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Table 1 Comparisons of clinical features (N = 334)

From: Decreased cardiac mortality with nicorandil in patients with ischemic heart failure

  Non-nicorandil group
(n = 218)
Nicorandil group
(n = 116)
P-value
Age (years) 71.7 ± 11.6 69.8 ± 10.5 0.146
Male gender (n, %) 169 (77.5) 86 (74.1) 0.488
Body mass index (kg/cm2) 23.7 ± 4.6 23.9 ± 4.2 0.708
Systolic blood pressure (mmHg) 132.3 ± 36.1 130.8 ± 35.9 0.716
Diastolic blood pressure (mmHg) 76.2 ± 23.3 72.4 ± 21.5 0.144
Heart rate (bpm) 82.2 ± 23.8 77.5 ± 21.2 0.071
New York Heart Association class III or IV (n, %) 5 (2.3) 3 (2.6) 0.868
LVEF (%) 43.3 ± 13.6 45.6 ± 14.5 0.211
LMT lesion (n, %) 9 (4.1) 10 (8.6) 0.134
3VD (n, %) 45 (20.6) 40 (34.5) 0.008
PCI (n, %) 159 (72.9) 86 (74.1) 0.813
CABG (n, %) 27 (12.4) 42 (36.2) <0.001
Co-morbidity
 Hypertension (n, %) 194 (89.0) 105 (90.5) 0.665
 Diabetes (n, %) 128 (58.7) 79 (68.1) 0.092
 Dyslipidemia (n, %) 193 (88.5) 107 (92.2) 0.286
 Atrial fibrillation (n, %) 64 (29.4) 27 (23.3) 0.235
 Chronic kidney disease (n, %) 151 (69.3) 78 (67.2) 0.704
 Dialysis (n, %) 28 (12.8) 16 (13.8) 0.865
 Anemia (n, %) 141 (64.7) 78 (67.2) 0.639
 Smoking (n, %) 155 (71.1) 74 (63.8) 0.171
Medications
 Angiotensin converting enzyme inhibitors (n, %) 123 (56.4) 71 (61.2) 0.417
 Angiotensin receptor blockers (n, %) 67 (30.7) 36 (31.0) 1.000
 Aldosterone antagonists (n, %) 91 (41.7) 42 (36.2) 0.325
 β-blockers (n, %) 176 (80.7) 102 (87.9) 0.094
 Calcium channel blockers (n, %) 94 (43.1) 47 (40.5) 0.727
 Diuretics (n, %) 153 (70.2) 79 (68.1) 0.694
 Inotropic agents (n, %) 27 (12.4) 11 (9.5) 0.426
 Anti-platelet agents (n, %) 186 (85.3) 113 (97.4) <0.001
 Anti-coagulations (n, %) 97 (44.5) 50 (43.1) 0.807
 Anti-diabetic agents (n, %) 92 (42.2) 59 (50.9) 0.135
 Statins (n, %) 132 (60.6) 88 (75.9) 0.005
 Nitrates (n, %) 44 (20.2) 34 (29.3) 0.077
Laboratory data
 BNP (pg/ml)a 306.5 (865.1) 377.5 (619.8) 0.374
 C-reactive protein (mg/dl)a 0.32 (1.19) 0.21 (0.78) 0.132
 Total protein (g/dl) 7.0 ± 0.8 7.0 ± 0.7 0.816
 Sodium (mEq/l) 138.2 ± 4.2 138.6 ± 3.5 0.492
  1. LVEF left ventricular ejection fraction, LMT left main trunk, 3VD three-vessel disease, PCI percutaneous coronary intervention, CABG coronary artery bypass graft, BNP B-type natriuretic peptide
  2. aData are presented as median (interquartile range)