥ 90 mm Hg) and subgroup analysis of trials with normotensive subjects at start of treatment (mean SBp < 140 mm Hg or mean DBp < 90 mm Hg).

Potential publication bias in the meta-analysis was assessed by Begg's funnel plots and Egger's regression test [49, 50].

Meta-regression was performed to find any association between blood pressure changes over time and the following continuous variables: dosage, length of intervention, and blood pressure at start of treatment. We also tested for any evidence of confounding related to source of funding (details on funding in Tables 2 and 3). Regression analyses were conducted using Stata version 9 [51].

Plotting of blood pressure changes over time

We integrated additional blood pressure data from studies included in the systematic review in BP/time plots for visual assessment of BP trends depending on BP at start of treatment (mean/median SBP at start ≥ or < 130 mm Hg, mean/median DBP ≥ or < 85 mm Hg). We included in the plots data of placebo and non-placebo controlled trials using garlic-only preparations, and reporting mean or median SBP and/or DBP.

Results

Eleven of 25 studies included in our systematic review and investigating the effect of garlic on blood pressure met the inclusion criteria for meta-analysis (Table 1) [11–21]. Fourteen studies were excluded from meta-analysis: six had no placebo control group [24, 25, 28, 32, 34, 35], another six reported incomplete data for mean SBP, DBP or SD [23, 26, 27, 30, 31, 33], and another two because they used garlic combination supplements containing other potentially hypotensive agents [22, 29] (Additional File 1). We were able to contact the authors of four studies with suitable study design but incompletely reported data required for meta-analysis [20, 26, 27, 33], and obtained complete data from one study [20].

Ten of the eleven studies included in the meta-analysis reported complete SBP and SD data required for meta-analysis, and eleven studies reported DBP and SD data (Table 1) (DBP data only [15]). Nine studies compared garlic preparations to placebo, and two studies compared the effect of garlic on blood pressure in addition to a drug compared to drug plus placebo [11: diuretic, antihypertensive, acts on sodium chloride reabsorption, 14: lipid-lowering drug]. Nine studies used garlic powder (mainly "Kwai", a standardised garlic supplement [52]), one study used aged garlic extract [19] and another used distilled garlic oil [21]. Dosage of garlic powder ranged between 600 and 900 mg per day, and duration of intervention ranged from 12 to 23 weeks. A total of 252 individuals allocated to a garlic intervention group and 251 individuals allocated to a control group were included in the meta-analysis on SBP, and 283 (garlic) versus 282 (control) on DBP. Mean blood pressure at start of intervention varied markedly, with four studies reporting mean SBP in the hypertensive range (≥140 mm Hg) and three studies reporting mean DBP in the hypertensive range ≥90 mm Hg) before treatment.

Meta-analysis of ten studies of the effect of garlic on SBP showed a significant difference between garlic and control groups, with garlic having a greater effect in reducing SBP than placebo by 4.56 [95% CI (confidence interval), -7.36, -1.77] mm Hg compared with placebo (p < 0.001) (Figure 2a). Subgroup analysis of studies with mean SBP in the hypertensive range at start of intervention revealed a greater SBP reduction in the garlic group than placebo by 8.38 [95% CI, -11.13, -5.62] mm Hg (p < 0.001) (Figure 3a). Subgroup analysis of the remaining studies with mean SBP in the normotensive range (<140 mm Hg) at start of intervention showed no significant difference between the garlic and placebo groups (Figure 3b).

Figure 2
figure2

Meta-analysis graphs on the effect of garlic on systolic blood pressure (A) or diastolic blood pressure (B). Abbreviations: N, number of participants; SD, standard deviation; WMD, weighted mean difference; CI, confidence interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; s1, study 1 [ref 11].

