Table 3 Progression of IE patients by clinical, microbiological and outcomes
2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | p | |
|---|---|---|---|---|---|---|---|---|---|---|
Total cohort | n = 629 | n = 761 | n = 812 | n = 854 | n = 903 | n = 967 | n = 903 | n = 892 | n = 853 | |
Male | 367 | 450 | 452 | 480 | 520 | 539 | 496 | 527 | 477 | 0.44 |
58.3% | 59.1% | 55.7% | 56.2% | 57.6% | 55.7% | 54.9% | 59.1% | 55.9% | ||
< 18 years | 9 | 11 | 8 | 7 | 10 | 9 | 10 | 12 | 15 | < 0.001 |
1.4% | 1.4% | 1.0% | 0.8% | 1.1% | 0.9% | 1.1% | 1.3% | 1.8% | ||
18–39 years | 63 | 76 | 69 | 57 | 56 | 56 | 51 | 36 | 39 | |
10.0% | 10.0% | 8.5% | 6.7% | 6.2% | 5.8% | 5.6% | 4.0% | 4.6% | ||
40–59 years | 105 | 164 | 147 | 143 | 144 | 159 | 126 | 146 | 119 | |
16.7% | 21.6% | 18.1% | 16.7% | 15.9% | 16.4% | 14.0% | 16.4% | 14.0% | ||
60–79 years | 316 | 353 | 383 | 394 | 433 | 429 | 433 | 434 | 390 | |
50.2% | 46.4% | 47.2% | 46.1% | 48.0% | 44.4% | 48.0% | 48.7% | 45.7% | ||
≥ 80 years | 136 | 157 | 205 | 253 | 260 | 314 | 283 | 264 | 290 | |
21.6% | 20.6% | 25.2% | 29.6% | 28.8% | 32.5% | 31.3% | 29.6% | 34.0% | ||
Diabetes mellitus | 129 | 182 | 204 | 225 | 241 | 283 | 243 | 262 | 247 | 0.001 |
20.5% | 23.9% | 25.1% | 26.3% | 26.7% | 29.3% | 26.9% | 29.4% | 29.0% | ||
Cardiac valve disease | 120 | 159 | 163 | 174 | 189 | 212 | 179 | 224 | 170 | 0.13 |
19.1% | 20.9% | 20.1% | 20.4% | 20.9% | 21.9% | 19.8% | 25.1% | 19.9% | ||
Rheumatic valve disease | 53 | 74 | 81 | 79 | 109 | 94 | 86 | 74 | 59 | 0.12 |
8.4% | 9.7% | 10.0% | 9.3% | 12.1% | 9.7% | 9.5% | 8. .3% | 6.9% | ||
Atrial fibrillation | 139 | 178 | 221 | 230 | 267 | 301 | 268 | 138 | 134 | < 0.001 |
22.1% | 23.4% | 27.2% | 26.9% | 29.6% | 31.1% | 29.7% | 15.5% | 15.7% | ||
Arterial hypertension | 185 | 222 | 284 | 295 | 332 | 368 | 350 | 390 | 402 | < 0.001 |
29.4% | 29.2% | 35.0% | 34.5% | 36.8% | 38.1% | 38.8% | 43.7% | 47.1% | ||
Chronic renal failure | 49 | 52 | 43 | 82 | 88 | 98 | 114 | 189 | 172 | < 0.001 |
7.8% | 6.8% | 5.3% | 9.6% | 9.7% | 10.1% | 12.6% | 21.2% | 20.2% | ||
HIV | 19 | 16 | 15 | 11 | 17 | 16 | 15 | 10 | 14 | 0.030 |
3.0% | 2.1% | 1.8% | 1.3% | 1.9% | 1.7% | 1.7% | 1.1% | 1.6% | ||
Cancer | 86 | 97 | 120 | 121 | 150 | 147 | 122 | 96 | 79 | 0.004 |
13.7% | 12.7% | 14.8% | 14.2% | 16.6% | 15.2% | 13.5% | 10.8% | 9.3% | ||
COPD | 62 | 75 | 74 | 87 | 109 | 120 | 85 | 43 | 47 | < 0.001 |
9.9% | 9.9% | 9.1% | 10.2% | 12.1% | 12.4% | 9.4% | 4.8% | 5.5% | ||
Cardiac valve prosthesis | 70 | 90 | 98 | 98 | 86 | 116 | 109 | 132 | 115 | 0.030 |
11.1% | 11.8% | 12.1% | 11.5% | 9.5% | 12.0% | 12.1% | 14.8% | 13.5% | ||
