Table 2 List of 23 lipid candidate biomarkers with significant fold-change > 1.5 following the 12-week MRP
No | BIOCHEMICAL | COMP ID | Sub-family | Fold Change | Direction Δ from BL | Adjusted P value (FDR = 0.05) |
|---|---|---|---|---|---|---|
1 | nisinate (24:6n3) | 57810 | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | -2.08 | ↓ | 0.005 |
2 | 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) | 52682 | Plasmalogen | 0.81 | ↑ | 0.002 |
3 | 1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1) | 52478 | Plasmalogen | 0.71 | ↑ | < 0.001 |
4 | 1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1) | 52713 | Plasmalogen | 0.77 | ↑ | < 0.001 |
5 | 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0) | 52716 | Plasmalogen | 0.80 | ↑ | 0.003 |
6 | 1-(1-enyl-palmitoyl)-GPC (P-16:0) | 52474 | Lysoplasmalogen | 0.64 | ↑ | 0.004 |
7 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | 19263 | Phosphatidylethanolamine (PE) | -1.55 | ↓ | 0.003 |
8 | 1-stearoyl-2-oleoyl-GPE (18:0/18:1) | 42448 | Phosphatidylethanolamine (PE) | -1.88 | ↓ | 0.001 |
9 | butyrylcarnitine (C4) | 32412 | Fatty Acid Metabolism | -1.39 | ↓ | 0.005 |
10 | dihomo-linoleoylcarnitine (C20:2) | 57520 | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 0.72 | ↑ | 0.003 |
11 | eicosenoylcarnitine (C20:1) | 57519 | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 0.69 | ↑ | 0.002 |
12 | hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH)) | 62851 | Sphingomyelins | 0.85 | ↑ | 0.004 |
13 | sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2) | 57481 | Sphingomyelins | 0.70 | ↑ | 0.001 |
14 | sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2) | 57477 | Sphingomyelins | 0.80 | ↑ | 0.002 |
15 | sphingomyelin (d18:2/16:0, d18:1/16:1) | 42459 | Sphingomyelins | 0.89 | ↑ | 0.004 |
16 | sphingomyelin (d18:2/18:1) | 57474 | Sphingomyelins | 0.83 | ↑ | 0.004 |
17 | sphingomyelin (d18:2/23:1) | 57482 | Sphingomyelins | 0.85 | ↑ | 0.007 |
18 | sphingomyelin (d18:2/24:1, d18:1/24:2) | 52437 | Sphingomyelins | 0.80 | ↑ | < 0.001 |
19 | sphingomyelin (d18:2/24:2) | 57479 | Sphingomyelins | 0.73 | ↑ | < 0.001 |
20 | glycosyl ceramide (d18:2/24:1, d18:1/24:2) | 57453 | Hexosylceramides (HCER) | 0.71 | ↑ | 0.001 |
21 | glycosyl-N-nervonoyl-sphingosine (d18:1/24:1) | 57369 | Hexosylceramides (HCER) | 0.72 | ↑ | < 0.001 |
22 | lactosyl-N-nervonoyl-sphingosine (d18:1/24:1) | 57370 | Lactosylceramides (LCER) | 0.76 | ↑ | 0.001 |
23 | lactosyl-N-palmitoyl-sphingosine (d18:1/16:0) | 53010 | Lactosylceramides (LCER) | 0.76 | ↑ | < 0.001 |