Coronary calcium density in relation to coronary heart disease and cardiovascular disease in adults with diabetes or metabolic syndrome: the Multi-ethnic Study of Atherosclerosis (MESA)

Table 4 Comparison of C-statistics for Discriminating CHD and CVD Risks Between Models with and Without CAC Density

	DM (n = 668)	MetS (n = 1122)	Neither DM/MetS (n = 2028)	Total (n = 3818)
CHD
Model 1	0.60†	0.64§	0.63‡	0.63§
Model 2	0.67	0.70†	0.70	0.69*
Model 3	0.67	0.70*	0.70	0.70
Model 4	0.67	0.72	0.70	0.70
CVD
Model 1	0.59‡	0.65†	0.66§	0.66§
Model 2	0.66	0.69	0.70	0.69*
Model 3	0.66	0.69	0.70	0.69
Model 4	0.67	0.70	0.71	0.70

Model 1 (Base model): 10-year ASCVD risk score + race/ethnicity + education + BMI + statin therapy
Model 2: Base model + ln(Agatston)
Model 3: Base model + ln(Volume)
Model 4: Base model + ln(Volume) + CAC Density
Harrell’s c-statistics were compared between model 4 versus model 1, 2 or 3
ASCVD Atherosclerotic cardiovascular disease, BMI Body mass index, CAC Coronary artery calcium, CHD Coronary heart disease, CVD Cardiovascular disease, DM Diabetes mellitus, MetS , Metabolic syndrome
*p < 0.05, †p < 0.01, ‡p < 0.001, § p < 0.0001

ISSN: 1471-2261