Fig. 8From: HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathwaySilencing HAPLN1 activated the PKA signaling pathway in HF rat model (n = 6). (A) HAPLN1 knockdown reduced MDA level and elevated GSH level in the HF rat model. (B) HAPLN1 knockdown inhibited the expression of apoptosis-related factors, including LDH, TNF-α, and IL-6 in the HF rat model. (C) In the HF rat model, silencing HAPLN1 reduced CAMKII protein phosphorylation and promoted PLB protein phosphorylation. The results are presented as the mean ± SD from three independent experiments. **P < 0.01, ***P < 0.001 vs. sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. HF + sh-NC groupBack to article page