Skip to main content

Prognostic of different glomerular filtration rate formulas in patients receiving percutaneous coronary intervention: insights from a multicenter observational cohort



The relationships of renal dysfunction (RD) and chronic kidney disease (CKD) with prognosis have been well established among non-ST elevation acute coronary syndrome (NSTE-ACS) patients who receive percutaneous coronary intervention (PCI), but the efficacy of different estimated glomerular filtration rate (eGFR) formulas for predicting the prognosis is unknown.


The cohort originated from a retrospective data, which consecutively enrolled 8197 patients. The eGFR was calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), CKD Epidemiology Collaboration-creatinine, CKD Epidemiology Collaboration-Cys-C, CKD Epidemiology Collaboration-Cys-C-creatinine and a modified abbreviated MDRD (c-aGFR) equations in Chinese CKD patients. Patients were excluded if the eGFR could not be obtained by one of the formulas. Patients were categorized as having normal renal function, mild RD, moderate RD, severe RD, or kidney failure to compare prognosis. The primary outcome was the in-hospital net adverse clinical events (NACE). The secondary outcomes were NACE and all-cause death during follow-up.


In total, 2159 NSTE-ACS patients (age: 64.23 ± 10.25 years; males: 73.7%) were enrolled. 39 (1.8%) patients with in-hospital NACE were observed. During the 3.23 ± 1.55-year follow-up, 1.7% death and 4.2% NACE were observed in 1 year. The percentage of severe RD patients ranged from 15.4 to 39.2% according to different calculation formulas. A high prevalence of in-hospital NACE was observed in the severe RD groups (ranging from 8 to 14.3% for different formulas). Multiple regression analysis showed that a high eGFR is a protect factor against NACE and all-cause death regardless of the formula use. Receiver operating characteristic curves showed similar predictive performance of the c-aGFR when compared to other formulas (in-hospital NACE: AUC = 0.612, follow-up NACE: AUC = 0.622, and follow-up death: AUC = 0.711).


Severe RD results in a high prevalence of in-hospital NACE in NSTE-ACS patients after PCI regardless of the formulas use. Different formulas have a similar ability to predict in-hospital and long-term prognosis in NSTE-ACS patients. The c-aGFR formula is the simplest and a more convenient formula for use in practice.

Peer Review reports


Renal function is a powerful predictor of short- and long-term outcomes in patients with acute coronary syndromes [1,2,3]. Studies have reported that 42.9% of patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) had concomitant chronic kidney disease (CKD) [4]. Therefore, in patients with acute coronary syndrome (ACS), the assessment of renal function is not only conducive to the judgment of the severity of kidney disease but also important for the prognosis. The estimated glomerular filtration rate (eGFR) is the clinical standard for the assessment of kidney function and provides a good overall evaluation of kidney function [5]. The currently available formulas for estimating the eGFR include the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), CKD Epidemiology Collaboration-creatinine (CKD-EPIcr), CKD Epidemiology Collaboration- Cystatin C (CKD-EPICysC), CKD Epidemiology Collaboration-Cys-C - creatinine (CKD-EPIcr-Cys-C) and c-aGFR (a modified abbreviated MDRD equation based on the Chinese CKD patients) equations. Despite the consensus that renal dysfunction (RD) is a risk predictor of prognosis according to the latest NSTE-ACS guidelines [6], the clinical variation in different eGFR formulas remains unknown. However, no consensus exists regarding which eGFR formula is most suitable for predicting the prognosis of ACS [7,8,9,10].

The purpose of this study was to analyze the value of the five eGFR formulas (c-aGFR, CG, CKD-EPIcr, CKD-EPICys-C and CKD-EPIcr-Cys-C) in predicting the prognosis of NSTE-ACS patients undergoing percutaneous coronary intervention (PCI).


