Skip to main content
  • Research article
  • Open access
  • Published:

Determinants of persistent smoking after acute myocardial infarction: an observational study



Smoking cessation is one of the most effective secondary prevention measures after acute myocardial infarction (AMI). However, around 50% of smokers do not quit smoking after AMI. The aim of the present study is to estimate the proportion of patients quitting smoking and to identify determinants of persistent smoking after AMI in a region with increased cardiovascular mortality. We also assessed the time of smoking cessation after AMI.


We used follow-up data of patients registered with the Regional Myocardial Infarction Registry in Saxony-Anhalt (RHESA) in Germany. We assessed smoking status and determinants of persistent smoking six weeks after discharge from hospital after AMI. Information on smoking, sociodemographic characteristics, risk factors for AMI, experienced symptoms of AMI, and clinical care were gathered in a computer-assisted telephone interview and questionnaires filled out by study subjects and physicians or study nurses.


Out of 372 smokers at the time of AMI, 191 (51.3%) reported that they quit smoking within six weeks after discharge from hospital after AMI. Strongest determinant of persistent smoking was a previous AMI before the current one (OR = 2.19, 95%CI 1.10–4.38) and strongest determinants of smoking cessation were experiencing complications in the hospital (0.37, 95%CI 0.12–1.12) and having a life partner (0.56, 95%CI 0.34–0.95). Most individuals who stopped smoking did so during the initial stay in the hospital, before the cardiac rehabilitation (CR).


Persistent smoking after AMI and its determinants were similar in our region to previous studies. CR cannot be viewed as determinant of smoking cessation – more likely the same teachable moment induces behavioural change with regard to smoking and participation in CR.

Peer Review reports


For many years, Saxony-Anhalt has been one of the federal states in Germany with the highest incidence and mortality of acute myocardial infarction (AMI) [1]. In 2013, the age-standardized incidence of AMI (349 / 100,000 persons) was 28.3% above the national average. In order to identify reasons for the high incidence and mortality, the Regional Myocardial Infarction Registry (RHESA) was established in 2013 [2]. One potential explanation for the high incidence is the highest or second highest prevalence of common risk factors for AMI in Saxony-Anhalt among the German federal states (i.e. smoking, diabetes mellitus, arterial hypertension, obesity, increased waist circumference and the metabolic syndrome) [3]. However, it still remains unclear whether there is additional contribution of insufficient secondary prevention in Saxony-Anhalt including behavioral change, resulting in elevated rates of repeated infarctions with poor prognosis.

One of the most effective secondary prevention measures after AMI is smoking cessation [4]. A meta-analysis of twelve studies with a follow-up from two to ten years after AMI reported a 0.54 (95% CI 0.46–0.62) times reduced overall mortality for quitters compared to those who continued smoking [5]. However, according to the multi-centre study EUROASPIRE IV survey, 40–60% of AMI survivors in Europe do not stop smoking after AMI [6]. In Würzburg, the German study centre of that study, the quit rate was 47%.

One suggested mechanism to explain smoking cessation after AMI is that of a teachable moment - a naturally occurring event resulting in higher motivation for a change in risk behaviour [7]. Additionally, support provided at the right time can increase the possibility of a strong teachable moment encouraging smoking cessation [7, 8]. This support is available to patients during rehabilitation where, for example, the duration of the smoke-free policy that started in the hospital is prolonged, or pharmacological or psychological assistance is offered [9,10,11]. Predictors of persistent smoking after AMI have been identified in previous studies. These are sociodemographic characteristics [6, 12,13,14,15], smoking behaviour [11, 12], risk factors for AMI [12, 15], and the extent of medical interventions in the context of AMI [12, 14, 15]. Nevertheless, these factors can have different importance in various regions.

In the current analysis, we aimed to estimate the proportion of patients successful in quitting smoking after AMI in Saxony-Anhalt and to identify factors that determine persistent smoking after AMI in our region. We also address the question, when patients after AMI quit smoking in our population.


