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  1. Dipping of blood pressure (BP) at night is a normal physiological phenomenon. However, a non-dipping pattern is associated with hypertension mediated organ damage, secondary forms of hypertension and poorer lo...

    Authors: Prossie Merab Ingabire, Dike B. Ojji, Brian Rayner, Elijah Ogola, Albertino Damasceno, Erika Jones, Anastase Dzudie, Okechukwu S. Ogah, Neil Poulter, Mahmoud U. Sani, Felix Ayub Barasa, Grace Shedul, John Mukisa, David Mukunya, Bonnie Wandera, Charles Batte…

    Citation: BMC Cardiovascular Disorders 2021 21:254

    Content type: Research

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  2. Accurate prediction of major adverse cardiovascular events (MACEs) is very important for the management of acute coronary syndrome (ACS) patients. We aimed to construct an effective prognostic nomogram for ind...

    Authors: Shuting Kong, Changxi Chen, Gaoshu Zheng, Hui Yao, Junfeng Li, Hong Ye, Xiaobo Wang, Xiang Qu, Xiaodong Zhou, Yucheng Lu and Hao Zhou

    Citation: BMC Cardiovascular Disorders 2021 21:253

    Content type: Research article

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  3. Diurnal temperature range (DTR) has been widely applied in exploring its effect on cardiovascular disease (CVD). However, few studies have investigated the correlations between DTR and CVD in poor rural areas ...

    Authors: Guangyu Zhai, Jintao Qi and Guorong Chai

    Citation: BMC Cardiovascular Disorders 2021 21:252

    Content type: Research

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  4. Patients with acute myocardial infarction (AMI) are usually treated with angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs) if ACEIs are not tolerated. However, there is ...

    Authors: Kyung-Hee Kim, Byoung Geol Choi, Seung-Woon Rha, Cheol Ung Choi and Myung-Ho Jeong

    Citation: BMC Cardiovascular Disorders 2021 21:251

    Content type: Research

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  5. The objective was to assess current training preferences, expertise, and comfort with transfemoral access (TFA) and transradial access (TRA) amongst cardiovascular training fellows and teaching faculty in the ...

    Authors: Khalid Changal, Mubbasher Ameer Syed, Ealla Atari, Salik Nazir, Sameer Saleem, Sajjad Gul, F. N. U. Salman, Asad Inayat and Ehab Eltahawy

    Citation: BMC Cardiovascular Disorders 2021 21:250

    Content type: Research article

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  6. Proinflammatory cytokine interleukin 17 (IL-17) is involved in ventricular remodeling, mainly of the left ventricle. This study was designed to explore the role of IL-17 played in the pathogenesis of right ven...

    Authors: Jing Huang, Wei Zhang, Cai-lian Zhang and Lei Wang

    Citation: BMC Cardiovascular Disorders 2021 21:249

    Content type: Research

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  7. Atherosclerosis (AS) is a primary cause of coronary heart and vascular diseases. Long non-coding RNAs (lncRNAs) are indicated to regulate AS progression. This study aimed to reveal the biological roles of lncR...

    Authors: Gang Ma, Shuting Bi and Pengfei Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:248

    Content type: Research article

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  8. Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We invest...

    Authors: Zakaria Almuwaqqat, J.’Neka S. Claxton, Faye L. Norby, Pamela L. Lutsey, Jingkai Wei, Elsayed Z. Soliman, Lin Y. Chen, Kunihiro Matsushita, Gerardo Heiss and Alvaro Alonso

    Citation: BMC Cardiovascular Disorders 2021 21:247

    Content type: Research

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  9. Structural and functional changes of the vascular wall in women occur already at the very early stages of reproductive aging. An emergence of applanation tonometry made it possible to evaluate arterial stiffne...

    Authors: Sergey N. Tolstov, Igor A. Salov, Anton R. Kiselev and Andrey P. Rebrov

    Citation: BMC Cardiovascular Disorders 2021 21:246

    Content type: Research

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  10. The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypert...

    Authors: Juan Yin, Minghui Li, Lingling Yu, Feng Hu, Yu Yu, Longlong Hu, Huihui Bao and Xiaoshu Cheng

    Citation: BMC Cardiovascular Disorders 2021 21:245

    Content type: Research article

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  11. Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular disease. The prevalence is increasing to 45–65% in the general population with routine health check-up, and most subject...