The present study originated from an observational cohort whose protocol were detailed in our previous study [11]. All 8197 patients who were recruited retrospectively from 5 centers in China were consecutively enrolled from January 1, 2010, to December 31, 2014. NSTE-ACS includes unstable angina pectoris (UA) and non-ST segment elevation myocardial infarction (NSTEMI). These definitions were consistent with our published study [11]. Patients for whom an eGFR could be calculated by the five formulas mentioned previously were included. The exclusion criteria were as follows: 1. patients who did not receive the PCI procedure, 2. patients who were readmitted, 3. ST-elevation myocardial infarction patients, 4. patients who were pregnant 5. patients with decompensated heart failure or cardiogenic shock who required intra-aortic balloon pump treatment. A total of 2158 patients were included in the final analysis (Fig. 1). All data were collected at the start of the study according to the predesigned form. The research program is consistent with the Helsinki Declaration and was approved by the local ethics committee.

Fig. 1
figure 1

Flowchart of the study. ACS: acute coronary syndrome; PCI: percutaneous coronary intervention; STEMI: ST-segment elevation myocardial infarction; IABP: intra-aortic balloon pump; eGFR: estimated glomerular filtration rate

Patients’ information was collected as we described in our previous study [11], and including preoperative creatinine level, age, sex, Cys-C, urea nitrogen, type of ACS (NSTEMI or UA), patient history, characteristic medications used during hospitalization, clinical presentation laboratory tests (NT-proBNP, peak troponin I, hemoglobin), and echocardiography. In-hospital, 30 day, 1-year and 3-year follow-up data were obtained by trained nurses through telephone interviews from November 7, 2015 to December 30, 2016. Relevant information was also collected from the clinical records of the residency registration system and from patients who were re-admitted.

We evaluated 5 formulas for assessing the eGFR based on creatinine and/or Cys-C levels as follows: c-aGFR, CG, CKD-EPIcr, CKD-EPICys-C and CKD-EPIcr-Cys-C (detail in supplemental materials). According to current Kidney Disease Improving Global Outcomes (KDIGO) guidelines, an eGFR of less than 60 ml/min/1.73 m2 was defined as significant RD [12]. Patients were categorized into 5 levels of renal function: normal (eGFR, > 90 ml/min per 1.73 m2), mild RD (eGFR, 60–90 ml/min per 1.73 m2), moderate RD (30–59 ml/min per 1.73 m2), severe RD (15–29 ml/min per 1.73 m2), or kidney failure (< 15 ml/min per 1.73 m2).

The primary endpoint was the in-hospital net adverse clinical events (NACE), which includes all-cause death, myocardial infarction and major bleeding (Bleeding Academic Research Consortium (BARC) score > 2,) [13]. the secondary outcomes were all-cause death as well as the NACE during the 1-year follow-up.

All data analyses were performed using SAS (version 9.4, SAS Institute, 210 Cary, North Carolina, USA), and a P value of less than 0.05 was considered as statistically significant. Categorical variables are expressed as counts (proportions), and differences among the groups were assessed using a chi-square test or Fisher’s exact probability method. Variables with a non-normal distribution are presented as the medians and IQRs. Continuous variables with a normal distribution are presented as the mean ± standard deviations. Differences among the groups were assessed using a t test or the Mann-Whitney U test for statistical analysis. Univariate analysis and multivariate logistic regression analyses were performed to calculate the adjusted odds ratios (ORs) and Hazard ratios (HRs) with 95% confidence intervals (CIs) for in-hospital mortality and NACE according to the eGFR (adjusted for sex, anemia, left main coronary artery stenosis, congestive heart failure, diagnosis (UA or NSTEMI), prior myocardial infarction (MI), prior stroke, stent number, stent length). The Kaplan–Meier method and log-rank test were used to analyze the all-cause mortality during the follow-up period. The area under each receiver operating characteristic curve (AUC) was calculated to assess the discriminative performance of each formula. All the missing data were eliminated.


Of all the 2159 NSTE-ACS patients, 39 (1.8%) patients with in-hospital NACE were observed. The clinical baseline characteristics of the patients between NACE and non-NACE are shown in Table 1. A total of 2159 patients were included in the study, of whom the mean age was 64.23 ± 10.25, 1591 (73.7%) were male. Patients with NACE were elder, have a higher rate of female, chronic heart failure and chronic kidney disease. They received more CCB, nitric acid, tirofiban and PCI stent. Notably, the serum creatinine and eGFR of the five formulas were all higher in the NACE patients’ group.

