Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy

Mėlinytė-Ankudavičė, Karolina; Šukys, Marius; Kasputytė, Gabrielė; Krikštolaitis, Ričardas; Ereminienė, Eglė; Galnaitienė, Grytė; Mizarienė, Vaida; Šakalytė, Gintarė; Krilavičius, Tomas; Jurkevičius, Renaldas

doi:10.1186/s12872-024-03888-x

Table 4 Genes associated with better clinical, 2D echocardiographic and MRI parameters

From: Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy

	GATAD1				LOX				RASA1
	No gene variants	Gene variants	p-value		No gene variants	Gene variants	p-value		No gene variants	Gene variants	p-value
Clinical parameters				Clinical parameters				2D echocardiographic parameters
BNP, ng/l	586.4 ± 1446.73	176 ± 1161.97	0.009	BNP, ng/l	622 ± 1272.34	246.2 ± 1564.83	0.026	RAV, ml	76.9 ± 27.56	70.3 ± 17.19	0.03
2D echocardiographic parameters				2D echocardiographic parameters				RVEDV, ml	165 ± 51.85	129.7 ± 36.82	0.026
LAVi, ml/m2	50.4 ± 26.04	41.7 ± 22.93	0.027	LVEDVm ml	232 ± 82.59	203 ± 43.03	0.033	MRI parameters
GRV, ml	61.5 ± 29.67	0 ± 37.95	0.004	LVESV, ml	164 ± 68.35	131.5 ± 40.38	0.013	LVESV, ml	210 ± 92.18	193.5 ± 79.65	0.041
LVEDV, ml	220.9 ± 75.71	189 ± 60.73	0.039	LVESVi, ml/m2	74.2 ± 37.91	60.4 ± 19.88	0.033	RVEDV, ml	211 ± 380.84	183 ± 51.52	0.01
LVEDVi, ml/m2	111.8 ± 37.59	100.5 ± 29.79	0.035	RVEDV, ml	158 ± 48.04	126.7 ± 37.75	0.006	RVESV, ml	128 ± 62.94	89.5 ± 46.56	0.001
LVESV, ml	161.5 ± 63.97	112 ± 47.44	0.007	RVEDVi, ml	74.3 ± 24.30	58.1 ± 16.52	0.013	RAA, cm2	30.7 ± 8.69	25.7 ± 8.45	0.006
LVESVi, ml/m2	75.5 ± 35.23	59.4 ± 22.98	0.004	RVESV, ml	93 ± 39.89	66.8 ± 29.11	0.002	LVEF, %	25.7 ± 11.31	34.7 ± 10.28	0.011
LVESDi, ml/m2	27.3 ± 4.21	25 ± 4.01	0.033	RVESVi, ml/m2	43.7 ± 20.02	35.5 ± 13.14	0.002	LVGLS,%	-9.0 ± 4.62	-13.3 ± 4.50	0.002
LVEF, %	27 ± 8.85	32 ± 7.22	0.012	MRI parameters				LA strain, %	-8.5 ± 7.23	-13.4 ± 14.40	0.027
LVGLS, %	-8.1 ± 2.64	-10.5 ± 3.10	0.002	LVEDV, ml	302.5 ± 92.40	254 ± 72.96	0.04	RV strain, %	-12.7 ± 6.71	-16.7 ± 5.44	0.002
MRI parameters				LVEDVi, ml/m2	146.03 ± 42.82	127.3 ± 39.69	0.027	RA strain%	-12.7 ± 6.75	-16.1 ± 8.95	0.007
LVGLS, %	-10.0 ± 4.78	-12.2 ± 4.36	0.019	RVEDV, ml/m2	208.5 ± 341.87	176 ± 40.64	0.014
LVGCS, %	-15.2 ± 7.22	-18.9 ± 7.55	0.014

LVEDD – left ventricular end–diastolic diameter; LVESV – left ventricular end–systolic volume; RVEF – right ventricular ejection fraction; LVEDV – left ventricular end–diastolic volume; LVEDVi – left ventricular end–diastolic volume index; LVESV – left ventricular end–systolic volume; LVESVi – left ventricular end–systolic volume index; RVEDV – right ventricular end–diastolic volume; LAA – left atrial area; RVEDVi – right ventricular end–diastolic volume index; RVESV – right ventricular end–systolic volume; RVESVi – right ventricular end–systolic volume index; RAA – right atrial area; 2D – two dimensional; MRI – magnetic resonance imaging

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ISSN: 1471-2261

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