    Authors: Chia-Chi Hsiao, Pai-Hsueh Teng, Yun-Ju Wu, Yi-Wen Shen, Guang-Yuan Mar and Fu-Zong Wu

    Citation: BMC Cardiovascular Disorders 2021 21:244

    Content type: Research

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  12. The aim of the current study is to assess the natural history and prognostic value of elevated left ventricular end-diastolic pressure (LVEDP) in patients with ST-segment elevation myocardial infarction (STEMI...

    Authors: Arshad A. Khan, Mohammed S. Al-Omary, Nicholas J. Collins, John Attia and Andrew J. Boyle

    Citation: BMC Cardiovascular Disorders 2021 21:243

    Content type: Research article

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  13. To investigate whether inflammatory and growth factors (IGFs) were associated with incomplete device endothelialization (IDE) at 6 months after successful left atrial appendage closure (LAAC).

    Authors: Jing Xu, Xin Gong, Chuanzhi Chen, Jun Xing, Qi Wang, Weifeng Shen and Qi Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:242

    Content type: Research

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  14. Clinical studies suggest increasing prevalence of cardiovascular disease (CVD) risk factors and diabetes among the elderly. Meanwhile, some food compounds, such as coffee, can also have beneficial effects on C...

    Authors: Hossein Sayed Ghavami, Mehran Khoshtinat, Sepehr Sadeghi-Farah, Arman Bayati Kalimani, Suzie Ferrie and Hossein Faraji

    Citation: BMC Cardiovascular Disorders 2021 21:241

    Content type: Research

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  15. Systemic studies of association of genome-wide DNA methylated sites with cardiovascular disease (CVD) in prospective cohorts are lacking. Our aim was to identify DNA methylation sites associated with the risk ...

    Authors: Yan Gao, Huifang Pang, Bowang Chen, ChaoQun Wu, Yanping Wang, Libo Hou, Siming Wang, Dianjianyi Sun and Xin Zheng

    Citation: BMC Cardiovascular Disorders 2021 21:240

    Content type: Research

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  16. Point-of-care cardiac ultrasound (cardiac POCUS) has potential to become a useful tool for improving cardiovascular care in Tanzania. We conducted a pilot program to train clinicians at peripheral health cente...

    Authors: Delilah Kimambo, Samuel Kennedy, Engerasiya Kifai, Neema Kailembo, Christie Eichberg, Sarah Markosky, Ishan Shah, Eric Powers, Peter Zwerner, Susan E. Dorman, Mohamed Janabi and Richard Bayer

    Citation: BMC Cardiovascular Disorders 2021 21:239

    Content type: Research

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  17. The utility of echocardiographic left ventricular (LV) geometry in the prediction of stroke/coronary heart disease (CHD) and all-cause mortality is not well characterized. This study aimed to evaluate the over...

    Authors: Tan Li, Guangxiao Li, Xiaofan Guo, Zhao Li and Yingxian Sun

    Citation: BMC Cardiovascular Disorders 2021 21:238

    Content type: Research

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  18. The effect of smoking on coronary vasomotion has been investigated in the past with various imaging techniques in both short- and long-term smokers. Additionally, coronary vasomotion has been shown to be norma...

    Authors: Andreas M. Weng, Herbert Köstler, Thorsten A. Bley and Christian O. Ritter

    Citation: BMC Cardiovascular Disorders 2021 21:237

    Content type: Research article

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  19. Data on the effect of smoking on In-hospital outcome in patients with left ventricular dysfunction undergoing coronary artery bypass graft (CABG) surgery are limited. We sought to determine the influence of sm...

    Authors: Hanwei Tang, Jianfeng Hou, Kai Chen, Xiaohong Huang, Sheng Liu and Shengshou Hu

    Citation: BMC Cardiovascular Disorders 2021 21:236

    Content type: Research

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  20. The study analyzes changes in lung function, pulmonary pressure and diffusing capacity of the lung in patients with mitral valve regurgitation (MR) treated by MitraClip implantation.

    Authors: Lucie Kretzler, Stephan Große, Stephan Wiedemann, Carsten Wunderlich, Chris Nowak, Christian Riedel, Tomáš Sieger and Steffen Schoen

    Citation: BMC Cardiovascular Disorders 2021 21:235

    Content type: Research article

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  21. 8–28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim...