Study design and setting

RHESA-CARE 1 and 3 (RC1, RC3) are follow-up studies of patients who agreed to participate in the Regional Myocardial Infarction Registry of Saxony-Anhalt (RHESA) [2, 16]. The inclusion criteria for RHESA were age of 25 or more and being an inhabitant of the city of Halle (Saale) or the rural area of Altmark in Saxony-Anhalt (Germany) and being diagnosed with AMI in the hospital. While in RHESA we used multiple sources of information on mortality and morbidity of AMI in the population, in the follow-up studies only patients who provided informed consent during their stay in a hospital were included. In RC1, we contacted all AMI survivors who were registered with RHESA between April 2014 and January 2018 and agreed to participate in an active follow-up. The contact was six weeks after their hospital discharge. Since RHESA continued to recruit patients beyond the end of the RC1 study, we conducted an additional follow-up to include patients registered after January 2018, but included all patients registered with RHESA between June 2013 and January 2019. This follow up was conducted between February and May 2019 for all patients independently from discharge date after AMI including some participants of RC1. RC3 used a substantially shortened RC1 questionnaire with some additional questions for example regarding time of smoking cessation. Only those participants that reported in RC1 (or RC3 if RC1 information was not available) that they have been smokers at the time of AMI are part of this analysis.


All variables of interest were gathered either through computer-assisted telephone interview (CATI) (RC1), written questionnaires (RC3) or by questionnaires answered by physicians or study nurses in the hospital (as part of RHESA). Quality and data comparability were ensured by using standardized and validated instruments that have been used in similar studies [17,18,19].

Smoking status at the time of AMI was self-reported in both, RC1 and RC3. In RC1 individuals were also asked about smoking status at the date of interview (six weeks after hospital discharge). In RC3, we asked if and when the individuals had stopped smoking and if and when they started smoking again. Thus, we were able to determine the smoking status six weeks after discharge from hospital also for those who participated only in RC3. Individuals that reported that they quit smoking within six weeks after discharge from hospital were considered as quitters. When continuation of daily or occasional smoking was reported six weeks after discharge from hospital, individuals were considered as persistent smokers. Based on a literature search, we identified four categories of potential determinants of smoking cessation: sociodemographic characteristics, risk factors for AMI, experienced symptoms of AMI, and clinical care.

For the first category of possible determinants of smoking cessation, we gathered information on age, sex, net income per household (metric variable assessed in steps of 500 €), education (according to the international standard classification of education (ISCED-97) with 3 levels (low, mid, high)), and having life partner. In the second category of potential determinants, we asked the participants for a confirmed diagnosis of arterial hypertension and diabetes mellitus and previous AMI. Participants were further asked if they had any intention to quit smoking before the AMI occurred. The third category of potential determinants included the presence of fear of death during the AMI as a binary variable. Information on the fourth category of potential determinants was gathered through hospital questionnaire answered by physicians or study nurses. The questionnaire contained information on the type of AMI (STEMI vs. NSTEMI) interventions after AMI (percutaneous coronary intervention (PCI)) or coronary artery bypass graft (CABG) vs. no intervention), complications in the hospital (i.e. shock, intubation, reanimation, severe bleeding, stroke or re-intervention, the number of newly prescribed drugs after hospital and the duration of hospitalisation (in days). We used the number of newly prescribed drugs as an auxiliary information for the perceived severity of heart disease. We assumed that this perceived severity can possibly strengthen the teachable moment associated with AMI and therefore increase the probability of smoking cessation.

In addition, we assessed the information on participation in cardiac rehabilitation (CR) within 2 weeks after hospital discharge in RC1 and in RC3, if it was not available in RC1. Using RC3 as a preferred source of information showed only minor differences in sensitivity analysis (data not shown).

Statistical analysis

For sample characteristics, continuous variables were expressed as mean ± standard deviation for normally distributed data or as median and interquartile range for non-normally distributed data. Categorical variables were reported as frequencies and percentages (%).

