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Table 7 Subgroups analysis for the associations of manganese with cancer-related mortality

From: The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study

 

Q1

Q2

Q3

Q4

P for trend

P for interaction

 

HR (95%CI)

HR (95%CI)

HR (95%CI)

HR (95%CI)

  

Age

     

0.147

 < 60

1.00

0.90 (0.30, 2.71)

1.11 (0.39, 3.19)

0.98 (0.32, 3.02)

0.930

 

 ≥ 60

1.00

1.60 (0.96, 2.67)

1.11 (0.63, 1.98)

1.23 (0.68, 2.24)

0.683

 

Gender

     

0.062

 Male

1.00

1.77 (1.00, 3.15) *

1.37 (0.73, 2.56)

0.93 (0.42, 2.04)

0.867

 

 Female

1.00

1.08 (0.47, 2.45)

0.89 (0.38, 2.09)

1.55 (0.71, 3.37)

0.333

 

Race

     

0.036

 Mexican

1.00

-

-

-

-

 

 American

      

  Other Hispanic

1.00

1.87 (0.40, 8.69)

0.06 (0.01, 0.50)*

0.75 (0.14, 4.07)

0.361

 

  Non-Hispanic

1.00

1.35 (0.44, 4.14)

1.28 (0.35, 4.68)

0.58 (0.12, 2.82)

0.690

 

 Black

      

  Non-Hispanic

1.00

1.47 (0.83, 2.61)

1.31 (0.71, 2.41)

1.19 (0.60, 2.36)

0.588

 

 White

      

  Other race

1.00

-

-

-

-

 

Hypertension

     

0.033

 No

1.00

1.01 (0.43, 2.38)

0.94 (0.39, 2.27)

0.42 (0.13, 1.35)

0.210

 

 Yes

1.00

1.73 (0.99, 3.01)

1.18 (0.63, 2.19)

1.74 (0.95, 3.19)

0.172

 

DM

     

0.043

 No

1.00

1.96 (1.11, 3.46) *

1.22 (0.64, 2.32)

1.21 (0.61, 2.41)

0.843

 

 Yes

1.00

0.74 (0.29, 1.85)

1.07 (0.48, 2.42)

1.27 (0.55, 2.97)

0.526

 

CHD

     

0.126

 No

1.00

1.43 (0.88, 2.33)

1.24 (0.74, 2.07)

1.35 (0.78, 2.32)

0.345

 

 Yes

1.00

-

-

-

-

 

CHF

     

0.013

 No

1.00

1.68 (1.03, 2.76) *

1.31 (0.77, 2.22)

1.58 (0.92, 2.73)

0.172

 

 Yes

1.00

-

-

-

-

 

Angina

     

0.084

 No

1.00

1.51 (0.94, 2.43)

1.25 (0.76, 2.07)

1.30 (0.76, 2.22)

0.412

 

 Yes

1.00

-

-

-

-

 

Heart attack

     

0.592

 No

1.00

1.47 (0.90, 2.39)

1.11 (0.65, 1.87)

1.27 (0.73, 2.19)

0.579

 

 Yes

1.00

-

-

-

-

 

Stroke

     

0.036

 No

1.00

1.44 (0.90, 2.32)

1.10 (0.65, 1.84)

1.36 (0.80, 2.32)

0.408

 

 Yes

1.00

-

-

-

-

 

BMI

     

0.399

   < 30 kg m2

1.00

1.38 (0.76, 2.48)

1.28 (0.70, 2.35)

1.28 (0.66, 2.48)

0.443

 

 ≥ 30 kg/m2

1.00

1.41 (0.65, 3.03)

0.94 (0.38, 2.34)

1.25 (0.51, 3.05)

0.841

 
  1. Analysis was adjusted for age, gender, race/ethnicity. education level, marital status, family poverty-income ratio, smoker, alcohol user, hypertension, diabetes mellitus, chronic heart disease, chronic heart failure, angina, heart attack, stroke, systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, physical activity, mean energy intake, hemoglobin, glucose, blood urea nitrogen, uric acid, serum creatinine, high density lipoprotein-cholesterol, total cholesterol, and triglycerides
  2. Abbreviations: Q1 1.570–7.415 ug/L, Q2 7.416–9.230 ug/L, Q3 9.231–11.555 ug/L, Q4 11.556–57.770 ug/L, *P < 0.05, DM diabetes mellitus, BMI body mass index, HR hazard ratio, CI confidence interval