Full size image
Figure 3
figure3

Subgroup meta-analysis on the effect of garlic on systolic blood pressure of hypertensive subjects (≥140 mm Hg at start of intervention) (A) or 'normotensive' subjects (<140 mm Hg at start of intervention) (B); on diastolic blood pressure of hypertensive subjects (≥90 mm Hg) (C) or normotensive subjects (<90 mm Hg) (D). For abbreviations see Fig 2.

Full size image

Meta-analysis of eleven studies of the effect of garlic on DBP did not show a significant difference between garlic and placebo groups (-2.44 [95% CI, -4.97, 0.09] mm Hg, p = 0.06) (Figure 2b). However, subgroup analysis of studies with mean DBP in the hypertensive range at the start of treatment revealed a significant difference between garlic and control groups. The results indicate that garlic was more effective in reducing DBP than placebo in hypertensive individuals by 7.27 [95% CI, -8.77, -5.76] mm Hg (p < 0.001) (Figure 3c). In contrast, subgroup meta-analysis of "normotensive" individuals was not significant (Figure 3d).

Heterogeneity was moderate for meta-analysis of SBP of all ten studies (I2 = 57.1%). However, we found no heterogeneity in the subgroup analysis of studies with hypertensive individuals at start of intervention (I2 = 0%). The same trend was observed for meta-analysis of DBP with I2 = 83.2% for pooled analysis of all ten studies and I2 = 0% for subgroup analysis of studies with hypertensive subjects at start of intervention.

Regression analysis was conducted to test whether heterogeneity between the studies could be explained by one or more of the following continuous variables: dosage (only studies using garlic powder were included, n = 8/9 (SBP/DBP), range 600–900 mg/d), duration of intervention (SBP/DBP: n = 10/11, range 12–23 wks), and SBP or DBP at start of intervention (SBP/DBP: n = 10/11, range 175–109 SBP/102-64 DBP). SBP or DBP at start of intervention proved to be a significant predictor for heterogeneity (SBP: R = -0.151, p = 0.03; DBP: R = -0.316, p = 0.02), strengthening the results of subgroup meta-analysis. None of the other variables tested showed a significant association with blood pressure outcomes (data not shown). Furthermore, regression analysis did not provide any evidence to suggest that receipt of industry funding (n = 3) was associated with blood pressure outcomes.

Funnel plots and Egger regression tests suggested no publication bias in the meta-analyses (Figure 4).

Figure 4
figure4

Funnel plots of studies included in meta-analysis on the effect of garlic on systolic blood pressure (A) and diastolic blood pressure (B). The vertical line of Begg's funnel plot represents the pooled mean effect size, the dotted lines the 95% confidence interval, p-values are derived from Egger's test. Abbreviations: SB, systolic blood pressure; DBP, diastolic blood pressure; SE, standard error; mm Hg, millimetre mercury.

Full size image

Figure 5 augments our systematic review, allowing a visual comparison of BP changes in garlic-only intervention arms of published randomised trials (Table 1 and Additional File 1). Blood pressure changes over time were plotted by blood pressure at start of treatment using data from 20 out of the 25 studies identified in our systematic review, which included placebo and non-placebo controlled trials, using garlic-only preparations, and reporting mean or median SBP and/or DBP (studies in meta-analysis [11–21]; as well as garlic-only intervention arms included in systematic review [24–28, 32, 33, 35, 53]). In total, mean or median SBP data was available for 23 garlic-only intervention arms and mean or median DBP data for 24 garlic intervention arms. Studies of groups with high blood pressure (mean SBP or DBP) at start of intervention generally showed a downward trend of blood pressure over time (Figure 5a and 5c). These included studies of groups with high normal blood pressure, also known as pre-hypertension (SBP≥130 mm Hg, DBP≥85 mm Hg). Blood pressure generally changed little for studies of groups with mean SBP lower than 130 mm Hg or mean DBP lower than 85 mm Hg at start of intervention (Figure 5b and 5d).

