Table 4 Relationship between change in LV mass/LVmass:volume ratio and strain rates and change in sphingolipids and ceramides at 12-weeks post MRP

Δ Candidate Biomarker

Δ LV mass

Δ LongPEDSR

Δ CircPEDSR

Δ MPR

Δ E/e’

Sphingomyelin species

 Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))

9.65 (-17.17, 36.46)

0.481

-0.04 (-0.39, 0.31)

0.820

 Sphingomyelin (d18:2/16:0, d18:1/16:1)

4.43(-30.90, 39.74)

0.806

-0.31 (-0.56, -0.07)

0.013*

-0.26 (-0.70, 0.19)

0.260

 Sphingomyelin (d18:2/24:1, d18:1/24:2)

7.51(-28.00, 43.02)

0.678

-0.23 (-0.49, 0.04)

0.098

-0.10 (-0.56, 0.36)

0.672

 Sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)

-7.25 (-29.94, 15.45)

0.531

-0.16 (-0.33, 0.00)

0.056

-0.20 (-0.48, 0.08)

0.164

 Sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)

-7.01 (-24.08, 10.07)

0.421

-0.11 (-0.33, 0.11)

0.326

 Sphingomyelin (d18:2/18:1)

-8.04(-30.59, 14.52)

0.485

 Sphingomyelin (d18:2/23:1)

-2.55(-27.39, 22.29)

0.841

0.70 (-0.25, 0.39)

0.669

 Sphingomyelin (d18:2/24:2)

-4.33(-26.50, 17.85)

0.702

-0.17 (-0.33, -0.01)

0.037*

-0.16 (-0.44, 0.12)

0.275

Ceramide species

 Glycosyl Ceramide (d18:2/24:1, d18:1/24:2)

-3.71 (-21.62, 14.19)

0.685

-0.12 (-0.25, 0.01)

0.081

0.15 (-0.07, 0.37)

0.189

 Glycosyl-N-nervonoyl-sphingosine (d18:1/24:1)

2.30 (-19.79, 24.39)

0.838

 Lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)

4.05(-19.96, 28.06)

0.741

 Lactosyl-N-palmitoyl-sphingosine (d18:1/16:0)

2.42(-27.84, 32.68)

0.876

0.06 (-0.01, 0.13)

0.068

0.01 (-0.01, 0.03)

0.202