BMC Cardiovascular Disorders

Table 3 Association according to the additive model (TT vs. TA vs. AA), between the rs2043211 polymorphism in the CARD8 gene encoding C10X truncated variant and expression of 15 proteins studied by Olink proteomics. A value of 0 was assigned to TT, 0.5 to TA, and 1 to AA

From: Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study

	Men					NEU women					EU Women
	Model 1^a			Model 2^b		Model 1^a			Model 2^b		Model 1^a			Model 2^b
	Coefficient	p		Coefficient	p	Coefficient	p		Coefficient	p	Coefficient	p		Coefficient	p
ADA	0.008	0.926		0.005	0.956	-0.017	0.793		-0.012	0.856	0.047	0.696		0.038	0.760
AXL	0.105	0.118		0.106	0.117	-0.091	0.069		-0.085	0.095	-0.004	0.968		0.004	0.969
CCL20	-0.361	0.023		-0.353	0.030	0.128	0.311		0.080	0.538	0.174	0.451		0.162	0.495
CD40	-0.177	0.027		-0.139	0.084	-0.080	0.271		-0.098	0.183	0.088	0.510		0.102	0.464
CXCL1	-0.152	0.296		-0.042	0.773	0.117	0.271		0.113	0.300	0.362	0.064		0.420	0.033
CXCL6	-0.200	0.177		-0.133	0.368	0.047	0.723		0.030	0.822	0.421	0.134		0.361	0.218
IL-6	-0.238	0.042		-0.241	0.039	0.111	0.300		0.092	0.358	0.020	0.923		0.005	0.981
IL-8	-0.015	0.878		0.006	0.951	0.059	0.448		0.030	0.705	0.003	0.986		-0.025	0.892
IL-18R1	0.063	0.404		0.049	0.513	0.066	0.302		0.049	0.429	0.052	0.644		0.053	0.630
MCP-1	0.087	0.151		0.108	0.082	0.007	0.887		0.003	0.956	-0.032	0.753		-0.026	0.811
OPG	0.113	0.034		0.109	0.049	0.013	0.788		-0.003	0.954	0.006	0.956		0.005	0.961
t-PA	0.007	0.974		0.061	0.785	0.149	0.463		0.000	1.000	0.037	0.910		-0.022	0.944
TWEAK	-0.069	0.225		-0.071	0.236	0.010	0.860		-0.012	0.833	0.185	0.147		0.158	0.222
VEGF-A	-0.026	0.698		-0.024	0.706	-0.025	0.684		-0.026	0.670	-0.082	0.464		-0.084	0.472
4E-BP1	-0.065	0.617		-0.083	0.520	-0.025	0.825		-0.036	0.759	0.186	0.390		0.156	0.493

^aModel 1 is adjusted for age
^bModel 2 model is adjusted for age, height, weight, body mass index, low density lipoprotein, triglycerides, systolic blood pressure, insulin, and C-reactive protein

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