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Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study

Abstract

Background

The platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS).

Methods

The patients in our study were divided into two groups (high PLR group and low PLR group). A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography (OCT).

Results

The non-culprit plaques in high PLR group exhibited thinner fibrous cap thickness (FCT) (88.60 ± 44.70 vs. 119.28 ± 50.22 μm, P = 0.001), greater maximum lipid arc (271.73 ± 71.66 vs. 240.60 ± 76.69°, P = 0.027) and increased incidence of thin-cap fibroatheroma (TCFA) (34.0% vs. 15.9%, P = 0.022) compared with those in low PLR group. Meanwhile, PLR was negatively associated with FCT (r = −0.329, P < 0.001). Furthermore, multivariate regression analysis showed that PLR [OR: 1.023 (95% CI: 1.005–1.041), P = 0.012] and LDL-C [OR: 1.892 (95% CI: 1.106–3.239), P = 0.020] were significant predictors of TCFA.

Conclusions

High level of PLR may be associated with vulnerable plaque features of non-culprit lesions in patients with ACS. PLR, a cheap and easily available index, may surve as a useful inflammatory marker in reflecting plaque vulnerability.

Peer Review reports

Background

Inflammation plays a vital role in the pathophysiological process of atherosclerotic disease [1]. At the instigation of atherogenic diet, endothelial cells became inflamed and proceeded with attracting leukocyte to the nascent atherosclerotic position. As the evolution of atherosclerotic lesions, leukocytes and other vascular wall cells secrete various proinflammatory mediators, which subsequently render the plaque vulnerable and prone to rupture. Vulnerable plaque, characterized by thin fibrous caps, large lipid core, macrophage infiltration and neovascularization, is closely related to inflammation [2,3,4]. The majority of acute coronary syndromes (ACS) can be attributed to plaque vulnerability [5].

Previous researches have demonstrated that elevated platelet counts or reduced lymphocyte counts were related to poor cardiovascular clinical outcomes [6,7,8,9,10]. Furthermore, platelet to lymphocyte ratio (PLR), initially served as a systemic inflammatory biomarker to predict the prognosis of neoplastic diseases [11,12,13], recently showed distinct predictive value on mortality or major adverse cardiovascular events [14, 15]. The severity of coronary artery disease was likewise shown to be associated with PLR [16, 17]. In spite of this, the relationship between PLR and atherosclerotic plaque vulnerability is still unclear.

Optical coherence tomography (OCT) has advantages in differentiating the vulnerable plaque including thin-cap fibroatheroma (TCFA) [18]. On account of high resolution, OCT made it possible to visualize the microstructure of vulnerable plaque in either culprit or non-culprit lesions in ACS [19]. Based on the above analyses, we aimed to evaluate whether high preoperative PLR was related to plaque vulnerability of non-culprit lesions in patients with ACS.

Methods

Study population

The present retrospective study included seventy-one patients who were diagnosed with ACS (non-ST segment elevated ACS and ST segment elevated myocardial infarction) and received percutaneous coronary intervention during admission between October 2012 and January 2014. Patients with chest pain that persisted for at least 30 min, ST-segment elevation > 1 mm in at least 2 contiguous leads or new-onset left bundle branch block on a 12-lead electrocardiogram, and elevated cardiac markers such as creatine kinase-myocardial band or troponin T/I were diagnosed with ST-segment elevated myocardial infarction (STEMI). The definition of non-ST segment elevated ACS included unstable angina pectoris (UAP) and non-ST segment elevated myocardial infarction (Non-STEMI). We defined non-STEMI as an acute myocardial infarction in the absence of elevated ST-segment on electrocardiogram. UAP was defined as new-onset angina, accelerated angina or angina at rest episodes but without cardiac markers elevation. In the present study, we defined non-culprit lesions as de novo atherosclerotic lesions with an angiographically intermediate diameter stenosis (50% to 75%) in the non-culprit/non-target locations. All of the patients had written informed consent prior to the enrollment. Our study was approved by the ethics committee at the Second Affiliated Hospital of Harbin Medical University (Harbin, China).

The exclusion criteria of this study comprised left main diseases, ostial lesions, severely calcified or tortuous lesions, left ventricular ejection fraction < 40%, cardiogenic shock, renal insufficiency (baseline serum creatinine > 2.0 mg/dl), or accompanied with malignant disease, peripheral arterial disease, chronic obstructive lung disease, hematologic disease, autoimmune disease, or other systemic inflammatory conditions.