    Authors: Shirjel R. Alam, Anoop S. V. Shah, Kevin O. Ombati, Edward Nganga, Samuel Gitau, Khalid Makhdomi, Michael H. Chung and Sudhir Vinayak

    Citation: BMC Cardiovascular Disorders 2021 21:234

    Content type: Study protocol

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  22. The Cathepsins family, including cathepsin B and cathepsin D, potentially affects the entire processes involved in atherosclerosis. Although coronary heart disease (CHD) has been widely studied as the basis of...

    Authors: Jialin Dai, Qiong Zhang, Changwu Wan, Jiangjin Liu, Qiaojun Zhang, Yanni Yu and Jie Wang

    Citation: BMC Cardiovascular Disorders 2021 21:233

    Content type: Research article

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  23. The jailed balloon technique is widely used for coronary bifurcation lesions, but a residual risk of SB occlusion remains, necessitating SB rewiring and further interventions, including balloon inflation or st...

    Authors: Hongbo Yang, Yanan Song, Jiatian Cao, Xueyi Weng, Feng Zhang, Yuxiang Dai, Hao Lu, Chenguang Li, Zheyong Huang, Juying Qian and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2021 21:232

    Content type: Technical advance

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  26. Little is known about the quality of life (QOL) and health status of adults with congenital heart disease (CHD) in developing countries. Therefore, this study aimed to describe the QOL and health status of hos...

    Authors: Thanh-Huong Truong, Ngoc-Thanh Kim, Mai-Ngoc Thi Nguyen, Doan-Loi Do, Hong Thi Nguyen, Thanh-Tung Le and Hong-An Le

    Citation: BMC Cardiovascular Disorders 2021 21:229

    Content type: Research

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  27. Acute decompensated heart failure (ADHF) contributes millions of emergency department (ED) visits and it is associated with high in-hospital mortality. The aim of this study was to develop and validate a multi...

    Authors: Ran Mo, Li-tian Yu, Hui-qiong Tan, Yang Wang, Yan-min Yang, Yan Liang and Jun Zhu

    Citation: BMC Cardiovascular Disorders 2021 21:228

    Content type: Research

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  28. Percutaneous left atrial appendage (LAA) closure is an alternative to oral anticoagulation (OAC) for atrial fibrillation (AF) patients with high thromboembolism risk, particularly with contraindications to OAC...

    Authors: Nicolas Lellouche, Raphaele Arrouasse, Julien Ternacle, Romain Gallet, Jean-Sylvain Hermida, David Hamon, Jean-Michel Juliard, Jean-Luc Pasquie, Tarvinder Dhanjal, Emmanuel Teiger and Philippe Le Corvoisier

    Citation: BMC Cardiovascular Disorders 2021 21:227

    Content type: Research article

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  29. Galectin-3 (Gal-3) is currently recognized as a promising biomarker for myocardial fibrosis. This study aimed to explore the potential association between plasma Gal-3 concentrations and atrial fibrillation (A...

    Authors: Qianhui Wang, Li Xu, Ying Dong, Yuan Fu, Yuxia Pan, Qianran Luan, Ye Liu, Zheng Liu, Xinchun Yang, Mulei Chen and Yuanfeng Gao

    Citation: BMC Cardiovascular Disorders 2021 21:226

    Content type: Research

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  30. Primary cardiac tumors are rare, and approximately 90% of them are benign. Myxoma is the most common type of these tumors occurring in the left atrium in 75–85% of cases. The tumor can cause the left atrio-ven...

    Authors: Sadegh Shabab, Majid Erfanzadeh, Shamsa Ahmadian, Maryam Mahmoudabady and Naser Mazloum

    Citation: BMC Cardiovascular Disorders 2021 21:225

    Content type: Case report

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  32. Incretin therapies appear to provide cardioprotection and improve cardiovascular outcomes in patients with diabetes, but the mechanism of this effect remains elusive. We have previously shown that glucagon-lik...