Table 1 Baseline characteristics between patients with NACE and non-NACE

The prevalence of significant RD, as identified by an eGFR of less than 60 ml/min/1.73 m2, ranged from a minimum of 15.4% using the c-aGFR formula to a maximum of 39.2% using the CKD-EPIcr-Cys-C formula, with the other formulas providing intermediate values (CG 33%, CKD-EPIcr 20.4%, CKD-EPICys-C 34.7%). The average eGFR values were 86.98 ± 29.53(c-aGFR), 73.03 ± 27.93(CG), 77.18 ± 21.52(CKD-EPIcr), 71.72 ± 26.44(CKD-EPICys-C), and 65.70 ± 21.18(CKD-EPIcr-Cys-C) ml / min / 1.73 m2 respectively (Table Appendix 1 in the supplemental materials).

The incidence rates of in-hospital NACE for different grades of renal function according to the various formulas are shown in Fig. 2 (Table Appendix 2 in the supplemental materials). Logistic regression analysis showed that a high eGFR is a protective factor against in-hospital NACE as well as follow-up NACE or death (Table 2). Five formulas showed the same discriminatory capacity for predicting NACE in the entire population, with AUC values of 0.612(c-aGFR), 0.658(CG), 0.645(CKD-EPIcr), 0.608(CKD-EPICys-C), and 0.630(CKD-EPIcr-Cys-C) respectively (Fig. 3a).

Fig. 2
figure 2

Incidence of in-hospital NACE based on renal function risk classification of different eGFR formulas. * indicates the P < 0.001; # indicates the P < 0.05

Table 2 Univariate and Multivariable Logistic or Cox Regression Risk Analysis for Prediction of Death and NACE
Fig. 3
figure 3

Receiver operating characteristic (ROC) curves for prognosis prediction using different eGFR equations. a the ROC curves for in-hospital NACE; b the ROC curves for 1-year NACE; c the ROC curves for 1-year death. AUC: area under the receiver operating characteristic curve; CI: confidence interval

During the 3.23 ± 1.55-year follow-up, 1.7% death and 4.2% NACE were observed in 1 year. Kaplan-Meier survival analyses of death and NACE within 1 year categorized by renal function status according to the 5 different formulas are shown in Fig. 4. A total of 154 patients died during the 3 years of follow-up. All 5 formulas yielded similar trends in mortality and incidence rates. CKD staged by the 5 formulas was related to increased rates of mortality and NACE. The results of multivariable model and Cox regression fitting for the prediction of death and NACE using the various formulas are shown in Table 2. Regardless of the formula used, the risk of death for patients with a low glomerular filtration rate was always higher, and all formulas predicted death and secondary endpoints. The discriminatory power of each formula was assessed by calculating the AUC for the in-hospital NACE and death and NACE within 1 year (Fig. 3b and c).

Fig. 4
figure 4

Kaplan-Meier survival curves for death (a) and NACE (b) within 1 year for different eGFR formulas


This study showed the following results. First, although the glomerular filtration rates calculated by the five formulas were different and the proportion of each eGFR categorization varied markedly, the predictive value for the prognosis was consistent. Second, consistent with other studies, our study also found that RD is a good prognostic factor for NSTE-ACS patients undergoing PCI. Third, the c-aGFR formula, including only age and the serum creatinine level, is sufficient and practical for the prediction of eGFR compared to other formulas that include Cys-C.

Renal insufficiency is a predictor of coronary heart disease prognosis. However, there is no indicator in clinical work that can accurately reflect renal function, Including creatinine and Cys-C. When the kidney damage affects more than half of the entire kidney, serum creatinine will increase. The blood concentration of Cys-C is dependent on glomerular filtration without including any external factors, such as sex, age, or diet [14]. Cys-C is considered by many studies to be a relatively early and more sensitive marker than creatinine for indicating changes in renal function, but it is not measured in many hospitals. Creatinine clearance is the gold standard for assessing kidney function, but its detection is very complex and is only used for scientific research. Therefore, many evaluation formulas based on clinical indicators have been proposed. Renal function, which can be derived from different GFR evaluation formulas is considered a major risk factor for cardiovascular complications in patients with ACS [15].

