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Table 4 Associations between NPAR, NLR, PLR, and all-cause mortality in patients with HF by obese and DM status

From: Association between neutrophil percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and long-term mortality in community-dwelling adults with heart failure: evidence from US NHANES 2005–2016

 

Univariate

 

Multivariable

Subgroup

AUC (95%CI)

Crude HR (95%CI)

P value

 

Adjusted HR (95%CI)

P value

Obese (BMI ≥ 30)

      

NPAR

0.65 (0.61,0.69)

1.17 (1.12, 1.21)

< 0.001

 

1.14 (1.08, 1.19)

< 0.001

NLR

0.66 (0.62,0.7)

1.29 (1.22, 1.36)

< 0.001

 

1.31 (1.20, 1.43)

< 0.001

PLR

0.61 (0.57,0.66)

1.00 (1.00, 1.01)

< 0.001

 

1.00 (1.00, 1.01)

< 0.001

Non-obese (BMI < 30)

      

NPAR

0.59 (0.55,0.64)

1.1 (1.06, 1.14)

< 0.001

 

1.04 (1.00, 1.09)

0.062

NLR

0.61 (0.56,0.66)

1.06 (1.03, 1.09)

< 0.001

 

1.01 (0.97, 1.06)

0.6

PLR

0.52 (0.48,0.57)

1.00 (1.00, 1.00)

0.205

 

1.00 (1.00, 1.00)

0.3

DM

      

NPAR

0.63 (0.58,0.68)

1.14 (1.10, 1.19)

< 0.001

 

1.15 (1.09, 1.20)

< 0.001

NLR

0.65 (0.6,0.7)

1.22 (1.15, 1.28)

< 0.001

 

1.28 (1.18, 1.38)

< 0.001

PLR

0.60 (0.55,0.65)

1.00 (1.00, 1.00)

< 0.001

 

1.00 (1.00, 1.01)

0.003

Non-DM

      

NPAR

0.60 (0.56,0.65)

1.1 (1.06, 1.14)

< 0.001

 

1.04 (0.99, 1.08)

0.093

NLR

0.62 (0.58,0.67)

1.07 (1.04, 1.11)

< 0.001

 

1.01 (0.96, 1.06)

0.7

PLR

0.56 (0.52,0.6)

1.00 (1.00, 1.00)

0.025

 

1.00 (1.00, 1.00)

0.6

  1. Multivariable analyses were adjusted for age (in years), gender, race, BMI (category), DM, CKD, COPD, history of MI, sleep disorder, and diuretics usage. Bold P values indicate significance
  2. Abbreviations: HR, hazard ratio; AUC, the area under the ROC curve; CI, confidence interval; NPAR, neutrophil percentage-to-albumin ratio; PLR, platelet-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; BMI, body mass index; DM, diabetes mellitus