Cardiac device | 39 | 61 | 63 | 58 | 61 | 79 | 88 | 87 | 113 | < 0.001 |
6.2% | 8.0% | 7.8% | 6.8% | 6.8% | 8.2% | 9.7% | 9.8% | 13.2% | ||
CAD | 60 | 81 | 107 | 97 | 130 | 130 | 122 | 114 | 129 | 0.001 |
9.5% | 10.6% | 13.2% | 11.4% | 14.4% | 13.4% | 13.5% | 12.8% | 15.1% | ||
Chronic hepatic disease | 30 | 41 | 39 | 45 | 62 | 47 | 42 | 28 | 32 | 0.03 |
4.8% | 5.4% | 4.8% | 5.3% | 6.9% | 4.9% | 4.7% | 3.1% | 3.8% | ||
Staphylococcus | 95 | 114 | 115 | 130 | 145 | 158 | 145 | 170 | 170 | < 0.001 |
15.1% | 15.0% | 14.2% | 15.2% | 16.1% | 16.3% | 16.1% | 19.1% | 19.9% | ||
Streptococcus | 83 | 124 | 114 | 120 | 149 | 124 | 125 | 104 | 87 | 0.002 |
13.2% | 16.3% | 14.0% | 14.1% | 16.5% | 12.8% | 13.8% | 11.7% | 10.2% | ||
Enterococcus | 40 | 53 | 57 | 54 | 74 | 63 | 75 | 61 | 58 | 0.60 |
6.4% | 7.0% | 7.0% | 6.3% | 8.2% | 6.5% | 8.3% | 6.8% | 6.8% | ||
Gram negatives | 57 | 87 | 98 | 104 | 132 | 140 | 123 | 65 | 92 | 0.69 |
9.1% | 11.4% | 12.1% | 12.2% | 14.6% | 14.5% | 13.6% | 7.3% | 10.8% | ||
Acute MI | 12 | 30 | 27 | 20 | 21 | 30 | 31 | 28 | 21 | 0.96 |
1.9% | 3.9% | 3.3% | 2.3% | 2.3% | 3.1% | 3.4% | 3.1% | 2.5% | ||
HF | 179 | 193 | 238 | 256 | 264 | 316 | 303 | 253 | 230 | 0.28 |
28.5% | 25.4% | 29.3% | 30.0% | 29.2% | 32.7% | 33.6% | 28.4% | 27.0% | ||
Ischemic stroke | 50 | 64 | 75 | 71 | 100 | 91 | 95 | 92 | 68 | 0.28 |
7.9% | 8.4% | 9.2% | 8.3% | 11.1% | 9.4% | 10.5% | 10.3% | 8.0% | ||
Hemorrhagic stroke | 11 | 18 | 24 | 20 | 31 | 22 | 25 | 34 | 19 | 0.24 |
1.7% | 2.4% | 3.0% | 23% | 3.4% | 2.3% | 2.8% | 3.8% | 2.2% | ||
Systemic embolism | 2 | 1 | 4 | 8 | 2 | 8 | 15 | 31 | 26 | < 0.001 |
0.3% | 0.1% | 0.5% | 0.9% | 0.2% | 0.8% | 1.7% | 3.5% | 3.0% | ||
Splenic abscess | 4 | 11 | 10 | 10 | 16 | 11 | 9 | 1 | 1 | 0.006 |
0.6% | 1.4% | 1.2% | 1.2% | 1.8% | 1.1% | 1.0% | 0.1% | 0.1% | ||
Acute renal failure | 68 | 88 | 63 | 78 | 80 | 70 | 81 | 141 | 150 | < 0.001 |
10.8% | 11.6% | 7.8% | 9.1% | 8.9% | 7.2% | 9.0% | 15.8% | 17.6% | ||
Sepsis | 64 | 102 | 113 | 101 | 128 | 142 | 102 | 108 | 108 | 0.88 |
10.2% | 13.4% | 13.9% | 11.8% | 14.2% | 14.7% | 11.3% | 12.1% | 12.7% | ||
In hospital IE related complications | 305 | 381 | 428 | 435 | 479 | 540 | 504 | 478 | 445 | 0.01 |
48.5% | 50.1% | 52.7% | 50.9% | 53.0% | 55.8% | 55.8% | 53.6% | 52.2% | ||
Cardiac valve surgery | 64 | 92 | 107 | 106 | 122 | 112 | 94 | 130 | 110 | 0.25 |
10.2% | 12.1% | 13.2% | 12.4% | 13.5% | 11.6% | 10.4% | 14.6% | 12.9% | ||
Death | 110 | 151 | 149 | 153 | 164 | 188 | 185 | 204 | 209 | < 0.001 |
17.5% | 19.8% | 18.3% | 17.9% | 18.2% | 19.4% | 20.5% | 22.9% | 24.5% |