Under the assumption of missing at random (MAR), we used multiple imputation to compensate incompleteness of information on age, sex, education, comorbidities (arterial hypertension, diabetes mellitus), fear of death during AMI, STEMI vs. non-STEMI status, intervention in the context of AMI, number of newly prescribed drugs, and duration of hospitalisation after AMI. Seventy complete data sets were generated according to the rounded-up percentage of incomplete cases. Fully conditional specification method was used in order to impute categorical variables and in order to not rely on normal distribution of continuous variables. The imputed models contained above-named variables, as well as information on region (Halle or Altmark) and on transfer between hospitals in order to conduct interventions after AMI (yes/ no). We used univariable logistic regression on the original dataset to obtain unadjusted effects of determinants on continuing smoking. We performed multivariable logistic regression on the imputed datasets and applied Rubin’s rule to combine their results [20]. Considering the high number of variables and to avoid overadjustment, we subdivided the covariates into 3 levels. Level 1 included information on the sociodemographic variables, level 2 information on the history of risk factors, and level 3 information on the symptoms of AMI and clinical care after AMI. Determinants where adjusted for all the variables in the same level and the previous level(s). All calculations were performed in SAS software version 9.4 (The SAS Institute, Cary, NC, USA).


Sample characteristics

One thousand one hundred fourteen persons were enrolled in our study, of whom 288 only participated in RC1, 313 only in RC3, and 513 in both, RC1 and RC3 (Fig. 1). Three hundred seventy-two individuals reported being smokers at the time of AMI and about half of them (51.3%) reported having stopped smoking within six weeks after hospital discharge. Differences between persistent smokers and those who stopped smoking existed for sociodemographic characteristics, risk factors for AMI, and clinical care after AMI but not for the experienced AMI symptoms (Table 1). Respondents of RC3 had on average slightly higher mean age at the time of AMI (0.83 years), had more often male sex (71.8% vs. 69.7%), and more often were from the urban region city of Halle (58.0% vs. 56.2%) compared to respondents of RC1.

Fig. 1
figure 1

“Flow diagram of study population”

Table 1 Sample characteristics of persistent smokers and quitters

Determinants of smoking cessation

We identified having a previous AMI compared to no previous AMI (OR = 2.19, 95%CI 1.10–4.38) and receiving PCI or CABG compared to no intervention (OR = 1.53, 95%CI 0.66–3.54) as the strongest determinants of persistent smoking, and having a life partner compared to no life partner (OR = 0.56, 95%CI 0.34–0.95) and experiencing complications in the hospital compared to no complications (OR = 0.37, 95%CI 0.12–1.12) as the strongest determinants of smoking cessation (Table 2). Effects of age, sex, having STEMI and the duration of hospitalisation were close to the null effect.

Table 2 Determinants of persistent smoking from logistic regression models

Time of smoking cessation

Among those who stopped smoking within six weeks after hospital discharge, most stopped smoking already during hospital stay (Table 3). Among those who attended CR, some stopped smoking before CR. Overall, smoking cessation was more common and restarting smoking less common among those who attended CR in comparison to those who did not, but the attendance to CR cannot be considered as the cause of smoking cessation, as it occurred mostly before CR.

Table 3 Time of smoking cessation


In our study population, about 50% of smoking AMI patients stopped smoking within six weeks after discharge from hospital after AMI. The strongest determinants of smoking cessation were having a life partner and having experienced complications in the hospital. Persistent smoking was most strongly determined by having previous myocardial infarction and by receiving PCI or CABG. More than 80% of those who stopped smoking after AMI did so before hospital discharge and thus also before CR.

Implications and comparison to previous studies

The proportion of quitters in our study population corresponded to the average quit rate of European patients with coronary heart disease [6]. The proportion of quitters in our study population was even slightly higher than the proportion reported for Germany in the above study (51% vs 47%). Thus, it does not appear that this factor could explain the morbidity/mortality excess in our region in Germany.

