Table 1 Inclusion and exclusion criteria PRO-FIT

Inclusion criteria:

 1. Diagnosis of SAP with residual anginal symptoms after OMT

 2. Established ischemia assessed by SPECT, PET, Stress echo, CMR, or cycle ergometry

 3. Access to a personal computer, laptop or tablet with Internet connectivity at home

 4. Possession of a mobile phone with short message service (SMS) functionality

Exclusion criteria:

 1. PCI or CABG in the past year

 2. Acute coronary syndrome in past 2 months

 3. Angina symptoms at rest or rapidly progressive (i.e. unstable angina)

 4. Ischemic threshold < 50 watts

 5. Left ventricular ejection fraction < 35%

 6. New-York Heart Association class III-IV heart failure symptoms

 7. Advanced chronic kidney failure (i.e. estimated Glomerular Filtration rate < 30 ml/min)

 8. Severe ventricular arrhythmia or exercise-induced arrythmia at baseline testing

 9. A comorbidity precluding exercise training (e.g. orthopaedic, neurological or cognitive conditions) or other contra-indications for exercise training

 10. Possible stenosis > 50% of the left main coronary artery on coronary CT of coronary angiography