Figure 5
figure5

Mean BP against time for garlic-only intervention arm(s) of studies using subjects with SBP≥130 mm Hg at start of intervention (A), SBP < 130 mm Hg (B), DBP≥85 mm Hg (C), DBP < 85 mm Hg (D). The plot incorporates garlic-only intervention arms of studies included in the systematic review: study arms in meta-analysis are in red/orange and marked with *, others are in black/grey. Diamonds illustrate trials using garlic powder and circles illustrate other garlic preparations. Studies in legend boxes are sorted by baseline blood pressure. Abbreviations: K88_2 = Kandziora 1988 (Study 2) [25], garlic vs drug; K88_1*= Kandziora 1988 (Study 1) [11], garlic+drug vs placebo+drug; A90* = Auer et al. 1990 [12]; DJ95 = De A Santos & Johns 1995 [28]; D04hyp = Durak et al. 2004 [32], hypertensive study arm; DJ04hyp = Dhawan & Jain 2004 [37], hypertensive study arm; VS90* = Vorberg & Schneider 1990 [13]; H92*= Holzgartner et al. 1992 [15]; DG93 = De A Santos & Grünwald 1993 [27]; J05swall = Jabbari et al. 2005 [35], swallowing garlic study arm; J05chew = Jabbari et al. 2005 [35], chewing garlic study arm; H88 = Harenberg et al. 1988 [24]; S96para = Steiner et al. 1996 [19], parallel study arm ; DJ04norm = Dhawan & Jain 2004 [34], normotensive study arm; S96cross = Steiner et al. 1996 [19], crossover study arm; J93 = Jain et al. 1993 [16]; S95 = Simons et al.1995 [18]; S94 = Saradeth et al. 1994 [17]; D04norm = Durak et al. 2004 [32], normotensive study arm ; Z00 = Zhang et al. 2000 [21]; Ki91 = Kiesewetter 1991 [26]; T04 = Turner et al. 2004 [33], median BP.

Full size image

Discussion

Our meta-analysis suggests that garlic supplementation exerts a hypotensive effect compared to placebo, in particular in individuals with high blood pressure (SBP ≥ 140 mm Hg, DBP ≥ 90 mm Hg). Meta-analysis of all studies showed a mean decrease of 4.6 ± 2.8 mm Hg for SBP in the garlic group compared to placebo (p = 0.001), while the mean decrease in the hypertensive subgroup was 8.4 ± 2.8 mm Hg for SBP and 7.3 ± 1.5 mm Hg for DBP (p < 0.00001). Low heterogeneity in the subgroup analyses in addition to regression analysis confirmed that starting blood pressure was a significant predictor for treatment effect of garlic on blood pressure.

Interestingly, garlic-only intervention arms of reviewed studies which were not suitable for meta-analysis also showed a trend for greater reduction in BP with higher starting BP. These observed trends are in line with the findings from our subgroup meta-analyses, supporting the evidence for a hypotensive effect of garlic in individuals with high or high normal blood pressure.

Whilst data from two studies [26, 27], included in a previous meta-analysis [41], were not available, our meta-analysis incorporates data from six additional recent studies [15, 17–21], allowing subgroup analysis and increasing generalisability. Quality of studies included in the meta-analysis was generally high, however, 20% loss to follow up in two trials and non-reporting of drop out rates in three trials might have biased the results in those studies.

Heterogeneity observed in the meta-analyses including all studies could only partly be explained by starting BP, while dosage and duration of treatment were not associated with BP outcome. The absence of an association between dosage and blood pressure change may suggest that the hypotensive effect of garlic is comparable for dosages between 600 and 900 mg per day of Kwai powder. On the other hand, detection of an association between duration of garlic intake and blood pressure change may have been limited because the majority of studies (7 out of 11) took final BP measurements at 12 weeks.

