From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
s | Model 1 (unadjusted) | Model 2 (adjusted for age, sex, and SEP) | Model 3 (Model 2 + BMI) | Model 4 (Model 2 + CVD) | Model 5 ( Model 2 + diabetes) | Model 6 (Model 2 + high cholesterol) | Model 7 (Model 2 + HT) | |||||||||
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Outcome | APOE ε4 status | n | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value | Exp β (95% CI) | p-value |
EF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2463 | 1.00 (0.98, 1.03) | 0.670 | 1.00 (0.99, 1.02) | 0.687 | 1.00 (0.98, 1.03) | 0.677 | 1.00 (0.99, 1.02) | 0.773 | 1.00 (0.98, 1.02) | 0.981 | 1.01 (0.98, 1.03) | 0.689 | 1.00 (0.98, 1.02) | 0.697 | |
E/e’ | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2490 | 0.99 (0.96, 1.01) | 0.263 | 0.99 (0.97, 1.02) | 0.453 | 0.99 (0.96, 1.01) | 0.274 | 0.98 (0.96, 1.01) | 0.214 | 0.99 (0.95, 1.03) | 0.529 | 0.98 (0.95, 1.01) | 0.116 | 0.99 (0.96, 1.04) | 0.302 | |
LVmass | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2230 | 1.02 (0.98, 1.07) | 0.347 | 1.01 (0.98, 1.04) | 0.607 | 1.03 (0.98, 1.07) | 0.258 | 1.03 (0.97, 1.09) | 0.320 | 1.03 (0.98, 1.09) | 0.249 | 1.02 (0.98, 1.06) | 0.294 | 1.03 (0.98, 1.08) | 0.308 | |
MCF | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2074 | 1.04 (1.01, 1.07) | 0.016 | 1.04 (1.01, 1.07) | 0.008 | 1.04 (1.01, 1.07) | 0.007 | 1.03 (1.00, 1.06) | 0.046 | 1.03 (1.00, 1.07) | 0.069 | 1.05 (1.00, 1.09) | 0.038 | 1.03 (1.00, 1.06) | 0.030 | |
LVPWTs | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2476 | 1.00 (0.97, 1.03) | 0.859 | 0.99 (0.97,1.02) | 0.621 | 1.00 (0.97, 1.03) | 0.847 | 1.00 (0.96, 1.03) | 0.907 | 1.00 (0.97, 1.04) | 0.891 | 1.00 (0.97, 1.03) | 0.971 | 1.00 (0.97, 1.03) | 0.882 | |
LVPWTd | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2488 | 1.00 (0.97, 1.04) | 0.780 | 1.00 (0.98, 1.02) | 0.967 | 1.01 (0.97, 1.04) | 0.745 | 1.00 (0.97, 1.04) | 0.805 | 1.01 (0.98, 1.04) | 0.710 | 1.00 (0.98, 1.02) | 0.807 | 1.01 (0.97, 1.04) | 0.751 | |
IVSs | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2478 | 1.00 (0.98, 1.01) | 0.843 | 0.99 (0.98, 1.01) | 0.480 | 0.99 (0.98, 1.01) | 0.478 | 1.00 (0.99, 1.02) | 0.262 | 1.00 (0.99, 1.02) | 0.881 | 0.99 (0.98, 1.01) | 0.518 | 1.00 (0.99, 1.02) | 0.992 | |
IVSd | No APOE ε4 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
APOE ε4 carriers | 2490 | 1.00 (0.98, 1.02) | 0.776 | 1.00 (0.98, 1.02) | 0.972 | 1.00 (0.99, 1.02) | 0.758 | 1.00 (0.99, 1.02) | 0.644 | 1.01 (0.99, 1.03) | 0.389 | 1.00 (0.98, 1.03) | 0.759 | 1.00 (0.99, 1.02) | 0.605 |