    Authors: Muhammad Aetesam-ur-Rahman, Joel P. Giblett, Bharat Khialani, Stephen Kyranis, Sophie J. Clarke, Tian X. Zhao, Denise M. Braganza, Sarah C. Clarke, Nick E. J. West, Martin R. Bennett and Stephen P. Hoole

    Citation: BMC Cardiovascular Disorders 2021 21:223

    Content type: Research article

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  33. There is limited evidence of Aboriginal and Torres Strait Islander people attending cardiac rehabilitation (CR) programs despite high levels of heart disease. One key enabler for CR attendance is a culturally ...

    Authors: Nicole Freene, Roslyn Brown, Paul Collis, Chris Bourke, Katharine Silk, Alicia Jackson, Rachel Davey and Holly L. Northam

    Citation: BMC Cardiovascular Disorders 2021 21:222

    Content type: Research article

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  34. The dysfunction and injury of human umbilical vein endothelial cells (HUVECs) are key events of atherosclerosis (AS). Atorvastatin (ATV) has been shown to play a protective role on endothelial cells. However, ...

    Authors: Gang Su, Guangli Sun, Jian Lv, Weiwei Zhang, Hai Liu, Yajing Tang and Haoang Su

    Citation: BMC Cardiovascular Disorders 2021 21:221

    Content type: Research article

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  35. Leriche syndrome is the triad of symptoms consisting of claudication, erectile dysfunction, and absence of femoral pulses. Inflammatory disease of the heart muscle, myocarditis, may occur because of immune sys...

    Authors: Abudi Mohamed, Gustav Mattsson and Peter Magnusson

    Citation: BMC Cardiovascular Disorders 2021 21:220

    Content type: Case report

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  36. In adult patients with pulmonary arterial hypertension (PAH), right ventricular (RV) failure may worsen rapidly, resulting in a poor prognosis. In this population, non-invasive assessment of RV function is cha...

    Authors: Raluca Jumatate, Annika Ingvarsson, Gustav Jan Smith, Anders Roijer, Ellen Ostenfeld, Johan Waktare, Göran Rådegran, Carl Meurling and Anna Werther Evaldsson

    Citation: BMC Cardiovascular Disorders 2021 21:219

    Content type: Research

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  37. Due to the technical limitations of coronary artery angiography (CAG), ramus intermedius (RI) is sometimes difficult to distinguish from a high-origin obtuse marginal branch or a high-origin diagonal branch. T...

    Authors: Xue Gong, Zheyong Huang, Zhonghan Sun, Qibing Wang, Juying Qian, Lei Ge and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2021 21:218

    Content type: Research

    Published on:

  38. Diabetes mellitus-related cardiomyopathy (DMCMP), defined as left ventricular (LV) dysfunction caused by hyperglycemia in the absence of coronary artery disease, leads to heart failure (HF). Previous studies h...

    Authors: Satoshi Oka, Takahiko Kai, Katsuomi Hoshino, Kazunori Watanabe, Jun Nakamura, Makoto Abe and Akinori Watanabe

    Citation: BMC Cardiovascular Disorders 2021 21:217

    Content type: Research article

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  39. To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to eva...

    Authors: Fang Liu, Zheng Wang, Xia Cao, Yingxia Pan, Erqiang Zhang, Jiahuan Zhou and Lina Zheng

    Citation: BMC Cardiovascular Disorders 2021 21:216

    Content type: Research

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  40. Myocardial ischemia–reperfusion injury (MIRI) is the main pathological manifestation of cardiovascular diseases such as myocardial infarction. The potential therapeutic effects of bone marrow-derived mesenchym...

    Authors: Ling-Xiao Pang, Wen-Wei Cai, Qian Li, Heng-Jie Li, Min Fei, Yong-Sheng Yuan, Bin Sheng, Ke Zhang, Rong-Cheng An, Ying-Wei Ou and Wen-Jie Zeng

    Citation: BMC Cardiovascular Disorders 2021 21:215

    Content type: Research

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  41. To clarify the appropriate initial dosage of heparin during radiofrequency catheter ablation (RFCA) in patients with atrial fibrillation (AF) receiving uninterrupted nonvitamin K antagonist oral anticoagulant ...

