Table 4 Association according to the dominant model (TA + AA vs. TT as reference) between the rs2043211 polymorphism in the CARD8 gene encoding C10X truncated variant and expression of 15 proteins studied by Olink proteomics

ADA

0.024

0.663

0.022

0.700

-0.032

0.457

-0.022

0.616

0.024

0.737

0.026

0.725

AXL

0.032

0.489

0.046

0.318

-0.052

0.113

-0.048

0.142

0.044

0.494

0.029

0.639

CCL20

-0.263

0.016

-0.241

0.030

0.051

0.525

0.027

0.744

0.142

0.300

0.136

0.334

CD40

-0.096

0.077

-0.072

0.187

-0.062

0.182

-0.062

0.191

0.059

0.452

0.080

0.340

CXCL1

-0.058

0.553

0.025

0.802

0.048

0.481

0.053

0.451

0.183

0.116

0.252

0.033

CXCL6

-0.141

0.157

-0.083

0.406

-0.021

0.806

-0.016

0.851

0.312

0.060

0.292

0.093

IL-6

-0.163

0.039

-0.159

0.045

0.019

0.788

0.024

0.713

-0.060

0.625

-0.089

0.440

IL-8

0.003

0.966

0.026

0.704

0.018

0.719

-0.001

0.984

0.021

0.837

0.008

0.938

IL-18R1

0.044

0.382

0.047

0.351

0.007

0.874

0.010

0.796

0.035

0.606

0.021

0.751

MCP-1

0.016

0.693

0.037

0.374

-0.005

0.893

-0.007

0.840

-0.011

0.864

-0.012

0.857

OPG

0.074

0.040

0.072

0.054

-0.001

0.970

-0.010

0.756

0.009

0.895

0.010

0.885

t-PA

-0.093

0.535

-0.030

0.840

0.074

0.570

0.022

0.862

0.033

0.869

0.034

0.861

TWEAK

-0.046

0.231

-0.047

0.248

0.006

0.865

-0.008

0.817

0.113

0.135

0.110

0.152

VEGF-A

-0.004

0.929

0.004

0.927

-0.022

0.580

-0.011

0.776

-0.068

0.304

-0.082

0.239

4E-BP1

-0.007

0.937

-0.013

0.884

-0.054

0.458

-0.047

0.532

0.069

0.590

0.062

0.648