Difference in the topography of atherosclerosis in the left versus right coronary artery in patients referred for coronary angiography
© Giannoglou et al; licensee BioMed Central Ltd. 2010
Received: 10 September 2009
Accepted: 10 June 2010
Published: 10 June 2010
We sought to determine the difference in the localization of coronary artery disease (CAD) between the left and right coronary artery system and investigate the effect of sex and age on that difference.
We retrospectively analyzed 17,323 consecutive angiographies from January 1st, 1984 to December 31st, 2003. The demographic parameters, in particular age and sex of the investigated cases as well as the angiographic results were recorded and summarized.
Of 13,305 cases with CAD, 861 (6.5%) had right coronary artery (RCA)-only disease, 4,621 (34.7%) had left coronary artery (LCA)-only disease, while 7,823 (58.8%) cases had concomitant RCA and LCA disease. LCA-only disease was more frequent than RCA-only disease [LCA-only/RCA-only odds ratio (OR): 5.37, 95% CI: 4.99 to 5.77, p < 0.001]. Women were more likely to have LCA-only disease (men/women OR 0.75 95% CI: 0.68 to 0.82, p < 0.001) compared with men who were more likely to present with concomitant RCA and LCA disease (men/women OR 1.33 95% CI: 1.21 to 1.45, p < 0.001). RCA-only and LCA-only disease were both more frequent in patients aged from 51 to 60 years, while concomitant RCA and LCA disease in patients between 61 and 70 years of age.
LCA-only disease is more frequent than RCA-only disease. Men have a higher probability than women to present with concomitant RCA and LCA disease while women are more likely than men to be found with LCA-only disease.
The localization of coronary artery disease (CAD) in the right or left coronary arterial system exhibits diverse clinical presentation and prognosis. Acute occlusions due to lesions in the left coronary artery (LCA) manifest as left ventricular infarction while respective lesions in the right coronary artery (RCA) most commonly lead to isolated infarction of the right ventricle. The origin of culprit lesions for inferior and posterior wall infarctions depends on coronary dominance thus more often arising from the RCA [1, 2]. The above clinical conditions show certain differences in their pharmacologic or interventional management, potential complications as well as patient follow-up. In this setting a further investigation of the frequency of CAD in the right or left coronary artery may be of interest.
In clinical practice, there is indirect evidence suggesting lower prevalence of atherosclerosis in the RCA than in the LCA, in particular with regards to unstable lesions. The main clinical manifestations of RCA occlusion, isolated right ventricular infarction and isolated left posterior wall infarction, are seen in only a minority of patients presenting with acute coronary syndrome [1, 2]. A topographic predilection for CAD in the LCA especially in its proximal segments has been shown in several studies, the larger being a histopathologic study of nearly 3,000 cases . Apart from this study, relevant data come either from autopsy [4, 5] or limited scale clinical studies [6–8] and have not been validated in large populations. The aim of the present study was to determine the prevalence of CAD in the LCA as compared to the RCA in a large registry of patients referred for coronary angiography to our institution and investigate the effect of sex and age on that prevalence.
Data of 17,323 consecutive patients who underwent coronary angiography for any reason in our institution from January 1st, 1984 to December 31st, 2003 were assessed through our database and retrospectively analyzed . The demographic parameters, in particular age and sex of the investigated cases were recorded and summarized. All the angiograms were evaluated by an independent expert interventional cardiologist blinded to the patients' clinical and laboratory data.
Age distribution of the study subjects
Age group (years)
Categorical variables were summarized as absolute values and percentages. Comparisons between RCA and LCA disease were carried out using McNemar test, and were expressed as p values and odds ratios (OR) for discordant cells with the corresponding 95% confidence intervals (95% CI). Comparisons between men and women were performed using Pearson's chi-square test, and were expressed as p values and OR with the corresponding 95% CI. A value of p < 0.05 was considered statistically significant.
