From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
s | Model 1 (unadjusted) | Model 2 (adjusted for age, sex, and SEP) | Model 3 (Model 2 + BMI) | Model 4 (Model 2 + CVD) | Model 5 (Model 2 + diabetes) | Model 6 (Model 2 + high cholesterol) | Model 7 (Model 2 + HT) | |||||||||
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Outcome | APOE ε4 status | n | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value |
EF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1327 | 1.00 (0.99, 1.01) | 0.905 | 1.00 (0.99, 1.01) | 0.737 | 1.00 (0.99, 1.01) | 0.891 | 1.00 (0.99, 1.01) | 0.953 | 1.00 (0.99, 1.01) | 0.899 | 1.00 (0.99, 1.01) | 0.890 | 1.00 (0.98, 1,01) | 0.745 | |
E/e’ | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1333 | 1.01 (0.98, 1.03) | 0.531 | 1.01 (0.98, 1.03) | 0.641 | 1.01 (0.98, 1.03) | 0.540 | 1.01 (0.98, 1.03) | 0.566 | 1.01 (0.98, 1.03) | 0.578 | 1.01 (0.98, 1.03) | 0.619 | 1.01 (0.99, 1.04) | 0.354 | |
LVmass | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1333 | 0.98 (0.95, 1.01) | 0.171 | 1.01 (0.98, 1.04) | 0.501 | 0.97 (0.94, 1.00) | 0.067 | 0.98 (0.95, 1.01) | 0.171 | 0.98 (0.95, 1.01) | 0.173 | 0.98 (0.94, 1.01) | 0.172 | 0.98 (0.95, 1.02) | 0.248 | |
MCF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1325 | 1.02 (1.00, 1.05) | 0.059 | 1.01 (0.99, 1.04) | 0.270 | 1.03 (1.00, 1.05) | 0.036 | 1.02 (1.00, 1.05) | 0.060 | 1.02 (0.99, 1.05) | 0.064 | 1.03 (1.00, 1.06) | 0.057 | 1.02 (0.99, 1.05) | 0.169 | |
LVPWTs | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1335 | 0.99 (0.98, 1.01) | 0.406 | 1.00 (0.99, 1.02) | 0.784 | 0.99 (0.98, 1.01) | 0.268 | 0.99 (0.98, 1.01) | 0.364 | 0.99 (0.98, 1.01) | 0.413 | 1.00 (0.98, 1.01) | 0.627 | 0.99 (0.98, 1.01) | 0.404 | |
LVPWTd | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1335 | 0.98 (0.97, 1.00) | 0.064 | 1.00 (0.98, 1.01) | 0.631 | 0.98 (0.97, 1.00) | 0.032 | 0.98 (0.97, 1.00) | 0.059 | 0.98 (0.97, 1.00) | 0.062 | 0.98 (0.96, 1.00) | 0.029 | 0.99 (0.97, 1.01) | 0.211 | |
IVSs | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1340 | 0.99 (0.98, 1.01) | 0.415 | 1.00 (0.99, 1.02) | 0.743 | 0.99 (0.97, 1.00) | 0.242 | 0.99 (0.98, 1.01) | 0.419 | 0.99 (0.98, 1.01) | 0.422 | 0.99 (0.98, 1.01) | 0.469 | 0.99 (0.97, 1.01) | 0.409 | |
IVSd | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 1340 | 0.98 (0.97, 1.00) | 0.057 | 1.00 (0.98, 1.01) | 0.605 | 0.98 (0.96, 1.00) | 0.0231 | 0.98 (0.97, 1.00) | 0.063 | 0.98 (0.97, 1.00) | 0.063 | 0.99 (0.97, 1.00) | 0.125 | 0.98 (0.96, 1.00) | 0.085 |