Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

Comorbidity “depression” in heart failure — Potential target of patient education and self-management

BMC Cardiovascular DisordersBMC series – open, inclusive and trusted201717:48

https://doi.org/10.1186/s12872-017-0487-4

Received: 30 November 2016

Accepted: 27 January 2017

Published: 15 February 2017

Abstract

The progress of the pharmacological and device treatment of heart failure (HF) has led to a substantial improvement of mortality and rehospitalization. Further potential for improvement may be heralded in the post-discharge management of HF patients, including patient education for self-management of HF. The study by Musekamp et al. is among the first publications providing evidence that improvements in self-management skills may improve outcomes of HF patients. It is concluded that multimodal approaches addressing comorbidities in HF patients with novel concepts, and by optimal and specific HF management, including patient education, may ultimately contribute to substantial improvement of HF prognosis.

Keywords

Comorbidities Depression Heart failure Patient education

The article by Musekamp et al. [1] focuses on a humanitarian and medical problem which is truly impressive, namely, the self-management of heart failure (HF) patients. It is an issue that shares some similitudes with the self-management of diabetes mellitus. Albeit we are lacking reliable laboratory parameters of the homeostatic balance control, as opposed to the situation in diabetes, which assist the patient and the physician in the decision-making (i.e. the blood glucose and glycosylated hemoglobin), the approach of patient education in HF gained importance also in the current ESC guidelines for heart failure (HF), and has been implemented in the discharge management after acute heart failure (AHF) [2, 3]. However, we are lacking data on the efficacy of patient education on endpoints of HF (i.e. rehospitalization, mortality). This issue may be of importance, since several telemedicine approaches have not consistently confirmed improvement of prognosis for HF [4, 5]. Hence, the manuscript by Musekamp et al., is among the first studies providing important evidence on this issue [1].

In HF, the guide for adjusting drug doses and for deciding changes in therapeutic program includes a varied constellation of clinical signs and symptoms (dyspnea, orthopnea, pulmonary rales, nycturia, peripheral edema, jugular venous distention, hepato-jugular reflux). They corroborate and complement the valuable information arising from repeated measurements of body weight, urine output and serum natriuretic peptide, along with echocardiographic assessment, in particular the changes over time in left ventricular ejection fraction (LVEF) and/or expiratory inferior vena cava diameter, as well as the alterations in left ventricular global longitudinal strain using speckle tracking technique. In CHF home management, the recommended approach is not simply based on diagnosis and therapy, but it is also an educational approach involving the patient, as well as the patient’s family [6]. It is important to remember that one of the main reasons of fulfillment and satisfaction for a patient is the achievement of a condition of fair autonomy regarding his usual daily activities and engagements in social life.

The relationship between the perception of a satisfactory degree of autonomy and the improvement of depressive symptoms in the CHF patient is underlined by Musekamp et al. [1]. Considerable frustration and discouragement may arise from the inability to perform normal activities of daily living, such as washing, dressing, going upstairs or driving the car. However, before soliciting training programs trying to retrieve these skills, it would be important to weigh the pros and cons, in particular to consider the risks related to the execution of relatively complex tasks that may put at further risk the patient’s health, or cause embittering disillusionment [7, 8]. There is growing transnational interest in education and self-management programs for patients with chronic illnesses [9, 10]. Today, a large repertoire of organizations including hospitals and community-based facilities are actively engaged in programs providing theoretical and practical bases for HF patient’s education and rehabilitation. In particular, the programs include techniques to decrease symptoms, to successfully antagonize distress, and to improve coping. The ultimate scheduled outcome for individuals attending these programs is improvement of the quality of life. Patient empowerment and self-management have also been found to be key intermediate outcomes.

Among the studies that deal with the topic of the empowerment of CHF patients, the one by Musekamp et al. [1] provides numerous relevant insights concerning rehabilitation practice. In particular, as regards self-reported self-management skills measured at the end of rehabilitation stage (duration 3 weeks), this variable predicted long-term improvement (after a 12-month follow-up) in physical quality of life. Moreover, the same variable predicted intermediate – term improvement in mental quality of life. Surprisingly, self-reported self-management skills after 3 weeks of rehabilitation were not able to predict neither intermediate nor long term changes in depressive symptoms. Conversely, self-reported self-management skills measured after a six-month follow-up were associated with favorable changes in quality of life and depressive symptoms estimated after 12 months.

Based on these findings, one would infer that, following a program of patient empowerment and functional rehabilitation specifically projected for CHF patients, an improvement in physical and mental quality of life may be achieved more rapidly compared to the target of earning an effective relief from depressive symptoms. Therefore, the educational and psychological support of dedicated professionals (specialized nurses, psychologists, sociologists) should also be continued beyond the term of the ordinary residential rehabilitation period.

All efforts should be made to provide the patient with an adequate educational support. For example, it would be very valuable the choice to enable the patient to understand the importance of practicing regular international normalized ratio (INR) measurements for patients under phenprocoumon oral anticoagulation. Additionally, the knowledge to independently perform adjustment of diuretics may be advantageous [11]. Similarly, it would be a wise initiative to inform the patient about the sometimes deleterious but well treatable comorbidities (from anemia to osteoporosis until prostatic hypertrophy), or the decision to enable him to recognize an incipient state of hemodynamic congestion based on weight gain or decrement of urine excretion. Likewise, it would be an appropriate educational strategy convincing the patient to comply with the precaution to practice prophylaxis with influenza vaccination annually, and to inform him about the risks related to prolonged immobility in case of bone fractures or sural thrombophlebitis [2].

The increased awareness of possible disturbances and workable remedies can elicit a sense of greater peace of mind, which in turn could aid the patient to better accept his condition of disability without becoming a victim of the anxiety and depression. The neutral results of escitalopram treatment of depressive CHF patients in the randomized controlled MOOD-HF trial [7] gave rise to the hypothesis that comorbidities such as depression, which undoubtedly contribute to outcome in HF, are not necessarily responsive to the standard treatment as the respective comorbidities per se. This notion is supported by the significant “antidepressive side effect” of left ventricular assist device (LVAD) treatment in advanced HF patients, which does not primarily target depression, but directly depressed systolic LV dysfunction [8]. A likewise discrepancy may be also attributable to the negative results of the SERVE-HF trial: the fact that adaptive servo-ventilation is helpful for central sleep apnea per se, does not necessarily mean that it is of advantage in central sleep apnea in HF patients [12]. A multimodal approach addressing comorbidities in HF patients with novel concepts, and by optimal and specific HF management, including patient education, may ultimately contribute to substantial improvement of HF prognosis [2]. We still have to pave a long way of standardization of patient education and self-management for this goal in HF management, and should encourage new studies for this rather neglected field of HF research.

Abbreviations

AHF: 

Acute heart failure

CHF: 

Chronic heart failure

HF: 

Heart failure

INR: 

International normalized ratio

LVAD: 

Left ventricular assist devices

Declarations

Acknowledgements

Not applicable.

Funding

Not applicable.

Availability of data and materials

Not applicable.

Authors’ contributions

RdV and MN mainly wrote the manuscript, and all authors were involved in reviewing the manuscript. All authors approved the final manuscript.

Competing interests

MN has participated in the MOOD-HF trial. MN has received honoraria for presentations and/or participated in advisory boards from AstraZeneca, Bayer, Fresenius, Miltenyi Biotech, Novartis, Pfizer, Roche and Zoll.

Consent for publication

Not applicable.

Ethics approval and consent to participate

Not applicable.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Cardiology Unit, Presidio Sanitario Intermedio “Elena d’Aosta”
(2)
Interventional Cardiology and Cardiology Department, Mediterraneo Hospital
(3)
Department of Psychiatry, Theodor-Wenzel-Werk
(4)
Department of Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum (CVK)
(5)
Deutsches Zentrum für Herz Kreislaufforschung (DZHK) — Standort Berlin, Charité, Universitätsmedizin Berlin, Campus Virchow Klinikum (CVK)
(6)
Berlin Center for Regenerative Therapies (BCRT), Campus Virchow Klinikum (CVK)
(7)
Department of Internal Medicine I, Division of Cardiology, Pneumology, Angiology and Intensive Medical Care, University Hospital Jena, Friedrich-Schiller-University Jena

References

  1. Musekamp G, Schuler M, Seekatz B, Bengel J, Faller H, Meng K: Does improvement in self-management skills predict improvement in quality of life and depressive symptoms? A prospective study in patients with heart failure up to one year after self-management education. BMC cardiovascular disorders 2016, in press.Google Scholar
  2. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200.View ArticlePubMedGoogle Scholar
  3. Mebazaa A, Yilmaz MB, Levy P, Ponikowski P, Peacock WF, Laribi S, Ristic AD, Lambrinou E, Masip J, Riley JP, et al. Recommendations on pre-hospital and early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine--short version. Eur Heart J. 2015;36(30):1958–66.View ArticlePubMedGoogle Scholar
  4. Ong MK, Romano PS, Edgington S, Aronow HU, Auerbach AD, Black JT, De Marco T, Escarce JJ, Evangelista LS, Hanna B, et al. Effectiveness of remote patient monitoring after discharge of hospitalized patients with heart failure: the better effectiveness after transition -- heart failure (BEAT-HF) randomized clinical trial. JAMA Intern Med. 2016;176(3):310–8.View ArticlePubMedPubMed CentralGoogle Scholar
  5. Yehle KS, Plake KS, Nguyen P, Smith D. Health-related quality of life in heart failure patients with varying levels of health literacy receiving telemedicine and standardized education. Home Healthc Now. 2016;34(5):267–72.PubMedGoogle Scholar
  6. Gardetto NJ. Self-management in heart failure: where have we been and where should we go? J Multidiscip Healthc. 2011;4:39–51.View ArticlePubMedPubMed CentralGoogle Scholar
  7. Angermann CE, Gelbrich G, Stork S, Gunold H, Edelmann F, Wachter R, Schunkert H, Graf T, Kindermann I, Haass M, et al. Effect of escitalopram on All-cause mortality and hospitalization in patients with heart failure and depression: the MOOD-HF randomized clinical trial. JAMA. 2016;315(24):2683–93.View ArticlePubMedGoogle Scholar
  8. Estep JD, Starling RC, Horstmanshof DA, Milano CA, Selzman CH, Shah KB, Loebe M, Moazami N, Long JW, Stehlik J, et al. Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: results from the ROADMAP study. J Am Coll Cardiol. 2015;66(16):1747–61.View ArticlePubMedGoogle Scholar
  9. Bodenheimer T, Wagner EH, Grumbach K. Improving primary care for patients with chronic illness: the chronic care model, Part 2. JAMA. 2002;288(15):1909–14.View ArticlePubMedGoogle Scholar
  10. Newman S, Steed L, Mulligan K. Self-management interventions for chronic illness. Lancet. 2004;364(9444):1523–37.View ArticlePubMedGoogle Scholar
  11. Maisel AS, Shah KS, Barnard D, Jaski B, Frivold G, Marais J, Azer M, Miyamoto MI, Lombardo D, Kelsay D, et al. How B-type natriuretic peptide (BNP) and body weight changes vary in heart failure with preserved ejection fraction compared with reduced ejection fraction: secondary results of the HABIT (HF assessment with BNP in the home) trial. J Card Fail. 2016;22(4):283–93.View ArticlePubMedGoogle Scholar
  12. Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. 2015;373(12):1095–105.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2017

Advertisement