Factors that were associated with smoking cessation were found in the category of sociodemographic characteristics, risk factors for AMI, and clinical care, but not in symptoms of AMI. We found no association between age at hospitalisation due to AMI and smoking cessation. Most of the previous studies showed similar results [13,14,15], although some studies showed a positive association between higher age and smoking cessation [6, 12]. Furthermore, we saw no association between sex and smoking cessation. While one other study showed a similar finding [14], some other studies showed a protective effect [6, 13, 15] and one other a harmful effect [12] of male sex on continuous smoking in comparison to female sex. There can be various explanations of these findings – including different smoking behaviors of the respective populations and the different survey periods. A higher net household income had a positive effect on smoking cessation which is concordant to other studies [12, 21]. The German Health Interview and Examination Survey for Adults (DEGS1) from 2013 showed that higher socio economic status is not only associated with lower prevalence of smoking, but also with higher cessation independently of AMI [22]. Having a life partner was associated more often with smoking cessation compared to not having a life partner, which has also been shown in previous studies [12, 14, 15]. We hypothesise that people having a life partner feel not only responsible for themselves, they might feel a responsibility for their partner as well. This may increase the emotional component of the teachable moment and could lead to a higher cessation rate. Additionally, those people may experience additional support in the process of quitting and staying away from cigarette smoking. Individuals diagnosed with arterial hypertension had a higher risk to continue smoking. This effect was also found elsewhere [12]. We found a strong association between having a history of AMI and continuous smoking. People that are not able to stop smoking after their first myocardial infarction are less likely to stop smoking after their next cardiac events. A comparison with other studies is not feasible because those either excluded subjects with previous myocardial infarctions in the first place, or they only provided descriptive data about cessation rates [12, 15]. In our study, we found that subjects who suffered complications in the hospital had the highest chance of quitting smoking. Since only a few people in the hospital suffered complications, the confidence interval is very wide. A longer stay in hospital and a higher number of newly prescribed drugs after AMI were only slightly associated with smoking cessation. The number of new drugs was used as a proxy for the perceived severity of heart disease. We can imagine that taking new drugs every day will give patients a lasting feeling of illness. In contrast to other studies [12, 14], we found a positive association between being subject of a PCI or CABG on the one side and continuing smoking on the other. However, more than 90% of the subjects in our study got a PCI, and thus the non-intervention group was very small. Nevertheless, many of the cited publications looking for predictors of smoking cessation have been published over 20 years ago. It could be interpreted as a signal suggesting that today’s hospital interventions and the stay itself are no longer considered as life-threatening as it was years before.

Several previous studies assessed CR as potential determinant of smoking cessation [11, 13, 23, 24]. We could show in our study, that those who participated in CR not only were more likely to quit smoking, they mostly quit already before attending CR. This may suggest that those who attend CR are more strongly motivated to modify their risk behavior even before attending CR compared to those who do not attend CR. Those who attend CR are also more likely not to restart smoking – but we cannot say if this is also due to selection, or possibly because of additional support during CR.

Strength and limitations

The strength of our study is the use of data from a population-based registry of AMI with a systematic follow up – in contrast to studies based on hospital samples only. Furthermore, we were able to assess a very broad set of determinants of smoking cessation after AMI.

At the same time, our study has some limitations. Information on smoking and several of the variables assessed as determinants was self-reported and thus subject to reporting bias. The recall bias could be increased by the fact that for some participants the AMI was several years ago. We had relatively limited information on smoking behavior before AMI. Furthermore, we were not able to shed light on whether CR contributes to smoking cessation – we could only show that it would be incorrect to attribute smoking cessation to CR. Although the sample size is relatively small, we could answer the posed questions. In regression analyses, the sample fulfilled the rule of thumb with at least 10 events per variable [25].


In our cohort of AMI patients from a population-based registry in a region with a comparably high cardiovascular morbidity and mortality, 51.3% stopped smoking within six weeks after discharge from hospital, similarly to other European and German data. Also, the determinants of smoking cessation were similar to previous studies, therefore an explanation of elevated mortality has to be searched in other areas. While CR was considered determinant of smoking cessation in previous studies, it appears that among those who attend CR, most stop smoking already before starting CR.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on request.