Laboratory tests

For all patients, venous blood samples were drawn from antecubital vein immediately after admission. The parameters of differential leukocyte count and platelet count were determined. Glycosylated hemoglobin, lipid profiles, creatinine and high sensitivity C-reactive protein (hs-CRP) were also assessed. The PLR was calculated as the ratio of platelet count to lymphocyte count and the neutrophil-to-lymphocyte ratio (NLR) was calculated by dividing neutrophil count by lymphocyte count.

Angiographic analysis

The lesion distribution and plaque location of patients were recorded. Quantitative coronary angiography (QCA) was analyzed using the off-line software (CAAS 5.10.1, Pie Medical Imaging BV, Maastricht, the Netherlands). The reference vessel diameter (RVD), minimum lumen diameter (MLD) and diameter stenosis (DS) were analyzed.

OCT image acquisition and analysis

Intracoronary OCT examination was performed by using frequency-domain OCT system and the procedure was conducted as previously described [20]. Two independent observers, blinded to angiographic and laboratory characteristics, analyzed the OCT images according to the criteria for plaque measurement [21]. A signal-poor region with unclearly delineated borders was identified as a lipid core. The fibrous cap on OCT images appeared as signal-rich homogeneous regions overlying the lipid core. The fibrous cap thickness (FCT) was measured 3 times at the thinnest part of fibrous cap and the average was recorded. The maximum lipid arc was measured likewise on the cross-sectional images. When a lipid core took up at least two quadrants (maximum lipid core > 90°), it was defined as a lipid-rich plaque. Thin-cap fibroatheroma (TCFA) was defined as a lipid-rich plaque with the thinnest FCT < 65 μm (Fig. 1a). Calcification on OCT images appeared as a sharply delineated, heterogeneous region. Macrophage infiltration was defined as clusters of signal-rich spots in fibrous cap with backward shadowing (Fig. 1b). Cholesterol crystals were identified as linear regions with high signal intensity in the plaque. The presence of a tubular structure with the diameter of 50-300 μm on more than 3 consecutive cross sections was considered as a microchannel (Fig. 1c). Plaque rupture was defined as a plaque with the fibrous cap discontinuity and a cavity formation within the plaque (Fig. 1d). Plaque erosion was defined as formation of thrombus adjacent to the plaque surface without signs of overlying fibrous cap discontinuity. Thrombus on OCT images appeared as an irregular mass protruding into the lumen or attached to luminal surface.

Fig. 1
figure 1

Representative optical coherence tomography images. a Thin cap fibroatheroma (TCFA) was displayed as a lipid-rich plaque (maximum lipid core > 90°) with fibrou cap thickness < 65 μm. b Macrophage infiltration (arrows) was defined as clusters of bright spots with backward shadowing. c Microchannel (arrow) was shown as a black hole in the plaque. d Ruptured plaque (arrow) was observed as a plaque with the discontinuous fibrous cap and a communication between the lipid core and the lumen

Statistical analysis

Continuous variables are expressed as mean ± standard deviation (SD) or median (25th to 75th percentiles), according to the distribution type of variables. Categorical variables are expressed as number (percentages). Continuous values were compared by independent sample t-test or Mann-Whitney U test. Categorical data were analyzed by chi-square or Fisher exact test. Correlations between PLR and plaque characteristics were assessed using Pearson correlation test or Spearman correlation rank test. To determine the important factors which indicate the presence of TCFA, univariate and multivariate logistic regression analysis were performed. Parameters with P < 0.05 in the univariate analysis were entered into the multivariate analysis models. A 2-tailed P value < 0.05 was considered statistically significant. All of the statistical analyses were performed by IBM SPSS version 19.0 (IBM Corp., Armonk, NY, USA).

Results

Baseline characteristics

Seventy-one patients with 119 non-culprit plaques were enrolled in this study. According to the median of PLR (109), enrolled patients were divided into low PLR group (PLR < 109, 36 patients with 69 plaques) and high PLR group (PLR > 109, 35 patients with 50 plaques). The baseline clinical characteristics and laboratory parameters of the two groups are shown in Tables 1 and 2. The prevalence of dyslipidemia was higher in low PLR group (41.7% vs. 20.0%, P = 0.048), whereas the percentage of renin-angiotensin system (RAS) blocker usage was lower in low PLR group (19.4% vs. 45.7%, P = 0.018). No other differences were observed between the two groups.