Our findings of the effect of garlic preparations on SBP/DBP are comparable to the hypotensive effects of commonly-prescribed blood pressure drugs, e.g. beta-blockers of 5 mm Hg for SBP, angiotension converting enzyme inhibitors (ACEI) of 8 mm Hg for SBP [54], and angiotensin II type 1 receptor antagonists of 10.3 mm Hg for DBP [55]. Our findings may have implications at a population level, where a reduction of 4 to 5 mm Hg in SBP and 2 to 3 mm Hg in DBP has been estimated to reduce the risk of cardiovascular morbidity and mortality by 8–20% [56]. While our study focuses on the short-term effects of garlic on blood pressure, larger scale long-term trials are needed to test the effectiveness of garlic on cardiovascular outcomes.

Most studies included in this review used garlic powder dosages of 600–900 mg per day, providing potentially 3.6–5.4 mg of allicin, the active compound in garlic [36]. In comparison, fresh garlic cloves (~2 g) each yield 5–9 mg allicin [2]. However, different garlic preparations have variable effectiveness on blood pressure, e.g. minimal allicin compounds are found in aged garlic extract or heat treated garlic, which may limit its hypotensive properties [4, 5]. Therefore it is advisable to use standardised garlic preparations in future trials [57, 58].

Supplementation with garlic preparations compared to raw garlic provides the advantage of reducing or avoiding garlic breath and body odour, and prevents possible destruction of active compounds in the cooking process. Since garlic generally has a high tolerability [36], supplementation with garlic preparations may provide an acceptable alternative or complementary treatment option for hypertension.

Future research investigating a dose-response relationship between standardised garlic preparations and blood pressure would be warranted, as limited data are available [59]. Moreover, future trials could investigate whether garlic has a blood pressure reducing effect in pre-hypertensive subjects (SBP 120–139 mmHg, DBP 80–90 mm Hg), which may help to forestall progression to hypertension [1, 60].

Conclusion

This systematic review and meta-analysis suggests that garlic preparations are superior to placebo in reducing blood pressure in individuals with hypertension. Future large scale long-term trials are needed to investigate whether standardised garlic preparations could provide a safe alternative or complementary treatment option for hypertension in clinical practice.

Abbreviations

BP:

blood pressure

CI:

confidence interval

DBP:

diastolic blood pressure

mg/d:

milligram per day

mm Hg:

millimetre mercury

RCT:

randomised controlled trial

SBP:

systolic blood pressure

SD:

standard deviation.

References

  1. 1.

    Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, et al: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Jama. 2003, 289 (19): 2560-2572. 10.1001/jama.289.19.2560.

  2. 2.

    Lawson L: Garlic: a review of its medicinal effects and indicated active compounds. Phytomedicines of Europe: Chemistry and Biological Activity. Edited by: Lawson L, Bauer R. 1998, Washington, D. C: American Chemical Society, 177-209.

  3. 3.

    Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW: Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA. 2007, 104 (46): 17977-17982. 10.1073/pnas.0705710104.

  4. 4.

    Banerjee SK, Mukherjee PK, Maulik SK: Garlic as an antioxidant: the good, the bad and the ugly. Phytother Res. 2003, 17 (2): 97-106. 10.1002/ptr.1281.

  5. 5.

    Higdon J, Lawson L: Garlic and Organosulfur Compounds. Micronutrient Information Center. Linus Pauling Institute, Oregon State University. 2005, accessed 24 March 08, [http://lpi.oregonstate.edu/infocenter/phytochemicals/garlic/#table1]

  6. 6.

    Al-Qattan KK, Khan I, Alnaqeeb MA, Ali M: Mechanism of garlic (Allium sativum) induced reduction of hypertension in 2K-1C rats: a possible mediation of Na/H exchanger isoform-1. Prostaglandins Leukot Essent Fatty Acids. 2003, 69 (4): 217-222. 10.1016/S0952-3278(03)00087-5.

  7. 7.

    Al-Qattan KK, Thomson M, Al-Mutawa'a S, Al-Hajeri D, Drobiova H, Ali M: Nitric oxide mediates the blood-pressure lowering effect of garlic in the rat two-kidney, one-clip model of hypertension. J Nutr. 2006, 136 (3 Suppl): 774S-776S.