Acute myocardial infarction


Coronary artery bypass graft


Computer assisted telephone interview


Cardiac rehabilitation


Percutaneous coronary intervention


RHESA-care 1


RHESA-care 3


Regional myocardial infarction registry


ST-elevation myocardial infarction


  1. German Heart Foundation (ed.). Deutscher Herzbericht 2015. Frankfurt am Main: 2015.

  2. Bohley S, Trocchi P, Robra B-P, Mau W, Stang A. The regional myocardial infarction registry of Saxony-Anhalt (RHESA) in Germany – rational and study protocol. BMC Cardiovasc Disord. 2015;15:45.

    Article  Google Scholar 

  3. Stang A, Stang M. An inter-state comparison of cardiovascular risk factors in Germany. Dtsch Aerzteblatt Online. 2014;111:530–6.

    Google Scholar 

  4. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2018;39:119–77.

    Article  Google Scholar 

  5. Wilson K, Gibson N, Willan A, Cook D. Effect of smoking cessation on mortality after myocardial infarction. Arch Intern Med. 2000;160:939.

    Article  CAS  Google Scholar 

  6. Snaterse M, Deckers JW, Lenzen MJ, Jorstad HT, De Bacquer D, Peters RJG, et al. Smoking cessation in European patients with coronary heart disease. Results from the EUROASPIRE IV survey: a registry from the European Society of Cardiology. Int J Cardiol. 2018;258:1–6.

    Article  CAS  Google Scholar 

  7. McBride CM, Emmons KM, Lipkus IM. Understanding the potential of teachable moments: the case of smoking cessation. Health Educ Res. 2003;18:156–70.

    Article  CAS  Google Scholar 

  8. Lawson PJ, Flocke SA. Teachable moments for health behavior change: a concept analysis. Patient Educ Couns. 2009;76:25–30.

    Article  Google Scholar 

  9. Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2013.

  10. Barth J, Critchley JA, Bengel J. Psychosocial interventions for smoking cessation in patients with coronary heart disease. In: Barth J, editor. Cochrane database of systematic reviews. Chichester: John Wiley & Sons, Ltd; 2008.

    Book  Google Scholar 

  11. Sochor O, Lennon RJ, Rodriguez-Escudero JP, Bresnahan JF, Croghan I, Somers VK, et al. Trends and predictors of smoking cessation after percutaneous coronary intervention (from Olmsted County, Minnesota, 1999 to 2010). Am J Cardiol. 2015;115:405–10.

    Article  Google Scholar 

  12. Gerber Y, Koren-Morag N, Myers V, Benyamini Y, Goldbourt U, Drory Y, et al. Long-term predictors of smoking cessation in a cohort of myocardial infarction survivors: a longitudinal study. Eur J Cardiovasc Prev Rehabil. 2011;18:533–41.

    Article  Google Scholar 

  13. Sverre E, Otterstad JE, Gjertsen E, Gullestad L, Husebye E, Dammen T, et al. Medical and sociodemographic factors predict persistent smoking after coronary events. BMC Cardiovasc Disord. 2017;17:241.

    Article  Google Scholar 

  14. Brummett BH, Babyak MA, Mark DC, Williams RB, Siegler IC, Clapp-Channing N, et al. Predictors of smoking cessation in patients with a diagnosis of coronary artery disease. J Cardiopulm Rehabil Prev. 2002;22:143–7.

    Article  Google Scholar 

  15. Di Tullio M, Granata D, Taioli E, Broccolino M, Recalcati F, Zaini G, et al. Early predictors of smoking cessation after myocardial infarction. Clin Cardiol. 1991;14:809–12.

    Article  Google Scholar 

  16. Hirsch K, Bohley S, Mau W, Schmidt-Pokrzywniak A. The RHESA-CARE study: an extended baseline survey of the regional myocardial infarction registry of Saxony-Anhalt (RHESA) design and objectives. BMC Cardiovasc Disord. 2016;16:159.

