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Table 1 Summary of the included studies

From: Transcatheter aortic valve implantation versus surgical aortic valve replacement for pure aortic regurgitation: a systematic review and meta-analysis of 33,484 patients

Study ID

Study design

Multicentric or single centric

Propensity-matched?

Country

Duration

Number of patients

Details of TAVI

Details of SAVR

Main inclusion criteria

Main exclusion criteria

Severity of AR

Implanted valve type

Valve size

Valve calcification

Follow-up period

Primary outcome

TAVI

SAVR

Total

Alharbi et al. 2020 [19]

Propensity-matched retrospective cohort study

Multicenter

Yes

United States

2016 to 2017

915

1390

2305

The NIS database lacks procedural details for TAVI and SAVR

Patients with pure AR

Infective endocarditis, concomitant AS, and those below the age of 18 years

NR

NR

NR

NR

In-hospital

In-hospital mortality

Mentias et al. 2023 [18]

Propensity-matched retrospective cohort study

Multicenter

Yes

United States

2016 to 2019

1147

9880

11,027

Transfemoral TAVI

NR

Patients with pure AR

Concomitant AS, valve-in-valve intervention, and other concomitant cardiac surgery or intervention

NR

NR

NR

NR

One year

One-year mortality

Oettinger et al. 2023 [31]

Retrospective cohort study

Multicenter

No

Germany

2018 to 2020

746

4025

4771

- Transapical TAVI - Transfemoral TAVI with a self-expandable and balloon-expandable valve

NR

Patients with pure AR

Concomitant AS, concomitant cardiac surgery or intervention

NR

Balloon-expandable and self-expanding valves

NR

NR

In-hospital

In-hospital mortality, major bleeding, and postoperative delirium

Rali et al. 2022 [32]

Retrospective cohort study

Multicenter

No

United States

2015 to 2018

105

50

155

The NIS database lacks procedural details for TAVR and SAVR.

Patients with pure AR

NR

NR

NR

NR

NR

NR

A composite of in-hospital mortality, stroke, transient ischemic stroke, myocardial infarction, pacemaker implantation, need for open surgery, vascular complications, and cardiac tamponade.

Stachon et al. 2020 [20]

Retrospective cohort study

Multicenter

No

Germany

2007 to 2015

724

10,528

11,252

Transapical and transfemoral TAVI

NR

Patients with pure AR and/or AS

NR

NR

NR

NR

NR

In-hospital

In-hospital mortality and complications (stroke, bleeding, post-operative delirium, ventilation, and length of hospital stay)

Zhou et al. 2023 [21]

Propensity-matched retrospective cohort study

Multicenter

Yes

China

2016 to 2019

1820

1820

3640

NR

Patients with AR

Concomitant AS, aged < 18 years, infective endocarditis, history of other cardiac surgeries

NR

NR

NR

NR

Six months

In-hospital mortality, mechanical ventilation, transfusion, sepsis, bacterial pneumonia, acute kidney injury, cardiac arrest, and intracranial hemorrhage

  1. Abbreviations: TAVI transcatheter aortic valve implantation, SAVR surgical aortic valve replacement, AR aortic regurgitation, ESC/EACTS European Society of Cardiology/European Association for cardiothoracic surgery, LVEF left ventricular ejection fraction, LVEED left ventricular end-diastolic diameter, NR not reported, and AS aortic stenosis