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Fig. 1 | BMC Cardiovascular Disorders

Fig. 1

From: Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade

Fig. 1

Mycn is poorly expressed in mice with cardiac hypertrophy. A, DEGs (|Log2Foldchange| > 1 and p < 0.01) between ISO-induced hearts and hearts of healthy control mice analyzed using the GEO dataset GSE18801. B, A GO enrichment analysis of the DEGs. C, a Venn diagram for the intersecting genes between DEGs and mouse transcription factors predicted using the AnimalTFDB v4.0 system. Mice were subcutaneously injected with ISO or PBS. D, HW/BW of mice. E, Myocardial injury of mice analyzed by HE staining. F, LVEF and LVFS or mice analyzed by echocardiographic assessment. G, Serum levels of CK, CK-MB, LDH, and cTnT in mice determined using ELISA kits. H, ROS content in the mouse heart determined using DHE staining. I, Concentrations of ANP and BNP in the mouse heart tissue determined using ELISA kits. J, Cell apoptosis in the mouse heart tissue examined using TUNEL assay. K-L, SOD activity (K) and MDA content (L) in the mouse heart tissue determined using ELISA kits. M, Mycn mRNA expression in the mouse heart tissue examined by RT-qPCR. In each group, n = 10. Differences were analyzed using the unpaired t test or the two-way ANOVA. *p < 0.05

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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