    Authors: Rong-feng Zhang, Cheng-ming Ma, Na Wang, Ming-hui Yang, Wen-wen Li, Xiao-meng Yin, Ying-xue Dong, Xiao-hong Yu, Xian-jie Xiao, Yun-long Xia and Lian-jun Gao

    Citation: BMC Cardiovascular Disorders 2021 21:214

    Content type: Research

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  42. Orthostatic hypotension (OH) and orthostatic hypertension (OHT) are often unrecognized in clinical care for diabetic individuals, yet they are associated with increased risk for adverse cardiovascular outcomes...

    Authors: Richard Migisha, David Collins Agaba, Godfrey Katamba, Jennifer Manne-Goehler, Anthony Muyingo and Mark J. Siedner

    Citation: BMC Cardiovascular Disorders 2021 21:213

    Content type: Research article

    Published on:

  43. Endovascular treatment is standard of care for transplant renal artery stenosis (TRAS). No study has evaluated long-term outcomes compared between percutaneous transluminal renal angioplasty (PTRA) and PTRA wi...

    Authors: Nattawut Wongpraparut, Thunyarat Chaipruckmalakarn, Thongtum Tongdee, Archan Jaspttananon, Attapong Vongwiwatana, Nalinee Premasathian, Kawin Anusonadisai and Rungtiwa Pongakasira

    Citation: BMC Cardiovascular Disorders 2021 21:212

    Content type: Research article

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  44. Coronary microvascular dysfunction (CMD) is common in end-stage renal disease (ESRD) and is an adverse prognostic marker. Coronary flow velocity reserve (CFVR) is a measure of coronary microvascular function a...

    Authors: Ashwin Radhakrishnan, Luke C. Pickup, Anna M. Price, Jonathan P. Law, Kirsty C. McGee, Larissa Fabritz, Roxy Senior, Richard P. Steeds, Charles J. Ferro and Jonathan N. Townend

    Citation: BMC Cardiovascular Disorders 2021 21:211

    Content type: Research

    Published on:

  45. Little is known regarding the effect of cardiopulmonary bypass (CPB) reoxygenation on cardiac function following tetralogy of Fallot repair. We hypothesized that hyperoxic reoxygenation would be more strongly ...

    Authors: Ji-nong Yang, Xiao-ming Zhang, Lu-yao Ma, Zhan-jie Lu, Si-qiang Zheng, Al-Wajih Hamzah, Yong-feng Shao, Hong Liu and Gao-li Liu

    Citation: BMC Cardiovascular Disorders 2021 21:210

    Content type: Research

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  46. Left ventricular geometry and left atrium (LA) enlargement are risk factors for cardiovascular disease. However, reports on the relationship between left ventricular geometry and LA volume yielded contradictor...

    Authors: Yong Zhang, Wen Shui, Yun Tian, Zhenxia Zhang, Juan Li and Jian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:209

    Content type: Research

    Published on:

  47. With the development of cardiac surgery techniques, myocardial injury is gradually reduced, but cannot be completely avoided. Myocardial injury biomarkers (MIBs) can quickly and specifically reflect the degree...

    Authors: Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li and Yangyang Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:208

    Content type: Research

    Published on:

  48. Circular RNAs have shown important regulatory roles in cardiovascular diseases, containing atherosclerosis (AS). We intended to explore the role of circ_0004104 in AS using oxidized low-density lipoprotein (ox...

    Authors: Chi Zhang, Liyue Wang and Ying Shen

    Citation: BMC Cardiovascular Disorders 2021 21:207

    Content type: Research article

    Published on:

  49. Antithrombotic medications (antiplatelets and anticoagulants) reduce the risk of cardiovascular disease (CVD), but with the disadvantage of increasing bleeding risk. Ethnicity and socioeconomic deprivation are...

    Authors: Wai Chung Tse, Corina Grey, Matire Harwood, Rod Jackson, Andrew Kerr, Suneela Mehta, Katrina Poppe, Romana Pylypchuk, Sue Wells and Vanessa Selak

    Citation: BMC Cardiovascular Disorders 2021 21:206

    Content type: Research article

    Published on:

  50. The purpose of the study is to identify off-pump patients who are at higher risk of mortality after re-exploration for bleeding or tamponade.

    Authors: Tongxiao Luan, Yingzhu Zhuang, Weihong Nie, Sumin Yang, Yuhui Wu, Rongmei Wang, Yunyan Dai and Hong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:204

    Content type: Research

    Published on:

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