Net clinical benefit of oral anticoagulants in Asian patients with atrial fibrillation based on a CHA2DS2-VASc score

Table 4 Annual major bleeding events in atrial fibrillation patients with or without oral anticoagulants (OACs) stratified by CHA₂DS₂-VASc score (CI = confidence interval)

CHA₂DS₂-VASc score	Number of patients	Number of events	100 person-years	Rate per 100 person-years	95% CI
All patients
0	196	2	4.0	0.49	0.06–1.81
1	422	5	8.9	0.56	0.18–1.31
2	694	26	14.5	1.79	1.17–2.63
3	782	40	16.7	2.39	1.71–3.26
4	618	37	13.0	2.85	2.00-3.92
5	419	28	9.1	3.07	2.04–4.45
≥ 6	271	14	5.6	2.48	1.37–4.19
Total	3402	152	71.9	2.11	1.79–2.48
OACs
0	61	2	1.3	1.54	0.19–5.56
1	236	4	4.9	0.82	0.22–2.09
2	539	23	11.0	2.10	1.33–3.14
3	641	35	13.6	2.57	1.79–3.58
4	515	32	10.6	3.01	2.06–4.26
5	352	26	7.6	3.41	2.23–5.01
≥ 6	222	11	4.6	2.38	1.19–4.28
Total	2566	133	53.6	2.48	2.08–2.94
No OACs
0	135	0	2.7	0.00	-
1	186	1	4.0	0.25	0.01–1.39
2	155	3	3.5	0.85	0.18–2.50
3	141	5	3.1	1.61	0.52–3.76
4	103	5	2.3	2.15	0.71–5.07
5	67	2	1.5	1.32	0.16–4.82
≥ 6	49	3	1.0	2.91	0.62–8.77
Total	836	19	18.3	1.04	0.63–1.62

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