  8. 8.

    Kaye AD, De Witt BJ, Anwar M, Smith DE, Feng CJ, Kadowitz PJ, Nossaman BD: Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat. J Appl Physiol. 2000, 89 (1): 353-358.

  9. 9.

    Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D, Preuss HG: Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats. Heart Dis. 2000, 2 (1): 3-9.

  10. 10.

    Sharifi AM, Darabi R, Akbarloo N: Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol. 2003, 86 (2–3): 219-224. 10.1016/S0378-8741(03)00080-1.

  11. 11.

    Kandziora J: Blutdruck- und lipidsenkende Wirkung eines Knoblauch-Präparates in Kombination mit einem Diuretikum (Study 1). Aerztliche Forschung. 1988, 35 (3): 3-8.

  12. 12.

    Auer W, Eiber A, Hertkorn E, Hoehfeld E, Koehrle U, Lorenz A, Mader F, Merx W, Otto G, Schmid-Otto B, et al: Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl. 1990, 69: 3-6.

  13. 13.

    Vorberg G, Schneider B: Therapy with garlic: results of a placebo-controlled, double-blind study. Br J Clin Pract Suppl. 1990, 69: 7-11.

  14. 14.

    Holzgartner H, Schmidt U, Kuhn U: Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. Arzneimittelforschung. 1992, 42: 1473-1477.

  15. 15.

    Kiesewetter H, Jung F, Jung EM, Blume J, Mrowietz C, Birk A, Koscielny J, Wenzel E: Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig. 1993, 71 (5): 383-386. 10.1007/BF00186628.

  16. 16.

    Jain AK, Vargas R, Gotzkowsky S, McMahon FG: Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med. 1993, 94 (6): 632-635. 10.1016/0002-9343(93)90216-C.

  17. 17.

    Saradeth T, Seidl S, Resch K, Ernst E: Does garlic alter the lipid pattern in normal volunteers?. Phytomedicine. 1994, 1: 183-185.

  18. 18.

    Simons LA, Balasubramaniam S, von Konigsmark M, Parfitt A, Simons J, Peters W: On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis. 1995, 113 (2): 219-225. 10.1016/0021-9150(94)05449-S.

  19. 19.

    Steiner M, Khan AH, Holbert D, Lin RI: A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr. 1996, 64 (6): 866-870.

  20. 20.

    Adler A, Holub B: Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr. 1997, 65 (445–450):

  21. 21.

    Zhang XH, Lowe D, Giles P, Fell S, Board AR, Baughan JA, Connock MJ, Maslin DJ: A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners. Blood Coagul Fibrinolysis. 2001, 12: 67-74. 10.1097/00001721-200101000-00010.

  22. 22.

    Lutomski J: Klinische Untersuchungen zur therapeutischen Wirksamkeit von Ilha Rogoff Knoblauchpillen mit Rutin. Z Phytother. 1984, 5: 938-942.

  23. 23.

    Barrie S, Wright J, JE P: Effects of garlic oil on platelet aggregation, serum lipids and blood pressure in humans. J Orthomolecular Med. 1987, 2: 15-21.

  24. 24.

    Harenberg J, Giese C, Zimmermann R: Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis. 1988, 74 (3): 247-249. 10.1016/0021-9150(88)90244-4.

  25. 25.

    Kandziora J: Antihypertensive Wirksamkeit und Verträglichkeit eines Knoblauch-Präparates (Study 2). Aerztliche Forschung. 1988, 35 (1): 1-8.

  26. 26.

    Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E: Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol. 1991, 29 (4): 151-155.

  27. 27.

    DeASantos O, Gruenwald J: Effect of garlic powder tablets on blood lipids and blood pressure: a six-month placebo-controlled, double-blind study. Br J Clin Res. 1993, 4: 37-44.

  28. 28.