In our registry, 13,305 out of 17,323 cases (76.8%) were found with angiographically severe CAD. Of those cases, 861 (6.5%) had RCA-only disease, 4,621 (34.7%) had LCA-only disease, while the remaining 7,823 cases (58.8%) had concomitant RCA and LCA disease. Overall, LCA-only disease was more frequent than RCA-only disease (LCA-only/RCA-only OR: 5.37, 95% CI: 4.99 to 5.77, p < 0.001).
Effects of Sex
Prevalence of RCA and LCA disease in men and women
RCA & LCA
Effects of Age
Age distribution of RCA and LCA disease in patients with significant stenoses.
Age group (years)
RCA & LCA (n)
Age distribution of RCA and LCA disease in men with significant stenoses.
Age group (years)
RCA & LCA (n)
Age distribution of RCA and LCA disease in women with significant stenoses.
Age group (years)
RCA & LCA (n)
We conducted an observational, retrospective, single-center study to evaluate the differences in the topography of CAD in the right as opposed to the left coronary arterial system in a large dataset of 17,323 patients who underwent coronary angiography during a 20-year period. The present study is the first large scale registry to demonstrate that LCA-only disease was more frequent than RCA-only disease. Our results of higher angiographic localization of atherosclerosis in LCA as compared to RCA further confirm previous findings derived from histopathologic (n = 2,964) , angiographic (n = 302) , intravascular ultrasound (n = 262)  and computed tomography (n = 102)  data. Furthermore, our results are in agreement with clinical evidence that isolated right ventricular or left posterior infarction, which are basically attributed to RCA lesions, are less common than left ventricular infarctions [1, 2].
Local hemodynamic and anatomic particulatiries of LCA vs RCA may be responsible for the predilection of atherosclerosis development in the left coronary system [12, 13]. First, the right coronary flow is more uniform during the cardiac cycle as compared to the left, which experiences a remarkable systolic decline accompanied by a significant diastolic increment [12, 14, 15]. As a result the local endothelial shear stress (ESS) in LCA is lower and more oscillatory, especially in atherosclerosis-prone regions, as compared to RCA . Low and oscillatory ESS shift the endothelial cell function and structure to a pro-atherosclerotic phenotype promoting atherosclerosis [12, 13, 16]. Second, increased wall stress is another potent atherogenic stimulus . LCA segments are exposed to higher wall stress during systole than RCA. This is a result of the different contractile properties of the left versus right ventricle [12, 17]. The greater wall stress throughout the cardiac cycle in LCA may form an atherogenic stimulus . Third, RCA and LCA have differences in anatomy. Left anterior descending artery exhibits twice the torsion of RCA . Torsion may play a major role in generating helical flow patterns, which may promote atherosclerosis progression [13, 19, 20]. Finally, the increased branching of the LCA as compared to the RCA contributes to the development of disturbed flow in the respective regions thus rendering a more atherosclerosis-susceptible environment in the LCA .
Our finding of a higher probability of men to present with concomitant RCA and LCA disease may indicate that male sex is prone to a more widespread form of atherosclerosis . On the other hand, the increased likelihood of women to present with LCA-only disease may in part explain their worse prognosis after a coronary event .
Concerning the effects of age in the localization of CAD, our findings suggest that concomitant RCA and LCA disease is found at older ages than isolated RCA or LCA involvement. This comes into consistence with previous autopsy studies exhibiting an increased prevalence of CAD with the progression of age [4, 5]. In women however, all three categories of CAD were most prevalent in an older age group than in men, and this is attributed to the established tendency for women to develop CAD at a later age than men .
