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Table 2 Cox regression analyses for factors associated with all-cause and cardiac-related mortality

From: Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study

Variable

Univariate

p-value

Multivariatea

p-value

 

HR (95 % CI)

 

HR (95 % CI)

 

All-cause mortality

    

Age

1.07 (1.03–1.11)

0.001

1.06 (1.02–1.11)

0.003

Gender

0.67 (0.28–1.61)

0.368

0.52 (0.21–1.27)

0.150

Arterial Hypertension

0.98 (0.79–1.21)

0.821

0.97 (0.78–1.20)

0.785

Diabetes mellitus

2.26 (0.98–5.20)

0.055

2.00 (0.85–4.68)

0.111

NYHA class

4.32 (2.23–8.35

<0.001

3.01 (1.44–6.29)

0.003

(ln)NT-pro-BNP

1.56 (1.16–2.11)

0.004

1.53 (1.13–2.07)

0.006

(ln)hs-CRP

1.32 (0.99–1.76)

0.062

1.26 (0.93–1.71)

0.137

(ln)IL-6

1.39 (0.90–2.14)

0.138

1.21 (0.77–1.90)

0.398

fT4

1.17 (1.06–1.28)

0.002

1.15 (1.04–1.27)

0.005

(ln)fT3

0.12 (0.02–0.96)

0.045

0.14 (0.01–1.36)

0.089

(ln)fT3/fT4

0.09 (0.03–0.31)

<0.001

0.08 (0.02–0.32)

<0.001

(ln)rT3

2.29 (1.11–4.73)

0.025

2.15 (1.01–4.58)

0.049

Cardiac-related mortality

    

Age

1.06 (1.01–1.11)

0.023

1.05 (1.00–1.10)

0.062

Gender

1.12 (0.44–2.84)

0.815

0.79 (0.30–2.06)

0.623

Arterial Hypertension

1.02 (0.78–1.34)

0.871

1.06 (0.81–1.38)

0.688

Diabetes mellitus

1.35 (0.40–4.56)

0.627

1.08 (0.31–3.76)

0.899

NYHA class

6.01 (3.57–14.05)

<0.001

3.58 (1.43–8.94)

0.006

(ln)NT-pro-BNP

1.65 (1.13–2.41)

0.009

1.62 (1.11–2.36)

0.013

(ln)hs-CRP

1.12 (0.78–1.60)

0.537

1.08 (0.75–1.56)

0.667

(ln)IL-6

1.41 (0.82–2.40)

0.213

1.35 (0.77–2.34)

0.293

fT4

1.17 (1.04–1.31)

0.007

1.15 (1.02–1.29)

0.018

(ln)fT3

0.13 (0.01–1.71)

0.122

0.23 (0.02–3.49)

0.287

(ln)fT3/fT4

0.09 (0.02–0.43)

0.002

0.10 (0.02–0.55)

0.008

(ln)rT3

2.46 (1.02–5.29)

0.045

2.05 (0.81–5.16)

0.128

  1. HR hazard ratio, CI confidence interval, ln natural logarithm, hs-CRP high-sensitivity C-reactive protein, fT3 Free Triiodothyronine, fT4 Free Thyroxine, IL-6 Interleukin-6, NT-pro-BNP N-terminal pro-B-Type natriuretic peptide, rT3 Reverse triiodothyronine, NYHA New York Heart Association functional class
  2. aFinal model: adjusted for age, arterial hypertension, diabetes mellitus, peripheral arterial disease