Table 1 Baseline Characteristics
Table 2 Laboratory Parameters

As shown in Table 2, among laboratory parameters, the platelet number and NLR were significantly higher (P = 0.01 and P = 0.007, respectively), whereas the lymphocyte count was obviously lower (P < 0.001) in high PLR group. Meanwhile, the high PLR group presented with a mildly lower triglyceride level compared with the low PLR group (P = 0.032).

Angiographic fingdings

The qualitative and quantitative characteristics of angiographic fingdings are listed in Table 3. There was no difference in the lesion distribution between the two groups. Meanwhile, we found no difference in RVD, MLD and DS between the low PLR and the high PLR group.

Table 3 Angiographic Findings

OCT findings

Table 4 shows OCT findings of the two groups. Patients in the high PLR group presented more frequent occurrence of TCFA than those in the low PLR group (34.0% vs. 15.9%, P = 0.022). FCT in the high PLR group was strikingly thinner (88.60 ± 44.70 vs. 119.28 ± 50.22 μm, P = 0.001), in addition, the high PLR group showed greater maximum lipid arc than the low PLR group (271.73 ± 71.66 vs. 240.60 ± 76.69°, P = 0.027).

Table 4 OCT Findings

PLR and OCT findings

According to whether presenting with TCFA in non-culprit lesions, we divided study population into TCFA group (22 patients with 28 plaques) and non-TCFA group (49 patients with 91 plaques) and compared the PLR values between them. As presented in Fig. 2, the TCFA group showed significantly greater PLR than the non-TCFA group (P = 0.003). As shown in Fig. 3, there was a significant negative correlation between PLR and FCT (r = −0.329, P < 0.001).

Fig. 2
figure 2

Comparison of PLR levels between patients with and without TCFA. The PLR value of the TCFA group (22 patients) was significantly greater than the non-TCFA group (49 patients) (P = 0.003)

Fig. 3
figure 3

Correlation analysis of plate-to-lymphocyte ratio (PLR) and fibrous cap thickness (FCT). The PLR was negatively associated with FCT (r = −0.329, P < 0.001)

We adopted univariate and multivariate logistic regression analysis to discuss which factors could predict the incidence of TCFA in non-culprit lesions of ACS (Table 5). Univariate regression analysis showed that LDL-C, PLR and NLR were possible predictors of the presence of TCFA. In multivariate regression analysis, LDL-C [odds ratio (OR): 1.892 (95% confidence interval (CI): 1.106–3.239), P = 0.020], PLR [OR: 1.023 (95% CI: 1.005–1.041), P = 0.012] remained independently predictable for TCFA.

Table 5 Logistic Regression Analysis of TCFA

Discussion

The main findings of this study are as follows: (i) non-culprit plaques in ACS patients with higher PLR values exhibited more vulnerable characteristics (thinner FCT, greater maximum lipid arc and higher incidence of OCT-detected TCFA); (ii) PLR values were significantly and negatively correlated with FCT of non-culprit plaques; (iii) in multivariate regression analysis, PLR manifested as an independent indicator of TCFA in non-culprit leisons. To the best of our knowledge, this is the first study assessing the relation between PLR values and non-culprit plaque vulnerability using OCT in ACS patients.

TCFA has been postulated to be the precursor lesion of plaque rupture and subsequent luminal thrombosis which is the leading cause of ACS [5, 22, 23]. In ACS patients, besides of culprit lesions, the non-culprit lesions are often characterised by TCFA. A previous intravascular ultrasound (IVUS) sutdy demonstrated that ACS patients possessed more IVUS-derived TCFA in non-culprit lesions comparing with stable patients [24]. In another study, Kato et al. [25] evaluated the plaque characteristics of non-culprit leisons in patients with and without ACS by means of OCT, the results showed that TCFA was more frequent in the non-culprit lesions of ACS patients (64.7% versus 14.9%). However, in our present study, the OCT-detected TCFA in non-culprit lesions was fewer (31.0%). This discordance perhaps due to the relatively fewer incidence of plaque rupture (14.1%) in our study. Vergallo et al. [26] previously showed that patients with non-culprit rupture presented with higher frequency of TCFA.