    DeASantos O, Johns R: Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well-being. Br J Clin Res. 1995, 6: 91-100.

  29. 29.

    Czerny B, Samochowiec J: Klinische Untersuchungen mit einem Knoblauch-Lezithin-Präparat. J Arztezeitschr Naturheilverf. 1996, 37: 126-129.

  30. 30.

    Mansell P, Reckless P, Lloyd L: The effect of dried garlic powder tablets on serum lipids in non-insulin dependent diabetic patients. Eur J Clin Res. 1996, 8: 25-26.

  31. 31.

    McCrindle BW, Helden E, Conner WT: Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med. 1998, 152 (11): 1089-1094.

  32. 32.

    Durak I, Kavutcu M, Aytac B, Avci A, Devrim E, Ozbek H, Ozturk HS: Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004, 15 (6): 373-377. 10.1016/j.jnutbio.2004.01.005.

  33. 33.

    Turner B, Molgaard C, Marckmann P: Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004, 92 (4): 701-706. 10.1079/BJN20041255.

  34. 34.

    Dhawan V, Jain S: Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 2004, 266 (1–2): 109-115. 10.1023/B:MCBI.0000049146.89059.53.

  35. 35.

    Jabbari A, Argani H, Ghorbanihaghjo A, Mahdavi R: Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in Renal Transplant Recipients. Lipids in Health and Disease. 2005, 4 (1): 11-10.1186/1476-511X-4-11.

  36. 36.

    Ackermann RT, Mulrow CD, Ramirez G, Gardner CD, Morbidoni L, Lawrence VA: Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med. 2001, 161 (6): 813-824. 10.1001/archinte.161.6.813.

  37. 37.

    Banerjee SK, Maulik SK: Effect of garlic on cardiovascular disorders: a review. Nutr J. 2002, 1: 4-10.1186/1475-2891-1-4.

  38. 38.

    Edwards QT, Colquist S, Maradiegue A: What's cooking with garlic: is this complementary and alternative medicine for hypertension?. J Am Acad Nurse Pract. 2005, 17 (9): 381-385. 10.1111/j.1745-7599.2005.00065.x.

  39. 39.

    Pittler MH, Ernst E: Clinical effectiveness of garlic (Allium sativum). Mol Nutr Food Res. 2007, 51 (11): 1382-1385. 10.1002/mnfr.200700073.

  40. 40.

    Rahman K, Lowe GM: Garlic and Cardiovascular Disease: A Critical Review. J Nutr. 2006, 136 (3): 736S-740.

  41. 41.

    Silagy CA, Neil HA: A meta-analysis of the effect of garlic on blood pressure. J Hypertens. 1994, 12 (4): 463-468. 10.1097/00004872-199404000-00017.

  42. 42.

    Ernst E: Complementary/alternative medicine for hypertension: a mini-review. Wien Med Wochenschr. 2005, 155 (17–18): 386-391. 10.1007/s10354-005-0205-1.

  43. 43.

    Yeh GY, Davis RB, Phillips RS: Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol. 2006, 98 (5): 673-680. 10.1016/j.amjcard.2006.03.051.

  44. 44.

    Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration. accessed 24 March 08, [http://www.cochrane.org/resources/handbook/]

  45. 45.

    Review Manager (RevMan) [Computer program]. Version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003. accessed 24 March 08, [http://www.cc-ims.net/RevMan]

  46. 46.

    Taubert D, Berkels R, Roesen R, Klaus W: Chocolate and Blood Pressure in Elderly Individuals with Isolated Systolic Hypertension. JAMA. 2003, 290 (8): 1029-1030. 10.1001/jama.290.8.1029.

  47. 47.

    Fleiss JL: The statistical basis of meta-analysis. Stat Methods Med Res. 1993, 2 (2): 121-145. 10.1177/096228029300200202.

  48. 48.

    Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21 (11): 1539-1558. 10.1002/sim.1186.

  49. 49.

