Table 1 The formula, ions concentration when used, application methods and prices of two kinds of cardioplegia solutions: DN versus HTK
DN | HTK | |||
|---|---|---|---|---|
Extracellular-type | Intracellular-type | |||
Formula | Plasma-lyte A | 500 ml | Water for injection | 1000 ml |
10% potassium chloride | 10 ml | NaCl | 0.8766 g | |
5% sodium bicarbonate | 11 ml | KCl | 0.6710 g | |
25% magnesium sulfate | 4 ml | MgCl2.6H2O | 0.8132 g | |
20% mannitol | 8.15 ml | mannitol | 5.4651 g | |
2% lidocaine | 3.25 ml | Histidine | 27.9289 g | |
Tryptophan | 0.4085 g | |||
Histidine.HCl.H2O | 3.7733 g | |||
CaCl2.2H2O | 0.0022 g | |||
2-Ketoglutarate-H–K | 0.1842 g | |||
Ions concentration when used | ||||
Na+ (mmol/L) | 150 | 15 | ||
Cl− (mmol/L) | 132 | 100 | ||
K+ (mmol/L) | 24 | 9 | ||
Mg2+ (mmol/L) | 6 | 4 | ||
Ca2+ (mmol/L) | 0.4 | 0.02 | ||
Lidocaine (mg/L) | 140 | 0 | ||
Mannitol (g/L) | 2.6 | 5.46 | ||
Histidine (mmol/L) | 0 | 198 | ||
Tryptophan (mmol/L) | 0 | 2 | ||
Ketoglutarate (mmol/L) | 0 | 1 | ||
Application method | ||||
Induction dose | mixing with 1/4 blood, 20 ml/kg, up to 1000 ml | 20–30 ml/kg, up to 2000 ml | ||
Temperature(°C) | 4–15 | 4 | ||
Pressure(antegrade/retrograde) | 140/45 | 140/45 | ||
Perfusion speed(minutes) | 3–5 | More than 5 | ||
Reinfusion interval (minutes) | 60–90 | 60–120,even more | ||
Maintenance dose | 200–300 ml | 500 ml | ||
Improvisation by doctors before use | Commercial product, use anytime | |||
Price | About ¥50/500 ml | About ¥1200/500 ml | ||