From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
s | Model 1 (unadjusted) | Model 2 (adjusted for age, sex, and SEP) | Model 3 (Model 2 + BMI) | Model 4 (Model 2 + CVD) | Model 5 (Model 2 + diabetes) | Model 6 (Model 2 + high cholesterol) | Model 7 (Model 2 + HT) | |||||||||
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Outcome | APOE ε4 status | n | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value |
EF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,644 | 1.00 (1.00, 1.00) | 0.916 | 1.00 (1.00, 1.00) | 0.453 | 1.00 (1.00, 1.00) | 0.902 | 1.00 (1.00, 1.00) | 0.836 | 1.00 (1.00, 1.00) | 0.830 | 1.00 (1.00, 1.00) | 0.840 | 1.00 (1.00, 1.00) | 0.914 | |
LPDSR | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,505 | 1.02 (1.00, 1.03) | 0.045 | 1.00 (0.99, 1.02) | 0.657 | 1.02 (1.00, 1.03) | 0.063 | 1.02 (1.00, 1.03) | 0.032 | 1.01 (1.00, 1.03) | 0.095 | 1.02 (1.01, 1.04) | 0.002 | 1.02 (1.00, 1.03) | 0.059 | |
RPDSR | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,505 | 0.95 (0.90, 1.00) | 0.05 | 0.98 (0.94, 1.04) | 0.536 | 0.96 (0.91, 1.01) | 0.102 | 0.95 (0.90, 1.00) | 0.034 | 0.96 (0.91, 1.01) | 0.106 | 0.93 (0.88, 0.98) | 0.004 | 0.95 (0.90, 1.00) | 0.063 | |
LVmass | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,644 | 1.00 (0.99, 1.01) | 0.568 | 1.00 (1.00, 1.01) | 0.242 | 1.00 (0.99, 1.01) | 0.798 | 1.00 (0.99, 1.00) | 0.350 | 1.00 (0.99, 1.01) | 0.815 | 1.00 (0.99, 1.00) | 0.127 | 1.00 (0.99, 1.01) | 0.695 | |
MCF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,643 | 1.01 (1.00, 1.01) | 0.020 | 1.01 (1.00, 1.01) | 0.080 | 1.00 (1.00, 1.01) | 0.079 | 1.01 (1.00, 1.01) | 0.006 | 1.00 (1.00, 1.01) | 0.058 | 1.01 (1.01, 1.01) | 0.0001 | 1.01 (1.00, 1.01) | 0.034 | |
PWT | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,605 | 1.00 (0.99, 1.00) | 0.094 | 1.00 (1.00, 1.00) | 0.881 | 1.00 (1.00, 1.00) | 0.448 | 1.00 (0.99, 1.00) | 0.037 | 1.00 (1.00, 1.00) | 0.257 | 0.99 (0.99, 1.00) | 0.002 | 1.00 (1.00, 1.00) | 0.132 | |
IVS | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 32,605 | 1.00 (0.99, 1.00) | 0.128 | 1.00 (1.00, 1.00) | 0.986 | 1.00 (1.00, 1.00) | 0.537 | 1.00 (0.99, 1.00) | 0.056 | 1.00 (0.99, 1.00) | 0.281 | 1.00 (0.99, 1.00) | 0.003 | 1.00 (0.99, 1.00) | 0.179 |