Table 1 Comparisons of clinical features (N = 334)
From: Decreased cardiac mortality with nicorandil in patients with ischemic heart failure
Non-nicorandil group (n = 218) | Nicorandil group (n = 116) | P-value | |
|---|---|---|---|
Age (years) | 71.7 ± 11.6 | 69.8 ± 10.5 | 0.146 |
Male gender (n, %) | 169 (77.5) | 86 (74.1) | 0.488 |
Body mass index (kg/cm2) | 23.7 ± 4.6 | 23.9 ± 4.2 | 0.708 |
Systolic blood pressure (mmHg) | 132.3 ± 36.1 | 130.8 ± 35.9 | 0.716 |
Diastolic blood pressure (mmHg) | 76.2 ± 23.3 | 72.4 ± 21.5 | 0.144 |
Heart rate (bpm) | 82.2 ± 23.8 | 77.5 ± 21.2 | 0.071 |
New York Heart Association class III or IV (n, %) | 5 (2.3) | 3 (2.6) | 0.868 |
LVEF (%) | 43.3 ± 13.6 | 45.6 ± 14.5 | 0.211 |
LMT lesion (n, %) | 9 (4.1) | 10 (8.6) | 0.134 |
3VD (n, %) | 45 (20.6) | 40 (34.5) | 0.008 |
PCI (n, %) | 159 (72.9) | 86 (74.1) | 0.813 |
CABG (n, %) | 27 (12.4) | 42 (36.2) | <0.001 |
Co-morbidity | |||
Hypertension (n, %) | 194 (89.0) | 105 (90.5) | 0.665 |
Diabetes (n, %) | 128 (58.7) | 79 (68.1) | 0.092 |
Dyslipidemia (n, %) | 193 (88.5) | 107 (92.2) | 0.286 |
Atrial fibrillation (n, %) | 64 (29.4) | 27 (23.3) | 0.235 |
Chronic kidney disease (n, %) | 151 (69.3) | 78 (67.2) | 0.704 |
Dialysis (n, %) | 28 (12.8) | 16 (13.8) | 0.865 |
Anemia (n, %) | 141 (64.7) | 78 (67.2) | 0.639 |
Smoking (n, %) | 155 (71.1) | 74 (63.8) | 0.171 |
Medications | |||
Angiotensin converting enzyme inhibitors (n, %) | 123 (56.4) | 71 (61.2) | 0.417 |
Angiotensin receptor blockers (n, %) | 67 (30.7) | 36 (31.0) | 1.000 |
Aldosterone antagonists (n, %) | 91 (41.7) | 42 (36.2) | 0.325 |
β-blockers (n, %) | 176 (80.7) | 102 (87.9) | 0.094 |
Calcium channel blockers (n, %) | 94 (43.1) | 47 (40.5) | 0.727 |
Diuretics (n, %) | 153 (70.2) | 79 (68.1) | 0.694 |
Inotropic agents (n, %) | 27 (12.4) | 11 (9.5) | 0.426 |
Anti-platelet agents (n, %) | 186 (85.3) | 113 (97.4) | <0.001 |
Anti-coagulations (n, %) | 97 (44.5) | 50 (43.1) | 0.807 |
Anti-diabetic agents (n, %) | 92 (42.2) | 59 (50.9) | 0.135 |
Statins (n, %) | 132 (60.6) | 88 (75.9) | 0.005 |
Nitrates (n, %) | 44 (20.2) | 34 (29.3) | 0.077 |
Laboratory data | |||
BNP (pg/ml)a | 306.5 (865.1) | 377.5 (619.8) | 0.374 |
C-reactive protein (mg/dl)a | 0.32 (1.19) | 0.21 (0.78) | 0.132 |
Total protein (g/dl) | 7.0 ± 0.8 | 7.0 ± 0.7 | 0.816 |
Sodium (mEq/l) | 138.2 ± 4.2 | 138.6 ± 3.5 | 0.492 |