PLR has recently been demonstrated to be correlated with various cardiovascular diseases [27,28,29,30]. In patients with acute myocardial infarction, PLR was also an independent predictor of short-term and long-term adverse clinical events [14, 15]. In addition, Kurtul et al. [16] demonstrated that higher PLR values (PLR ≥ 116) on admission were positively associated with the intermediate to high SYNTAX score in patients with ACS. Even so, the relationship between PLR and plaque characteristics has not been directly explored. By virtue of OCT which has advantages in identifying vulnerable plaques in vivo, our study provided the direct association of PLR and non-culprit plaques vulnerability in ACS patients. The mechanisms of the link between PLR and plaque vulnerability may be associated with immuno-inflammatory response which plays a crucial role in the plaque destabilization [31]. Previous studies demonstrated that PLR was positively associated with systemic inflammation markers such as CRP [16, 17]. Furthermore, higher platelet or lower lymphocyte counts per se can be regarded as the response to inflammatory stimuli [32, 33]. In ACS patients, platelet-derived chemokines, such as CXCL4 and CCL5, were elevated and played an important role in mediating the inflammatory response to plaque destabilization [34]. On the other hand, lymphocytopenia was also a pervasive phenomenon in the setting of ACS, which may be associated with lymphocytes apoptosis induced by inflammation [35].

In accordance with our findings, the ACS patients in the high PLR group possessed higher NLR values likewise (Table 2). Meanwhile, we found that the PLR was significantly correlated with NLR (r = 0.463, P < 0.001) which has been well-defined as a predictive marker for coronary artery disease severity. Arbel et al. [36] found that higher NLR values (NLR > 3) were associated with more serious coronary artery disease and worse prognosis. Nilsson et al. [37] showed that NLR was significantly associated with non-calcified plaques detected by coronary computed tomographic angiography. The combined usefulness of PLR and NLR in predicting adverse clinical events in patients with CAD was also demonstrated by Cho et al. [38], their findings showed that higher preoperative PLR and NLR, alone or combined, were significant predictors of long-term adverse clinical events. Further studies will be needed to identify the combined usefulness of PLR and NLR in predicting atherosclerotic plaque vulnerability.

It has been verified that the majority of ACS patients were at a high risk of recurrent cardiac events due to the lesions irrelevant to the initial ischemic events [39, 40]. According to the findings of PROSPECT study [41], non-culprit lesions and culprit lesions at baseline were equally contributed to the recurrence of major adverse cardiovascular events, furthermore, the non-culprit lesions associated with recurrent events were more likely to be IVUS-detected TCFA. In our study, the PLR presented as an independent indicator of OCT-detected TCFA in non-culprit lesions of ACS patients in multivariate regression analysis. We speculated that PLR, a simple and immediately obtained parameter, may be useful in identifying vulnerable plaques and patients with high risks. However, further studies are needed to verify all of our speculations.

Limitations

There are several limitations in the present study. Firstly, the sample size in the current study was small, so more well-designed studies are warranted to confirm our findings. Secondly, this is a retrospective, single-central, cross-sectional study with a specific patient cohort, therefore we should be cautious to generalize the results to all patients. Thirdly, instead of assessing dynamic changes, we just evaluated the spot value of PLR so that we cannot ensure whether it remains an indicator of TCFA subsequently. Finally, because of the limited penetration of OCT, we were not able to show additional characteristics related to plaque vulnerability (for example plaque burden).

Conclusions

The OCT-detected TCFA in non-culprit lesions is more frequent in ACS patients with higher levels of PLR. Higher PLR levels show an important indicator of TCFA in non-culprit lesions. These findings reflect that PLR may serve as a useful indicator of atherosclerotic plaque vulnerability. Future prospective studies with large-scale samples are expected to validate the findings in our study.

Abbreviations

ACS:

Acute coronary syndrome

DS:

Diameter stenosis

FCT:

Fibrous cap thickness

hs-CRP:

High sensitivity C-reacitve protein

IVUS:

Intravascular ultrasound

MLD:

Minimum lumen diameter

NLR:

Neutrophil-to-lymphocyte ratio

OCT:

Optical coherence tomography

PLR:

Platelet to lymphocyte ratio

QCA:

Quantitative coronary angiography

RVD:

Reference vessel diameter

STEMI:

ST-segment elevated myocardial infarction

TCFA:

Thin-cap fibroatheroma

UAP:

Unstable angina pectoris.

