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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade

Fig. 5

USP2 overexpression alleviates cardiac hypertrophy and dysfunction in mice. Mice were administrated with lentiviral vectors-carried OE-USP2 or OE-NC, followed by ISO injection. A, HW/BW of mice. B, Myocardial injury of mice analyzed by HE staining. C, LVEF and LVFS or mice analyzed by echocardiographic assessment. D, Serum levels of CK, CK-MB, LDH, and cTnT in mice determined using ELISA kits. E, ROS content in the mouse heart determined using DHE staining. F, SOD activity and MDA content in the mouse heart tissue determined using ELISA kits. G, Concentrations of ANP and BNP in the mouse heart tissue determined using ELISA kits. H, Cell apoptosis in the mouse heart tissue examined using TUNEL assay. I, Mycn mRNA expression in the mouse heart tissue examined by RT-qPCR. In each group, n = 10. Differences were analyzed using the unpaired t test or the two-way ANOVA. *p < 0.05

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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