Table 3 Difference of clinical and genetic factors between patients with INR > 4 or without INR > 4

Age, y

48.57 ± 10.10

45.65 ± 10.33

0.001

 Age ≥ 50y

89 (38.86%)

109 (27.25%)

0.003

 Age < 50y

140 (61.14%)

291(72.75%)

High, cm

159.04 ± 7.49

161.20 ± 7.82

0.001

Weight, kg

56.74 ± 10.12

57.92 ± 9.78

0.82

BMI

22.37 ± 3.33

22.21 ± 2.99

0.27

Sexual, F/M

155 (67.68%)/74 (32.32%)

230 (57.50%)/170 (42.50%)

0.014

Pausimenia

47 (30.32%)

93 (40.43%)

0.052

Smoking habit

21 (9.17%)

46 (11.5%)

0.42

Drinking history

10 (4.37%)

26 (6.50%)

0.29

MHVR

203 (88.65%)

353 (88.25%)

1.00

BHVR

26 (11.35%)

47 (11.75%)

AVR, (n = 306)

101 (44.10%)

205 (51.25%)

0.24

MVR, (n = 521)

208 (40.00%)

313 (60.00%)

4.15E-5

TVR, (n = 33)

17 (51.51%)

16 (48.49%)

0.76

Hypertension

19 (8.30%)

39 (9.95%)

0.57

CHD

5 (2.18%)

14 (3.5%)

0.47

T2D

9 (3.93%)

4 (1.0%)

0.018

AF before surgery

104 (45.41%)

164 (41.0%)

0.31

Stroke history

15 (6.55%)

13 (3.25%)

0.069

MAZE

32 (13.97%)

67 (16.75%)

0.43

AF after surgery

72 (31.44%)

97 (24.25%)

0.061

Infectious endocarditis

9 (3.93%)

30 (7.5%)

0.086

Digestive tract disease

6 (2.62%)

8 (2.0%)

0.59

Gallbladder disorders

8 (3.49%)

13 (3.25%)

1.00

Hepatitis

4 (1.75%)

13 (3.25%)

0.32

Hyperthyroidism

11 (4.80%)

5 (1.25%)

0.015

Drug increase INR

13 (5.24%)

8 (2.25%)

2.09E-4

VKORC1

0.037

 AA

199 (86.90%)

321 (80.25%)

 AG + GG

30 (13.10%)

79 (19.75%)

CYP2C9

0.005

 *1*1

199 (86.90%)

375 (93.75%)

 *1*3

30 (13.1%)

25 (6.25%)