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Femoral neuropathy following venoarterial-extracorporeal membrane oxygenation therapy: a case report
BMC Cardiovascular Disorders volume 20, Article number: 393 (2020)
Although life-threatening complications of extracorporeal membrane oxygenation (ECMO) are well described, non-life threatening complications are less known. Herein, we report a case of femoral neuropathy (FN) due to nerve compression caused by cannula compression and deep vein thrombosis (DVT) after successful ECMO therapy, which seriously undermined one’s quality of life.
A 70-year old male presented to the emergency department for chest pain. The patient had cardiac arrest before percutaneous coronary intervention (PCI) and was inserted with ECMO. Although he was successfully weaned from ECMO 4 days after PCI, he consistently complained swelling, abnormal sensation, and weakness in his right lower extremity, where the cannulas were inserted. Imaging studies showed deep vein thrombosis (DVT) in his right leg, which was further treated with anticoagulants. Symptoms, however, remained after the regression of DVT. Nerve conduction study revealed femoral neuropathy, which may have been caused by ECMO cannula compression and tissue swelling.
The current case proposes that non-life threatening complications of ECMO therapy can seriously affect quality of life. Venous drainage distant from the arterial cannula may prevent such complications.
Extracorporeal membrane oxygenation (ECMO) is a mechanical circulatory supporting device in patients with critical respiratory, cardiac, or combined failure. Due to great survival benefit, more than 24,000 cases of ECMOs were inserted in adults in the United States in 2019, which is approximately 6 times more compared with 2005 . Life threatening neurologic complications, such as stroke, seizure, or intracranial hemorrhage have been reported ; however non-life threatening neurologic complications, such as neuropathy associated with ECMO cannulation are less known. Herein, we report a case of femoral neuropathy (FN) caused by nerve compression and massive swelling due to deep vein thrombosis (DVT) following ECMO cannulation, which seriously undermined the patient’s quality of life.
A 70-year-old male with a history of hypertension, diabetes mellitus, and atrial fibrillation presented to the emergency department with chest pain lasting for 1 hour. The patient did not have any previous neurologic deficits or surgical, family, or genetic history, although he was a heavy smoker (75 pack-years). His initial blood pressure was 109/62 mmHg with a heart rate of 103 beats per minute. There were no remarkable findings upon physical exam. The electrocardiogram (ECG) showed ST segment elevation in leads II, III, and aVF and reciprocal changes in leads I and aVL, suggestive of ST elevation myocardial infarction. Initial troponin I level (0.021 ng/mL [0–5 ng/mL]) was unremarkable. The patient was started on intravenous unfractionated heparin (UFH).
The patient was immediately moved to the catheterization lab for emergent percutaneous coronary intervention (PCI) of ST elevation myocardial infarction. Vital signs were normal during the femoral artery puncture and insertion of a 6 French (Fr) sheath into the right femoral artery (FA). We punctured at the femoral head level without any mispuncutures during the process. After puncture and before coronary angiography (CAG), however, the patient went into ventricular fibrillation and the blood pressure became unmeasurable. Cardiopulmonary resuscitation (CPR) was immediately initiated with defibrillation every 2 min, although normal rhythm of vital signs were not recovered. As CPR was performed for a total of 30 min, we concurrently inserted a venoarterial ECMO. A 16.5 Fr (external diameter: 5.5 mm) arterial and 21 Fr (external diameter: 7 mm) venous cannula was inserted through the right FA and femoral vein (FV), respectively. CAG revealed an extensive thrombotic occlusion of the mid right coronary artery (RCA) with thrombolysis in myocardial infarction (TIMI) 0 flow distally. A drug eluting stent (Biomime™ 4.0 × 19 mm) was inserted to the lesion and the RCA restored a TIMI 2 flow (pain-to-balloon time: 120 min).
After the PCI, the patient was moved to the intensive care unit for ECMO care. Initial echocardiography showed a left ventricular ejection fraction (LVEF) of 15% and an extensive regional wall motion abnormality of the RCA territory. However, there was blood pressure drop with concurrent massive nasal and gastrointestinal bleeding. Hemoglobin level became 5.9 g/dL, which was approximately 8 g/dL decrease compared with initial levels. Blood pressure was recovered to normal after massive transfusion; however, we lowered the target activated partial thromboplastin time to approximately 40 s to prevent additional bleeding. There were no cannulation site complications such as hematoma or signs of infection during ECMO care, although diffuse swelling developed in the right lower extremity (LE) the next few days. Pneumatic compression devices were applied to both LEs to prevent DVT. ECMO therapy was maintained for 4 days, while vital signs slowly recovered. As the LVEF was restored to 46% on the 4th day, the ECMO was weaned and removed. The ECMO cannulas were removed by manual compression. Despite the risk of stent thrombosis, dual-antiplatelet therapy was stopped after ECMO removal (day 4) in concern of additional bleeding.
