Table 1 Outcomes which have been reported in the original studies

Caravaca2020 [14]

Ischemic stroke/TIA, acute MI, mortality, major bleeding, clinically relevant non-major bleeding, any bleeding

Non-valvular AF

Follow up by nurse every 6 months

Fuenzalida2017 [15]

Heart failure, stroke or systemic embolism, anti-arrhythmic treatment-related complications, death, emergency visits, admissions

Mainly permanent AF followed by paroxysmal AF

3 months follow-up

Hendriks2012 [16]

Composite endpoints, cardiovascular deaths, cardiac arrhythmic, cardiac non-arrhythmic death, vascular non-cardiac death, cardiovascular hospitalization, arrhythmic events, atrial fibrillation, syncope, ventricular tachycardia, cardiac arrest, heart failure, acute MI, stroke, systemic embolism, major bleeding, life-threatening effects of drug

Mainly symptomatic AF followed by paroxysmal AF and then permanent AF

3, 6 and 12 months

Inglis2004 [17]

All-cause mortality, acute MI, angina, atrial fibrillation, congestive heart failure, stroke

Chronic AF

Regular follow-up during a period of 5 years

Wijtvliet2020 [18]

Composite endpoints, cardiovascular deaths, cardiac arrhythmic, cardiac non-arrhythmic death, vascular non-cardiac death, cardiovascular hospitalization, arrhythmic events, atrial fibrillation, syncope, ventricular tachycardia, cardiac arrest, heart failure, acute MI, stroke, systemic embolism, major bleeding, life-threatening effects of drug

First time detected AF, mostly paroxysmal AF

3, 6, 12 months and yearly follow-up

Yan2022 [19]

Cardiovascular hospitalization, atrial fibrillation, heart failure, stroke, ventricular tachycardia, cardiovascular death

Chronic AF

1, 3, 6, 12 months follow-up