Skip to main content
Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways

Fig. 5

Nrf2 mediates the protective effects of Allicin on LPS-induced injury and NLRP3 inhibition. H9c2 cells were transfected with Nrf2 siRNA, and the silencing efficiency was verified by western blot at 48 h after transfection (A, B). (C) Cell viability of H9c2 cells with Nrf2 silencing. (D) Representative western blot images of HO-1 and NLRP3. (E-F) Quantitative results show that Allicin increased HO-1 protein and decreased NLRP3 protein, which was reversed by silencing of Nrf2 (siNrf2). ***P < 0.001 vs. control group; ###P < 0.001 vs. LPS group; $$$P < 0.001 vs. Allicin group

Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us