Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy

Table 3 Genes associated with worse clinical, 2D echocardiographic and MRI parameters

	KRAS				KRIT1
	No gene variants	Gene variants	p- value		No gene variants	Gene variants	p- value
2D echocardiographic parameters				2D echocardiographic parameters
LVEDD, mm	62 ± 5.65	64.5 ± 6.39	0.041	RVEDV, ml	131.14 ± 40.23	174 ± 50.96	0.002
LVESV, ml	138 ± 63.71	161.5 ± 55.02	0.043	RVEDVi, ml/2	61.86 ± 19.80	76.99 ± 25.22	0.004
MRI parameters				MRI parameters
RVEF, %	43.5 ± 6.96	40 ± 10.45	0.023	RVEF, %	43.48 ± 7.42	38 ± 9.93	0.037
LVEDD, mm	69 ± 6.70	75 ± 17.30	0.003	RVESV, ml	96 ± 54.14	117 ± 67.26	0.022
LVEDV, ml	272 ± 76.66	356 ± 92.29	0	RVESVi, ml/m2	36.85 ± 15.04	45.8 ± 21.95	0.001
LVEDVi, ml/m2	135.0 ± 40.36	174.6 ± 39.46	0	LVEDV, ml	290 ± 75.73	377 ± 109.77	0.038
LVESV , ml	186 ± 78.84	274 ± 90.67	0.001	RVEDV, ml	192.5 ± 56.16	228 ± 57.49	0.004
LVESVi, ml/m2	90.0 ± 42.31	126.4 ± 39.50	0.001	RAA, cm2	26.7 ± 8.52	31 ± 8.76	0.006
RVEDV, ml	188 ± 328.56	219 ± 67.57	0.033
LAA, cm2	30.5 ± 9.55	36.5 ± 9.99	0.009

2D – two dimensional; LAA – left atrial area; LVEDD – left ventricular end-diastolic diameter; LVEDV – left ventricular end-diastolic volume; LVEDVi – left ventricular end-diastolic volume index; LVESV – left ventricular end-systolic volume; LVESVi – left ventricular end-systolic volume index; LVGLS – left ventricular global longitudinal strain; LVGCS – left ventricular global circumferential strain; MRI - magnetic resonance imaging; RA – right atrial; RAA - right atrial area; RVEF – right ventricular ejection fraction; RVEDV – right ventricular end-diastolic volume; RVESV – right ventricular end-systolic volume; RVESVi – right ventricular end-systolic volume index

ISSN: 1471-2261