Several studies have focused on assessing the prognostic value of eGFR formulas in different clinical situations. In the TRILOGY ACS Trial [2], Chiara Melloni et al. evaluated 8953 patients with ACS and found that worse CKD staging was significantly related to increased long-term risks of ischemic and bleeding outcomes. Conversely, in a recent registry study involving 1699 ACS patients, the CG equation presented a superior predictive ability for major adverse cardiovascular events to the MDRD-4 equation and was superior to the CKD-EPI equation [16]. Therefore, the difference between the predictive values of the CG formula and the CKD-EPI formula for prognosis showed mixed results.

Renal function is considered a major risk factor for cardiovascular complications in patients with ACS [15]. However, the conclusions of different studies vary regarding which formula has the best correlation with prognosis.

Piercarlo Ballo et al. followed 222 NSTE-ACS patients who underwent PCI, for 10 years to compare the predictive value of four creatinine-based eGFR formulas (CG, MDRD, CKD-EPI and Mayo-Quadratic). The Mayo-Quadratic formula was the best predictor of mortality, while the CKD-EPI formula showed the best performance in predicting cardiovascular events [7]. Katia Orvin et al. also suggested that the Mayo-Quadratic formula had better accuracy in predicting mortality than the MDRD, CG, CKD-EPI, and IB (an inulin clearance–based eGFR formula) formulas in patients with ACS [17]. The HOMAGE study, which used the CG formula adjusted for BSA, revealed a slight superiority in predicting cardiovascular mortality over the CKD-EPI and MDRD4 formulas in population with cardiovascular risk, heart failure and MI, but this advantage was not obvious in the general population [18]. Inês Almeida retrospectively assessed eGFR with the MDRD, CKD-EPIcreat, CKD-EPIcyst and CKD-EPIcreat/cyst formulas and suggested that the CKD-EPIcyst equation was superior to the MDRD formula for evaluating the mid-term mortality risk in patients admitted for ACS and added prognostic power to the GRACE score [19]. Conversely, in another larger sample size study, Axel Akerblom analyzed data from 13,632 patients in the PLATO study and found no difference in prognostic values for risk prediction of Cys-C- and creatinine-based formulas [17].

The simplified MDRD formula includes only 4 variables: sex, age, creatinine, and race; no difference in accuracy was found compared with other formulas recommended by the US CKD and dialysis clinical practice (K/DOQI) guidelines. The renal tubular secretion of creatinine differs in the Asian population, which exhibits differences in racial background and muscle mass. The national eGFR research team developed an improved original abbreviated MDRD formula (c-aGFR) based on the relevant data of 684 CKD patients in 2006, which showed smaller deviations and higher accuracy in Chinese CKD patients [20].

However, the current study focused on NSTE-ACS patients with PCI. These patients tended to be older, have more comorbidities (including worse renal function) and have worse long-term prognosis than ST segment elevation ACS patients [21]. Therefore, accurate long-term risk stratification of NSTE-ACS patients is even more crucial. Our study may therefore show that the five formulas have similar prognostic value for NSTE-ACS patients. Based on the original abbreviated MDRD formula, the c-aGFR formula is the simplest among the 5 formulas, can be easily used for the assessment of CKD patients [14] and is sufficient for assessing the prognosis of NSTE-ACS patients. Patients may not need to undergo Cys-C assessment as a routine clinical practice. Although a significant difference was observed between the CKD-EPICys-C formula and combined CKD-EPI formula for predicting mortality, the range of superiority was limited. Additionally, according to our findings, the CKD-EPICys-C formula may result in an overestimation of renal dysfunction, which does not affect the long-term prognosis.


