Effect of sacubitril valsartan on heart failure with mid-range or preserved ejection fraction in patients on maintenance hemodialysis: real-world experience in a single-center, prospective study

Table 2 Echocardiography results at baseline for the sacubitril valsartan and control groups

	SV N = 59	Abnormal	control N = 59	Abnormal	P	Definition of abnormal
LV structure
LVEDd (mm)	53.14 ± 7.67	25	49.45 ± 7.54	15	0.01	> 54 (men), > 50 (women)
LVESd (mm)	38.61 ± 9.52	30	35.30 ± 9.12	16	0.06	> 38.8 (men), > 35.5 (women)
IVSEd (mm)	12.66 ± 2.00	46	12.42 ± 1.91	40	0.5	> 11.5 (men), > 10.7 (women)
RWT	0.46 ± 0.09	41	0.49 ± 0.08	48	0.1	> 0.42
LVMI (g/m²)	165.70 ± 44.63	50	138.18 ± 44.69	44	< 0.001	> 115 (men), > 95 (women)
LV geometry					0.5
Normal n (%)	2 (3.39)		2 (3.39)		—	—
Concentric remodeling n (%)	6 (10.17)		11 (18.64)		—	—
Concentric hypertrophy n (%)	37 (62.71)		31 (52.54)		—	—
Eccentric hypertrophy n (%)	14 (23.73)		15 (25.42)		—	—
LV systolic function						< 52 (men), 53 (women)
LVEF (%)	57.89 ± 9.35		58.00 ± 11.82		0.9
≥ 57		38		42
50–57		9		6
40–49		12		11
LVGLS	-14.87 ± 4.40	53	-16.91 ± 2.64	45	0.03	<-20%
LV diastolic function
E/e′	17.19 ± 8.74		12.31 ± 6.42		0.002	> 14
>14		28		16	0.04
≤14		31		43
TRPV (m/s)	260.19 ± 37.19	24	254.73 ± 39.11	19	0.2	> 2.8
LA size and function
LAV (ml)	66.54 ± 24.68	36	58.33 ± 23.94	26	0.08	> 58 (men), > 52 (women)
LAVI (ml/m ²)	37.69 ± 14.31		33.70 ± 13.40		0.1	> 34
>34		33		23	0.05
≤34		26		36
Valvular calcification		21		22	0.8
MV		3		4
AV		18		18
Pulmonary pressure and right ventricle
TAPSE (mm)	20.51 ± 4.12	7	20.12 ± 4.39	10	0.5	< 16
FAC (%)	46.72 ± 7.11	3	44.69 ± 8.03	5	0.3	< 35
PAsP (mmHg)	34.06 ± 9.75	31	31.57 ± 9.82	30	0.5	> 30
RIMP	0.49 ± 0.15	14	0.52 ± 0.13	21	0.2	> 0.55
RVGLS (%)	26.83 ± 6.82	17	27.45 ± 5.40	12	0.4	<-21
TAPSE/PAsP	0.69 ± 0.23		0.69 ± 0.25		0.8
RVGLS/PAsP	0.84 ± 0.36		0.98 ± 0.29		0.1

Values are expressed as n, mean ± SD, or n (%), unless specifically indicated
Abbreviations: SV, sacubitril valsartan; LVEDd, left ventricular end-diastolic diameters; IVSEd, interventricular septum end-diastolic thickness; RWT, relative wall thickness; LVMI, left ventricular mass index; LV, left ventricular; LVEF, left ventricular ejection fraction; LVGLS, left ventricular global longitudinal strain; E/e′, peak early diastolic transmitral flow velocity/peak early diastolic mitral annular tissue velocity; TRPV, tricuspid regurgitation peak velocity; LA, left atrial volume; LAV; left atrial volume; LAVI, left atrial volume index; MV, mitral valvula; AV, aortic valvula; TAPSE, tricuspid annular plane systolic excursion; FAC, fractional area change; PASP, pulmonary artery systolic pressure; RIMP, right ventricular myocardial work index; RVGLS, right ventricular global longitudinal strain

ISSN: 1471-2261