    Begg CB, Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994, 50 (4): 1088-1101. 10.2307/2533446.

  50. 50.

    Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997, 315 (7109): 629-634.

  51. 51.

    StataCorp. 2005 Stata Statistical Software: Release 9. College Station, TX: StataCorp LP.

  52. 52.

    Kwai, garlic supplement. accessed 24 March 08, [http://www.kwaigarlic.com/]

  53. 53.

    Dhawan V, Jain S: Garlic supplementation prevents oxidative DNA damage in essential hypertension. Mol Cell Biochem. 2005, 275 (1–2): 85-94. 10.1007/s11010-005-0824-2.

  54. 54.

    Morgan TO, Anderson AI, MacInnis RJ: ACE inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension. Am J Hypertens. 2001, 14 (3): 241-247. 10.1016/S0895-7061(00)01266-8.

  55. 55.

    Baguet JP, Legallicier B, Auquier P, Robitail S: Updated meta-analytical approach to the efficacy of antihypertensive drugs in reducing blood pressure. Clin Drug Investig. 2007, 27 (11): 735-753.

  56. 56.

    McInnes GT: Lowering blood pressure for cardiovascular risk reduction. J Hypertens Suppl. 2005, 23 (1): S3-8. 10.1097/00004872-200501000-00002.

  57. 57.

    Lawson LD, Gardner CD: Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem. 2005, 53 (16): 6254-6261. 10.1021/jf050536+.

  58. 58.

    Lawson LD, Wang ZJ: Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity. J Agric Food Chem. 2001, 49 (5): 2592-2599. 10.1021/jf001287m.

  59. 59.

    Andrianova IV, Fomchenkov IV, Orekhov AN: [Hypotensive effect of long-acting garlic tablets allicor (a double-blind placebo-controlled trial)]. Ter Arkh. 2002, 74 (3): 76-78.

  60. 60.

    Julius S, Nesbitt SD, Egan BM, Weber MA, Michelson EL, Kaciroti N, Black HR, Grimm RH, Messerli FH, Oparil S, et al: Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med. 2006, 354 (16): 1685-1697. 10.1056/NEJMoa060838.

Pre-publication history

  1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/8/13/prepub

Download references

Acknowledgements

We gratefully acknowledge the assistance by the 'Adler A & Holub B' study team who provided unpublished data for inclusion in our meta-analysis. This study was supported by the Royal Australian College of General Practitioners (RACGP) 2006 Vicki Kotsirilos Integrative Medicine Grant, and the Australian Government Primary Health Care Research Evaluation Development (PHCRED) Program.

Author information

Affiliations

  1. Discipline of General Practice, The University of Adelaide, Adelaide, South Australia
    • Karin Ried
    • , Oliver R Frank
    • , Nigel P Stocks
    •  & Peter Fakler
  2. Discipline of Public Health, The University of Adelaide, Adelaide, South Australia
    • Thomas Sullivan
Authors
  1. Karin Ried
    View author publications
    You can also search for this author in
  2. Oliver R Frank
    View author publications
    You can also search for this author in
  3. Nigel P Stocks
    View author publications
    You can also search for this author in
  4. Peter Fakler
    View author publications
    You can also search for this author in
  5. Thomas Sullivan
    View author publications
    You can also search for this author in

Corresponding author

Correspondence to Karin Ried.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

KR, ORF and NPS conceptualised the study and obtained funding. Data was acquired independently by KR and PF. KR, PF and TS undertook data analysis and interpretation. KR prepared the manuscript with contributions from all co-authors. All authors approved the final version.

Electronic supplementary material

Authors’ original submitted files for images

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Ried, K., Frank, O.R., Stocks, N.P. et al. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord 8, 13 (2008). https://doi.org/10.1186/1471-2261-8-13

Download citation

Keywords

  • Systolic Blood Pressure
  • Diastolic Blood Pressure
  • Blood Pressure Change
  • Aged Garlic Extract
  • Eleven Study

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us