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Table 1 Characteristics of randomised controlled trials included in meta-analysis examining the effect of garlic on blood pressure

From: Effect of garlic on blood pressure: A systematic review and meta-analysis

Source Study design; Intervention/control groups Type of garlic preparation, Dosage, Duration Number of participants in intervention vs control group Mean SBP (SD) at start/end of intervention vs control in mm Hg Mean DBP (SD) at start/end of intervention vs control in mm Hg
Kandziora J 1988 (Study 1), [11] Parallel, Garlic powder (Kwai), 20/20 Garlic: 174 (4)/158 (10) Garlic: 99 (3)/83 (4)
  Diuretic drug (Dytide H) + garlic/drug only 600 mg/d, (standing) Control: 175 (8)/169 (6) Control: 98 (5)/90 (3)
   12 wks    
Auer et al. 1990, [12] Parallel, Kwai, 24/23 Garlic: 171 (21.6)/152 (19.6) Garlic: 102 (13)/89 (4.4)
  Garlic/placebo 600 mg/d,   Control: 161 (19)/153 (19) Control: 97 (12.9)/93 (10.6)
   12 wks    
Vorberg & Schneider 1990, [13] Parallel, Kwai, 20/20 Garlic: 144.5 (13.4)/138.5 (4.3) Garlic: 91 (3.9)/87 (3.7)
  Garlic/placebo 900 mg/d,   Control: 144 (10.4)/147 (7.1) Control: 88 (6.1)/90 (3.7)
   16 wks    
Holzgartner et al. 1992, [14] Parallel, Kwai, 47/47 Garlic: 143.4 (15.4)/135.4 (14.6) Garlic: 82.8 (10.5)/78.6 (9.3)
  Lipid-lowering drug (Benzafibrate) + garlic/drug only 900 mg/d,   Control: 140.6 (18.7)/137.2 (14.6) Control: 82.4 (9.5)/78.4 (9.2)
   12 wks    
Kiesewetter et al. 1993, [15] Parallel, Kwai, 32/32 Not reported Garlic: 84.7 (13.7)/81.7 (12.1)
  Garlic/placebo 800 mg/d,    Control: 83.3 (11)/81.7 (11)
   12 wks,    
Jain et al. 1993, [16] Parallel, Kwai, 20/22 Garlic: 129 (13)/130 (17) Garlic: 82 (6)/81 (10)
  Garlic/placebo 900 mg/d,   Control: 128 (10)/127 (12) Control: 83 (8)/82 (6)
   12 wks    
Saradeth et al. 1994, [17] Parallel, Kwai, 25/27 Garlic: 125 (17)/127.4 (16) Garlic: 80.8 (8)/82.7 (10)
  Garlic/placebo 600 mg/d,   Control: 124.6 (15.6)/122.8 (12.5) Control: 81.8 (9.4)/81.1 (9.4)
   15 wks    
Simons et al. 1995, [18] Crossover, Kwai, 28/28 Garlic: 127 (14)/119 (7) Garlic: 80 (8)/76 (5)
  Garlic/placebo 900 mg/d,   Control: 127 (14)/122 (10) Control: 80 (8)/76 (6)
   12 wks    
Steiner et al. 1996, [19] Parallel study arm, Aged garlic extract, 41/41 Garlic: 134 (14)/126 (14) Garlic: 84 (8.6)/82.3 (9)
  Garlic/placebo 2400 mg/d,   Control: 134 (11)/129.6 (12) Control: 85 (7.4)/81.7 (8)
   23 wks    
Adler & Holub 1997, [20] Parallel, Kwai, 12/13/10/11 Garlic: 123.3 (14.5)/118.5 (9.4) Garlic: 83.2 (2.5)/80 (2.2)
  Garlic/garlic+fish oil/fish oil/placebo 900 mg/d,   Control: 118.3 (3.2)/119.6 (3) Control: 79.6 (2.2)/80.9 (2)
   12 wks    
Zhang et al. 2000, [21] Parallel, Distilled garlic oil, 14/13 Garlic: 117 (8)/113.5 (6.4) Garlic: 72 (7)/68.2 (9.4)
  Garlic/placebo 12.3 mg/d,   Control: 109 (9)/109.9 (9.4) Control: 64 (7)/62.8 (5.4)
   16 wks    
  1. SBP, systolic blood pressure; DBP, diastolic blood pressure; SD, standard deviation; vs, versus; mm Hg, millimetre mercury; mg/d, milligram per day; wks, weeks; mths, months.