On the 7th day of admission, the patient recovered orientation. However, leg edema did not improve despite ECMO removal. He also started complaining impaired function, pain, and hypesthesia of the LE. Compartment syndrome was initially suspected. We clinically ruled out compartment syndrome , since the patient was negative for Homan’s sign and had good distal pulsation with warm circulation. The patient had burning sensation and Grade 3 weakness in hip and knee flexion motions with no deep tendon reflex. Neurologic findings were not dermatome specific. LE Doppler sonography and computed tomography (CT) showed DVT extending from the right external iliac vein to the calf vein without any evidence of puncture site hematoma or intramural bleeding (Fig. 1a). The patient was started on rivaroxaban (15 mg twice daily) for DVT (day 8). The swelling of the right LE gradually improved over the next 30 days, although his pain and weakness were not alleviated. As the patient was suspected to have post-thrombotic syndrome (PTS), which is pain and abnormal sensation after the onset of DVT, further studies such as the nerve conduction study (NCS) or electromyography were not considered until later on. The patient was discharged to a rehabilitation hospital on the 35th day.
During outpatient department follow up, the patient consistently had pain, abnormal sensation, and weakness in the right LE, which resulted in insomnia and depression. Although he was given thioctic acid (600 mg qd) and pregabalin (150 mg bid) during outpatient department follow up, his pain remained. Femoral and pulmonary arterial CT angiography was performed 100 days post-ECMO insertion showed no thrombus in the right LE or pulmonary arteries. However, the NCS revealed no sensory nerve action potential in the right peroneal nerve and tibial nerve, suggestive of impaired sensation. Additionally, the compound muscle action potential was not observed in the right femoral (Fig. 1b), peroneal and tibial nerve, indicating motor nerve palsy. These results collectively suggested FN. The patient is continuing rehabilitation exercises and slowly recovering from the weakness, although the tingling sensation remains to a lesser degree. The patient shares his regrets on his previous smoking habits which caused his myocardial infarction and eventually FN. An informed consent for publishing data was obtained from the patient. A timeline of events is summarized in Table 1.
Discussions and conclusions
As the clinical outcomes of ECMO therapy is improving, attention to the complications that determine the post-ECMO quality of life are emerging. Neuropathy caused by limb ischemia  or compartment syndrome  following ECMO therapy have been observed. However, FN caused by DVT and/or cannula-related nerve compression after ECMO therapy have not been reported.
FN is a rare complication most associated with intra-abdominal or hip surgery. Prolonged pneumatic compression by the tourniquet also causes FN. The mainly suggested mechanism is stretch or prolonged compression of the nerve resulting in microvascular congestion, impaired tissue perfusion, and axonal degeneration [6, 7], leading to transient or permanent pain, paresthesia, or loss of function. FN can be confirmed by an NCS or electromyography. FN can be differentiated from critical illness neuropathy (CIP), because CIP is usually manifested with symmetry involving all extremities. Physical therapy is the mainstay of FN treatment unless the cause of compression can be removed, such as a tumor. Anatomically, the femoral nerve is located within the femoral triangle, which contains the femoral nerve, FA, and FV. The femoral nerve, FA and the FV is located from lateral to medial, where the lateral border is the sartorius and medial border is the abductor longus muscle.
FN in the current case is suspected to be caused by nerve compression due to two bulky inserted cannulas and diffuse swelling of surrounding tissues caused by PTS. Although ipsilateral arterial and venous ECMO cannulation (cannulation of both arterial and venous sheaths in the same leg) is frequently done in the real-world practice [2, 8], the related complications are not known. Large diameter cannulas inserted in the ipsilateral side may increase the risk of compression of the adjacent structures such as the nerve (Fig. 1a, c, and d). Additionally, PTS caused by DVT may have aggravated the compression of the nerve. PTS is an often-overlooked complication of DVT, which is caused by the injury of endothelium and low venous flow. It leads to the distension of collateral vessels and general swelling of the tissue, which may result in pain and cramping . DVT is also frequently observed after ECMO decannulation . Routine evaluation of DVT may be necessary to prevent further complications . We suspect that the femoral nerve already compressed by both large cannulas may have been additionally pressured by the general swelling of the tissues (Fig. 1c-d). Immediately after the removal of cannulas, PTS was initially suspected. However, as the symptoms were consistent even after the improvement of DVT, we concluded that the symptoms may have been caused by FN.