References

  1. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–74.

    Article  CAS  PubMed  Google Scholar 

  2. Hansson GK, Libby P, Tabas I. Inflammation and plaque vulnerability. J Intern Med. 2015;278:483–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Newby AC, George SJ, Ismail Y, Johnson JL, Sala-Newby GB, Thomas AC. Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes. Thromb Haemost. 2009;101:1006–11.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Yamada S, Ding Y, Tanimoto A, Wang KY, Guo X, Li Z, et al. Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis. Arterioscler Thromb Vasc Biol. 2011;31:1555–64.

    Article  CAS  PubMed  Google Scholar 

  5. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.

    Article  CAS  PubMed  Google Scholar 

  6. Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation. 1991;84:613–7.

    Article  CAS  PubMed  Google Scholar 

  7. Ly HQ, Kirtane AJ, Murphy SA, Buros J, Cannon CP, Braunwald E, et al. Association of platelet counts on presentation and clinical outcomes in ST-elevation myocardial infarction (from the TIMI trials). Am J Cardiol. 2006;98:1–5.

    Article  PubMed  Google Scholar 

  8. Iijima R, Ndrepepa G, Mehilli J, Bruskina O, Schulz S, Schömig A, et al. Relationship between platelet count and 30-day clinical outcomes after percutaneous coronary interventions: pooled analysis of four ISAR trials. Thromb Haemost. 2007;98:852–7.

    CAS  PubMed  Google Scholar 

  9. Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ. Predictive power of the relative lymphocyte concentration in patients with advanced heart failure. Circulation. 1998;97:19–22.

    Article  CAS  PubMed  Google Scholar 

  10. Zouridakis EG, Garcia-Moll X, Kaski JC. Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris. Am J Cardiol. 2000;86:449–51.

    Article  CAS  PubMed  Google Scholar 

  11. Krenn-Pilko S, Langsenlehner U, Thurner EM, Stojakovic T, Pichler M, Gerger A, et al. The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer. 2014;110:2524–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zhang H, Gao L, Zhang B, Zhang L, Wang C. Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis. Sci Rep. 2016;6:22618.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. J. Y, GQ. Z, L. X. Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget. 2016;7:25516–27.

    Google Scholar 

  14. Ozcan Cetin EH, Cetin MS, Aras D, Topaloglu S, Temizhan A, Kisacik HL, et al. Platelet to lymphocyte ratio as a prognostic marker of in-Hospital and long-term major adverse cardiovascular events in ST-segment elevation myocardial infarction. Angiology. 2016;67:336–45.

    Article  PubMed  Google Scholar 

  15. Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis. 2012;34:326–34.

    Article  CAS  PubMed  Google Scholar 

  16. Kurtul A, Murat SN, Yarlioglues M, Duran M, Ergun G, Acikgoz SK, et al. Association of platelet-to-lymphocyte ratio with severity and complexity of coronary artery disease in patients with acute coronary syndromes. Am J Cardiol. 2014;114:972–8.

    Article  PubMed  Google Scholar 

  17. Akboga MK, Canpolat U, Yayla C, Ozcan F, Ozeke O, Topaloglu S, et al. Association of Platelet to lymphocyte ratio with inflammation and severity of coronary atherosclerosis in patients with stable coronary artery disease. Angiology. 2016;67:89–95.

    Article  CAS  PubMed  Google Scholar 

  18. Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F, Iftima N, et al. In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation. 2005;111:1551–5.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kubo T, Imanishi T, Kashiwagi M, Ikejima H, Tsujioka H, Kuroi A, et al. Multiple coronary lesion instability in patients with acute myocardial infarction as determined by optical coherence tomography. Am J Cardiol. 2010;105:318–22.

    Article  PubMed  Google Scholar 

  20. Jia H, Dai J, Hou J, Xing L, Ma L, Liu H, et al. Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study). Eur Heart J. 2017;38:792–800.

    PubMed  Google Scholar 

  21. Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the international working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012;59:1058–72.

