Table 1 Baseline characteristics according to C-NLR level

Basic characteristics

 Sex, male, %

740(62.1)

358(60.1)

382(64.1)

0.152

 Age, years

66.82 ± 12.52

64.97 ± 12.47

68.68 ± 12.31

< 0.001

 BMI, kg/m²

23.01 ± 3.80

23.03 ± 3.91

23.00 ± 3.70

0.882

 SBP, mmHg

122.05 ± 22.96

123.19 ± 22.79

120.91 ± 23.08

0.086

 DBP, mmHg

76.19 ± 15.05

77.09 ± 15.41

75.30 ± 14.64

0.041

 HR,

85.27 ± 21.03

82.69 ± 19.73

87.85 ± 21.96

< 0.001

beat/minute

 Smoking, %

407(34.1)

191(32.0)

216(36.2)

0.127

 NYHA IV, %

442(37.1)

187(31.4)

255(42.8)

< 0.001

Aetiologies

 Coronary disease, %

616(51.7)

284(47.7)

332(55.7)

0.005

 Hypertension, %

658(55.2)

326(54.7)

332(55.7)

0.727

 Diabetes, %

340(28.5)

151(25.3)

189(31.7)

0.015

 Peripheral vascular disease, %

376(31.5)

174(29.2)

202(33.9)

0.081

 Atrial fibrillation, %

405(34.0)

204(34.2)

201(33.7)

0.854

Laboratory data

 RBC, 10^12/L

4.54 ± 0.76

4.60 ± 0.72

4.48 ± 0.80

0.005

 WBC, 10^9/L

 NEU, 10^9/L

7.96 ± 3.84

5.55 ± 3.36

6.79 ± 2.64

4.30 ± 2.01

9.12 ± 4.46

6.80 ± 3.93

< 0.001

< 0.001

 LYM, 10^9/L

1.50 ± 0.76

1.72 ± 0.82

1.27 ± 0.62

< 0.001

 Haemoglobin, g/L

138.04 ± 24.14

140.10 ± 22.37

135.98 ± 25.64

0.003

 Sodium, mmol/L

141.00 ± 4.43

141.65 ± 3.99

140.36 ± 4.74

< 0.001

 Potassium, mmol/L

3.94 ± 0.60

3.95 ± 0.56

3.94 ± 0.64

0.759

 Albumin, g/l

36.69 ± 4.54

37.81 ± 4.26

35.57 ± 4.54

< 0.001

 ALT, IU/L

25.05 (16.70,42.30)

24.20 (16.53,38.48)

26.75 (16.73,49.80)

0.009

 AST, IU/L

28.60 (20.10,43.28)

27.20 (20.00,37.40)

30.00 (20.53,53.33)

< 0.001

 STB, μmol/L

15.80 (10.40,24.60)

15.10 (10.10,23.18)

16.30 (10.73,25.70)

0.053

 CB, μmol/L

7.10 (4.60,12.00)

6.70 (4.40,10.90)

7.40 (4.93,12.88)

0.002

 TC, mmol/L

3.66 (3.00,4.21)

3.67 (3.12,4.27)

3.60 (2.94,4.15)

0.016

 TG, mmol/L

1.12 (0.87,1.43)

1.13 (0.86,1.51)

1.10 (0.87,1.36)

0.150

 Cre, μmol/L

103.50 (83.20,134.10)

98.00 (81.60,123.85)

109.30 (85.70,144.03)

< 0.001

 Urea, mmol/L

7.48 (5.72,10.26)

6.93 (5.60,9.29)

8.11 (5.91,11.63)

< 0.001

 UA, μmol/L

485.10 (376.48,586.00)

474.20 (374.20,569.70)

494.73 (379.60,604.38)

0.063

 eGFR, ml/min

44.10 (32.29,56.69)

47.20 (35.52,59.50)

41.11 (28.30,53.70)

< 0.001

 BNP, pg/ml

1405.00 (877.48,2307.50)

1240.00 (811.25,2067.50)

1570.00 (952.25,2627.50)

< 0.001

 lgBNP

3.17 ± 0.28

3.13 ± 0.27

3.21 ± 0.29

< 0.001

 CRP, mg/L

7.50 (3.02,21.78)

3.02 (1.59,5.44)

21.61 (12.50,47.80)

< 0.001

 NLR

3.31 (2.17,5.71)

2.52 (1.78,3.55)

4.89 (3.09,8.28)

< 0.001

 C-NLR

27.56 (7.88,95.15)

7.90 (3.97,15.24)

95.02 (51.16,238.38)

< 0.001

ECG parameters and Echocardiographic data

 QRS wave, ms

106.00 (94.00,128.00)

106.00 (95.00,128.00)

106.00 (93.00,128.00)

0.257

 LVEF, %

43.00 (33.00,58.00)

42.00 (32.00,58.00)

44.00 (34.00,58.00)

0.156

 LVEF group

 HFrEF

523(43.9)

278(46.6)

245(41.1)

 HFmrEF

205(17.2)

91(15.3)

114(19.1)

0.087

 HFpEF

464(38.9)

227(38.1)

237(39.8)

 LVEDV, ml

180.00 (126.00,238.00)

186.00 (139.25,244.00)

171.50 (118.00,230.75)

< 0.001

 LVESV, ml

105.00 (55.00,158.00)

111.50 (61.00,164.00)

96.00 (51.00,150.00)

0.001

Treatment

 ACEI/ARB/ARNI, %

655(54.9)

325(54.5)

330(55.4)

0.771

 Beta-blocker, %

592(49.7)

312(52.3)

280(47.0)

0.064

 CRT/D,%

116(9.7)

61(10.2)

55(9.2)

0.558

 SGLT2i, %

240(20.1)

123(20.6)

117(19.6)

0.665

 Diuretics, %

983(82.5)

486(81.5)

497(83.4)

0.402