Table 3 Results from the ordinal logistic regression analysis regarding the cumulative number of conditions from none to one condition (frailty or sarcopenia), to two coexisting conditions (frailty and sarcopenia)

Age

1.03 (1.00, 1.07)

0.050

1.13 (1.06, 1.20)

< 0.001

Sex

 Men

1

1

 Women

10.81 (4.42, 26.49)

< 0.001

65.65 (13.50, 319.15)

< 0.001

LVEF

 HFrEF + HFmrEF

1

1

 HFpEF

2.09 (0.91, 4.80)

0.081

5.61 (1.22, 25.76)

0.026

NYHA Classification

 Classes II + III

1

1

 Class I

0.29 (0.11, 0.76)

0.012

1.32 (0.26, 6.79)

0.742

Medicines

 ACE inhibitors

0.82 (0.32, 2.07)

0.668

0.74 (0.09, 6.15)

0.783

 Beta blockers

0.45 (0.09, 2.29)

0.340

0.52 (0.04, 6.84)

0.638

 Aldosterone antagonists

0.51 (0.23, 1.32)

0.098

0.71 (0.17, 2.97)

0.879

 Statins

0.42 (0.19, 0.93)

0.032

0.06 (0.01, 0.30)

0.001

 Furosemide

2.76 (1.26, 6.08)

0.011

3.95 (1.07, 14.55)

0.039

 Sacubitril/valsartan

0.64 (0.16, 2.46)

0.514

0.81 (0.05, 12.43)

0.879

 Ivabradine

0.79 (0.27, 2.33)

0.669

0.82 (0.14, 4.79)

0.828

 Thiazide diuretics

0.44 (0.05, 3.93)

0.464

0.04 (0.01, 1.52)

0.083

 Acetylsalicylic acid

0.92 (0.37, 2.27)

0.856

5.01 (1.10, 22.90)

0.038

 Nitrates

1.13 (0.35, 3.72)

0.837

0.20 (0.03, 1,38)

0.103

 Digoxin

0.96 (0.25, 3.73)

0.954

0.21 (0.02, 1.85)

0.158

 Antiarrhythmic drugs

2.33 (0.79, 6.86)

0.124

1.09 (0.16, 7.64)

0.928

 Anticoagulants

1.88 (0.85, 4.14)

0.118

6.11 (1.69, 22.07)

0.006

 Antidepressants

2.37 (0.95, 5.89)

0.063

11.05 (2.50, 48.82)

0.002

 Anxiolytics

0.75 (0.30, 1.90)

0.545

0.26 (0.06, 1.17)

0.078