From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
Model 1 (unadjusted) | Model 2 (adjusted for age, sex and SEP) | Model 3 (Model 2 + BMI) | Model 4 (Model 2 + CVD) | Model 5 (Model 2 + diabetes) | Model 6 (Model 2 + high cholesterol) | Model 7 (Model 2 + HT) | |||||||||||
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Outcome: | Cohort | Analysis | n | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value |
MCF | UK biobank | APOE ε4-linear | 32,644 | 1.01 (1.00, 1.02) | 0.082 | 1.01 (1.00, 1.02) | 0.152 | 1.01 (1.00, 1.02) | 0.239 | 1.01 (1.00, 1.02) | 0.036 | 1.01 (1.00, 1.02) | 0.123 | 1.01 (1.00, 1.02) | 0.006 | 1.01 (1.00, 1.02) | 0.109 |
SABRE + NSHD meta-analysis | APOE ε4-linear | 2074 | 1.02 (0.96, 1.08) | 0.544 | 1.02 (0.96, 1.08) | 0.516 | 1.03 (0.97, 1.09) | 0.906 | 1.01 (0.95, 1.07) | 0.729 | 1.00 (0.95, 1.07) | 0.870 | 1.01 (0.94, 1.08) | 0.780 | 1.01 (0.96, 1.07) | 0.670 | |
ALSPAC | APOE ε4-linear | 1325 | 1.00 (0.97, 1.03) | 0.984 | 1.02 (0.96, 1.08) | 0.604 | 1.01 (0.95, 1.07) | 0.74 | 1.00 (0.94, 1.06) | 0984 | 1.00 (0.95, 1.06) | 0.310 | 0.99 (0.93, 1.05) | 0.685 | 1.01 (0.94, 1.08) | 0.874 | |
UK biobank | APOE ε4 -quadratic | 32,644 | 1.00 (0.99, 1.01) | 0.770 | 1.00 (1.00, 1.01) | 0.424 | 1.00 (0.99, 1.01) | 0.972 | 1.00 (1.00, 1.01) | 0.687 | 1.00 (1.00, 1.01) | 0.711 | 1.00 (1.00, 1.01) | 0.723 | 1.00 (0.99, 1.01) | 0.803 | |
SABRE + NSHD meta-analysis | APOE ε4 -quadratic | 2074 | 0.98 (0.93, 1.03) | 0.475 | 0.98 (0.93, 1.03) | 0.451 | 0.99 (0.94, 1.04) | 0.675 | 0.98 (0.94, 1.02) | 0.327 | 0.98 (0.94, 1.02) | 0.251 | 0.97 (0.92, 1.01) | 0.174 | 0.98 (0.94, 1.02) | 0.312 | |
ALSPAC | APOE ε4 -quadratic | 1325 | 0.99 (0.98, 1.00) | 0.286 | 1.00 (0.96, 1.04) | 0.865 | 0.98 (0.95, 1.02) | 0.281 | 098 (0.95, 1.02) | 0.286 | 0.98 (0.95, 1.02) | 0.326 | 0.97 (0.94, 1.01) | 0.149 | 0.99 (0.95, 1.03) | 0.537 | |
Longitudinal PDSR | UK biobank | APOE ε4-linear | 32,505 | 1.01 (0.98, 1.04) | 0.557 | 1.00 (0.97, 1.03) | 0.855 | 1.01 (0.97, 1.04) | 0.756 | 1.01 (0.98, 1.04) | 0.476 | 1.01 (0.98, 1.04) | 0.678 | 1.02 (0.99, 1.05) | 0.199 | 1.01 (0.97, 1.04) | 0.630 |
UK biobank | APOE ε4 -quadratic | 0.99 (0.97, 1.01) | 0.499 | 1.00 (0.98, 1.02) | 0.640 | 0.99 (0.97, 1.01) | 0.388 | 0.99 (0.97, 1.02) | 0.524 | 0.99 (0.97, 1.02) | 0.524 | 0.99 (0.97, 1.02) | 0.526 | 0.99 (0.97, 1.01) | 0.477 | ||
Radial PDSR | UK biobank | APOE ε4-linear | 32,505 | 0.98 (0.88, 1.09) | 0.725 | 1.02 (0.92, 1.13) | 0.786 | 0.99 (0.89, 1.10) | 0.282 | 0.97 (0.87, 1.08) | 0.614 | 0.99 (0.89, 1.10) | 0.858 | 0.95 (0.85, 1.06) | 0.321 | 0.99 (0.88, 1.10) | 0.789 |
UK biobank | APOE ε4 -quadratic | 1.03 (0.96, 1.11) | 0.379 | 1.02 (0.96, 1.10) | 0.503 | 1.03 (0.96, 1.11) | 0.416 | 1.03 (0.96, 1.11) | 0.405 | 1.03 (0.96, 1.11) | 0.400 | 1.03 (0.96, 1.11) | 0.399 | 1.04 (0.96, 1.11) | 0.365 |