The placement of the venous catheter in a distant site may possibly reduce the compression of the nerve. As both artery and venous cannulas inserted in the same area is thought to cause compression of adjacent structures, locating the drainage cannula in the superior vena cava through the internal jugular vein (IJV) or the contralateral FV may reduce such disadvantages. In fact, some studies assert that the venous drainage catheter should be placed in the IJV for better circulation of oxygenated blood . Although initial jugular access for ECMO therapy may be cumbersome in emergent situations, placing the jugular cannula in the contralateral side may be a feasible option. Early rehabilitation in patients with damaged nerves has been shown to improve outcomes and shorten the duration of recovery of FN. However, the rehabilitation in our patient was delayed to prevent DVT progressing to acute pulmonary thromboembolism. Also, the medical staff in the rehabilitation hospital were reluctant of conducting aggressive rehabilitation in a patient with a history of cardiac arrest. We suspect that such circumstances may have resulted in the slow recovery of FN.
The importance of complications that determine the quality of life of the patient after ECMO therapy is emerging, as the outcomes of ECMO therapy are improving . The current case proposes that FN can seriously undermine one’s quality of life even after successfully weaning from ECMO. Considering venous drainage in the vessel distant from the arterial cannula or early rehabilitation may be critical in preventing such a detrimental complication.
Availability of data and materials
The datasets generated and/or analyzed during the current study are not publicly available due to privacy reasons.
Extracorporeal membrane oxygenation
Deep vein thrombosis
Right coronary artery
Nerve conduction study
Internal jugular vein
Extracorporeal Life Support Registry report: International summary. Extracorporeal Life Support Organization. 2020. https://www.elso.org/Registry/Statistics/InternationalSummary.aspx. Accessed 25 Mar 2020.
Keebler ME, Haddad EV, Choi CW, McGrane S, Zalawadiya S, Schlendorf KH, Brinkley DM, Danter MR, Wigger M, Menachem JN, et al. Venoarterial extracorporeal membrane oxygenation in cardiogenic shock. JACC Heart Fail. 2018;6(6):503–16 https://doi.org/10.1016/j.jchf.2017.11.017.
Vazquez SR, Kahn SR. Postthrombotic syndrome. Cardiology Patient Page. Circulation. 2010;121(8):e217–9 https://doi.org/10.1161/CIRCULATIONAHA.109.925651.
Aydin S, Pazarci N, Akan O, Buyukkale S, Bakan ND, Sayar A. A case report of a drop foot developed after common femoral artery Cannulation for Venoarterial extracorporeal membrane oxygenation. Noro Psikiyatr Ars. 2019;56(1):75–8 https://doi.org/10.5152/npa.2017.19340.
Go JY, Min YS, Jung TD. Delayed onset of acute limb compartment syndrome with neuropathy after venoarterial extracorporeal membrane oxygenation therapy. Ann Rehabil Med. 2014;38(4):575–80 https://doi.org/10.5535/arm.2014.38.4.575.
Celebrezze JP Jr, Pidala MJ, Porter JA, Slezak FA. Femoral neuropathy: an infrequently reported postoperative complication. Report of four cases. Dis Colon Rectum. 2000;43(3):419–22 https://doi.org/10.1007/BF02258312.
Mackinnon SE. Pathophysiology of nerve compression. Hand Clin. 2002;18(2):231–41 https://doi.org/10.1016/s0749-0712(01)00012-9.
Lee S, Chaturvedi A. Imaging adults on extracorporeal membrane oxygenation (ECMO). Insights Imaging. 2014;5(6):731–42 https://doi.org/10.1007/s13244-014-0357-x.
Fisser C, Reichenbacher C, Muller T, Schneckenpointner R, Malfertheiner MV, Philipp A, Foltan M, Lunz D, Zeman F, Lubnow M. Incidence and risk factors for cannula-related venous thrombosis after Venovenous extracorporeal membrane oxygenation in adult patients with acute respiratory failure. Crit Care Med. 2019;47(4):e332–9 https://doi.org/10.1097/CCM.0000000000003650.
Frenckner B, Broman M, Broome M. Position of draining venous cannula in extracorporeal membrane oxygenation for respiratory and respiratory/circulatory support in adult patients. Crit Care. 2018;22(1):163 https://doi.org/10.1186/s13054-018-2083-0.
Chang CH, Chen HC, Caffrey JL, Hsu J, Lin JW, Lai MS, Chen YS. Survival analysis after extracorporeal membrane oxygenation in critically ill adults: a Nationwide cohort study. Circulation. 2016;133(24):2423–33 https://doi.org/10.1161/CIRCULATIONAHA.115.019143.
Ethics approval and consent to participate
This study conforms to the Declaration of Helsinki. Institutional review board approval is waived for case reports in our institution.
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Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal. All authors have read and approved the final version of the manuscript.
The authors declare that they have no competing interests. This study was not funded.
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Jang, A.Y., Oh, Y.J., Lee, S. et al. Femoral neuropathy following venoarterial-extracorporeal membrane oxygenation therapy: a case report. BMC Cardiovasc Disord 20, 393 (2020). https://doi.org/10.1186/s12872-020-01675-y
- Femoral neuropathy
- Extracorporeal membrane oxygenation
- Case report