| Case 1 | Case 2 | Case 3 |
---|---|---|---|
Patients’ characteristics | |||
 Age and sex | 79 yo male | 73 yo female | 78 yo female |
 Clinical diagnosis | Severe AS Atrial fibrillation LV dysfunction Functional MR | Transient ischemic attack LA mobile mass | AS LVOT obstruction |
 History of carpal tunnel syndrome or lumber canal stenosis | No | No | No |
 Surgical interventions | Aortic valve replacement Mitral valve plasty Cryo-Maze LA appendage resection | LA mass and partial LA wall resection | Aortic valve replacement Subaortic septal myectomy |
Amyloid deposition and types | |||
 Left atrium / left atrial appendage | AANP + ATTR | AANP + ATTR | n/a |
 Aortic valve | ATTR | n/a | ATTR |
 Ventricles | Unlikely by PYP scintigraphy and CMR | Unlikely by PYP scintigraphy and CMR | Non-significant (ATTR limited to vessel walls of both ventricles) |
Post surgical course | |||
 | • Normalized ejection fraction and significantly decreased BNP at 6 months • Uneventful for 24 months with no echocardiogram findings suggesting ventricular cardiac amyloidosis | • Normal ventricular function • Uneventful for 24 months, with normal troponin and no echocardiogram findings suggesting ventricular cardiac amyloidosis | • No heart failure events and no echocardiogram findings suggesting ventricular cardiac amyloidosis for 5 years |