There are some limitations of our research. First, our study is a retrospective cohort study with inherent limitations. Second, the estimation of GFR in this study is based on the creatinine value at admission. Importantly, creatinine may vary significantly in patients with ACS; therefore, the eGFR may be unstable. Third and notably, this study was conducted in NSTE-ACS patients undergoing PCI procedures, and therefore, our results cannot be extrapolated to patients who did not receive PCI. However, the PCI procedure has been recommended as a priority treatment among NSTE-ACS patients in the current guidelines. The current findings may be applicable to most current patients.


Among NSTE-ACS patients who received PCI, those with severe RD exhibited a high prevalence of in-hospital NACE as well as follow-up NACE and death regardless of the formula used to calculate the eGFR. All five eGFR assessment formulas can be used to evaluate the prognosis of ACS patients and have similar predictive value. The c-aGFR, the simplest formula for assessing eGFR and is sufficient and practical for prognosis prediction in clinical work.

Availability of data and materials

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.



Area under the curve


Bleeding academic research consortium


A modified abbreviated MDRD equation based on the Chinese CKD patients




95% confidence intervals


CKD epidemiology collaboration-creatinine


CKD epidemiology collaboration- Cystatin C


CKD epidemiology collaboration-Cys-C creatinine


Chronic kidney disease


Estimated glomerular filtration rate


Hazard ratios


The US CKD and dialysis clinical practice guidelines


Modification of diet in renal disease


Net adverse clinical events


Non-ST elevation acute coronary syndrome


Odds ratios


Percutaneous coronary intervention


Renal dysfunction


Unstable angina pectoris


  1. Anavekar NS, Mcmurray JJ, Velazquez EJ, et al. Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med. 2004;351:1285–95.

    Article  CAS  Google Scholar 

  2. Melloni C, Cornel JH, Hafley G, et al. Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: insights from the TRILOGY ACS trial. Eur Heart J Acute Cardiovasc Care. 2016;5:443–54.

    Article  Google Scholar 

  3. Al SJ, Reddan DN, Williams K, et al. Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes. Circulation. 2002;106:974–80.

    Article  Google Scholar 

  4. Fox CS, Muntner P, Chen AY, et al. Use of evidence-based therapies in and short-term outcomes of STEMI and NSTEMI in patients with chronic kidney disease: a report from the National Cardiovascular Data ACTION registry. Circulation. 2010;121(3):357–65.

    Article  CAS  Google Scholar 

  5. Stevens LA, Coresh J, Greene T, et al. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med. 2006;354:2473–83.

    Article  CAS  Google Scholar 

  6. Roffi M, Patrono C, Collet JP, et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the Management of Acute Coronary Syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267–315.

    Article  CAS  Google Scholar 

  7. Zamora E, Lupon J, de Antonio M, et al. Long-term prognostic value for patients wit8 chronic heart failure of estimated glomerular filtration rate calculated with the new CKD-EPI equations containing Cys-C. Clin Chem. 2014;60(3):481–9.

    Article  CAS  Google Scholar 

  8. Ballo P, Chechi T, Spaziani G, et al. Prognostic comparison between creatinine-based glomerular filtration rate formulas for the prediction of 10-year outcome in patients with non-ST elevation acute coronary syndrome treated by percutaneous coronary intervention. Eur Heart J Acute Cardiovasc Care. 2018;7(8):689–702.

    Article  Google Scholar 

  9. Szummer K, Lundman P, Jacobson SH, et al. Cockcroft-Gault is better than the modification of diet inRenal disease study formula at predicting outcome after a myocardial infarction: data from the Swedish web-system for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART). Am Heart J. 2010;159:979–86.

    Article  Google Scholar 

  10. Flores-Blanco PJ, Lopez-Cuenca A, Januzzi JL, et al. Comparison of risk prediction with the CKD-EPI and MDRD equations in non–ST-segment elevation acute coronary syndrome. Clin Cardiol. 2016;39(9):507–15.

