Table 6 Subgroups analysis for the associations of manganese with CVD-related mortality

Age

0.006

 < 60

1.00

0.81 (0.27, 2.41)

0.31 (0.07, 1.34)

2.32 (0.99, 5.47)

0.139

 ≥ 60

1.00

0.83 (0.50, 1.37)

1.01 (0.61, 1.66)

0.82 (0.47, 1.42)

0.623

Sex

0.163

 Male

1.00

1.00 (0.56, 1.80)

0.79 (0.42, 1.48)

1.01 (0.51, 2.01)

0.754

 Female

1.00

0.65 (0.28, 1.49)

0.85 (0.40, 1.80)

1.13 (0.55, 2.30)

0.690

Race

<0.001

 Mexican

1.00

-

-

-

-

 American

  Other Hispanic

1.00

-

-

-

-

  Non-Hispanic

1.00

0.67 (0.26, 1.71)

0.39 (0.12, 1.22)

0.73 (0.22, 2.36)

0.213

 Black

  Non-Hispanic

1.00

0.70 (0.37, 1.32)

0.83 (0.45, 1.54)

0.81 (0.43, 1.53)

0.541

 White

  Other race

1.00

-

-

-

-

Hypertension

0.004

 No

1.00

0.14 (0.03, 0.73) *

0.52 (0.15, 1.75)

1.25 (0.39, 4.02)

0.986

 Yes

1.00

1.12 (0.67, 1.86)

1.01 (0.59, 1.71)

1.14 (0.67, 1.97)

0.718

DM

0.022

 No

1.00

0.76 (0.40, 1.44)

0.62 (0.30, 1.27)

1.16 (0.62, 2.16)

0.894

 Yes

1.00

1.05 (0.51, 2.13)

1.23 (0.63, 2.41)

0.89 (0.39, 2.01)

0.966

CHD

0.019

 No

1.00

0.61 (0.35, 1.07)

0.77 (0.45, 1.32)

1.06 (0.62, 1.80)

0.947

 Yes

1.00

3.11 (0.94, 10.33)

1.58 (0.47, 5.28)

1.78 (0.48, 6.52)

0.609

CHF

0.021

 No

1.00

0.68 (0.40, 1.15)

0.61 (0.35, 1.06)

0.95 (0.56, 1.63)

0.511

 Yes

1.00

1.68 (0.45, 6.21)

5.65 (1.59, 20.12)**

2.72 (0.68, 10.83)

0.045

Angina pectoris

0.015

 No

1.00

0.66 (0.40, 1.09)

0.84 (0.52, 1.37)

1.06 (0.65, 1.73)

0.863

 Yes

1.00

-

-

-

-

Heart attack

0.005

 No

1.00

0.66 (0.39, 1.11)

0.70 (0.41, 1.18)

1.01 (0.60, 1.69)

0.782

 Yes

1.00

3.39 (0.86, 13.45)

5.48 (1.26, 23.80)*

1.54 (0.33, 7.20)

0.391

Stroke

0.003

 No

1.00

0.68 (0.41, 1.13)

0.93 (0.57, 1.51)

0.86 (0.50, 1.49)

0.726

 Yes

1.00

1.92 (0.49, 7.57)

0.03 (0.01, 0.65)*

2.72 (0.62, 11.84)

0.313

BMI

0.025

 < 30 kg m²

1.00

0.60 (0.30, 1.19)

0.94 (0.52, 1.71)

0.89 (0.46, 1.73)

0.845

 ≥ 30 kg/m²

1.00

1.35 (0.67, 2.70)

0.79 (0.34, 1.82)

1.51 (0.71, 3.19)

0.526