Several limitations apply within our study. First, it was performed to a specific group of patients referred for coronary angiography; thus, the generalizability of our results to the general population is limited and the real prevalence of the localization of CAD in the community remains unknown. Also, a referral bias regarding the clinical presentation of the patients cannot be excluded as the study was conducted in a tertiary care center. Detailed information on the medical history of the subjects was not available due to heterogeneity of cases studied in terms of the cardiology center they were referred from and due to the lack of electronic patient records for the first years of the study. These, in association with the large number of study subjects and the long period in the past our report extends to, render not feasible to investigate on potential differences with regards to coronary artery disease risk factors. Also, we were unable to assess variations in the localization of atherosclerosis within the proximal or distal parts of the coronary arteries, although there is evidence that most thin-cap fibroatheromas and ruptured plaques are found in the proximal third of the coronaries . The burden of CAD in human coronaries was based on data from conventional angiography, although newer imaging modalities, such as intravascular ultrasound, have been proved more accurate in imaging of the anatomy and extent of CAD . Finally, the unavailability of follow up data did not permit us to evaluate the long-term outcome of CAD in relation to its localization.
In conclusion, this study attempted to provide an anatomic description of the localization of CAD in a large population referred for cardiac catheterization and to examine possible differences in atherosclerosis between RCA and LCA. LCA-only disease was more common than RCA-only disease across all ages. LCA-only disease was more likely to occur in women, while concomitant RCA and LCA disease to men. Further studies are needed to investigate the factors which may account for the variation in the localization of coronary atherosclerosis.
The authors would like to thank Dr Katerina Stoeter for her assistance in data collection.
- Andersen HR, Falk E, Nielsen D: Right ventricular infarction: frequency, size and topography in coronary heart disease: a prospective study comprising 107 consecutive autopsies from a coronary care unit. J Am Coll Cardiol. 1987, 10: 1223-1232. 10.1016/S0735-1097(87)80122-5.View ArticlePubMedGoogle Scholar
- Brady WJ, Erling B, Pollack M, Chan TC: Electrocardiographic manifestations: acute posterior wall myocardial infarction. J Emerg Med. 2001, 20: 391-401. 10.1016/S0736-4679(01)00318-3.View ArticlePubMedGoogle Scholar
- Montenegro MR, Eggen DA: Topography of atherosclerosis in the coronary arteries. Lab Invest. 1968, 18: 586-593.PubMedGoogle Scholar
- Ackerman RF, Dry TJ, Edwards JE: Relationship of Various Factors to the Degree of Coronary Atherosclerosis in Women. Circulation. 1950, 1: 1345-1354.View ArticlePubMedGoogle Scholar
- White NK, Edwards JE, Dry TJ: The Relationship of the Degree of Coronary Atherosclerosis with Age, in Men. Circulation. 1950, 1: 645-654.View ArticleGoogle Scholar
- Halon DA, Sapoznikov D, Lewis BS, Gotsman MS: Localization of lesions in the coronary circulation. Am J Cardiol. 1983, 52: 921-926. 10.1016/0002-9149(83)90506-4.View ArticlePubMedGoogle Scholar
- Schmermund A, Baumgart D, Mohlenkamp S, Kriener P, Pump H, Gronemeyer D, Seibel R, Erbel R: Natural history and topographic pattern of progression of coronary calcification in symptomatic patients: An electron-beam CT study. Arterioscler Thromb Vasc Biol. 2001, 21: 421-426.View ArticlePubMedGoogle Scholar
- Tuzcu EM, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE: High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation. 2001, 103: 2705-2710.View ArticlePubMedGoogle Scholar
- Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas GE: Prevalence of narrowing >or = 50% of the left main coronary artery among 17,300 patients having coronary angiography. Am J Cardiol. 2006, 98: 1202-1205. 10.1016/j.amjcard.2006.05.052.View ArticlePubMedGoogle Scholar
- Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Sopko G, Reis SE: Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome Evaluation. Circulation. 2004, 109: 714-721. 10.1161/01.CIR.0000115517.26897.A7.View ArticlePubMedGoogle Scholar
- Budoff MJ, Yang TP, Shavelle RM, Lamont DH, Brundage BH: Ethnic differences in coronary atherosclerosis. J Am Coll Cardiol. 2002, 39: 408-412. 10.1016/S0735-1097(01)01748-X.View ArticlePubMedGoogle Scholar
- Chatzizisis YS, Giannoglou GD, Parcharidis GE, Louridas GE: Is left coronary system more susceptible to atherosclerosis than right? A pathophysiological insight. Int J Cardiol. 2007, 116: 7-13. 10.1016/j.ijcard.2006.03.029.View ArticlePubMedGoogle Scholar
- Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH: Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007, 49: 2379-2393. 10.1016/j.jacc.2007.02.059.View ArticlePubMedGoogle Scholar
- Chatzizisis YS, Giannoglou GD: Pulsatile flow: a critical modulator of the natural history of atherosclerosis. Med Hypotheses. 2006, 67: 338-340. 10.1016/j.mehy.2006.02.005.View ArticlePubMedGoogle Scholar
- Chatzizisis YS, Giannoglou GD, Matakos A, Basdekidou C, Sianos G, Panagiotou A, Dimakis C, Parcharidis GE, Louridas GE: In-vivo accuracy of geometrically correct three-dimensional reconstruction of human coronary arteries: is it influenced by certain parameters?. Coron Artery Dis. 2006, 17: 545-551. 10.1097/00019501-200609000-00008.View ArticlePubMedGoogle Scholar
- Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley W, Rogers C, Edelman ER, et al: Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation. 2008, 117: 993-1002. 10.1161/CIRCULATIONAHA.107.695254.View ArticlePubMedGoogle Scholar
- Thubrikar MJ, Robicsek F: Pressure-induced arterial wall stress and atherosclerosis. Ann Thorac Surg. 1995, 59: 1594-1603. 10.1016/0003-4975(94)01037-D.View ArticlePubMedGoogle Scholar
- Ding Z, Zhu H, Friedman MH: Coronary artery dynamics in vivo. Ann Biomed Eng. 2002, 30: 419-429. 10.1114/1.1467925.View ArticlePubMedGoogle Scholar
- Zhu H, Ding Z, Piana RN, Gehrig TR, Friedman MH: Cataloguing the geometry of the human coronary arteries: A potential tool for predicting risk of coronary artery disease. Int J Cardiol. 2008Google Scholar
- Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN, Serruys PW: Helical velocity patterns in a human coronary artery: a three-dimensional computational fluid dynamic reconstruction showing the relation with local wall thickness. Circulation. 2000, 102: E22-24.View ArticlePubMedGoogle Scholar
- Feldman CL, Stone PH: Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque. Curr Opin Cardiol. 2000, 15: 430-440. 10.1097/00001573-200011000-00010.View ArticlePubMedGoogle Scholar
- Lerner DJ, Kannel WB: Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986, 111: 383-390. 10.1016/0002-8703(86)90155-9.View ArticlePubMedGoogle Scholar
- Schwartz LM, Fisher ES, Tosteson NA, Woloshin S, Chang CH, Virnig BA, Plohman J, Wright B: Treatment and health outcomes of women and men in a cohort with coronary artery disease. Arch Intern Med. 1997, 157: 1545-1551. 10.1001/archinte.157.14.1545.View ArticlePubMedGoogle Scholar
- Roeters van Lennep JE, Zwinderman AH, Roeters van Lennep HW, Westerveld HE, Plokker HW, Voors AA, Bruschke AV, van der Wall EE: Gender differences in diagnosis and treatment of coronary artery disease from 1981 to 1997. No evidence for the Yentl syndrome. Eur Heart J. 2000, 21: 911-918. 10.1053/euhj.1999.1941.View ArticlePubMedGoogle Scholar
- Cheruvu PK, Finn AV, Gardner C, Caplan J, Goldstein J, Stone GW, Virmani R, Muller JE: Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study. J Am Coll Cardiol. 2007, 50: 940-949. 10.1016/j.jacc.2007.04.086.View ArticlePubMedGoogle Scholar
- Schoenhagen P, Nissen S: Understanding coronary artery disease: tomographic imaging with intravascular ultrasound. Heart. 2002, 88: 91-96. 10.1136/heart.88.1.91.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/10/26/prepub
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