    Article  Google Scholar 

  11. Chen J, He P, Liu Y, et al. Association of Parenteral Anticoagulation Therapy with Outcomes in Chinese patients undergoing percutaneous coronary intervention for non–ST-segment elevation acute coronary syndrome. JAMA Intern Med. 2019;179(2):186.

    Article  Google Scholar 

  12. Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013; 158(11):825–30.

  13. Mehran R, Rao SV, Bhatt DL, et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. Circulation. 2011;123(23):2736–47.

    Article  Google Scholar 

  14. Taglieri N, Koenig W, Kaski J. Cys-C and cardiovascular risk. Clin Chem. 2009;55:1932–43.

    Article  CAS  Google Scholar 

  15. Ozenbaum Z, Benchetrit S, Minha S, et al. The effect of admission renal function on the treatment and outcome of patients with acute coronary syndrome. Cardiorenal Med. 2017;7:169–78.

    Article  Google Scholar 

  16. Rivera-Caravaca JM, Ruiz-Nodar JM, Tello-Montoliu A, et al. Low body weight and clinical outcomes in acute coronary syndrome patients: results of the ACHILLES registry. Eur J Cardiovasc Nurs. 2017;16:696–703.

  17. Orvin K, Eisen A, Goldenberg I, et al. The proxy of renal function that most accurately predicts short- and long-term outcome after acute coronary syndrome. Am Heart J. 2015;169(5):702–71.

    Article  Google Scholar 

  18. Ferreira JP, Girerd N, Pellicori P, et al. Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Med. 2016;14(1):181.

  19. Almeida I, Caetano F, Barra S, et al. Estimating glomerular filtration rate in acute coronary syndromes: different equations, different mortality risk prediction. Eur Heart J Acute Cardiovasc Care. 2016;5(3):223–30.

    Article  Google Scholar 

  20. Kong X, Ma Y, Chen J, et al. Evaluation of the chronic kidney disease epidemiology collaboration equation for estimating glomerular filtration rate in the Chinese population. Nephrol Dial Transplant. 2013;28(3):641–51.

    Article  CAS  Google Scholar 

  21. Akerblom A, Wallentin L, Larsson A, et al. Cystatin C- and creatinine-based estimates of renal function and their value for risk prediction in patients with acute coronary syndrome: results from the PLATelet Inhibition and Patient Outcomes (PLATO) study. Clin Chem. 2013;59(9):1369–75.

    Article  Google Scholar 

Download references


Not applicable.


This study was supported by the Outstanding Young Talent Program of Guangdong Provincial People’s Hospital (grant number: KJ012019084), National Natural Science Foundation of China General Program (No. 81873495), Natural Science Foundation of Fujian Province (grant No. 2018 J01242) and Fujian Provincial Health Commission Youth Key Talents Project (Key Category) (No. 2014-ZQN-ZD-2). The funders had no role in the design of the study, the data collection and analysis, the decision to publish, or the preparation of the manuscript. The work was not funded by any industry sponsors. The authors have no other conflicts that need to be disclosed.

Author information

Authors and Affiliations



Conceptualization, G.Y. and H.P.; methodology, C.W.; software, C.P. and L.Y; validation, T.N. and C.J.; formal analysis, L.Y.; investigation, N.Z and W.X.; resources, G.W.; data curation, J.L.; writing—original draft preparation, C.W., C.P. and N.Z.; writing—review and editing, G.Y.; visualization, G.Y.; supervision, G.Y.; project administration, G.Y. and H.P.; funding acquisition, G.Y. All authors have read and approved the manuscript.

Corresponding authors

Correspondence to Pengcheng He or Yansong Guo.

Ethics declarations

Ethics approval and consent to participate

The study protocol was approved by the central ethics committee of the Guangdong Provincial People’s Hospital (NO. GDREC2016210H(R1)). Patients were included with a waiver of informed consent.

Consent for publication

Not applicable.

Competing interests

The authors declare that there is no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, W., Chen, P., Ni, Z. et al. Prognostic of different glomerular filtration rate formulas in patients receiving percutaneous coronary intervention: insights from a multicenter observational cohort. BMC Cardiovasc Disord 20, 341 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: