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Table 2 Cox regression analyses for factors associated with all-cause and cardiac-related mortality

From: Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study

Variable Univariate p-value Multivariatea p-value
  HR (95 % CI)   HR (95 % CI)  
All-cause mortality     
Age 1.07 (1.03–1.11) 0.001 1.06 (1.02–1.11) 0.003
Gender 0.67 (0.28–1.61) 0.368 0.52 (0.21–1.27) 0.150
Arterial Hypertension 0.98 (0.79–1.21) 0.821 0.97 (0.78–1.20) 0.785
Diabetes mellitus 2.26 (0.98–5.20) 0.055 2.00 (0.85–4.68) 0.111
NYHA class 4.32 (2.23–8.35 <0.001 3.01 (1.44–6.29) 0.003
(ln)NT-pro-BNP 1.56 (1.16–2.11) 0.004 1.53 (1.13–2.07) 0.006
(ln)hs-CRP 1.32 (0.99–1.76) 0.062 1.26 (0.93–1.71) 0.137
(ln)IL-6 1.39 (0.90–2.14) 0.138 1.21 (0.77–1.90) 0.398
fT4 1.17 (1.06–1.28) 0.002 1.15 (1.04–1.27) 0.005
(ln)fT3 0.12 (0.02–0.96) 0.045 0.14 (0.01–1.36) 0.089
(ln)fT3/fT4 0.09 (0.03–0.31) <0.001 0.08 (0.02–0.32) <0.001
(ln)rT3 2.29 (1.11–4.73) 0.025 2.15 (1.01–4.58) 0.049
Cardiac-related mortality     
Age 1.06 (1.01–1.11) 0.023 1.05 (1.00–1.10) 0.062
Gender 1.12 (0.44–2.84) 0.815 0.79 (0.30–2.06) 0.623
Arterial Hypertension 1.02 (0.78–1.34) 0.871 1.06 (0.81–1.38) 0.688
Diabetes mellitus 1.35 (0.40–4.56) 0.627 1.08 (0.31–3.76) 0.899
NYHA class 6.01 (3.57–14.05) <0.001 3.58 (1.43–8.94) 0.006
(ln)NT-pro-BNP 1.65 (1.13–2.41) 0.009 1.62 (1.11–2.36) 0.013
(ln)hs-CRP 1.12 (0.78–1.60) 0.537 1.08 (0.75–1.56) 0.667
(ln)IL-6 1.41 (0.82–2.40) 0.213 1.35 (0.77–2.34) 0.293
fT4 1.17 (1.04–1.31) 0.007 1.15 (1.02–1.29) 0.018
(ln)fT3 0.13 (0.01–1.71) 0.122 0.23 (0.02–3.49) 0.287
(ln)fT3/fT4 0.09 (0.02–0.43) 0.002 0.10 (0.02–0.55) 0.008
(ln)rT3 2.46 (1.02–5.29) 0.045 2.05 (0.81–5.16) 0.128
  1. HR hazard ratio, CI confidence interval, ln natural logarithm, hs-CRP high-sensitivity C-reactive protein, fT3 Free Triiodothyronine, fT4 Free Thyroxine, IL-6 Interleukin-6, NT-pro-BNP N-terminal pro-B-Type natriuretic peptide, rT3 Reverse triiodothyronine, NYHA New York Heart Association functional class
  2. aFinal model: adjusted for age, arterial hypertension, diabetes mellitus, peripheral arterial disease