    Article  PubMed  Google Scholar 

  22. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–82.

    Article  CAS  PubMed  Google Scholar 

  23. Kolodgie FD, Burke AP, Farb A, Gold HK, Yuan J, Narula J, et al. The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol. 2001;16:285–92.

    Article  CAS  PubMed  Google Scholar 

  24. Rodriguez-Granillo GA, Garcia-Garcia HM, Mc Fadden EP, Valgimigli M, Aoki J, de Feyter P, et al. In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol. 2005;46:2038–42.

    Article  PubMed  Google Scholar 

  25. Kato K, Yonetsu T, Kim SJ, Xing L, Lee H, McNulty I, et al. Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study. Circ Cardiovasc Imaging. 2012;5:433–40.

    Article  PubMed  Google Scholar 

  26. Vergallo R, Uemura S, Soeda T, Minami Y, Cho JM, Ong DS, et al. Prevalence and predictors of multiple coronary plaque ruptures: in vivo 3-vessel optical coherence tomography Imaging study. Arterioscler Thromb Vasc Biol. 2016;36:2229–38.

    Article  CAS  PubMed  Google Scholar 

  27. Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One. 2013;8:e67688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 2014;36:217–21.

    Article  PubMed  Google Scholar 

  29. Yayla C, Canpolat U, Akyel A, Yayla KG, Yilmaz S, Acikgoz SK, et al. Association between platelet to lymphocyte ratio and saphenous vein graft disease. Angiology. 2016;67:133–8.

    Article  CAS  PubMed  Google Scholar 

  30. Yayla C, Akboga MK, Canpolat U, Akyel A, Yayla KG, Dogan M, et al. Platelet to lymphocyte ratio can be a predictor of infarct-related artery patency in patients with ST-segment elevation myocardial infarction. Angiology. 2015;66:831–6.

    Article  CAS  PubMed  Google Scholar 

  31. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–95.

    Article  CAS  PubMed  Google Scholar 

  32. Damas JK, Waehre T, Yndestad A, Otterdal K, Hognestad A, Solum NO, et al. Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets. Circulation. 2003;107:2670–6.

    Article  CAS  PubMed  Google Scholar 

  33. Nunez J, Minana G, Bodi V, Nunez E, Sanchis J, Husser O, et al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem. 2011;18:3226–33.

    Article  CAS  PubMed  Google Scholar 

  34. Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Kuchenhoff H, et al. Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome. Thromb Haemost. 2014;112:1277–87.

    Article  CAS  PubMed  Google Scholar 

  35. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138–50.

    Article  CAS  PubMed  Google Scholar 

  36. Arbel Y, Finkelstein A, Halkin A, Birati EY, Revivo M, Zuzut M, et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis. 2012;225:456–60.

    Article  CAS  PubMed  Google Scholar 

  37. Nilsson L, Wieringa WG, Pundziute G, Gjerde M, Engvall J, Swahn E, et al. Neutrophil/lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease. PLoS One. 2014;9:e108183.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Cho KI, Ann SH, Singh GB, Her AY, Shin ES. Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One. 2015;10:e0133934.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Kubo T, Maehara A, Mintz GS, Doi H, Tsujita K, Choi SY, et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol. 2010;55:1590–7.

    Article  CAS  PubMed  Google Scholar 

  40. Cheruvu PK, Finn AV, Gardner C, Caplan J, Goldstein J, Stone GW, et al. Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study. J Am Coll Cardiol. 2007;50:940–9.

    Article  PubMed  Google Scholar 

  41. Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226–35.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Not applicable.

Funding

This study was supported by the National Natural Science Foundation of China (Grant No. 81271675).

Availability of data and materials

In consideration of patient privacy protection, the data and materials of the study are only available from the corresponding author on reasonable request.

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Authors

Contributions

XW contributed to the study design, participated in the interpretation of data and drafted the manuscript. JH contributed to the conception and design of the study and final revision of the manuscript. ZX, XL and XH participated in the study design and contributed to the data collection. JL and DH performed the statistical analysis and participated in drafting the manuscript. BY participated in the study design and data interpretation. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jingbo Hou.

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Wang, X., Xie, Z., Liu, X. et al. Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study. BMC Cardiovasc Disord 17, 175 (2017). https://doi.org/10.1186/s12872-017-0618-y

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