    Article  Google Scholar 

  17. Böthig S. WHO MONICA project: objectives and design. Int J Epidemiol. 1989;18:S29–37.

    Article  Google Scholar 

  18. Greiser KH, Kluttig A, Schumann B, Kors JA, Swenne CA, Kuss O, et al. Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, living and ageing in Halle (CARLA) study. BMC Cardiovasc Disord. 2005;5:33.

    Article  Google Scholar 

  19. Lamprecht J, Behrens J, Mau WSM. Das intensivierte rehabilitationsnachsorgeprogramm (irena) der deutschen rentenversicherung bund - berufsbegleitende inanspruchnahme und veränderungen berufsbezogener parmeter. Rehabil. 2011;50:186–94.

    CAS  Google Scholar 

  20. Rubin DB. Multiple imputation for nonresponse in surveys. New York: Wiley; 1987.

    Book  Google Scholar 

  21. Holtrop JS, Stommel M, Corser W, Holmes-Rovner M, Holtrop JS. Predictors of smoking cessation and relapse after hospitalization for acute coronary syndrome. J Hosp Med. 2009;4:E3–9.

    Article  Google Scholar 

  22. Lampert T, Lippe E von der, Müters S. Verbreitung des Rauchens in der Erwachsenenbevölkerung in Deutschland. Berlin: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung; 2013.

  23. Katz DA, Buchanan DM, Vander Weg MW, Faseru B, Horwitz PA, Jones PG, et al. Does outpatient cardiac rehabilitation help patients with acute myocardial infarction quit smoking? Prev Med (Baltim). 2019;118:51–8.

    Article  Google Scholar 

  24. Attebring MF, Hartford M, Hjalmarson A, Caidahl K, Karlsson T, Herlitz J. Smoking habits and predictors of continued smoking in patients with acute coronary syndromes. J Adv Nurs. 2004;46:614–23.

    Article  Google Scholar 

  25. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373–9.

    Article  CAS  Google Scholar 

Download references


We thank the reporting hospitals for their willingness to cooperate and the recruitment of patients for the follow-up in RHESA-Care, in particular the doctors, the nurses and our study nurse. Furthermore, we are particularly grateful for the willingness of our participants to participate in our study.


RHESA has been funded by Bundesministerium für Gesundheit (Bundesverwaltungsamt), Ministerium für Arbeit, Soziales und Integration des Landes Sachsen-Anhalt, Ministerium für Wissenschaft, Wirtschaft und Digitalisierung des Lande Sachsen-Anhalt, Deutsche Herzstiftung e.V., AOK Sachsen-Anhalt, IKK Gesund Plus, Verband der Ersatzkassen e.V. Landesvertretung Sachsen-Anhalt, and Sozialversicherung für Landwirtschaft, Forsten und Gartenbau Kassel. RHESA-CARE has been funded by the Wilhelm Roux Program of the Faculty of Medicine of the Martin-Luther University Halle-Wittenberg [grant number FKZ 28/35]. The funders had no role in preparation of the manuscript or any decision regarding its submission. Open access funding provided by Projekt DEAL.

Author information

Authors and Affiliations



JH drafted the manuscript. ASP, JH conducted and coordinated the study. JH and CF conducted the literature search on the topic. JH, UJ, CF, and RM contributed to the analysis and to the interpretation of the data. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Rafael Mikolajczyk.

Ethics declarations

Ethics approval and consent to participate

RHESA was approved by the Ethics Committee of the Medical Faculty of the Martin Luther University Halle-Wittenberg and by the State Data Protection and Privacy Commissioner of Saxony-Anhalt. The ethics for the RHESA-CARE Study are included in those of the RHESA. All patients gave their written informed consent to participate in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Höpner, J., Junge, U., Schmidt-Pokrzywniak, A. et al. Determinants of persistent smoking after acute myocardial infarction: an observational study. BMC Cardiovasc Disord 20, 384 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: