Table 3 CMR and clinical variables correlated to the need of pharmacological therapy
Variable | No outcome (N = 93) | Outcome (N = 37) | All patients (N = 130) | p | |||
|---|---|---|---|---|---|---|---|
VO2max (ml/kg/min), N = 71 | 29.0 | (27.1–34.1) | 23.9 | (17.3–31.1) | 28.0 | (23.9–32.5) | 0.002 |
VO2max pre-homograft (ml/kg/min), N = 38 | 29.5 | (24.0 -32.4) | 20.2 | (15.4–22.2) | 27.0 | (20.8–31.0) | 0.006 |
Body mass index (kg/m2) | 22.1 | (20.3–24.2) | 24.2 | (22.6–26.2) | 22.6 | (20.7–25.0) | 0.005 |
Weight (kg) | 60.0 | (55.0–70.0) | 68.0 | (60.0–78.0) | 64.0 | (55.0–73.0) | 0.041 |
LV mass/volume (g/ml) | 0.6 | (0.5–0.6) | 0.6 | (0.5–0.7) | 0.6 | (0.5–0.7) | 0.025 |
RA transverse diameter (cm) | 4.7 | (4.2–5.2) | 5.5 | (4.7–6.7) | 4.9 | (4.3–5.5) | < 0.001 |
RA longitudinal diameter (cm) | 4.9 | (4.2–5.3) | 5.7 | (5.0 -6.9) | 5.0 | (4.4–5.6) | < 0.001 |
RA area (cm2) | 19.0 | (16.0–23.0) | 27.0 | (22.0–36.0) | 20.0 | (16.0–25.0) | < 0.001 |
IVS LGE (cm) | 0.0 | (0.0–0.0) | 0.0 | (0.0 -2.2) | 0.0 | (0.0 -1.5) | 0.009 |
RVOT aneurysm coronal diameter (mm), N = 32 | 34.0 | (32.0–36.0) | 43.0 | (38.0–54.0) | 35.5 | (33.5–42.5) | 0.003 |
Age at first CMR (years) | 19.9 | (17.6–25.1) | 43.9 | (34.9–50.6) | 22.1 | (18.0 -36.7) | < 0.001 |
Age at TOF repair (months), N = 127 | 14.7 | (7.6–34.5) | 93.6 | (36.5 -170.2) | 23.1 | (9.5–67.7) | < 0.001 |
Time from repair to CMR (years), N = 127 | 17.9 | (16.7–21.5) | 32.6 | (21.0 -41.2) | 19.1 | (16.8–28.5) | < 0.001 |
Type of TOF repair | 0.048 | ||||||
Transannular patch | 62 | (66.7%) | 18 | (48.6%) | 80 | (61.5%) | |
Infundibular patch | 25 | (26.9%) | 10 | (27.0%) | 35 | (26.9%) | |
Double revision of repair | 3 | (3.2%) | 3 | (8.1%) | 6 | (4.6%) | |
Other | 1 | (1.1%) | 1 | (2.7%) | 2 | (1.5%) | |
Unknown | 2 | (2.2%) | 5 | (13.5%) | 7 | (5.4%) | |
IVS LGE | 0.018 | ||||||
No | 72 | (77.4%) | 21 | (56.8%) | 93 | (71.5%) | |
Yes | 21 | (22.6%) | 16 | (43.2%) | 37 | (28.5%) | |
RPA, N = 129 | 0.044 | ||||||
Normal anatomy | 64 | (69.6%) | 18 | (48.6%) | 82 | (63.6%) | |
Stenosis | 11 | (12.0%) | 4 | (10.8%) | 15 | (11.6%) | |
Hypoplasia | 3 | (3.3%) | 1 | (2.7%) | 4 | (3.1%) | |
Dilation | 14 | (15.2%) | 14 | (37.8%) | 28 | (21.7%) | |
MPA bifurcation geometry | 0.007 | ||||||
Normal | 80 | (86.0%) | 24 | (64.9%) | 104 | (80.0%) | |
Angled | 13 | (14.0%) | 13 | (35.1%) | 26 | (20.0%) | |
Sinus rhythm | 0.001 | ||||||
No | 0 | (0.0%) | 4 | (10.8%) | 4 | (3.1%) | |
Yes | 93 | (100.0%) | 33 | (89.2%) | 126 | (96.9%) | |
NYHA class, N = 129 | 0.012 | ||||||
1 | 84 | (90.3%) | 25 | (69.4%) | 109 | (84.5%) | |
2 | 8 | (8.6%) | 7 | (19.4%) | 15 | (11.6%) | |
3 | 1 | (1.1%) | 3 | (8.3%) | 4 | (3.1%) | |
4 | 0 | (0.0%) | 1 | (2.8%) | 1 | (0.8%) | |
Number of stenotic/hypoplastic/dilated PA, N = 129 | 0.021 | ||||||
0 | 35 | (38.0%) | 7 | (18.9%) | 42 | (32.6%) | |
1 | 34 | (37.0%) | 12 | (32.4%) | 46 | (35.7%) | |
2 | 23 | (25.0%) | 18 | (48.6%) | 41 | (31.8%) | |